{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:30:52Z","timestamp":1790127052114,"version":"4.0.1"},"reference-count":57,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T00:00:00Z","timestamp":1685145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan","award":["26461703"],"award-info":[{"award-number":["26461703"]}]},{"name":"Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan","award":["21K08309"],"award-info":[{"award-number":["21K08309"]}]},{"name":"Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan","award":["2019-3006"],"award-info":[{"award-number":["2019-3006"]}]},{"name":"Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan","award":["2020"],"award-info":[{"award-number":["2020"]}]},{"name":"Institute for Environmental and Gender-specific Medicine, Juntendo University","award":["26461703"],"award-info":[{"award-number":["26461703"]}]},{"name":"Institute for Environmental and Gender-specific Medicine, Juntendo University","award":["21K08309"],"award-info":[{"award-number":["21K08309"]}]},{"name":"Institute for Environmental and Gender-specific Medicine, Juntendo University","award":["2019-3006"],"award-info":[{"award-number":["2019-3006"]}]},{"name":"Institute for Environmental and Gender-specific Medicine, Juntendo University","award":["2020"],"award-info":[{"award-number":["2020"]}]},{"name":"Lydia O\u2019Leary Memorial Pias Dermatological Foundation","award":["26461703"],"award-info":[{"award-number":["26461703"]}]},{"name":"Lydia O\u2019Leary Memorial Pias Dermatological Foundation","award":["21K08309"],"award-info":[{"award-number":["21K08309"]}]},{"name":"Lydia O\u2019Leary Memorial Pias Dermatological Foundation","award":["2019-3006"],"award-info":[{"award-number":["2019-3006"]}]},{"name":"Lydia O\u2019Leary Memorial Pias Dermatological Foundation","award":["2020"],"award-info":[{"award-number":["2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Atopic dermatitis and psoriasis are prevalent chronic inflammatory skin diseases that are characterized by dysfunctional skin barriers and substantially impact patients\u2019 quality of life. Vitamin D3 regulates immune responses and keratinocyte differentiation and improves psoriasis symptoms; however, its effects on atopic dermatitis remain unclear. Here, we investigated the effects of calcitriol, an active form of vitamin D3, on an NC\/Nga mouse model of atopic dermatitis. We observed that the topical application of calcitriol decreased the dermatitis scores and epidermal thickness of NC\/Nga mice with atopic dermatitis compared to untreated mice. In addition, both stratum corneum barrier function as assessed by the measurement of transepidermal water loss and tight junction barrier function as evaluated by biotin tracer permeability assay were improved following calcitriol treatment. Moreover, calcitriol treatment reversed the decrease in the expression of skin barrier-related proteins and decreased the expression of inflammatory cytokines such as interleukin (IL)-13 and IL-33 in mice with atopic dermatitis. These findings suggest that the topical application of calcitriol might improve the symptoms of atopic dermatitis by repairing the dysfunctional epidermal and tight junction barriers. Our results suggest that calcitriol might be a viable therapeutic agent for the treatment of atopic dermatitis in addition to psoriasis.<\/jats:p>","DOI":"10.3390\/ijms24119347","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T16:19:37Z","timestamp":1685204377000},"page":"9347","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Calcitriol, an Active Form of Vitamin D3, Mitigates Skin Barrier Dysfunction in Atopic Dermatitis NC\/Nga Mice"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9039-0644","authenticated-orcid":false,"given":"Yoshie","family":"Umehara","sequence":"first","affiliation":[{"name":"Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Valentin","family":"Trujillo-Paez","sequence":"additional","affiliation":[{"name":"Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hainan","family":"Yue","sequence":"additional","affiliation":[{"name":"Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3278-2604","authenticated-orcid":false,"given":"Ge","family":"Peng","sequence":"additional","affiliation":[{"name":"Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9566-2458","authenticated-orcid":false,"given":"Hai Le Thanh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko","family":"Okumura","sequence":"additional","affiliation":[{"name":"Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideoki","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0588-8315","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Niyonsaba","sequence":"additional","affiliation":[{"name":"Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Faculty of International Liberal Arts Global Health Studies, Juntendo University, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sroka-Tomaszewska, J., and Trzeciak, M. 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