{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T19:28:56Z","timestamp":1776626936608,"version":"3.51.2"},"reference-count":100,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Although radiation therapy plays a crucial role in cancer treatment, and techniques have improved continuously, irradiation induces side effects in healthy tissue. Radiation cystitis is a potential complication following the therapeutic irradiation of pelvic cancers and negatively impacts patients\u2019 quality of life (QoL). To date, no effective treatment is available, and this toxicity remains a therapeutic challenge. In recent times, stem cell-based therapy, particularly the use of mesenchymal stem cells (MSC), has gained attention in tissue repair and regeneration due to their easy accessibility and their ability to differentiate into several tissue types, modulate the immune system and secrete substances that help nearby cells grow and heal. In this review, we will summarize the pathophysiological mechanisms of radiation-induced injury to normal tissues, including radiation cystitis (RC). We will then discuss the therapeutic potential and limitations of MSCs and their derivatives, including packaged conditioned media and extracellular vesicles, in the management of radiotoxicity and RC.<\/jats:p>","DOI":"10.3390\/ijms24109068","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T03:57:32Z","timestamp":1684727852000},"page":"9068","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Revolutionizing Radiotoxicity Management with Mesenchymal Stem Cells and Their Derivatives: A Focus on Radiation-Induced Cystitis"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7774-349X","authenticated-orcid":false,"given":"Carole","family":"Helissey","sequence":"first","affiliation":[{"name":"Clinical Unit Research, HIA B\u00e9gin, 69 Avenu de Paris, 94160 Saint-Mand\u00e9, France"},{"name":"Department of Radiation Biological Effects, French Armed Forces Biomedical Research Institute, Place G\u00e9n\u00e9ral Val\u00e9rie Andr\u00e9, 91220 Br\u00e9tigny-sur-Orge, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6581-3369","authenticated-orcid":false,"given":"Sophie","family":"Cavallero","sequence":"additional","affiliation":[{"name":"Department of Radiation Biological Effects, French Armed Forces Biomedical Research Institute, Place G\u00e9n\u00e9ral Val\u00e9rie Andr\u00e9, 91220 Br\u00e9tigny-sur-Orge, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Guitard","sequence":"additional","affiliation":[{"name":"Department of Radiation Biological Effects, French Armed Forces Biomedical Research Institute, Place G\u00e9n\u00e9ral Val\u00e9rie Andr\u00e9, 91220 Br\u00e9tigny-sur-Orge, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Th\u00e9ry","sequence":"additional","affiliation":[{"name":"Department of Radiation Biological Effects, French Armed Forces Biomedical Research Institute, Place G\u00e9n\u00e9ral Val\u00e9rie Andr\u00e9, 91220 Br\u00e9tigny-sur-Orge, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyrus","family":"Chargari","sequence":"additional","affiliation":[{"name":"Department of Radiation Biological Effects, French Armed Forces Biomedical Research Institute, Place G\u00e9n\u00e9ral Val\u00e9rie Andr\u00e9, 91220 Br\u00e9tigny-sur-Orge, France"},{"name":"Department of Radiation Oncology, Piti\u00e9 Salp\u00eatri\u00e8re University Hospital, 47-83 Bd de l\u2019H\u00f4pital, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Fran\u00e7ois","sequence":"additional","affiliation":[{"name":"Department of Radiation Biological Effects, French Armed Forces Biomedical Research Institute, Place G\u00e9n\u00e9ral Val\u00e9rie Andr\u00e9, 91220 Br\u00e9tigny-sur-Orge, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"811044","DOI":"10.3389\/fpubh.2022.811044","article-title":"Prostate Cancer Incidence and Mortality: Global Status and Temporal Trends in 89 Countries From 2000 to 2019","volume":"10","author":"Wang","year":"2022","journal-title":"Front. 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