{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:48:34Z","timestamp":1787028514813,"version":"build-2736575974"},"reference-count":200,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Voltage-gated calcium channels (VGCCs) are targeted to treat pain conditions. Since the discovery of their relation to pain processing control, they are investigated to find new strategies for better pain control. This review provides an overview of naturally based and synthetic VGCC blockers, highlighting new evidence on the development of drugs focusing on the VGCC subtypes as well as mixed targets with pre-clinical and clinical analgesic effects.<\/jats:p>","DOI":"10.3390\/ijms24119223","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T03:56:58Z","timestamp":1684987018000},"page":"9223","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Current Drug Development Overview: Targeting Voltage-Gated Calcium Channels for the Treatment of Pain"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0620-2984","authenticated-orcid":false,"given":"Flavia Tasmin Techera","family":"Antunes","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, University of Calgary, Calgary, AB T2N 1N4, Canada"},{"name":"Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 1N4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7738-9892","authenticated-orcid":false,"given":"Maria Martha","family":"Campos","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Odontologia, Escola de Ci\u00eancias da Sa\u00fade e da Vida, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Porto Alegre 90619-900, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanice de Paula Ricardo","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Faculdade Santa Casa BH, Belo Horizonte 30110-005, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Antonio","family":"da Silva Junior","sequence":"additional","affiliation":[{"name":"Faculdade Santa Casa BH, Belo Horizonte 30110-005, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Alexandre Viana","family":"Magno","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Faculdade Ci\u00eancias M\u00e9dicas de Minas Gerais (FCMMG), Belo Horizonte 30110-005, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra Hubner","family":"de Souza","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Faculdade Ci\u00eancias M\u00e9dicas de Minas Gerais (FCMMG), Belo Horizonte 30110-005, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6082-930X","authenticated-orcid":false,"given":"Marcus Vinicius","family":"Gomez","sequence":"additional","affiliation":[{"name":"Faculdade Santa Casa BH, Belo Horizonte 30110-005, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1097\/j.pain.0000000000000454","article-title":"Pain and the global burden of disease","volume":"157","author":"Rice","year":"2016","journal-title":"Pain"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Goldberg, D.S., and McGee, S.J. 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