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In this context, the tools of Network Medicine are compatible as a platform to systematically explore not only the molecular complexity of a specific disease but may also lead to the identification of disease modules and pathways. Such an approach enables us to gain a better understanding of how environmental chemical exposures affect the function of human cells, providing better perceptions about the mechanisms involved and helping to monitor\/prevent exposure and disease to chemicals such as benzene and malathion. We selected differentially expressed genes for exposure to benzene and malathion. The construction of interaction networks was carried out using GeneMANIA and STRING. Topological properties were calculated using MCODE, BiNGO, and CentiScaPe, and a Benzene network composed of 114 genes and 2415 interactions was obtained. After topological analysis, five networks were identified. In these subnets, the most interconnected nodes were identified as: IL-8, KLF6, KLF4, JUN, SERTAD1, and MT1H. In the Malathion network, composed of 67 proteins and 134 interactions, HRAS and STAT3 were the most interconnected nodes. Path analysis, combined with various types of high-throughput data, reflects biological processes more clearly and comprehensively than analyses involving the evaluation of individual genes. We emphasize the central roles played by several important hub genes obtained by exposure to benzene and malathion.<\/jats:p>","DOI":"10.3390\/ijms24119415","type":"journal-article","created":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T15:30:47Z","timestamp":1685287847000},"page":"9415","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Network Analysis of Biomarkers Associated with Occupational Exposure to Benzene and Malathion"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7096-5156","authenticated-orcid":false,"given":"Marcus Vinicius C.","family":"Santos","sequence":"first","affiliation":[{"name":"Studies Center of Worker\u2019s Health and Human Ecology (CESTEH), Sergio Arouca National School of Public Health (ENSP), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21041-210, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur S.","family":"Feltrin","sequence":"additional","affiliation":[{"name":"Center for Mathematics, Computation and Cognition, Federal University of ABC, Santo Andr\u00e9 09210-580, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabele C.","family":"Costa-Amaral","sequence":"additional","affiliation":[{"name":"Studies Center of Worker\u2019s Health and Human Ecology (CESTEH), Sergio Arouca National School of Public Health (ENSP), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21041-210, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane R.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Studies Center of Worker\u2019s Health and Human Ecology (CESTEH), Sergio Arouca National School of Public Health (ENSP), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21041-210, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamila A.","family":"Perini","sequence":"additional","affiliation":[{"name":"Research Laboratory of Pharmaceutical Sciences (LAPESF), State University of Rio de Janeiro (West Zone-UERJ-ZO), Rio de Janeiro 23070-200, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"David C.","family":"Martins","sequence":"additional","affiliation":[{"name":"Center for Mathematics, Computation and Cognition, Federal University of ABC, Santo Andr\u00e9 09210-580, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane L.","family":"Larentis","sequence":"additional","affiliation":[{"name":"Studies Center of Worker\u2019s Health and Human Ecology (CESTEH), Sergio Arouca National School of Public Health (ENSP), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21041-210, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1039\/C5MB00815H","article-title":"Network-based methods for identifying critical pathways of complex diseases: A survey","volume":"12","author":"Zhang","year":"2016","journal-title":"Mol. 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