{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T04:08:48Z","timestamp":1767586128200,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T00:00:00Z","timestamp":1685232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Primary localized cutaneous nodular amyloidosis (PLCNA) is included in the primary forms of cutaneous amyloidosis along with macular and lichenoid amyloidosis. It is a rare disease attributed to plasma cell proliferation and deposition of immunoglobulin light chains in the skin. We present the case of a 75-year-old woman with a personal history of Sjogren\u2019s syndrome (SjS), who consulted for asymptomatic yellowish, waxy nodules on the left leg. Dermoscopy of the lesions showed a smooth, structureless, yellowish surface with hemorrhagic areas and few telangiectatic vessels. Histopathology revealed an atrophic epidermis and deposits of amorphous eosinophilic material in the dermis with a positive Congo red stain. The diagnosis of nodular amyloidosis was made. Periodic reevaluation was indicated after the exclusion of systemic amyloidosis. PLCNA is often associated with autoimmune connective tissue diseases, and up to 25% of all PLCNA cases occur in patients with SjS. Therefore, in addition to ruling out systemic amyloidosis, screening for possible underlying SjS should be performed when the diagnosis of PLCNA is confirmed.<\/jats:p>","DOI":"10.3390\/ijms24119409","type":"journal-article","created":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T15:30:47Z","timestamp":1685287847000},"page":"9409","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Localized Cutaneous Nodular Amyloidosis in a Patient with Sj\u00f6gren\u2019s Syndrome"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1658-7251","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"Llamas-Molina","sequence":"first","affiliation":[{"name":"Department of Dermatology, Hospital Universitario San Cecilio, Avda Conocimiento 33, 18016 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Pablo","family":"Velasco-Amador","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hospital Universitario San Cecilio, Avda Conocimiento 33, 18016 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"De La Torre-Gomar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hospital Universitario San Cecilio, Avda Conocimiento 33, 18016 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Carrero-Casta\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy, Hospital Universitario San Cecilio, Avda Conocimiento 33, 18016 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0381-6174","authenticated-orcid":false,"given":"Ricardo","family":"Ruiz-Villaverde","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hospital Universitario San Cecilio, Avda Conocimiento 33, 18016 Granada, Spain"},{"name":"Instituto Biosanitario de Granada, Ibs, 18014 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/03009742.2019.1656285","article-title":"Nodular localized primary cutaneous amyloidosis and primary Sj\u00f6gren\u2019s syndrome","volume":"49","author":"Davies","year":"2020","journal-title":"Scand. 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