{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:52:16Z","timestamp":1791453136397,"version":"4.3.3"},"reference-count":165,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Since the first description of COVID-19 infection, among clinical manifestations of the disease, including fever, dyspnea, cough, and fatigue, it was observed a high incidence of thromboembolic events potentially evolving towards acute respiratory distress syndrome (ARDS) and COVID-19-associated-coagulopathy (CAC). The hypercoagulation state is based on an interaction between thrombosis and inflammation. The so-called CAC represents a key aspect in the genesis of organ damage from SARS-CoV-2. The prothrombotic status of COVID-19 can be explained by the increase in coagulation levels of D-dimer, lymphocytes, fibrinogen, interleukin 6 (IL-6), and prothrombin time. Several mechanisms have been hypothesized to explain this hypercoagulable process such as inflammatory cytokine storm, platelet activation, endothelial dysfunction, and stasis for a long time. The purpose of this narrative review is to provide an overview of the current knowledge on the pathogenic mechanisms of coagulopathy that may characterize COVID-19 infection and inform on new areas of research. New vascular therapeutic strategies are also reviewed.<\/jats:p>","DOI":"10.3390\/ijms24108945","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T08:09:44Z","timestamp":1684397384000},"page":"8945","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Interrelationship between COVID-19 and Coagulopathy: Pathophysiological and Clinical Evidence"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5969-8501","authenticated-orcid":false,"given":"Beatrice","family":"Ragnoli","sequence":"first","affiliation":[{"name":"Respiratory Unit, Sant\u2019Andrea Hospital, 13100 Vercelli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Da Re","sequence":"additional","affiliation":[{"name":"Respiratory Unit, Sant\u2019Andrea Hospital, 13100 Vercelli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Galantino","sequence":"additional","affiliation":[{"name":"Respiratory Unit, Sant\u2019Andrea Hospital, 13100 Vercelli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Kette","sequence":"additional","affiliation":[{"name":"Respiratory Unit, Sant\u2019Andrea Hospital, 13100 Vercelli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Salotti","sequence":"additional","affiliation":[{"name":"Respiratory Unit, Sant\u2019Andrea Hospital, 13100 Vercelli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1246-4892","authenticated-orcid":false,"given":"Mario","family":"Malerba","sequence":"additional","affiliation":[{"name":"Respiratory Unit, Sant\u2019Andrea Hospital, 13100 Vercelli, Italy"},{"name":"Department of Traslational Medicine, University of Eastern Piedmont (UPO), 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"key":"ref_1","first-page":"e2020157","article-title":"Supporting healthcare workers on front lines of the COVID-19 fight","volume":"91","author":"Malerba","year":"2020","journal-title":"Acta Biomed. 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