{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:07:33Z","timestamp":1791587253633,"version":"4.3.4"},"reference-count":89,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T00:00:00Z","timestamp":1686614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014810","name":"Fondazione di Sardegna","doi-asserted-by":"publisher","award":["F72F20000260007"],"award-info":[{"award-number":["F72F20000260007"]}],"id":[{"id":"10.13039\/100014810","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Bipolar disorder (BD) is a severe chronic disorder that represents one of the main causes of disability among young people. To date, no reliable biomarkers are available to inform the diagnosis of BD or clinical response to pharmacological treatment. Studies focused on coding and noncoding transcripts may provide information complementary to genome-wide association studies, allowing to correlate the dynamic evolution of different types of RNAs based on specific cell types and developmental stage with disease development or clinical course. In this narrative review, we summarize findings from human studies that evaluated the potential utility of messenger RNAs and noncoding transcripts, such as microRNAs, circular RNAs and long noncoding RNAs, as peripheral markers of BD and\/or response to lithium and other mood stabilizers. The majority of available studies investigated specific targets or pathways, with large heterogeneity in the included type of cells or biofluids. However, a growing number of studies are using hypothesis-free designs, with some studies also integrating data on coding and noncoding RNAs measured in the same participants. Finally, studies conducted in neurons derived from induced-pluripotent stem cells or in brain organoids provide promising preliminary findings supporting the power and utility of these cellular models to investigate the molecular determinants of BD and clinical response.<\/jats:p>","DOI":"10.3390\/ijms241210067","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T01:32:15Z","timestamp":1686706335000},"page":"10067","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["RNA Biomarkers in Bipolar Disorder and Response to Mood Stabilizers"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9151-4319","authenticated-orcid":false,"given":"Claudia","family":"Pisanu","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, 09042 Monserrato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7415-7607","authenticated-orcid":false,"given":"Alessio","family":"Squassina","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, 09042 Monserrato, Italy"},{"name":"Department of Psychiatry, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 2E2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0140-6736(15)00241-X","article-title":"Bipolar disorder","volume":"387","author":"Grande","year":"2016","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/s41588-019-0397-8","article-title":"Genome-wide association study identifies 30 loci associated with bipolar disorder","volume":"51","author":"Stahl","year":"2019","journal-title":"Nat. Genet."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41588-021-00857-4","article-title":"Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology","volume":"53","author":"Mullins","year":"2021","journal-title":"Nat. Genet."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"942","DOI":"10.4088\/JCP.v63n1013","article-title":"Is Response to Prophylactic Lithium a Familial Trait?","volume":"63","author":"Grof","year":"2002","journal-title":"J. Clin. Psychiatry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0140-6736(16)00143-4","article-title":"Genetic variants associated with response to lithium treatment in bipolar disorder: A genome-wide association study","volume":"387","author":"Hou","year":"2016","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1038\/s41380-020-0689-5","article-title":"Association of polygenic score for major depression with response to lithium in patients with bipolar disorder","volume":"26","author":"Amare","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_7","unstructured":"International Consortium on Lithium Genetics (ConLi+Gen) (2018). Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study. JAMA Psychiatry, 75, 65\u201374."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/s41398-021-01702-2","article-title":"Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients","volume":"11","author":"Schubert","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s40291-018-0335-y","article-title":"The Role of Pharmacogenomics in Bipolar Disorder: Moving Towards Precision Medicine","volume":"22","author":"Pisanu","year":"2018","journal-title":"Mol. Diagn. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1159\/000449152","article-title":"Test Pricing and Reimbursement in Genomic Medicine: Towards a General Strategy","volume":"19","author":"Vozikis","year":"2016","journal-title":"Public Health Genom."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrm3838","article-title":"Regulation of microRNA biogenesis","volume":"15","author":"Ha","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.tins.2012.01.004","article-title":"MicroRNAs in neuronal function and dysfunction","volume":"35","author":"Im","year":"2012","journal-title":"Trends Neurosci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.cell.2018.12.021","article-title":"The Landscape of Circular RNA in Cancer","volume":"176","author":"Vo","year":"2019","journal-title":"Cell"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.tins.2016.06.006","article-title":"Circular RNAs in Brain and Other Tissues: A Functional Enigma","volume":"39","author":"Chen","year":"2016","journal-title":"Trends Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","article-title":"Gene regulation by long non-coding RNAs and its biological functions","volume":"22","author":"Statello","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3004338","DOI":"10.1155\/2022\/3004338","article-title":"Circulating hsa-let-7e-5p and hsa-miR-125a-5p as Possible Biomarkers in the Diagnosis of Major Depression and Bipolar Disorders","volume":"2022","author":"Gecys","year":"2022","journal-title":"Dis. Markers"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"718976","DOI":"10.3389\/fgene.2021.718976","article-title":"Bioinformatics Analysis of circRNA Expression and Construction of \u201ccircRNA-miRNA-mRNA\u201d Competing Endogenous RNAs Networks in Bipolar Disorder Patients","volume":"12","author":"Fu","year":"2021","journal-title":"Front. Genet."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Eghtedarian, R., Ghafouri-Fard, S., Bouraghi, H., Hussen, B.M., Arsang-Jang, S., and Taheri, M. (2022). Abnormal pattern of vitamin D receptor-associated genes and lncRNAs in patients with bipolar disorder. BMC Psychiatry, 22.","DOI":"10.1186\/s12888-022-03811-8"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"15653","DOI":"10.1038\/s41598-021-94122-7","article-title":"Identification of lncRNA NR_028138.1 as a biomarker and construction of a ceRNA network for bipolar disorder","volume":"11","author":"He","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3389\/fpsyt.2020.00757","article-title":"Plasma microRNA Array Analysis Identifies Overexpressed miR-19b-3p as a Biomarker of Bipolar Depression Distinguishing From Unipolar Depression","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Psychiatry"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/s41598-020-58195-0","article-title":"Serum miRNA as a possible biomarker in the diagnosis of bipolar II disorder","volume":"10","author":"Lee","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1080\/15622975.2017.1282172","article-title":"Insulin-like growth factor binding protein 2 in bipolar disorder: An expression study in peripheral tissues","volume":"19","author":"Milanesi","year":"2018","journal-title":"World J. Biol. Psychiatry"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s00406-019-01057-2","article-title":"A miRNome analysis of drug-free manic psychotic bipolar patients versus healthy controls","volume":"270","author":"Tabano","year":"2020","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jad.2019.05.020","article-title":"Preliminary investigation of peripheral extracellular vesicles\u2019 microRNAs in bipolar disorder","volume":"255","author":"Fries","year":"2019","journal-title":"J. Affect. Disord."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jad.2019.10.038","article-title":"Circulating exosomal microRNAs in bipolar disorder","volume":"262","author":"Ceylan","year":"2020","journal-title":"J. Affect. Disord."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"738442","DOI":"10.3389\/fnins.2021.738442","article-title":"The Emerging Role of Neural Cell-Derived Exosomes in Intercellular Communication in Health and Neurodegenerative Diseases","volume":"15","author":"Huo","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jad.2019.09.060","article-title":"MicroRNA dysregulation in manic and euthymic patients with bipolar disorder","volume":"261","author":"Camkurt","year":"2020","journal-title":"J. Affect. Disord."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neulet.2017.06.019","article-title":"Dysregulation of miR-499, miR-708 and miR-1908 during a depression episode in bipolar disorders","volume":"654","author":"Banach","year":"2017","journal-title":"Neurosci. Lett."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jad.2016.04.021","article-title":"Peripheral whole blood microRNA alterations in major depression and bipolar disorder","volume":"200","author":"Maffioletti","year":"2016","journal-title":"J. Affect. Disord."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s00109-021-02070-6","article-title":"Dysregulation of circRNA expression in the peripheral blood of individuals with schizophrenia and bipolar disorder","volume":"99","author":"Mahmoudi","year":"2021","journal-title":"J. Mol. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.euroneuro.2012.06.013","article-title":"Blood microRNA changes in depressed patients during antidepressant treatment","volume":"23","author":"Maffioletti","year":"2013","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jad.2021.10.081","article-title":"Logistic ridge regression to predict bipolar disorder using mRNA expression levels in the N-methyl-D-aspartate receptor genes","volume":"297","author":"Lin","year":"2021","journal-title":"J. Affect. Disord."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.pnpbp.2017.08.011","article-title":"Regulation of gene transcription in bipolar disorders: Role of DNA methylation in the relationship between prodynorphin and brain derived neurotrophic factor","volume":"82","author":"Palazzo","year":"2018","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1176\/appi.ajp.2012.11091431","article-title":"Up-Regulation of NOTCH4 Gene Expression in Bipolar Disorder","volume":"169","author":"Dieset","year":"2012","journal-title":"Am. J. Psychiatry"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"7479","DOI":"10.1038\/s41598-022-11674-y","article-title":"Downregulation of long non-coding RNAs in patients with bipolar disorder","volume":"12","author":"Maloum","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Maloum, Z., Taheri, M., Ghafouri-Fard, S., and Shirvani-Farsani, Z. (2022). Significant reduction of long non-coding RNAs expression in bipolar disorder. BMC Psychiatry, 22.","DOI":"10.1186\/s12888-022-03899-y"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e54420","DOI":"10.15252\/embr.202154420","article-title":"Bipolar-associated miR-499-5p controls neuroplasticity by downregulating the Cav1.2 subunit CACNB2","volume":"23","author":"Martins","year":"2022","journal-title":"EMBO Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e614","DOI":"10.1038\/tp.2015.110","article-title":"A composite peripheral blood gene expression measure as a potential diagnostic biomarker in bipolar disorder","volume":"5","author":"Munkholm","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.neulet.2018.12.044","article-title":"Significant increasing of DISC2 long non-coding RNA expression as a potential biomarker in bipolar disorder","volume":"696","author":"Zahirodin","year":"2019","journal-title":"Neurosci. Lett."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jad.2019.02.034","article-title":"Peripheral expression of long non-coding RNAs in bipolar patients","volume":"249","author":"Sayad","year":"2019","journal-title":"J. Affect. Disord."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jad.2022.08.034","article-title":"Decreased miR-15b-5p\/miR-155-5p levels and increased miR-134-5p\/miR-652-3p levels among BD patients under lithium treatment","volume":"317","author":"Tekdemir","year":"2022","journal-title":"J. Affect. Disord."},{"key":"ref_42","first-page":"378","article-title":"Biomarker potential of hsa-miR-145-5p in peripheral whole blood of manic bipolar I patients","volume":"40","author":"Tekin","year":"2022","journal-title":"Braz. J. Psychiatry"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"20941","DOI":"10.1038\/s41598-022-25670-9","article-title":"Expression analysis of NF-\u0199B-related long non-coding RNAs in bipolar disorder","volume":"12","author":"Teshnizi","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.euroneuro.2017.09.003","article-title":"Distinct lithium-induced gene expression effects in lymphoblastoid cell lines from patients with bipolar disorder","volume":"27","author":"Fries","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"110691","DOI":"10.1016\/j.pnpbp.2022.110691","article-title":"Gene expression of circadian genes and CIART in bipolar disorder: A preliminary case-control study","volume":"122","author":"Courtin","year":"2023","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1007\/s12031-015-0567-9","article-title":"Preliminary Transcriptome Analysis in Lymphoblasts from Cluster Headache and Bipolar Disorder Patients Implicates Dysregulation of Circadian and Serotonergic Genes","volume":"56","author":"Costa","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1017\/S1461145713000655","article-title":"Differential effect of lithium on spermidine\/spermine N1-acetyltransferase expression in suicidal behaviour","volume":"16","author":"Squassina","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_48","first-page":"102","article-title":"Implication of the polyamine system in mental disorders","volume":"33","author":"Fiori","year":"2008","journal-title":"J. Psychiatry Neurosci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.euroneuro.2020.03.005","article-title":"MicroRNA expression profiling of lymphoblasts from bipolar disorder patients who died by suicide, pathway analysis and integration with postmortem brain findings","volume":"34","author":"Squassina","year":"2020","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/mp.2014.176","article-title":"Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder","volume":"20","author":"Bavamian","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13073-020-00733-6","article-title":"Transcriptome analysis and functional characterization of cerebral organoids in bipolar disorder","volume":"12","author":"Kathuria","year":"2020","journal-title":"Genome Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1089\/scd.2020.0046","article-title":"MicroRNA Alterations in Induced Pluripotent Stem Cell-Derived Neurons from Bipolar Disorder Patients: Pathways Involved in Neuronal Differentiation, Axon Guidance, and Plasticity","volume":"29","author":"Bame","year":"2020","journal-title":"Stem Cells Dev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jad.2021.04.042","article-title":"Abnormal gene expression of BDNF, but not BDNF-AS, in iPSC, neural stem cells and postmortem brain samples from bipolar disorder","volume":"290","author":"Ishima","year":"2021","journal-title":"J. Affect. Disord."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jpsychires.2018.12.007","article-title":"Plasma microRNA expression levels and their targeted pathways in patients with major depressive disorder who are responsive to duloxetine treatment","volume":"110","author":"Kim","year":"2019","journal-title":"J. Psychiatr. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/mp.2015.7","article-title":"Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities","volume":"20","author":"Madison","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1038\/s41380-020-0844-z","article-title":"Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids","volume":"25","author":"Sawada","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1097\/CHI.0b013e31817eecd9","article-title":"Brain-Derived Neurotrophic Factor Gene Expression in Pediatric Bipolar Disorder: Effects of Treatment and Clinical Response","volume":"47","author":"Pandey","year":"2008","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jpsychires.2010.04.028","article-title":"MicroRNA-134 plasma levels before and after treatment for bipolar mania","volume":"45","author":"Rong","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/tpj.2013.16","article-title":"Gene-expression differences in peripheral blood between lithium responders and non-responders in the Lithium Treatment-Moderate dose Use Study (LiTMUS)","volume":"14","author":"Beech","year":"2013","journal-title":"Pharmacogenom. J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/2045-5380-2-15","article-title":"Increased ratio of anti-apoptotic to pro-apoptotic Bcl2 gene-family members in lithium-responders one month after treatment initiation","volume":"2","author":"Lowthert","year":"2012","journal-title":"Biol. Mood Anxiety Disord."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1159\/000446348","article-title":"Effects of Lithium Monotherapy for Bipolar Disorder on Gene Expression in Peripheral Lymphocytes","volume":"2","author":"Anand","year":"2016","journal-title":"Complex Psychiatry"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41398-020-0784-z","article-title":"Integrative analysis of lithium treatment associated effects on brain structure and peripheral gene expression reveals novel molecular insights into mechanism of action","volume":"10","author":"Anand","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"ref_63","first-page":"19","article-title":"Telomere length and hTERT in mania and subsequent remission","volume":"40","year":"2018","journal-title":"Braz. J. Psychiatry"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.euroneuro.2015.02.002","article-title":"Decreased AKT1\/mTOR pathway mRNA expression in short-term bipolar disorder","volume":"25","author":"Zanetti","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41398-018-0237-0","article-title":"A gene co-expression module implicating the mitochondrial electron transport chain is associated with long-term response to lithium treatment in bipolar affective disorder","volume":"8","author":"Stacey","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Cattane, N., Courtin, C., Mombelli, E., Maj, C., Mora, C., Etain, B., Bellivier, F., Marie-Claire, C., and Cattaneo, A. (2022). Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorder. BMC Psychiatry, 22.","DOI":"10.1186\/s12888-022-04286-3"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e504","DOI":"10.1038\/tp.2014.139","article-title":"Novel integrative genomic tool for interrogating lithium response in bipolar disorder","volume":"5","author":"Hunsberger","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Pisanu, C., Papadima, E.M., Melis, C., Congiu, D., Loizedda, A., Orr\u00f9, N., Calza, S., Carcassi, C., Severino, G., and Ardau, R. (2019). Whole Genome Expression Analyses of miRNAs and mRNAs Suggest the Involvement of miR-320a and miR-155-3p and their Targeted Genes in Lithium Response in Bipolar Disorder. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20236040"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Manchia, M., Adli, M., Akula, N., Ardau, R., Aubry, J.-M., Backlund, L., Banzato, C.E., Baune, B.T., Bellivier, F., and Bengesser, S. (2013). Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0065636"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/tpj.2016.50","article-title":"Lithium-responsive genes and gene networks in bipolar disorder patient-derived lymphoblastoid cell lines","volume":"16","author":"Breen","year":"2016","journal-title":"Pharmacogenom. J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41398-018-0126-6","article-title":"Lithium-associated transcriptional regulation of CRMP1 in patient-derived olfactory neurons and symptom changes in bipolar disorder","volume":"8","author":"McLean","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1080\/15622975.2017.1282174","article-title":"Lithium response in bipolar disorders and core clock genes expression","volume":"19","author":"Geoffroy","year":"2018","journal-title":"World J. Biol. Psychiatry"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1080\/15622975.2017.1346281","article-title":"Involvement of core clock genes in lithium response","volume":"19","author":"Pisanu","year":"2018","journal-title":"World J. Biol. Psychiatry"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Niemsiri, V., Rosenthal, S.B., Nievergelt, C.M., Maihofer, A.X., Marchetto, M.C., Santos, R., Shekhtman, T., Alliey-Rodriguez, N., Anand, A., and Balaraman, Y. (2023). Focal adhesion is associated with lithium response in bipolar disorder: Evidence from a network-based multi-omics analysis. Mol. Psychiatry.","DOI":"10.1038\/s41380-022-01909-9"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nature15526","article-title":"Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder","volume":"527","author":"Mertens","year":"2015","journal-title":"Nature"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1038\/s41380-020-00981-3","article-title":"Deficient LEF1 expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients","volume":"26","author":"Santos","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1080\/15622975.2017.1396357","article-title":"Lithium-induced gene expression alterations in two peripheral cell models of bipolar disorder","volume":"20","author":"Hilscher","year":"2019","journal-title":"World J. Biol. Psychiatry"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s12031-015-0523-8","article-title":"Insulin-like Growth Factor 1 Differentially Affects Lithium Sensitivity of Lymphoblastoid Cell Lines from Lithium Responder and Non-responder Bipolar Disorder Patients","volume":"56","author":"Milanesi","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1080\/15622975.2017.1372629","article-title":"RNA sequencing of bipolar disorder lymphoblastoid cell lines implicates the neurotrophic factor HRP-3 in lithium\u2019s clinical efficacy","volume":"20","author":"Milanesi","year":"2019","journal-title":"World J. Biol. Psychiatry"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.psychres.2017.02.022","article-title":"Lithium response in bipolar disorder: No difference in GADL1 gene expression between cell lines from excellent-responders and non-responders","volume":"251","author":"Moreira","year":"2017","journal-title":"Psychiatry Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s12031-017-0938-5","article-title":"Evidence towards RNA Binding Motif (RNP1, RRM) Protein 3 (RBM3) as a Potential Biomarker of Lithium Response in Bipolar Disorder Patients","volume":"62","author":"Papadima","year":"2017","journal-title":"J. Mol. Neurosci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"7428","DOI":"10.1038\/s41598-020-64202-1","article-title":"Lithium response in bipolar disorder correlates with improved cell viability of patient derived cell lines","volume":"10","author":"Paul","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/ajmg.b.32663","article-title":"Convergent analysis of genome-wide genotyping and transcriptomic data suggests association of zinc finger genes with lithium response in bipolar disorder","volume":"177","author":"Pisanu","year":"2018","journal-title":"Am. J. Med. Genet. Part B Neuropsychiatr. Genet."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.phrs.2008.03.011","article-title":"The PDLIM5 gene and lithium prophylaxis: An association and gene expression analysis in Sardinian patients with bipolar disorder","volume":"57","author":"Squassina","year":"2008","journal-title":"Pharmacol. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2013.04.004","article-title":"Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients","volume":"73","author":"Squassina","year":"2013","journal-title":"Pharmacol. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/sj.npp.1300383","article-title":"Identification of Lithium-Regulated Genes in Cultured Lymphoblasts of Lithium Responsive Subjects with Bipolar Disorder","volume":"29","author":"Sun","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0165-0327(94)90066-3","article-title":"Lithium response and genetics of affective disorders","volume":"32","author":"Grof","year":"1994","journal-title":"J. Affect. Disord."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00406-009-0085-2","article-title":"Duration of untreated illness and suicide in bipolar disorder: A naturalistic study","volume":"260","author":"Altamura","year":"2010","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2147\/CEOR.S259338","article-title":"The Economic Burden of Bipolar Disorder in the United States: A Systematic Literature Review","volume":"12","author":"Bessonova","year":"2020","journal-title":"Clin. Outcomes Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/12\/10067\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:53:57Z","timestamp":1760126037000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/12\/10067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,13]]},"references-count":89,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["ijms241210067"],"URL":"https:\/\/doi.org\/10.3390\/ijms241210067","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,13]]}}}