{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:14:51Z","timestamp":1779300891477,"version":"3.51.4"},"reference-count":48,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,11]],"date-time":"2023-06-11T00:00:00Z","timestamp":1686441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["2018YFA0801004"],"award-info":[{"award-number":["2018YFA0801004"]}]},{"name":"National Natural Science Foundation of China","award":["81870359"],"award-info":[{"award-number":["81870359"]}]},{"name":"National Natural Science Foundation of China","award":["22KJB320020"],"award-info":[{"award-number":["22KJB320020"]}]},{"name":"National Natural Science Foundation of China","award":["202210304129Y"],"award-info":[{"award-number":["202210304129Y"]}]},{"name":"National Natural Science Foundation of China","award":["KX-22-C186"],"award-info":[{"award-number":["KX-22-C186"]}]},{"name":"National Natural Science Foundation of China","award":["Q202229"],"award-info":[{"award-number":["Q202229"]}]},{"name":"Natural Science Foundation of the Jiangsu Higher Education Institutions of China","award":["2018YFA0801004"],"award-info":[{"award-number":["2018YFA0801004"]}]},{"name":"Natural Science Foundation of the Jiangsu Higher Education Institutions of China","award":["81870359"],"award-info":[{"award-number":["81870359"]}]},{"name":"Natural Science Foundation of the Jiangsu Higher Education Institutions of China","award":["22KJB320020"],"award-info":[{"award-number":["22KJB320020"]}]},{"name":"Natural Science Foundation of the Jiangsu Higher Education Institutions of China","award":["202210304129Y"],"award-info":[{"award-number":["202210304129Y"]}]},{"name":"Natural Science Foundation of the Jiangsu Higher Education Institutions of China","award":["KX-22-C186"],"award-info":[{"award-number":["KX-22-C186"]}]},{"name":"Natural Science Foundation of the Jiangsu Higher Education Institutions of China","award":["Q202229"],"award-info":[{"award-number":["Q202229"]}]},{"name":"\u201cInnovation and Entrepreneurship Doctor\u201d Project of Jiangsu Province, Jiangsu Students\u2019 Platform for innovation and entrepreneurship training program","award":["2018YFA0801004"],"award-info":[{"award-number":["2018YFA0801004"]}]},{"name":"\u201cInnovation and Entrepreneurship Doctor\u201d Project of Jiangsu Province, Jiangsu Students\u2019 Platform for innovation and entrepreneurship training program","award":["81870359"],"award-info":[{"award-number":["81870359"]}]},{"name":"\u201cInnovation and Entrepreneurship Doctor\u201d Project of Jiangsu Province, Jiangsu Students\u2019 Platform for innovation and entrepreneurship training program","award":["22KJB320020"],"award-info":[{"award-number":["22KJB320020"]}]},{"name":"\u201cInnovation and Entrepreneurship Doctor\u201d Project of Jiangsu Province, Jiangsu Students\u2019 Platform for innovation and entrepreneurship training program","award":["202210304129Y"],"award-info":[{"award-number":["202210304129Y"]}]},{"name":"\u201cInnovation and Entrepreneurship Doctor\u201d Project of Jiangsu Province, Jiangsu Students\u2019 Platform for innovation and entrepreneurship training program","award":["KX-22-C186"],"award-info":[{"award-number":["KX-22-C186"]}]},{"name":"\u201cInnovation and Entrepreneurship Doctor\u201d Project of Jiangsu Province, Jiangsu Students\u2019 Platform for innovation and entrepreneurship training program","award":["Q202229"],"award-info":[{"award-number":["Q202229"]}]},{"name":"Soft Science Research Topic of Wuxi Association for Science and Technology","award":["2018YFA0801004"],"award-info":[{"award-number":["2018YFA0801004"]}]},{"name":"Soft Science Research Topic of Wuxi Association for Science and Technology","award":["81870359"],"award-info":[{"award-number":["81870359"]}]},{"name":"Soft Science Research Topic of Wuxi Association for Science and Technology","award":["22KJB320020"],"award-info":[{"award-number":["22KJB320020"]}]},{"name":"Soft Science Research Topic of Wuxi Association for Science and Technology","award":["202210304129Y"],"award-info":[{"award-number":["202210304129Y"]}]},{"name":"Soft Science Research Topic of Wuxi Association for Science and Technology","award":["KX-22-C186"],"award-info":[{"award-number":["KX-22-C186"]}]},{"name":"Soft Science Research Topic of Wuxi Association for Science and Technology","award":["Q202229"],"award-info":[{"award-number":["Q202229"]}]},{"name":"Project of Wuxi Health Committee","award":["2018YFA0801004"],"award-info":[{"award-number":["2018YFA0801004"]}]},{"name":"Project of Wuxi Health Committee","award":["81870359"],"award-info":[{"award-number":["81870359"]}]},{"name":"Project of Wuxi Health Committee","award":["22KJB320020"],"award-info":[{"award-number":["22KJB320020"]}]},{"name":"Project of Wuxi Health Committee","award":["202210304129Y"],"award-info":[{"award-number":["202210304129Y"]}]},{"name":"Project of Wuxi Health Committee","award":["KX-22-C186"],"award-info":[{"award-number":["KX-22-C186"]}]},{"name":"Project of Wuxi Health Committee","award":["Q202229"],"award-info":[{"award-number":["Q202229"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Damages of sensory hair cells (HCs) are mainly responsible for sensorineural hearing loss, however, its pathological mechanism is not yet fully understood due to the fact that many potential deafness genes remain unidentified. N-myc downstream-regulated gene 2 (ndrg2) is commonly regarded as a tumor suppressor and a cell stress-responsive gene extensively involved in cell proliferation, differentiation, apoptosis and invasion, while its roles in zebrafish HC morphogenesis and hearing remains unclear. Results of this study suggested that ndrg2 was highly expressed in the HCs of the otic vesicle and neuromasts via in situ hybridization and single-cell RNA sequencing. Ndrg2 loss-of-function larvae showed decreased crista HCs, shortened cilia, and reduced neuromasts and functional HCs, which could be rescued by the microinjection of ndrg2 mRNA. Moreover, ndrg2 deficiency induced attenuated startle response behaviors to sound vibration stimuli. Mechanistically, there were no detectable HC apoptosis and supporting cell changes in the ndrg2 mutants, and HCs were capable of recovering by blocking the Notch signaling pathway, suggesting that ndrg2 was implicated in HC differentiation mediated by Notch. Overall, our study demonstrates that ndrg2 plays crucial roles in HC development and auditory sensory function utilizing the zebrafish model, which provides new insights into the identification of potential deafness genes and regulation mechanism of HC development.<\/jats:p>","DOI":"10.3390\/ijms241210002","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T01:28:21Z","timestamp":1686533301000},"page":"10002","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The ndrg2 Gene Regulates Hair Cell Morphogenesis and Auditory Function during Zebrafish Development"],"prefix":"10.3390","volume":"24","author":[{"given":"Cheng","family":"Wang","sequence":"first","affiliation":[{"name":"Nantong Laboratory of Development and Diseases, School of Life Sciences, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5536-793X","authenticated-orcid":false,"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Nantong University, Nantong 226001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Medicine, Nantong University, Nantong 226001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Yao","sequence":"additional","affiliation":[{"name":"Nantong Laboratory of Development and Diseases, School of Life Sciences, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqing","family":"Xiang","sequence":"additional","affiliation":[{"name":"Nantong Laboratory of Development and Diseases, School of Life Sciences, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2764-6544","authenticated-orcid":false,"given":"Dong","family":"Liu","sequence":"additional","affiliation":[{"name":"Nantong Laboratory of Development and Diseases, School of Life Sciences, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China"},{"name":"Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Nantong University, Nantong 226001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.pharmthera.2019.05.003","article-title":"New molecular therapies for the treatment of hearing loss","volume":"200","author":"Ma","year":"2019","journal-title":"Pharmacol. Therapeut."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"107981","DOI":"10.1016\/j.heares.2020.107981","article-title":"Gene therapy for hair cell regeneration: Review and new data","volume":"394","author":"Shibata","year":"2020","journal-title":"Hear. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"732507","DOI":"10.3389\/fncel.2021.732507","article-title":"Research progress on the mechanism of cochlear hair cell regeneration","volume":"15","author":"Xu","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1242\/dev.114926","article-title":"Sensory hair cell development and regeneration: Similarities and differences","volume":"142","author":"Atkinson","year":"2015","journal-title":"Development"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5522717","DOI":"10.1155\/2021\/5522717","article-title":"Key signaling pathways regulate the development and survival of auditory hair cells","volume":"2021","author":"Liu","year":"2021","journal-title":"Neural Plast."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Brown, R., and Groves, A.K. (2020). Hear, hear for Notch: Control of cell fates in the inner ear by Notch signaling. Biomolecules, 10.","DOI":"10.3390\/biom10030370"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"108161","DOI":"10.1016\/j.heares.2020.108161","article-title":"Signaling pathways (Notch, Wnt, Bmp and Fgf) have additive effects on hair cell regeneration in the chick basilar papilla after streptomycin injury in vitro Additive effects of signaling pathways on hair cell regeneration","volume":"401","author":"Bai","year":"2021","journal-title":"Hear. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00441-021-03493-w","article-title":"The crosstalk between the Notch, Wnt, and SHH signaling pathways in regulating the proliferation and regeneration of sensory progenitor cells in the mouse cochlea","volume":"386","author":"Wu","year":"2021","journal-title":"Cell Tissue Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jgg.2022.11.008","article-title":"ftr82 is necessary for hair cell morphogenesis and auditory function during zebrafish","volume":"50","author":"Yin","year":"2023","journal-title":"J. Genet. Genom."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/2058738420959554","article-title":"Use of zebrafish larvae lateral line to study protection against cisplatin-induced ototoxicity: A scoping review","volume":"34","author":"Domarecka","year":"2020","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"107906","DOI":"10.1016\/j.heares.2020.107906","article-title":"Small fish, big prospects: Using zebrafish to unravel the mechanisms of hereditary hearing loss","volume":"397","author":"Vona","year":"2020","journal-title":"Hear. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10162-021-00798-z","article-title":"How zebrafish can drive the future of genetic-based hearing and balance research","volume":"22","author":"Sheets","year":"2021","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"108055","DOI":"10.1016\/j.heares.2020.108055","article-title":"The role of gfi1.2 in the development of zebrafish inner ear","volume":"396","author":"Yu","year":"2020","journal-title":"Hear. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.jgg.2020.07.007","article-title":"Phosphatidylinositol 4 kinase-\u03b2 is required for the ciliogenesis of zebrafish otic vesicle","volume":"47","author":"Feng","year":"2020","journal-title":"J. Genet. Genom."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1007\/s00018-019-03406-9","article-title":"Astrocyte-specific NDRG2 gene: Functions in the brain and neurological diseases","volume":"77","author":"Li","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Lee, K.W., Lim, S., and Kim, K.D. (2022). The function of N-myc downstream-regulated gene 2 (NDRG2) as a negative regulator in tumor cell metastasis. Int. J. Mol. Sci., 3.","DOI":"10.3390\/ijms23169365"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Kim, G., Lim, S., and Kim, K.D. (2021). N-myc downstream-regulated gene 2 (NDRG2) function as a positive regulator of apoptosis: A new insight into NDRG2 as a tumor suppressor. Cells, 10.","DOI":"10.3390\/cells10102649"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1745-7270.2008.00434.x","article-title":"NDRG2: A Myc-repressed gene involved in cancer and cell stress","volume":"40","author":"Yao","year":"2008","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s10495-016-1244-3","article-title":"Clinical and pathological significance of N-myc downstream-regulated gene 2 (NDRG2) in diverse human cancers","volume":"21","author":"Hu","year":"2016","journal-title":"Apoptosis"},{"key":"ref_20","first-page":"655","article-title":"Potential role of NDRG2 in reprogramming cancer metabolism and epithelial-tomesenchymal transition","volume":"33","author":"Chen","year":"2018","journal-title":"Histol. Histopathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0014-5793(03)01030-5","article-title":"Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells","volume":"553","author":"Choi","year":"2003","journal-title":"FEBS Lett."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1038\/s41388-017-0118-7","article-title":"NDRG2 facilitates colorectal cancer differentiation through the regulation of Skp2-p21\/p27 axis","volume":"37","author":"Shen","year":"2018","journal-title":"Oncogene"},{"key":"ref_23","first-page":"e918541","article-title":"N-myc downstream-regulated gene 2 (NDRG2) promotes bone morphogenetic protein 2 (BMP2)-induced osteoblastic differentiation and calcification by Janus kinase 3 (JAK3)\/signal transducer and activator of transcription 3 (STAT3) signaling pathway","volume":"26","author":"Chen","year":"2020","journal-title":"Med. Sci. Monit."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1007\/s10620-021-07188-8","article-title":"Colorectal cancer cell differentiation is dependent on the repression of aerobic glycolysis by NDRG2-TXNIP axis","volume":"67","author":"Hu","year":"2022","journal-title":"Dig. Dis. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1113\/jphysiol.2008.167882","article-title":"NDRG2, a novel regulator of myoblast proliferation, is regulated by anabolic and catabolic factors","volume":"587","author":"Foletta","year":"2009","journal-title":"J. Physiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"348","DOI":"10.4110\/in.2011.11.6.348","article-title":"NDRG2 promotes GATA-1 expression through regulation of the JAK2\/STAT pathway in PMA-stimulated U937 cells","volume":"11","author":"Kang","year":"2011","journal-title":"Immune Netw."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.ydbio.2012.07.001","article-title":"Ndrg2 regulates vertebral specification in differentiating somites","volume":"369","author":"Zhu","year":"2012","journal-title":"Dev. Biol."},{"key":"ref_28","unstructured":"Thisse, B., and Thisse, C. (2004). Fast Release Clones: A High throughput Expression Analysis, The Zebrafish Information Network. Available online: http:\/\/zfin.org."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00018-022-04410-2","article-title":"Single-cell RNA-sequencing of zebrafish hair cells reveals novel genes potentially involved in hearing loss","volume":"79","author":"Qian","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e21961","DOI":"10.1096\/fj.202100443R","article-title":"Differential expression and hypoxia-mediated regulation of the N-myc downstream regulated gene family","volume":"35","author":"Le","year":"2021","journal-title":"FASEB J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1523\/JNEUROSCI.2216-16.2017","article-title":"Functional analysis of the transmembrane and cytoplasmic domains of pcdh15a in zebrafish hair cells","volume":"37","author":"Maeda","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Chen, F., Yang, Y., Chen, J., Tang, Z., Peng, Q., Wang, J., and Ding, J. (2021). Promotion of in vitro hair cell-like cell differentiation from human embryonic stem cells through the regulation of Notch signaling. Metabolites, 11.","DOI":"10.21203\/rs.3.rs-935209\/v1"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00109-005-0706-9","article-title":"Inhibition of Notch\/RBP-J signaling induces hair cell formation in neonate mouse cochleas","volume":"84","author":"Yamamoto","year":"2006","journal-title":"J. Mol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuron.2012.10.032","article-title":"Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma","volume":"77","author":"Mizutari","year":"2013","journal-title":"Neuron"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.stemcr.2014.01.008","article-title":"Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea","volume":"2","author":"Bramhall","year":"2014","journal-title":"Stem Cell Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/cas.14716","article-title":"Pathophysiological significance of N-myc downstream-regulated gene 2 in cancer development through protein phosphatase 2A phosphorylation regulation","volume":"112","author":"Morishita","year":"2021","journal-title":"Cancer Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.bbrc.2010.04.162","article-title":"NDRG2 is one of novel intrinsic factors for regulation of IL-10 production in human myeloid cell","volume":"396","author":"Choi","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.bbrc.2015.10.167","article-title":"Inhibition of osteoclast differentiation by overexpression of NDRG2 in monocytes","volume":"468","author":"Kang","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"81","DOI":"10.5483\/BMBRep.2022.55.2.114","article-title":"Regulation of tumor-associated macrophage (TAM) differentiation by NDRG2 expression in breast cancer cells","volume":"55","author":"Lee","year":"2022","journal-title":"BMB Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41420-018-0101-2","article-title":"NDRG2 suppression as a molecular hallmark of photoreceptor-specific cell death in the mouse retina","volume":"4","author":"Hu","year":"2018","journal-title":"Cell Death Discov."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s11684-017-0507-x","article-title":"Behavioral methods for the functional assessment of hair cells in zebrafish","volume":"11","author":"Yang","year":"2017","journal-title":"Front. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"8086","DOI":"10.1523\/JNEUROSCI.1288-08.2008","article-title":"Semicircular canal size determines the developmental onset of angular vestibuloocular reflexes in larval Xenopus","volume":"28","author":"Lambert","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3389\/fncel.2018.00257","article-title":"An assay for systematically quantifying the vestibulo-ocular reflex to assess vestibular function in zebrafish larvae","volume":"12","author":"Sun","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s101620020035","article-title":"Age- and size-related changes in the inner ear and hearing ability of the adult zebrafish (Danio rerio)","volume":"3","author":"Higgs","year":"2002","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1113\/JP281522","article-title":"Functional development and regeneration of hair cells in the zebrafish lateral line","volume":"599","author":"Hardy","year":"2021","journal-title":"J. Physiol."},{"key":"ref_46","unstructured":"Llanos, P., and Andrijauskaite, K. (2019, January 21\u201325). Examination of Molecular Mechanisms on Vascular Formation and Stress Response in Zebrafish by Different Microgravity Environments. Proceedings of the International Astronautical Congress (IAC) 2019, IAC-19-A2.7.14, Washington, DC, USA."},{"key":"ref_47","first-page":"117","article-title":"Involvement of Ndrg2 in the neurogenesis of adult rat cortex after traumatic injury","volume":"33","author":"Zhang","year":"2017","journal-title":"Chin. J. Neuroanat."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1007\/s12035-023-03262-6","article-title":"Loss of ndrg2 function is involved in Notch activation in neuromast hair cell regeneration in zebrafish","volume":"60","author":"Wang","year":"2023","journal-title":"Mol. Neurobiol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/12\/10002\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:52:29Z","timestamp":1760125949000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/12\/10002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,11]]},"references-count":48,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["ijms241210002"],"URL":"https:\/\/doi.org\/10.3390\/ijms241210002","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,11]]}}}