{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:26:28Z","timestamp":1790612788861,"version":"4.1.0"},"reference-count":148,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado del Instituto Polit\u00e9cnico Nacional (SIP-IPN)","award":["20230853-2023"],"award-info":[{"award-number":["20230853-2023"]}]},{"name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado del Instituto Polit\u00e9cnico Nacional (SIP-IPN)","award":["319355-2022"],"award-info":[{"award-number":["319355-2022"]}]},{"name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado del Instituto Polit\u00e9cnico Nacional (SIP-IPN)","award":["2140-2021"],"award-info":[{"award-number":["2140-2021"]}]},{"name":"CONACYT CB","award":["20230853-2023"],"award-info":[{"award-number":["20230853-2023"]}]},{"name":"CONACYT CB","award":["319355-2022"],"award-info":[{"award-number":["319355-2022"]}]},{"name":"CONACYT CB","award":["2140-2021"],"award-info":[{"award-number":["2140-2021"]}]},{"name":"SIP-IPN","award":["20230853-2023"],"award-info":[{"award-number":["20230853-2023"]}]},{"name":"SIP-IPN","award":["319355-2022"],"award-info":[{"award-number":["319355-2022"]}]},{"name":"SIP-IPN","award":["2140-2021"],"award-info":[{"award-number":["2140-2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>(Thio)ureas ((T)Us) and benzothiazoles (BTs) each have demonstrated to have a great variety of biological activities. When these groups come together, the 2-(thio)ureabenzothizoles [(T)UBTs] are formed, improving the physicochemical as well as the biological properties, making these compounds very interesting in medicinal chemistry. Frentizole, bentaluron and methabenzthiazuron are examples of UBTs used for treatment of rheumatoid arthritis and as wood preservatives and herbicides in winter corn crops, respectively. With this antecedent, we recently reported a bibliographic review about the synthesis of this class of compounds, from the reaction of substituted 2-aminobenzothiazoles (ABTs) with iso(thio)cyanates, (thio)phosgenes, (thio)carbamoyl chlorides, 1,1\u2019-(thio)carbonyldiimidazoles, and carbon disulfide. Herein, we prepared a bibliographic review about those features of design, chemical synthesis, and biological activities relating to (T)UBTs as potential therapeutic agents. This review is about synthetic methodologies generated from 1968 to the present day, highlighting the focus to transform (T)UBTs to compounds containing a range substituents, as illustrated with 37 schemes and 11 figures and concluded with 148 references. In this topic, the scientists dedicated to medicinal chemistry and pharmaceutical industry will find useful information for the design and synthesis of this interesting group of compounds with the aim of repurposing these compounds.<\/jats:p>","DOI":"10.3390\/ijms24119488","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T04:40:51Z","timestamp":1685508051000},"page":"9488","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Design, Synthesis and Biological Activities of (Thio)Urea Benzothiazole Derivatives"],"prefix":"10.3390","volume":"24","author":[{"given":"Jessica E.","family":"Mendieta-Wejebe","sequence":"first","affiliation":[{"name":"Laboratorio de Biof\u00edsica y Biocat\u00e1lisis, Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y Salvador D\u00edaz Mir\u00f3n s\/n, Casco de Santo Tom\u00e1s, Ciudad de Mexico 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0012-580X","authenticated-orcid":false,"given":"Martha C.","family":"Rosales-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratorio de Biof\u00edsica y Biocat\u00e1lisis, Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y Salvador D\u00edaz Mir\u00f3n s\/n, Casco de Santo Tom\u00e1s, Ciudad de Mexico 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9645-2049","authenticated-orcid":false,"given":"Itzia I.","family":"Padilla-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Laboratorio de Qu\u00edmica Supramolecular y Nanociencias, Unidad Profesional Interdisciplinaria de Biotecnolog\u00eda, Instituto Polit\u00e9cnico Nacional, Av. Acueducto s\/n, Barrio la Laguna Ticom\u00e1n, Ciudad de Mexico 07340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efr\u00e9n V.","family":"Garc\u00eda-B\u00e1ez","sequence":"additional","affiliation":[{"name":"Laboratorio de Qu\u00edmica Supramolecular y Nanociencias, Unidad Profesional Interdisciplinaria de Biotecnolog\u00eda, Instituto Polit\u00e9cnico Nacional, Av. Acueducto s\/n, Barrio la Laguna Ticom\u00e1n, Ciudad de Mexico 07340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6255-9112","authenticated-orcid":false,"given":"Alejandro","family":"Cruz","sequence":"additional","affiliation":[{"name":"Laboratorio de Qu\u00edmica Supramolecular y Nanociencias, Unidad Profesional Interdisciplinaria de Biotecnolog\u00eda, Instituto Polit\u00e9cnico Nacional, Av. Acueducto s\/n, Barrio la Laguna Ticom\u00e1n, Ciudad de Mexico 07340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1016\/j.bmc.2004.04.050","article-title":"Effect of stereochemistry on the anti-HIV activity of chiral thiourea compounds","volume":"12","author":"Venkatachalam","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1016\/j.bmcl.2004.02.002","article-title":"Analysis of structure\u2013activity relationships for the B-region of N-(3-acyloxy-2-benzylpropyl)-N0-[4-(methylsulfonylamino)-benzyl]thiourea analogues as vanilloid receptor antagonists: Discovery of an N-hydroxythiourea analogue with potent analgesic activity","volume":"14","author":"Lee","year":"2004","journal-title":"Bioorg. Med. Chem. 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