{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:25:53Z","timestamp":1793363153796,"version":"4.5.0"},"reference-count":58,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sepsis is a time-dependent and life-threating condition related to macro- and micro-circulatory impairment leading to anaerobic metabolism and lactate increase. We assessed the prognostic accuracy of capillary lactates (CLs) vs. serum ones (SLs) on 48-h and 7-day mortality in patients with suspected sepsis. This observational, prospective, single-centre study was conducted between October 2021 and May 2022. Inclusion criteria were: (i) suspect of infection; (ii) qSOFA \u2265 2; (iii) age \u2265 18 years; (iv) signed informed consent. CLs were assessed with LactateProTM2\u00ae. 203 patients were included: 19 (9.3%) died within 48 h from admission to the Emergency Department, while 28 (13.8%) within 7 days. Patients deceased within 48 h (vs. survived) had higher CLs (19.3 vs. 5 mmol\/L, p &lt; 0.001) and SLs (6.5 vs. 1.1 mmol\/L, p = 0.001). The best CLs predictive cut-off for 48-h mortality was 16.8 mmol\/L (72.22% sensitivity, 94.02% specificity). Patients within 7 days had higher CLs (11.5 vs. 5 mmol\/L, p = 0.020) than SLs (2.75 vs. 1.1 mmol\/L, p &lt; 0.001). The multivariate analysis confirmed CLs and SLs as independent predictors of 48-h and 7-day mortality. CLs can be a reliable tool for their inexpensiveness, rapidity and reliability in identifying septic patients at high risk of short-term mortality.<\/jats:p>","DOI":"10.3390\/ijms24119121","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T08:14:28Z","timestamp":1684829668000},"page":"9121","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparison between Capillary and Serum Lactate Levels in Predicting Short-Term Mortality of Septic Patients at the Emergency Department"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5841-8555","authenticated-orcid":false,"given":"Matteo","family":"Guarino","sequence":"first","affiliation":[{"name":"Department of Translational Medicine, St. Anna University Hospital of Ferrara, University of Ferrara, 44124 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4365-2968","authenticated-orcid":false,"given":"Benedetta","family":"Perna","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, St. Anna University Hospital of Ferrara, University of Ferrara, 44124 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice Eleonora","family":"Cesaro","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, St. Anna University Hospital of Ferrara, University of Ferrara, 44124 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2285-327X","authenticated-orcid":false,"given":"Michele Domenico","family":"Spampinato","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, St. Anna University Hospital of Ferrara, University of Ferrara, 44124 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Previati","sequence":"additional","affiliation":[{"name":"Emergency Department, St. Anna University Hospital of Ferrara, 44124 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8644-1135","authenticated-orcid":false,"given":"Anna","family":"Costanzini","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, St. Anna University Hospital of Ferrara, University of Ferrara, 44124 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Maritati","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Infectious and Dermatology Diseases, St. Anna University Hospital of Ferrara, University of Ferrara, 44124 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8809-6470","authenticated-orcid":false,"given":"Carlo","family":"Contini","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Infectious and Dermatology Diseases, St. Anna University Hospital of Ferrara, University of Ferrara, 44124 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0867-5873","authenticated-orcid":false,"given":"Roberto","family":"De Giorgio","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, St. Anna University Hospital of Ferrara, University of Ferrara, 44124 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving sepsis campaign: International guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans","year":"2021","journal-title":"Intensive Care Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/ACO.0000000000000958","article-title":"Epidemiology of sepsis and septic shock","volume":"34","author":"Chiu","year":"2021","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"ref_4","unstructured":"(2020). Global Report on the Epidemiology and Burden of Sepsis: Current Evidence, Identifying Gaps and Future Directions, World Health Organization."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.mcna.2020.02.011","article-title":"Sepsis and Septic Shock\u2014Basics of diagnosis, pathophysiology and clinical decision making","volume":"104","author":"Font","year":"2020","journal-title":"Med. Clin. N. Am."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1177\/0885066607301444","article-title":"Plasma endothelin-1 levels in septic patients","volume":"22","author":"Piechota","year":"2007","journal-title":"J. Intensive Care Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1056\/NEJMra1208623","article-title":"Severe sepsis and septic shock","volume":"369","author":"Angus","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ccc.2019.08.009","article-title":"Lactate: Where Are We Now?","volume":"36","author":"Bakker","year":"2020","journal-title":"Crit. Care Clin."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1056\/NEJMra1208943","article-title":"Circulatory shock","volume":"369","author":"Vincent","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/01.ccx.0000235208.77450.15","article-title":"Lactate and shock state: The metabolic view","volume":"12","author":"Levy","year":"2006","journal-title":"Curr. Opin. Crit. Care."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13049-019-0609-3","article-title":"Prognostic accuracy of the serum lactate level, the SOFA score and the qSOFA score for mortality among adults with Sepsis","volume":"27","author":"Liu","year":"2019","journal-title":"Scand. J. Trauma Resusc. Emerg. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/s13054-014-0503-3","article-title":"Sepsis-associated hyperlactatemia","volume":"18","author":"Marik","year":"2014","journal-title":"Crit. Care"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1007\/s11739-019-02196-z","article-title":"Prognostic value of serial lactate levels in septic patients with and without shock","volume":"14","author":"Innocenti","year":"2019","journal-title":"Intern. Emerg. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e011450","DOI":"10.1136\/bmjopen-2016-011450","article-title":"Prognostic value of plasma lactate levels in a retrospective cohort presenting at a university hospital emergency department","volume":"7","author":"Brouwers","year":"2017","journal-title":"BMJ Open"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s15010-022-01768-0","article-title":"A 2-year retrospective analysis of the prognostic value of MqSOFA compared to lactate, NEWS and qSOFA in patients with sepsis","volume":"50","author":"Guarino","year":"2022","journal-title":"Infection"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","article-title":"Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016","volume":"43","author":"Rhodes","year":"2017","journal-title":"Intensive Care Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e14453","DOI":"10.1097\/MD.0000000000014453","article-title":"Relative efficacy and safety of early lactate clearance-guided therapy resuscitation in patients with sepsis: A meta-analysis","volume":"98","author":"Pan","year":"2019","journal-title":"Medicine"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1177\/0885066616663169","article-title":"The Correlation Between Arterial Lactate and Venous Lactate in Patients With Sepsis and Septic Shock","volume":"33","author":"Theerawit","year":"2018","journal-title":"J. Intensive Care Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jcrc.2019.05.019","article-title":"Arterial vs venous lactate: Correlation and predictive value of mortality of patients with sepsis during early resuscitation phase","volume":"58","author":"Mahmoodpoor","year":"2020","journal-title":"J. Crit. Care"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ccc.2019.12.007","article-title":"Endothelial Glycocalyx","volume":"36","author":"Jedlicka","year":"2020","journal-title":"Crit. Care Clin."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"94","DOI":"10.5152\/TJAR.2021.21224","article-title":"The Glycocalyx Shedding Influences Hemodynamic and Metabolic Response to Fluid Load in Septic Shock","volume":"50","author":"Ilyina","year":"2022","journal-title":"Turk. J. Anaesthesiol. Reanim."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1164\/rccm.201910-1911TR","article-title":"Endothelial Responses in Sepsis","volume":"202","author":"Joffre","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.annemergmed.2019.06.027","article-title":"Demystifying Lactate in the Emergency Department","volume":"75","author":"Wardi","year":"2020","journal-title":"Ann. Emerg. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1177\/0885066620982585","article-title":"Macrocirculatory and Microcirculatory Endpoints in Sepsis Resuscitation","volume":"36","author":"Mok","year":"2021","journal-title":"J. Intensive Care Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/ACO.0000000000000957","article-title":"Septic shock: A microcirculation disease","volume":"34","author":"Ricottilli","year":"2021","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s00134-021-06595-9","article-title":"Current practice and evolving concepts in septic shock resuscitation","volume":"48","author":"Bakker","year":"2022","journal-title":"Intensive Care Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13049-020-00776-z","article-title":"Validation of a point-of-care capillary lactate measuring device (Lactate Pro 2)","volume":"28","author":"Raa","year":"2020","journal-title":"Scand. J. Trauma Resusc. Emerg. Med."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Viana, M.V., Pantet, O., Bagnoud, G., Martinez, A., Favre, E., Charri\u00e8re, M., Favre, D., Eckert, P., and Berger, M.M. (2019). Metabolic and Nutritional Characteristics of Long-Stay Critically Ill Patients. J. Clin. Med., 8.","DOI":"10.3390\/jcm8070985"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"58","DOI":"10.5811\/westjem.2011.5.6706","article-title":"Accuracy of Handheld Point-of-Care Fingertip Lactate Measurement in the Emergency Department","volume":"14","author":"Gaieski","year":"2013","journal-title":"West J. Emerg. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13613-019-0511-1","article-title":"Narrative review: Clinical assessment of peripheral tissue perfusion in septic shock","volume":"9","author":"Hariri","year":"2019","journal-title":"Ann. Intensive Care"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.accpm.2016.08.007","article-title":"Comparison of capillary and arterial lactate levels in patients with shock","volume":"36","author":"Collange","year":"2017","journal-title":"Anaesth. Crit. Care Pain Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e026109","DOI":"10.1136\/bmjopen-2018-026109","article-title":"Agreement between capillary and venous lactate in emergency department patients: Prospective observational study","volume":"9","author":"Leung","year":"2019","journal-title":"BMJ Open"},{"key":"ref_33","first-page":"74","article-title":"Brief report: Serial capillary lactate measurement predict the evolution of early sepsis","volume":"9","author":"Purcarea","year":"2016","journal-title":"J. Med. Life"},{"key":"ref_34","first-page":"S175","article-title":"Correlation of arterial, central venous and capillary lactate levels in septic shock patients","volume":"94","author":"Pattharanitima","year":"2011","journal-title":"J. Med. Assoc. Thai."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.clinbiochem.2018.03.006","article-title":"Lactate POCT in mobile intensive care units for septic patients? A comparison of capillary blood method versus venous blood and plasma-based reference methods","volume":"55","author":"Jouffroy","year":"2018","journal-title":"Clin. Biochem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/ACO.0000000000001098","article-title":"Sepsis and the microcirculation: The impact on outcomes","volume":"35","author":"Yajnik","year":"2022","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"ref_37","first-page":"e13779","article-title":"Can capillary lactate improve early warning scores in emergency department? An observational, prospective, multicentre study","volume":"75","author":"Pastor","year":"2021","journal-title":"Int. J. Clin. Pract."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e859","DOI":"10.3399\/bjgp17X693665","article-title":"Point-of-care lactate testing for sepsis at presentation to health care: A systematic review of patient outcomes","volume":"67","author":"Morris","year":"2017","journal-title":"Br. J. Gen. Pract."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1017\/S1049023X13009254","article-title":"Use of point-of-care lactate in the prehospital aeromedical environment","volume":"29","author":"Mullen","year":"2014","journal-title":"Prehospital Disaster Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ajem.2014.11.003","article-title":"Effectiveness of arterial, venous, and capillary blood lactate as a sepsis triage tool in ED patients","volume":"33","author":"Contenti","year":"2015","journal-title":"Am. J. Emerg. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.ajem.2014.06.027","article-title":"ED bedside point-of-care lactate in patients with suspected sepsis is associated with reduced time to iv fluids and mortality","volume":"32","author":"Singer","year":"2014","journal-title":"Am. J. Emerg. Med."},{"key":"ref_42","first-page":"S327","article-title":"Early lactate measurement triggers early treatment and improves outcomes in critically ill patients","volume":"1","author":"Maung","year":"2014","journal-title":"Acad. Med. Singap."},{"key":"ref_43","first-page":"P2062","article-title":"Impact of point-of-care lactate measurement on mortality in critically-ill patients requiring mechanical ventilation. European Respiratory Society Annual Congress","volume":"44","author":"See","year":"2014","journal-title":"Eur. Respir. J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13613-015-0047-y","article-title":"Capillary lactate as a tool for the triage nurse among patients with SIRS at emergency department presentation: A preliminary report","volume":"5","author":"Manzon","year":"2015","journal-title":"Ann. Intensive Care"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1001\/archinte.1984.00350190125022","article-title":"Shock. Diagnosis and management","volume":"144","author":"Houston","year":"1984","journal-title":"Arch. Intern. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000503775","article-title":"Microcirculation: Physiology, Pathophysiology, and Clinical Application","volume":"49","author":"Guven","year":"2020","journal-title":"Blood Purif."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1164\/rccm.201905-0968OC","article-title":"Effects of a Resuscitation Strategy Targeting Peripheral Perfusion Status versus Serum Lactate Levels among Patients with Septic Shock. A Bayesian Reanalysis of the ANDROMEDA-SHOCK Trial","volume":"201","author":"Zampieri","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1001\/jama.2019.0071","article-title":"Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs. Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial","volume":"321","author":"Damiani","year":"2019","journal-title":"JAMA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1007\/s00134-014-3326-4","article-title":"Capillary refill time exploration during septic shock","volume":"40","author":"Bige","year":"2014","journal-title":"Intensive Care Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s00134-011-2163-y","article-title":"Mottling score predicts survival in septic shock","volume":"37","author":"Lemoinne","year":"2011","journal-title":"Intensive Care Med."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Lara, B., Enberg, L., Ortega, M., Leon, P., Kripper, C., Aguilera, P., Kattan, E., Castro, R., Bakker, J., and Hernandez, G. (2017). Capillary refill time during fluid resuscitation in patients with sepsis-related hyperlactatemia at the emergency department is related to mortality. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0188548"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.accpm.2017.04.001","article-title":"Are capillary and arterial lactates interchangeable?","volume":"36","author":"Legrand","year":"2017","journal-title":"Anaesth. Crit. Care Pain Med."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"La Via, L., Sanfilippo, F., Continella, C., Triolo, T., Messina, A., Robba, C., Astuto, M., Hernandez, G., and Noto, A. (2023). Agreement between Capillary Refill Time measured at Finger and Earlobe sites in different positions: A pilot prospective study on healthy volunteers. BMC Anesthesiol., 23.","DOI":"10.1186\/s12871-022-01920-1"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Jacquet-Lagr\u00e8ze, M., Wiart, C., Schweizer, R., Didier, L., Ruste, M., Coutrot, M., Legrand, M., Baudin, F., Javouhey, E., and D\u00e9pret, F. (2022). Capillary refill time for the management of acute circulatory failure: A survey among pediatric and adult intensivists. BMC Emerg. Med., 22.","DOI":"10.1186\/s12873-022-00681-x"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s10096-020-04086-1","article-title":"Predicting in-hospital mortality for sepsis: A comparison between qSOFA and modified qSOFA in a 2-year single-centre retrospective analysis","volume":"40","author":"Guarino","year":"2021","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Guarino, M., Perna, B., Cesaro, A.E., Maritati, M., Spampinato, M.D., Contini, C., and De Giorgio, R. (2023). 2023 Update on Sepsis and Septic Shock in Adult Patients: Management in the Emergency Department. J. Clin. Med., 12.","DOI":"10.3390\/jcm12093188"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/bja\/aem214","article-title":"Using the Bland\u2013Altman method to measure agreement with repeated measures","volume":"99","author":"Myles","year":"2007","journal-title":"Br. J. Anaesth."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/11\/9121\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:40:05Z","timestamp":1760125205000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/11\/9121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,23]]},"references-count":58,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["ijms24119121"],"URL":"https:\/\/doi.org\/10.3390\/ijms24119121","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,23]]}}}