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Due to the high number of patients and expensive treatments, according to the Federal Statistical Office (2017) in Germany, cardiovascular diseases account for around 15% of total health costs. Advanced coronary artery disease is mainly the result of chronic disorders such as high blood pressure, diabetes, and dyslipidemia. In the modern obesogenic environment, many people are at greater risk of being overweight or obese. The hemodynamic load on the heart is influenced by extreme obesity, which often leads to myocardial infarction (MI), cardiac arrhythmias, and heart failure. In addition, obesity leads to a chronic inflammatory state and negatively affects the wound-healing process. It has been known for many years that lifestyle interventions such as exercise, healthy nutrition, and smoking cessation drastically reduce cardiovascular risk and have a preventive effect against disorders in the healing process. However, little is known about the underlying mechanisms, and there is significantly less high-quality evidence compared to pharmacological intervention studies. Due to the immense potential of prevention in heart research, the cardiologic societies are calling for research work to be intensified, from basic understanding to clinical application. The topicality and high relevance of this research area are also evident from the fact that in March 2018, a one-week conference on this topic with contributions from top international scientists took place as part of the renowned \u201cKeystone Symposia\u201d (\u201cNew Insights into the Biology of Exercise\u201d). Consistent with the link between obesity, exercise, and cardiovascular disease, this review attempts to draw lessons from stem-cell transplantation and preventive exercise. The application of state-of-the-art techniques for transcriptome analysis has opened new avenues for tailoring targeted interventions to very individual risk factors.<\/jats:p>","DOI":"10.3390\/ijms24109017","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T10:35:11Z","timestamp":1684492511000},"page":"9017","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["New Approaches in Heart Research: Prevention Instead of Cardiomyoplasty?"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7161-3459","authenticated-orcid":false,"given":"Ralf","family":"Gaebel","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Rostock University Medical Center, 18057 Rostock, Germany"},{"name":"Department of Life, Light & Matter, Interdisciplinary Faculty, Rostock University, 18059 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cajetan","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Rostock University Medical Center, 18057 Rostock, Germany"},{"name":"Department of Life, Light & Matter, Interdisciplinary Faculty, Rostock University, 18059 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praveen","family":"Vasudevan","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Rostock University Medical Center, 18057 Rostock, Germany"},{"name":"Department of Life, Light & Matter, Interdisciplinary Faculty, Rostock University, 18059 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa","family":"L\u00fchrs","sequence":"additional","affiliation":[{"name":"Advanced Therapy and Cellular Biotechnology in Regenerative Medicine Department, Pel\u00e9 Pequeno Pr\u03afncipe Research Institute & Pequeno Pr\u03afncipe Faculties, Ave. Silva Jardim, P.O. Box 80240-020, Curitiba 1632, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4860-2855","authenticated-orcid":false,"given":"Katherine Athayde Teixeira","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Advanced Therapy and Cellular Biotechnology in Regenerative Medicine Department, Pel\u00e9 Pequeno Pr\u03afncipe Research Institute & Pequeno Pr\u03afncipe Faculties, Ave. Silva Jardim, P.O. Box 80240-020, Curitiba 1632, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eltyeb","family":"Abdelwahid","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine, Feinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL 60611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"David","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Rostock University Medical Center, 18057 Rostock, Germany"},{"name":"Department of Life, Light & Matter, Interdisciplinary Faculty, Rostock University, 18059 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"ref_1","unstructured":"Herold, G. (2007). 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