{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:37:49Z","timestamp":1791297469766,"version":"4.1.0"},"reference-count":46,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T00:00:00Z","timestamp":1684540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"JSPS","doi-asserted-by":"publisher","award":["19J14665"],"award-info":[{"award-number":["19J14665"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS","doi-asserted-by":"publisher","award":["18K05656"],"award-info":[{"award-number":["18K05656"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS KAKENHI","doi-asserted-by":"publisher","award":["19J14665"],"award-info":[{"award-number":["19J14665"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS KAKENHI","doi-asserted-by":"publisher","award":["18K05656"],"award-info":[{"award-number":["18K05656"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Systemic acquired resistance (SAR) is a potent innate immunity system in plants that is induced through the salicylic acid (SA)-mediated signaling pathway. Here, we characterized 3-chloro-1-methyl-1H-pyrazole-5-carboxylic acid (CMPA) as an effective SAR inducer in Arabidopsis. The soil drench application of CMPA enhanced a broad range of disease resistance against the bacterial pathogen Pseudomonas syringae and fungal pathogens Colletotrichum higginsianum and Botrytis cinerea in Arabidopsis, whereas CMPA did not show antibacterial activity. Foliar spraying with CMPA induced the expression of SA-responsible genes such as PR1, PR2 and PR5. The effects of CMPA on resistance against the bacterial pathogen and the expression of PR genes were observed in the SA biosynthesis mutant, however, while they were not observed in the SA-receptor-deficient npr1 mutant. Thus, these findings indicate that CMPA induces SAR by triggering the downstream signaling of SA biosynthesis in the SA-mediated signaling pathway.<\/jats:p>","DOI":"10.3390\/ijms24109037","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T03:57:32Z","timestamp":1684727852000},"page":"9037","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Characterization of Disease Resistance Induced by a Pyrazolecarboxylic Acid Derivative in Arabidopsis thaliana"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2397-9621","authenticated-orcid":false,"given":"Michiko","family":"Yasuda","sequence":"first","affiliation":[{"name":"Plant Acquired Immunity Research Unit, RIKEN Advanced Science Institute, Wako 351-0198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moeka","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, Fukui Prefectural University, Fukui 910-1195, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khamsalath","family":"Soudthedlath","sequence":"additional","affiliation":[{"name":"Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 819-0395, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4151-6698","authenticated-orcid":false,"given":"Miyuki","family":"Kusajima","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5398-1867","authenticated-orcid":false,"given":"Hideki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural Science, Tohoku University, Sendai 980-8572, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, Fukui Prefectural University, Fukui 910-1195, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Futo","family":"Narita","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, Fukui Prefectural University, Fukui 910-1195, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadao","family":"Asami","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3240-2843","authenticated-orcid":false,"given":"Akiko","family":"Maruyama-Nakashita","sequence":"additional","affiliation":[{"name":"Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 819-0395, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Nakashita","sequence":"additional","affiliation":[{"name":"Plant Acquired Immunity Research Unit, RIKEN Advanced Science Institute, Wako 351-0198, Japan"},{"name":"Department of Bioscience and Biotechnology, Fukui Prefectural University, Fukui 910-1195, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1086\/394440","article-title":"The problem of acquired physiological immunity in plants","volume":"8","author":"Chester","year":"1933","journal-title":"Q. 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