{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:37:49Z","timestamp":1792571869628,"version":"4.5.0"},"reference-count":71,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>REV-ERB receptors are members of the nuclear receptor superfamily of proteins, which act as both intracellular receptors and transcription factors, therefore modulating the expression of target genes. REV-ERBs act as transcription repressors because of their unique structure. Their predominant role involves the control of peripheral circadian rhythmicity by participating in a transcription\u2013translation feedback loop with other major clock genes. Regarding their role in cancer pathogenesis, recent studies in various cancerous tissues have revealed that their expression was downregulated in the majority of the cases. Dysregulation of their expression was also implicated in cancer-associated cachexia. The pharmacological restoration of their effects is feasible with synthetic agonists, which have been explored in preclinical studies but with scarce data. There is a need for further investigation, primarily with mechanistic studies, on the effect of the REV-ERB-induced circadian rhythm deregulation in carcinogenesis and cancer-related systemic effects, such as cachexia, in order to address the potential of relevant therapeutic implications.<\/jats:p>","DOI":"10.3390\/ijms24108980","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T01:26:41Z","timestamp":1684459601000},"page":"8980","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Role of REV-ERB Receptors in Cancer Pathogenesis"],"prefix":"10.3390","volume":"24","author":[{"given":"Georgia","family":"Gomatou","sequence":"first","affiliation":[{"name":"Oncology Unit, Third Department of Medicine, \u201cSotiria\u201d General Hospital for Diseases of the Chest, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Karachaliou","sequence":"additional","affiliation":[{"name":"Oncology Unit, Third Department of Medicine, \u201cSotiria\u201d General Hospital for Diseases of the Chest, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0032-9081","authenticated-orcid":false,"given":"Orsalia-Zoi","family":"Veloudiou","sequence":"additional","affiliation":[{"name":"Oncology Unit, Third Department of Medicine, \u201cSotiria\u201d General Hospital for Diseases of the Chest, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Karvela","sequence":"additional","affiliation":[{"name":"Oncology Unit, Third Department of Medicine, \u201cSotiria\u201d General Hospital for Diseases of the Chest, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8082-594X","authenticated-orcid":false,"given":"Nikolaos","family":"Syrigos","sequence":"additional","affiliation":[{"name":"Oncology Unit, Third Department of Medicine, \u201cSotiria\u201d General Hospital for Diseases of the Chest, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2563-0968","authenticated-orcid":false,"given":"Elias","family":"Kotteas","sequence":"additional","affiliation":[{"name":"Oncology Unit, Third Department of Medicine, \u201cSotiria\u201d General Hospital for Diseases of the Chest, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1210\/me.2007-0519","article-title":"Nuclear hormone receptors for heme: REV-ERBalpha and REV-ERBbeta are ligand-regulated components of the mammalian clock","volume":"22","author":"Burris","year":"2008","journal-title":"Mol. 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