{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:58:13Z","timestamp":1789430293115,"version":"build-2803163510"},"reference-count":93,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Versailles-Saint-Quentin-en-Yvelines"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Maternal obesity is increasingly prevalent and is associated with elevated morbidity and mortality rates in both mothers and children. At the interface between the mother and the fetus, the placenta mediates the impact of the maternal environment on fetal development. Most of the literature presents data on the effects of maternal obesity on placental functions and does not exclude potentially confounding factors such as metabolic diseases (e.g., gestational diabetes). In this context, the focus of this review mainly lies on the impact of maternal obesity (in the absence of gestational diabetes) on (i) endocrine function, (ii) morphological characteristics, (iii) nutrient exchanges and metabolism, (iv) inflammatory\/immune status, (v) oxidative stress, and (vi) transcriptome. Moreover, some of those placental changes in response to maternal obesity could be supported by fetal sex. A better understanding of sex-specific placental responses to maternal obesity seems to be crucial for improving pregnancy outcomes and the health of mothers and children.<\/jats:p>","DOI":"10.3390\/ijms24119770","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T02:57:30Z","timestamp":1686020250000},"page":"9770","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Human Placental Adaptive Changes in Response to Maternal Obesity: Sex Specificities"],"prefix":"10.3390","volume":"24","author":[{"given":"Esther Dos","family":"Santos","sequence":"first","affiliation":[{"name":"UFR des Sciences de la Sant\u00e9 Simone Veil, Universit\u00e9 de Versailles-Saint Quentin en Yvelines\u2014Universit\u00e9 Paris Saclay (UVSQ), INRAE, BREED, F-78350 Jouy-en-Josas, France"},{"name":"Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort (EnvA), BREED, F-94700 Maisons-Alfort, France"},{"name":"Service de Biologie M\u00e9dicale, Centre Hospitalier de Poissy-Saint Germain, F-78300 Poissy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Hita","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"UFR des Sciences de la Sant\u00e9 Simone Veil, Universit\u00e9 de Versailles-Saint Quentin en Yvelines\u2014Universit\u00e9 Paris Saclay (UVSQ), INRAE, BREED, F-78350 Jouy-en-Josas, France"},{"name":"Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort (EnvA), BREED, F-94700 Maisons-Alfort, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"S\u00e9razin","sequence":"additional","affiliation":[{"name":"UFR des Sciences de la Sant\u00e9 Simone Veil, Universit\u00e9 de Versailles-Saint Quentin en Yvelines\u2014Universit\u00e9 Paris Saclay (UVSQ), INRAE, BREED, F-78350 Jouy-en-Josas, France"},{"name":"Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort (EnvA), BREED, F-94700 Maisons-Alfort, France"},{"name":"Service de Biologie M\u00e9dicale, Centre Hospitalier de Poissy-Saint Germain, F-78300 Poissy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5774-2756","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Vialard","sequence":"additional","affiliation":[{"name":"UFR des Sciences de la Sant\u00e9 Simone Veil, Universit\u00e9 de Versailles-Saint Quentin en Yvelines\u2014Universit\u00e9 Paris Saclay (UVSQ), INRAE, BREED, F-78350 Jouy-en-Josas, France"},{"name":"Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort (EnvA), BREED, F-94700 Maisons-Alfort, France"},{"name":"Service de Biologie M\u00e9dicale, Centre Hospitalier de Poissy-Saint Germain, F-78300 Poissy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-No\u00eblle","family":"Dieudonn\u00e9","sequence":"additional","affiliation":[{"name":"UFR des Sciences de la Sant\u00e9 Simone Veil, Universit\u00e9 de Versailles-Saint Quentin en Yvelines\u2014Universit\u00e9 Paris Saclay (UVSQ), INRAE, BREED, F-78350 Jouy-en-Josas, France"},{"name":"Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort (EnvA), BREED, F-94700 Maisons-Alfort, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.metabol.2018.09.005","article-title":"The Epidemiology of Obesity","volume":"92","author":"Chooi","year":"2019","journal-title":"Metabolism"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"GBD 2015 Eastern Mediterranean Region Obesity Collaborators (2018). 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