{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:45:08Z","timestamp":1791499508125,"version":"4.3.4"},"reference-count":298,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T00:00:00Z","timestamp":1686614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Centro de Neurobiolog\u00eda y Fisiopatolog\u00eda Integrativa (CENFI), Universidad de Valpara\u00edso","award":["DIUV-CI 01\/2006"],"award-info":[{"award-number":["DIUV-CI 01\/2006"]}]},{"name":"Centro de Neurobiolog\u00eda y Fisiopatolog\u00eda Integrativa (CENFI), Universidad de Valpara\u00edso","award":["11220927"],"award-info":[{"award-number":["11220927"]}]},{"name":"Centro de Neurobiolog\u00eda y Fisiopatolog\u00eda Integrativa (CENFI), Universidad de Valpara\u00edso","award":["1201816"],"award-info":[{"award-number":["1201816"]}]},{"name":"Centro de Neurobiolog\u00eda y Fisiopatolog\u00eda Integrativa (CENFI), Universidad de Valpara\u00edso","award":["1200474"],"award-info":[{"award-number":["1200474"]}]},{"name":"Centro de Neurobiolog\u00eda y Fisiopatolog\u00eda Integrativa (CENFI), Universidad de Valpara\u00edso","award":["20993"],"award-info":[{"award-number":["20993"]}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["DIUV-CI 01\/2006"],"award-info":[{"award-number":["DIUV-CI 01\/2006"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["11220927"],"award-info":[{"award-number":["11220927"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1201816"],"award-info":[{"award-number":["1201816"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1200474"],"award-info":[{"award-number":["1200474"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["20993"],"award-info":[{"award-number":["20993"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PUENTE UVA","award":["DIUV-CI 01\/2006"],"award-info":[{"award-number":["DIUV-CI 01\/2006"]}]},{"name":"PUENTE UVA","award":["11220927"],"award-info":[{"award-number":["11220927"]}]},{"name":"PUENTE UVA","award":["1201816"],"award-info":[{"award-number":["1201816"]}]},{"name":"PUENTE UVA","award":["1200474"],"award-info":[{"award-number":["1200474"]}]},{"name":"PUENTE UVA","award":["20993"],"award-info":[{"award-number":["20993"]}]},{"name":"IBRO Early Career Award","award":["DIUV-CI 01\/2006"],"award-info":[{"award-number":["DIUV-CI 01\/2006"]}]},{"name":"IBRO Early Career Award","award":["11220927"],"award-info":[{"award-number":["11220927"]}]},{"name":"IBRO Early Career Award","award":["1201816"],"award-info":[{"award-number":["1201816"]}]},{"name":"IBRO Early Career Award","award":["1200474"],"award-info":[{"award-number":["1200474"]}]},{"name":"IBRO Early Career Award","award":["20993"],"award-info":[{"award-number":["20993"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Many diseases and degenerative processes affecting the nervous system and peripheral organs trigger the activation of inflammatory cascades. Inflammation can be triggered by different environmental conditions or risk factors, including drug and food addiction, stress, and aging, among others. Several pieces of evidence show that the modern lifestyle and, more recently, the confinement associated with the COVID-19 pandemic have contributed to increasing the incidence of addictive and neuropsychiatric disorders, plus cardiometabolic diseases. Here, we gather evidence on how some of these risk factors are implicated in activating central and peripheral inflammation contributing to some neuropathologies and behaviors associated with poor health. We discuss the current understanding of the cellular and molecular mechanisms involved in the generation of inflammation and how these processes occur in different cells and tissues to promote ill health and diseases. Concomitantly, we discuss how some pathology-associated and addictive behaviors contribute to worsening these inflammation mechanisms, leading to a vicious cycle that promotes disease progression. Finally, we list some drugs targeting inflammation-related pathways that may have beneficial effects on the pathological processes associated with addictive, mental, and cardiometabolic illnesses.<\/jats:p>","DOI":"10.3390\/ijms241210083","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T01:32:15Z","timestamp":1686706335000},"page":"10083","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Central and Peripheral Inflammation: A Common Factor Causing Addictive and Neurological Disorders and Aging-Related Pathologies"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4035-8827","authenticated-orcid":false,"given":"Ang\u00e9lica P.","family":"Escobar","sequence":"first","affiliation":[{"name":"Centro de Neurobiolog\u00eda y Fisiopatolog\u00eda Integrativa (CENFI), Instituto de Fisiolog\u00eda, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso 2360102, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Bonansco","sequence":"additional","affiliation":[{"name":"Centro de Neurobiolog\u00eda y Fisiopatolog\u00eda Integrativa (CENFI), Instituto de Fisiolog\u00eda, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso 2360102, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1458-3599","authenticated-orcid":false,"given":"Gonzalo","family":"Cruz","sequence":"additional","affiliation":[{"name":"Centro de Neurobiolog\u00eda y Fisiopatolog\u00eda Integrativa (CENFI), Instituto de Fisiolog\u00eda, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso 2360102, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9909-9826","authenticated-orcid":false,"given":"Alexies","family":"Dagnino-Subiabre","sequence":"additional","affiliation":[{"name":"Centro de Neurobiolog\u00eda y Fisiopatolog\u00eda Integrativa (CENFI), Instituto de Fisiolog\u00eda, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso 2360102, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1785-6748","authenticated-orcid":false,"given":"Marco","family":"Fuenzalida","sequence":"additional","affiliation":[{"name":"Centro de Neurobiolog\u00eda y Fisiopatolog\u00eda Integrativa (CENFI), Instituto de Fisiolog\u00eda, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso 2360102, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Negr\u00f3n","sequence":"additional","affiliation":[{"name":"Centro de Neurobiolog\u00eda y Fisiopatolog\u00eda Integrativa (CENFI), Instituto de Fisiolog\u00eda, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso 2360102, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1239-5367","authenticated-orcid":false,"given":"Ram\u00f3n","family":"Sotomayor-Z\u00e1rate","sequence":"additional","affiliation":[{"name":"Centro de Neurobiolog\u00eda y Fisiopatolog\u00eda Integrativa (CENFI), Instituto de Fisiolog\u00eda, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso 2360102, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8628-892X","authenticated-orcid":false,"given":"Jonathan","family":"Mart\u00ednez-Pinto","sequence":"additional","affiliation":[{"name":"Centro de Neurobiolog\u00eda y Fisiopatolog\u00eda Integrativa (CENFI), Instituto de Fisiolog\u00eda, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso 2360102, Chile"},{"name":"Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA"},{"name":"Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7890-7321","authenticated-orcid":false,"given":"Gonzalo","family":"Jorquera","sequence":"additional","affiliation":[{"name":"Centro de Neurobiolog\u00eda y Fisiopatolog\u00eda Integrativa (CENFI), Instituto de Fisiolog\u00eda, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso 2360102, Chile"},{"name":"Instituto de Nutrici\u00f3n y Tecnolog\u00eda de los Alimentos (INTA), Universidad de Chile, Santiago 7830490, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"Furman","year":"2019","journal-title":"Nat. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1007\/s40618-021-01587-4","article-title":"Reduced Th1 response is associated with lower glycolytic activity in asctivated peripheral blood mononuclear cells after metabolic and bariatric surgery","volume":"44","author":"Castillo","year":"2021","journal-title":"J. Endocrinol. Investig."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00281-020-00829-6","article-title":"Adrenergic regulation of immune cell function and inflammation","volume":"42","author":"Sharma","year":"2020","journal-title":"Semin. Immunopathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e1352","DOI":"10.1002\/cti2.1352","article-title":"Inflammation neuroscience: Neuro-immune crosstalk and interfaces","volume":"10","author":"Tarnawski","year":"2021","journal-title":"Clin. Transl. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Grosso, G., Laudisio, D., Frias-Toral, E., Barrea, L., Muscogiuri, G., Savastano, S., and Colao, A. (2022). Anti-Inflammatory Nutrients and Obesity-Associated Metabolic-Inflammation: State of the Art and Future Direction. Nutrients, 14.","DOI":"10.3390\/nu14061137"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3389\/fnagi.2019.00369","article-title":"Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer\u2019s Disease","volume":"11","author":"Bhatti","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3389\/fpsyt.2019.00350","article-title":"What Is the Role of Dietary Inflammation in Severe Mental Illness? A Review of Observational and Experimental Findings","volume":"10","author":"Firth","year":"2019","journal-title":"Front. Psychiatry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"672455","DOI":"10.3389\/fneur.2021.672455","article-title":"Cross-talk of the CNS with immune cells and functions in health and disease","volume":"12","author":"Matejuk","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ibneur.2022.12.003","article-title":"Neurodegeneration and inflammation crosstalk: Therapeutic targets and perspectives","volume":"14","author":"Mohamed","year":"2023","journal-title":"IBRO Neurosci. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neuroscience.2018.11.010","article-title":"Diversity and Specificity of Astrocyte-neuron Communication","volume":"396","author":"Durkee","year":"2019","journal-title":"Neuroscience"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-40764-7_1","article-title":"Glial Cells and Integrity of the Nervous System","volume":"949","author":"Flores","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/1073858418783959","article-title":"Microglia-astrocyte crosstalk: An intimate molecular conversation","volume":"25","author":"Jha","year":"2019","journal-title":"Neuroscientist"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Greiner, T., and Kipp, M. (2021). What Guides Peripheral Immune Cells into the Central Nervous System?. Cells, 10.","DOI":"10.3390\/cells10082041"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"H1","DOI":"10.1530\/VB-19-0033","article-title":"Immune cell trafficking across the blood-brain barrier in the absence and presence of neuroinflammation","volume":"2","author":"Marchetti","year":"2020","journal-title":"Vasc. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"661838","DOI":"10.3389\/fncel.2021.661838","article-title":"Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction","volume":"15","author":"Takata","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"805657","DOI":"10.3389\/fimmu.2022.805657","article-title":"How Does the Immune System Enter the Brain?","volume":"13","author":"Mapunda","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/s11481-009-9166-2","article-title":"CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease?","volume":"4","author":"Gate","year":"2009","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-immunol-051116-052358","article-title":"Microglia Function in the Central Nervous System During Health and Neurodegeneration","volume":"35","author":"Colonna","year":"2017","journal-title":"Annu. Rev. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.3389\/fphar.2019.01114","article-title":"Astrocytes: Role and Functions in Brain Pathologies","volume":"10","author":"Siracusa","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.tins.2009.05.001","article-title":"Tripartite synapses: Astrocytes process and control synaptic information","volume":"32","author":"Perea","year":"2009","journal-title":"Trends Neurosci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1126\/science.aat0473","article-title":"Glia as architects of central nervous system formation and function","volume":"362","author":"Allen","year":"2018","journal-title":"Science"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4942","DOI":"10.1523\/JNEUROSCI.4485-14.2015","article-title":"Microglia-dependent alteration of glutamatergic synaptic transmission and plasticity in the hippocampus during peripheral inflammation","volume":"35","author":"Riazi","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuropharm.2014.12.020","article-title":"Immune dysregulation and cognitive vulnerability in the aging brain: Interactions of microglia, IL-1\u03b2, BDNF and synaptic plasticity","volume":"96","author":"Patterson","year":"2015","journal-title":"Neuropharmacology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.biopsych.2013.10.003","article-title":"Major histocompatibility complex I in brain development and schizophrenia","volume":"75","author":"McAllister","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1126\/science.1202529","article-title":"Synaptic pruning by microglia is necessary for normal brain development","volume":"333","author":"Paolicelli","year":"2011","journal-title":"Science"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.neuron.2008.05.017","article-title":"There\u2019s more than one way to scale a synapse","volume":"58","author":"Aizenman","year":"2008","journal-title":"Neuron"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.tips.2008.06.005","article-title":"Neuroinflammation and synaptic plasticity: Theoretical basis for a novel, immune-centred, therapeutic approach to neurological disorders","volume":"29","author":"Sarchielli","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2398212820979802","DOI":"10.1177\/2398212820979802","article-title":"The role of cytokines in modulating learning and memory and brain plasticity","volume":"4","author":"Bourgognon","year":"2020","journal-title":"Brain Neurosci. Adv."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/jnc.13607","article-title":"Neuroinflammation: The devil is in the details","volume":"139","author":"DiSabato","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.it.2016.06.006","article-title":"Astrocytes: Key Regulators of Neuroinflammation","volume":"37","author":"Colombo","year":"2016","journal-title":"Trends Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.nbd.2009.07.030","article-title":"Structure and function of the blood-brain barrier","volume":"37","author":"Abbott","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2003.12.016","article-title":"The blood-brain barrier: An overview: Structure, regulation, and clinical implications","volume":"16","author":"Ballabh","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/npp.2016.199","article-title":"Inflammation, Glutamate, and Glia: A Trio of Trouble in Mood Disorders","volume":"42","author":"Haroon","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3389\/fimmu.2020.00294","article-title":"Glial Cells: Role of the Immune Response in Ischemic Stroke","volume":"11","author":"Xu","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1152\/physrev.00041.2013","article-title":"Astrocyte reactivity and reactive astrogliosis: Costs and benefits","volume":"94","author":"Pekny","year":"2014","journal-title":"Physiol. Rev."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"O\u2019Callaghan, J.P., Kelly, K.A., VanGilder, R.L., Sofroniew, M.V., and Miller, D.B. (2014). Early activation of STAT3 regulates reactive astrogliosis induced by diverse forms of neurotoxicity. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0102003"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000364934","article-title":"Low-grade systemic inflammation connects aging, metabolic syndrome and cardiovascular disease","volume":"40","author":"Guarner","year":"2015","journal-title":"Interdiscip. Top. Gerontol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/iid3.391","article-title":"Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease","volume":"9","author":"Luo","year":"2021","journal-title":"Immun. Inflamm. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-3-319-48382-5_9","article-title":"The Pathogenesis of Obesity-Associated Adipose Tissue Inflammation","volume":"960","author":"Engin","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Nativel, B., Marimoutou, M., Thon-Hon, V.G., Gunasekaran, M.K., Andries, J., Stanislas, G., Planesse, C., Da Silva, C.R., C\u00e9sari, M., and Iwema, T. (2013). Soluble HMGB1 is a novel adipokine stimulating IL-6 secretion through RAGE receptor in SW872 preadipocyte cell line: Contribution to chronic inflammation in fat tissue. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076039"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Rogero, M.M., and Calder, P.C. (2018). Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids. Nutrients, 10.","DOI":"10.3390\/nu10040432"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1136\/gutjnl-2016-313654","article-title":"Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice","volume":"67","author":"Bijnen","year":"2018","journal-title":"Gut"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"597648","DOI":"10.3389\/fendo.2020.597648","article-title":"Chronic Inflammation in Non-Alcoholic Steatohepatitis: Molecular Mechanisms and Therapeutic Strategies","volume":"11","author":"Luci","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s11011-011-9261-y","article-title":"Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction","volume":"26","author":"Ghareeb","year":"2011","journal-title":"Metab. Brain Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-015-0467-5","article-title":"Non-alcoholic fatty liver disease induces signs of Alzheimer\u2019s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model","volume":"13","author":"Kim","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"George, E.S., Sood, S., Daly, R.M., and Tan, S.Y. (2022). Is there an association between non-alcoholic fatty liver disease and cognitive function? A systematic review. BMC Geriatr., 22.","DOI":"10.1186\/s12877-021-02721-w"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.1210\/en.2004-1520","article-title":"Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus","volume":"146","author":"Araujo","year":"2005","journal-title":"Endocrinology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1210\/en.2009-1019","article-title":"Changes in melanocortin expression and inflammatory pathways in fetal offspring of nonhuman primates fed a high-fat diet","volume":"151","author":"Grayson","year":"2010","journal-title":"Endocrinology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cmet.2017.05.015","article-title":"Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility","volume":"26","author":"Valdearcos","year":"2017","journal-title":"Cell. Metab."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.molmet.2017.01.010","article-title":"Astrocyte IKK\u03b2\/NF-\u03baB signaling is required for diet-induced obesity and hypothalamic inflammation","volume":"6","author":"Douglass","year":"2017","journal-title":"Mol. Metab."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1002\/oby.21248","article-title":"Radiologic evidence that hypothalamic gliosis is associated with obesity and insulin resistance in humans","volume":"23","author":"Schur","year":"2015","journal-title":"Obesity"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S1474-4422(17)30084-4","article-title":"Neurological consequences of obesity","volume":"16","author":"Hinder","year":"2017","journal-title":"Lancet Neurol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"E1003","DOI":"10.1152\/ajpendo.90377.2008","article-title":"Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet","volume":"296","author":"Posey","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nrendo.2016.222","article-title":"The cellular and molecular bases of leptin and ghrelin resistance in obesity","volume":"13","author":"Cui","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/ncb2562","article-title":"IKK\u03b2\/NF-\u03baB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes","volume":"14","author":"Li","year":"2012","journal-title":"Nat. Cell. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1172\/JCI59660","article-title":"Obesity is associated with hypothalamic injury in rodents and humans","volume":"122","author":"Thaler","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.bbrc.2015.07.097","article-title":"One-day high-fat diet induces inflammation in the nodose ganglion and hypothalamus of mice","volume":"464","author":"Waise","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.tins.2017.02.005","article-title":"Obesity-Induced Neuroinflammation: Beyond the Hypothalamus","volume":"40","author":"Muccioli","year":"2017","journal-title":"Trends Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neuroscience.2019.10.021","article-title":"Immunometabolic Changes in Glia\u2013A Potential Role in the Pathophysiology of Obesity and Diabetes","volume":"447","author":"Robb","year":"2020","journal-title":"Neuroscience"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"846","DOI":"10.3389\/fnins.2018.00846","article-title":"Hypothalamic Microglial Activation in Obesity: A Mini-Review","volume":"12","author":"Mendes","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal. Transduct. Target. Ther."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.molmet.2014.10.001","article-title":"Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice","volume":"4","author":"Buckman","year":"2015","journal-title":"Mol. Metab."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Dinel, A.L., Andr\u00e9, C., Aubert, A., Ferreira, G., Lay\u00e9, S., and Castanon, N. (2011). Cognitive and emotional alterations are related to hippocampal inflammation in a mouse model of metabolic syndrome. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0024325"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bbi.2014.03.012","article-title":"Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: Focus on brain indoleamine 2,3-dioxygenase activation","volume":"41","author":"Dinel","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bbi.2015.08.023","article-title":"Dietary obesity reversibly induces synaptic stripping by microglia and impairs hippocampal plasticity","volume":"51","author":"Hao","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fendo.2013.00052","article-title":"Mechanisms of obesity-induced inflammation and insulin resistance: Insights into the emerging role of nutritional strategies","volume":"4","author":"McArdle","year":"2013","journal-title":"Front. Endocrinol."},{"key":"ref_67","first-page":"678159","article-title":"Obesity and inflammation: Epidemiology, risk factors, and markers of inflammation","volume":"2013","year":"2013","journal-title":"Int. J. Endocrinol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nm1166","article-title":"Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB","volume":"11","author":"Cai","year":"2005","journal-title":"Nat. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1210\/en.2006-0692","article-title":"Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression","volume":"148","author":"Jager","year":"2007","journal-title":"Endocrinology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"E745","DOI":"10.1152\/ajpendo.2001.280.5.E745","article-title":"Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance","volume":"280","author":"Kern","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1172\/JCI28898","article-title":"TLR4 links innate immunity and fatty acid-induced insulin resistance","volume":"116","author":"Shi","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1093\/ptj\/73.12.878","article-title":"The role of skeletal muscle in glucose transport, glucose homeostasis, and insulin resistance: Implications for physical therapy","volume":"73","author":"Sinacore","year":"1993","journal-title":"Phys. Ther."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/oby.20615","article-title":"Pro-inflammatory macrophages increase in skeletal muscle of high fat-fed mice and correlate with metabolic risk markers in humans","volume":"22","author":"Fink","year":"2014","journal-title":"Obesity"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1038\/ijo.2015.104","article-title":"Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance","volume":"39","author":"Khan","year":"2015","journal-title":"Int. J. Obes."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.2337\/db11-0263","article-title":"Elevated NF-\u03baB activation is conserved in human myocytes cultured from obese type 2 diabetic patients and attenuated by AMP-activated protein kinase","volume":"60","author":"Green","year":"2011","journal-title":"Diabetes"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1007\/s00125-021-05418-2","article-title":"High extracellular ATP levels released through pannexin-1 channels mediate inflammation and insulin resistance in skeletal muscle fibres of diet-induced obese mice","volume":"64","author":"Jorquera","year":"2021","journal-title":"Diabetologia"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1523\/JNEUROSCI.4200-13.2014","article-title":"Obesity elicits interleukin 1-mediated deficits in hippocampal synaptic plasticity","volume":"34","author":"Erion","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1172\/JCI126078","article-title":"Visceral adipose NLRP3 impairs cognition in obesity via IL-1R1 on CX3CR1+ cells","volume":"130","author":"Guo","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Lee, T.H., and Yau, S.Y. (2020). From Obesity to Hippocampal Neurodegeneration: Pathogenesis and Non-Pharmacological Interventions. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010201"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"76","DOI":"10.15698\/cst2021.06.250","article-title":"The evolution of the concept of stress and the framework of the stress system","volume":"5","author":"Lu","year":"2021","journal-title":"Cell. Stress."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.taap.2007.02.015","article-title":"Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework","volume":"222","author":"Calabrese","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0278-5846(03)00162-3","article-title":"Psychoneuroendocrinological links between chronic stress and depression","volume":"27","author":"Tafet","year":"2003","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrn2647","article-title":"Neural regulation of endocrine and autonomic stress responses","volume":"10","author":"Herman","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1314.001","article-title":"Protection and damage from acute and chronic stress: Allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders","volume":"1032","author":"McEwen","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1196\/annals.1314.037","article-title":"Psychoneuroendocrinological studies on chronic stress and depression","volume":"1032","author":"Tafet","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Mucci, F., Marazziti, D., Della Vecchia, A., Baroni, S., Morana, P., Carpita, B., Mangiapane, P., Morana, F., Morana, B., and Dell\u2019Osso, L. (2020). State-of-the-Art: Inflammatory and Metabolic Markers in Mood Disorders. Life, 10.","DOI":"10.3390\/life10060082"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bbi.2015.06.001","article-title":"Cumulative meta-analysis of interleukins 6 and 1\u03b2, tumour necrosis factor \u03b1 and C-reactive protein in patients with major depressive disorder","volume":"49","author":"Haapakoski","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.nbd.2009.11.015","article-title":"Neuroimmune mechanisms of cytokine-induced depression: Current theories and novel treatment strategies","volume":"37","author":"Loftis","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jpsychires.2012.12.001","article-title":"Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder","volume":"47","author":"Sasayama","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3389\/fpsyt.2015.00138","article-title":"Cellular and Molecular Inflammatory Profile of the Choroid Plexus in Depression and Suicide","volume":"6","author":"Devorak","year":"2015","journal-title":"Front. Psychiatry"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1001\/jamapsychiatry.2014.2427","article-title":"Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes","volume":"72","author":"Setiawan","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.bbi.2011.04.005","article-title":"Acute amygdaloid response to systemic inflammation","volume":"25","author":"Engler","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1523\/JNEUROSCI.3642-17.2018","article-title":"Maternal and Early Postnatal Immune Activation Produce Dissociable Effects on Neurotransmission in mPFC-Amygdala Circuits","volume":"38","author":"Li","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.yfrne.2018.02.003","article-title":"Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation","volume":"49","author":"Meijer","year":"2018","journal-title":"Front. Neuroendocrinol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1210\/endo-117-6-2505","article-title":"Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation","volume":"117","author":"Reul","year":"1985","journal-title":"Endocrinology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1677\/joe.0.1150459","article-title":"Relative occupation of type-I and type-II corticosteroid receptors in rat brain following stress and dexamethasone treatment: Functional implications","volume":"115","author":"Reul","year":"1987","journal-title":"J. Endocrinol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1749-6632.1994.tb39206.x","article-title":"Corticosteroids and the control of function in the hypothalamo-pituitary-adrenal (HPA) axis","volume":"746","author":"Dallman","year":"1994","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_98","first-page":"269","article-title":"Brain corticosteroid receptor balance in health and disease","volume":"19","author":"Vreugdenhil","year":"1998","journal-title":"Endocr. Rev."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1152\/physrev.00011.2010","article-title":"Physiology of microglia","volume":"91","author":"Kettenmann","year":"2011","journal-title":"Physiol. Rev."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3389\/fncel.2013.00229","article-title":"The role of microglia in adult hippocampal neurogenesis","volume":"7","author":"Gemma","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3389\/fncel.2015.00476","article-title":"Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation","volume":"9","author":"Brites","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"9075","DOI":"10.1523\/JNEUROSCI.1537-11.2011","article-title":"Constant darkness induces IL-6-dependent depression-like behavior through the NF-\u03baB signaling pathway","volume":"31","author":"Monje","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/(SICI)1098-1136(199705)20:1<23::AID-GLIA3>3.0.CO;2-6","article-title":"Glucocorticoid- and mineralocorticoid receptors in microglial cells: The two receptors mediate differential effects of corticosteroids","volume":"20","author":"Tanaka","year":"1997","journal-title":"Glia"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/1742-2094-9-260","article-title":"Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells","volume":"9","author":"Chantong","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1038\/s41467-021-24967-z","article-title":"Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors","volume":"12","author":"Mifsud","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1210\/en.2012-2187","article-title":"Two populations of glucocorticoid receptor-binding sites in the male rat hippocampal genome","volume":"154","author":"Polman","year":"2013","journal-title":"Endocrinology"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/jlb.60.5.563","article-title":"Regulation of cytokine and cytokine receptor expression by glucocorticoids","volume":"60","author":"Almawi","year":"1996","journal-title":"J. Leukoc. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.4049\/jimmunol.169.4.1837","article-title":"Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo","volume":"169","author":"Brewer","year":"2002","journal-title":"J. Immunol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1620\/tjem.185.157","article-title":"Suppression of gene expression and production of interleukin 13 by dexamethasone in human peripheral blood mononuclear cells","volume":"185","author":"Fushimi","year":"1998","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1006\/cimm.1993.1134","article-title":"Immunosuppression by glucocorticoids: Inhibition of production of multiple lymphokines by in vivo administration of dexamethasone","volume":"149","author":"Kunicka","year":"1993","journal-title":"Cell. Immunol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cytogfr.2016.05.002","article-title":"A gradient of glucocorticoid sensitivity among helper T cell cytokines","volume":"31","author":"Banuelos","year":"2016","journal-title":"Cytokine Growth Factor. Rev."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"189","DOI":"10.5114\/reum.2017.69779","article-title":"Glucocorticoid management in rheumatoid arthritis: Morning or night low dose?","volume":"55","author":"Paolino","year":"2017","journal-title":"Reumatologia"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1523\/JNEUROSCI.0733-19.2019","article-title":"Revisiting the Stress Concept: Implications for Affective Disorders","volume":"40","author":"McEwen","year":"2020","journal-title":"J. Neurosci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neuroscience.2020.07.023","article-title":"Emotional Impairments and Neuroinflammation are Induced in Male Mice Invulnerable to Repeated Social Defeat Stress","volume":"443","author":"Ito","year":"2020","journal-title":"Neuroscience"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1742-2094-1-14","article-title":"Microglia and neuroinflammation: A pathological perspective","volume":"1","author":"Streit","year":"2004","journal-title":"J. Neuroinflammation"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3389\/fnbeh.2018.00240","article-title":"Putative Inflammatory Sensitive Mechanisms Underlying Risk or Resilience to Social Stress","volume":"12","author":"Finnell","year":"2018","journal-title":"Front. Behav. Neurosci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ynstr.2015.12.004","article-title":"Stress-induced neuroinflammatory priming: A liability factor in the etiology of psychiatric disorders","volume":"4","author":"Frank","year":"2016","journal-title":"Neurobiol. Stress."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/nn.3234","article-title":"Neurobiology of resilience","volume":"15","author":"Russo","year":"2012","journal-title":"Nat. Neurosci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/nprot.2011.361","article-title":"A standardized protocol for repeated social defeat stress in mice","volume":"6","author":"Golden","year":"2011","journal-title":"Nat. Protoc."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"6277","DOI":"10.1523\/JNEUROSCI.0450-11.2011","article-title":"beta-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat","volume":"31","author":"Wohleb","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.biopsych.2017.08.005","article-title":"Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study","volume":"83","author":"Holmes","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.biopsych.2019.04.011","article-title":"Neurobiology of Resilience: Interface Between Mind and Body","volume":"86","author":"Cathomas","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1038\/s41593-017-0010-3","article-title":"Social stress induces neurovascular pathology promoting depression","volume":"20","author":"Menard","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1002\/jnr.24902","article-title":"Long-term effects of stress resilience: Hippocampal neuroinflammation and behavioral approach in male rats","volume":"99","author":"Fernandez","year":"2021","journal-title":"J. Neurosci. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"117669","DOI":"10.1016\/j.lfs.2020.117669","article-title":"Ginsenoside Rg1 ameliorates chronic social defeat stress-induced depressive-like behaviors and hippocampal neuroinflammation","volume":"252","author":"Jiang","year":"2020","journal-title":"Life Sci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000153423","article-title":"Diet-induced inflammation of the hypothalamus in obesity","volume":"15","author":"Velloso","year":"2008","journal-title":"Neuroimmunomodulation"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1037\/a0015011","article-title":"Body mass index and alcohol consumption: Family history of alcoholism as a moderator","volume":"23","author":"Gearhardt","year":"2009","journal-title":"Psychol. Addict. Behav."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"26977","DOI":"10.1073\/pnas.2007918117","article-title":"Nucleus accumbens cytoarchitecture predicts weight gain in children","volume":"117","author":"Rapuano","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/adb.12541","article-title":"Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation","volume":"23","author":"Girard","year":"2018","journal-title":"Addict. Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molmet.2018.01.018","article-title":"Nucleus accumbens inflammation mediates anxiodepressive behavior and compulsive sucrose seeking elicited by saturated dietary fat","volume":"10","author":"Sharma","year":"2018","journal-title":"Mol. Metab."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Lenoir, M., Serre, F., Cantin, L., and Ahmed, S.H. (2007). Intense sweetness surpasses cocaine reward. PLoS ONE, 2.","DOI":"10.1371\/journal.pone.0000698"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1017\/S0007114507812037","article-title":"A maternal \u2018junk food\u2019 diet in pregnancy and lactation promotes an exacerbated taste for \u2018junk food\u2019 and a greater propensity for obesity in rat offspring","volume":"98","author":"Bayol","year":"2007","journal-title":"Br. J. Nutr."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.physbeh.2012.04.024","article-title":"Effects of perinatal exposure to palatable diets on body weight and sensitivity to drugs of abuse in rats","volume":"107","author":"Bocarsly","year":"2012","journal-title":"Physiol. Behav."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"e911","DOI":"10.1038\/tp.2016.176","article-title":"Enhanced sensitivity to drugs of abuse and palatable foods following maternal overnutrition","volume":"6","author":"Sarker","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Maldonado-Ruiz, R., Cardenas-Tueme, M., Montalvo-Martinez, L., Vidaltamayo, R., Garza-Ocanas, L., Resendez-Perez, D., and Camacho, A. (2019). Priming of Hypothalamic Ghrelin Signaling and Microglia Activation Exacerbate Feeding in Rats\u2019 Offspring Following Maternal Overnutrition. Nutrients, 11.","DOI":"10.3390\/nu11061241"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1080\/1028415X.2018.1512783","article-title":"Reduced astrocytic expression of GFAP in the offspring of female rats that received hypercaloric diet","volume":"23","author":"Molina","year":"2020","journal-title":"Nutr. Neurosci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1152\/physrev.00014.2018","article-title":"The Neuroscience of Drug Reward and Addiction","volume":"99","author":"Volkow","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fpsyt.2014.00083","article-title":"Stress modulates illness-course of substance use disorders: A translational review","volume":"5","author":"Lijffijt","year":"2014","journal-title":"Front. Psychiatry"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1111\/acer.13416","article-title":"Nalmefene Prevents Alcohol-Induced Neuroinflammation and Alcohol Drinking Preference in Adolescent Female Mice: Role of TLR4","volume":"41","author":"Montesinos","year":"2017","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Alasmari, F., Alhaddad, H., Wong, W., Bell, R.L., and Sari, Y. (2020). Ampicillin\/Sulbactam Treatment Modulates NMDA Receptor NR2B Subunit and Attenuates Neuroinflammation and Alcohol Intake in Male High Alcohol Drinking Rats. Biomolecules, 10.","DOI":"10.3390\/biom10071030"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/acer.14275","article-title":"Prenatal Ethanol Exposure and Postnatal Environmental Intervention Alter Dopaminergic Neuron and Microglia Morphology in the Ventral Tegmental Area During Adulthood","volume":"44","author":"Aghaie","year":"2020","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Juarez-Rodriguez, P., Godinez-Rubi, M., Guzman-Brambila, C., Padilla-Velarde, E., Orozco-Barocio, A., Ortuno-Sahagun, D., and Rojas-Mayorquin, A.E. (2020). Prenatal Alcohol Exposure in Rats Diminishes Postnatal Cxcl16 Chemokine Ligand Brain Expression. Brain Sci., 10.","DOI":"10.3390\/brainsci10120987"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"6362","DOI":"10.4049\/jimmunol.172.10.6362","article-title":"The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10","volume":"172","author":"Abel","year":"2004","journal-title":"J. Immunol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1254\/jphs.14032FP","article-title":"CC-chemokine ligand 2 facilitates conditioned place preference to methamphetamine through the activation of dopamine systems","volume":"125","author":"Wakida","year":"2014","journal-title":"J. Pharmacol. Sci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.4049\/jimmunol.156.11.4363","article-title":"Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain","volume":"156","author":"Glabinski","year":"1996","journal-title":"J. Immunol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.1021\/acschemneuro.9b00225","article-title":"Methamphetamine Activates Toll-Like Receptor 4 to Induce Central Immune Signaling within the Ventral Tegmental Area and Contributes to Extracellular Dopamine Increase in the Nucleus Accumbens Shell","volume":"10","author":"Wang","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.intimp.2019.04.053","article-title":"Methamphetamine exacerbates neuroinflammatory response to lipopolysaccharide by activating dopamine D1-like receptors","volume":"73","author":"Wang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.bbi.2015.08.001","article-title":"The danger-associated molecular pattern HMGB1 mediates the neuroinflammatory effects of methamphetamine","volume":"51","author":"Frank","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Costa, G., Porceddu, P.F., Serra, M., Casu, M.A., Schiano, V., Napolitano, F., Pinna, A., Usiello, A., and Morelli, M. (2019). Lack of Rhes Increases MDMA-Induced Neuroinflammation and Dopamine Neuron Degeneration: Role of Gender and Age. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20071556"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.bbi.2017.08.012","article-title":"Innate immune signaling in the ventral tegmental area contributes to drug-primed reinstatement of cocaine seeking","volume":"67","author":"Brown","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"ref_151","first-page":"14","article-title":"Astrocytic hypertrophy in the rat ventral tegmental area following chronic morphine differs with age","volume":"3","author":"Goins","year":"2018","journal-title":"J. Neurol. Neurorehabilit. Res."},{"key":"ref_152","first-page":"66","article-title":"Ginger Extract Reduces Chronic Morphine-Induced Neuroinflammation and Glial Activation in Nucleus Accumbens of Rats","volume":"11","author":"Nasri","year":"2019","journal-title":"Addict. Health"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"108469","DOI":"10.1016\/j.neuropharm.2021.108469","article-title":"Sexually dimorphic neuroimmune response to chronic opioid treatment and withdrawal","volume":"186","author":"Kumar","year":"2021","journal-title":"Neuropharmacology"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"e13027","DOI":"10.1111\/adb.13027","article-title":"Neurometabolic alterations in the nucleus accumbens of smokers assessed with (1) H magnetic resonance spectroscopy: The role of glutamate and neuroinflammation","volume":"26","author":"Steinegger","year":"2021","journal-title":"Addict. Biol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.neuroscience.2021.03.030","article-title":"Ceftriaxone Reduces Waterpipe Tobacco Smoke Withdrawal-induced Anxiety in rats via Modulating the Expression of TNF-alpha\/NFkB, Nrf2, and GLT-1","volume":"463","author":"Hammad","year":"2021","journal-title":"Neuroscience"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"7026198","DOI":"10.1155\/2018\/7026198","article-title":"Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia","volume":"2018","author":"Picca","year":"2018","journal-title":"Mediators Inflamm."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Ticinesi, A., Lauretani, F., Milani, C., Nouvenne, A., Tana, C., Del Rio, D., Maggio, M., Ventura, M., and Meschi, T. (2017). Aging Gut Microbiota at the Cross-Road between Nutrition, Physical Frailty, and Sarcopenia: Is There a Gut-Muscle Axis?. Nutrients, 9.","DOI":"10.3390\/nu9121303"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S0140-6736(03)12489-0","article-title":"Gut flora in health and disease","volume":"361","author":"Guarner","year":"2003","journal-title":"Lancet"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3233\/NHA-170030","article-title":"Gut microbiome and aging: Physiological and mechanistic insights","volume":"4","author":"Nagpal","year":"2018","journal-title":"Nutr. Healthy Aging"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/1574-6976.12075","article-title":"The first 1000 cultured species of the human gastrointestinal microbiota","volume":"38","year":"2014","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nature11319","article-title":"Gut microbiota composition correlates with diet and health in the elderly","volume":"488","author":"Claesson","year":"2012","journal-title":"Nature"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Biagi, E., Nylund, L., Candela, M., Ostan, R., Bucci, L., Pini, E., Nikk\u00efla, J., Monti, D., Satokari, R., and Franceschi, C. (2010). Through ageing, and beyond: Gut microbiota and inflammatory status in seniors and centenarians. PLoS ONE, 5.","DOI":"10.1371\/annotation\/df45912f-d15c-44ab-8312-e7ec0607604d"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","article-title":"Inflammaging: A new immune-metabolic viewpoint for age-related diseases","volume":"14","author":"Franceschi","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.exger.2015.11.010","article-title":"Impaired mitochondrial degradation by autophagy in the skeletal muscle of the aged female interleukin 10 null mouse","volume":"73","author":"Ko","year":"2016","journal-title":"Exp. Gerontol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40635-016-0115-0","article-title":"Deletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy","volume":"5","author":"Huang","year":"2017","journal-title":"Intensive Care Med. Exp."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"E222","DOI":"10.1152\/ajpendo.00060.2017","article-title":"The NLRP3 inflammasome contributes to sarcopenia and lower muscle glycolytic potential in old mice","volume":"313","author":"McBride","year":"2017","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1093\/gerona\/glz079","article-title":"Lack of NLRP3 Inflammasome Activation Reduces Age-Dependent Sarcopenia and Mitochondrial Dysfunction, Favoring the Prophylactic Effect of Melatonin","volume":"74","author":"Sayed","year":"2019","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Kelley, N., Jeltema, D., Duan, Y., and He, Y. (2019). The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133328"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.redox.2018.02.007","article-title":"Differential effects of short chain fatty acids on endothelial Nlrp3 inflammasome activation and neointima formation: Antioxidant action of butyrate","volume":"16","author":"Yuan","year":"2018","journal-title":"Redox Biol."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Bian, F., Xiao, Y., Zaheer, M., Volpe, E.A., Pflugfelder, S.C., Li, D.Q., and de Paiva, C.S. (2017). Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18030562"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"12676","DOI":"10.1038\/srep12676","article-title":"Sodium butyrate alleviates adipocyte inflammation by inhibiting NLRP3 pathway","volume":"5","author":"Wang","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"6626","DOI":"10.1038\/s41598-019-43112-x","article-title":"Gut microbiota and butyrate level changes associated with the long-term administration of proton pump inhibitors to old rats","volume":"9","author":"Lee","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1038\/s41598-021-84031-0","article-title":"Alterations in intestinal microbiota diversity, composition, and function in patients with sarcopenia","volume":"11","author":"Kang","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"110039","DOI":"10.1016\/j.pnpbp.2020.110039","article-title":"Gut microbiota in dementia. Critical review of novel findings and their potential application","volume":"104","author":"Luc","year":"2021","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"710","DOI":"10.3389\/fneur.2018.00710","article-title":"Sarcopenia and Muscle Functions at Various Stages of Alzheimer Disease","volume":"9","author":"Ogawa","year":"2018","journal-title":"Front. Neurol."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Stadlbauer, V., Engertsberger, L., Komarova, I., Feldbacher, N., Leber, B., Pichler, G., Fink, N., Scarpatetti, M., Schippinger, W., and Schmidt, R. (2020). Dysbiosis, gut barrier dysfunction and inflammation in dementia: A pilot study. BMC Geriatr., 20.","DOI":"10.1186\/s12877-020-01644-2"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"8088","DOI":"10.1038\/s41598-020-65196-6","article-title":"Relationship between dementia and gut microbiome-associated metabolites: A cross-sectional study in Japan","volume":"10","author":"Saji","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/jcbfm.2015.164","article-title":"The neuropathology and cerebrovascular mechanisms of dementia","volume":"36","author":"Raz","year":"2016","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41398-021-01349-z","article-title":"Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer\u2019s disease","volume":"11","author":"Lyra","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"ref_180","first-page":"59","article-title":"Inflammatory process in Alzheimer\u2019s Disease","volume":"7","year":"2013","journal-title":"Front. Integr. Neurosci."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"12050","DOI":"10.1038\/s41598-018-30487-6","article-title":"IL-1beta, IL-6, TNF- alpha and CRP in Elderly Patients with Depression or Alzheimer\u2019s disease: Systematic Review and Meta-Analysis","volume":"8","author":"Ng","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1093\/ije\/dyaa099","article-title":"Higher risk of dementia in English older individuals who are overweight or obese","volume":"49","author":"Ma","year":"2020","journal-title":"Int. J. Epidemiol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41398-020-0799-5","article-title":"Association between sedentary behavior and the risk of dementia: A systematic review and meta-analysis","volume":"10","author":"Yan","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.numecd.2014.03.009","article-title":"Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes","volume":"24","author":"Falconer","year":"2014","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Rodas, L., Riera-Sampol, A., Aguilo, A., Martinez, S., and Tauler, P. (2020). Effects of Habitual Caffeine Intake, Physical Activity Levels, and Sedentary Behavior on the Inflammatory Status in a Healthy Population. Nutrients, 12.","DOI":"10.3390\/nu12082325"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Akter, T., Zeba, Z., Hosen, I., Al-Mamun, F., and Mamun, M.A. (2022). Impact of the COVID-19 pandemic on BMI: Its changes in relation to socio-demographic and physical activity patterns based on a short period. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0266024"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.amepre.2022.01.012","article-title":"Obesity Prevalence Among U.S. Adults During the COVID-19 Pandemic","volume":"63","author":"Restrepo","year":"2022","journal-title":"Am. J. Prev. Med."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"e000960","DOI":"10.1136\/bmjsem-2020-000960","article-title":"Changes in physical activity and sedentary behaviours from before to during the COVID-19 pandemic lockdown: A systematic review","volume":"7","author":"Stockwell","year":"2021","journal-title":"BMJ Open. Sport. Exerc. Med."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1001\/jamaneurol.2022.0461","article-title":"One-Year Trajectory of Cognitive Changes in Older Survivors of COVID-19 in Wuhan, China: A Longitudinal Cohort Study","volume":"79","author":"Liu","year":"2022","journal-title":"JAMA Neurol."},{"key":"ref_190","unstructured":"World Health Organization (2017). Global Action Plan on the Public Health Response to Dementia 2017\u20132025."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"748212","DOI":"10.1155\/2015\/748212","article-title":"Working memory and executive function decline across normal aging, mild cognitive impairment, and Alzheimer\u2019s disease","volume":"2015","author":"Kirova","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/ene.13439","article-title":"Alzheimer\u2019s disease","volume":"25","author":"Lane","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3389\/fnagi.2018.00101","article-title":"Theta-Gamma Coupling and Working Memory in Alzheimer\u2019s Dementia and Mild Cognitive Impairment","volume":"10","author":"Goodman","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"101878","DOI":"10.1016\/j.pneurobio.2020.101878","article-title":"Neural oscillations and brain stimulation in Alzheimer\u2019s disease","volume":"194","author":"Jafari","year":"2020","journal-title":"Prog. Neurobiol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"7218","DOI":"10.1523\/JNEUROSCI.2574-18.2019","article-title":"Neuroinflammation and Functional Connectivity in Alzheimer\u2019s Disease: Interactive Influences on Cognitive Performance","volume":"39","author":"Passamonti","year":"2019","journal-title":"J. Neurosci."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.neuron.2020.06.023","article-title":"Disrupted Place Cell Remapping and Impaired Grid Cells in a Knockin Model of Alzheimer\u2019s Disease","volume":"107","author":"Jun","year":"2020","journal-title":"Neuron"},{"key":"ref_197","first-page":"581","article-title":"Treatment of glomerulonephritis","volume":"95","author":"Lison","year":"1989","journal-title":"Verh. Dtsch. Ges. Inn. Med."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/416535a","article-title":"Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo","volume":"416","author":"Walsh","year":"2002","journal-title":"Nature"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer\u2019s disease: The amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1001\/archneur.65.11.1509","article-title":"Frequent amyloid deposition without significant cognitive impairment among the elderly","volume":"65","author":"Aizenstein","year":"2008","journal-title":"Arch. Neurol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrneurol.2013.21","article-title":"Alzheimer disease: Abeta-independent processes-rethinking preclinical AD","volume":"9","author":"Chetelat","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2217\/nmt.14.29","article-title":"Clearing the amyloid in Alzheimer\u2019s: Progress towards earlier diagnosis and effective treatments\u2013an update for clinicians","volume":"4","author":"Asih","year":"2014","journal-title":"Neurodegener. Dis. Manag."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.2174\/156802611795860942","article-title":"gamma-secretase inhibitors and modulators for the treatment of Alzheimer\u2019s disease: Disappointments and hopes","volume":"11","author":"Imbimbo","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/alzrt220","article-title":"Treating Alzheimer\u2019s disease with monoclonal antibodies: Current status and outlook for the future","volume":"5","author":"Prins","year":"2013","journal-title":"Alzheimers Res. Ther."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jalz.2016.02.010","article-title":"Neuroinflammation in Alzheimer\u2019s disease: Current evidence and future directions","volume":"12","author":"Calsolaro","year":"2016","journal-title":"Alzheimers Dement."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41583-019-0240-3","article-title":"Amyloid-beta-independent regulators of tau pathology in Alzheimer disease","volume":"21","author":"Goldstein","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00005-012-0181-2","article-title":"The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer\u2019s disease brain","volume":"60","author":"Varnum","year":"2012","journal-title":"Arch. Immunol. Ther. Exp. (Warsz)"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1749-6632.1988.tb27086.x","article-title":"Occurrence of HLA-DR reactive microglia in Alzheimer\u2019s disease","volume":"540","author":"McGeer","year":"1988","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer\u2019s disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ijdevneu.2005.11.014","article-title":"Contribution of inflammatory processes to Alzheimer\u2019s disease: Molecular mechanisms","volume":"24","author":"Sastre","year":"2006","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41586-020-03160-0","article-title":"Restoring metabolism of myeloid cells reverses cognitive decline in ageing","volume":"590","author":"Minhas","year":"2021","journal-title":"Nature"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: Where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0165-5728(89)90115-X","article-title":"Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease","volume":"24","author":"Itagaki","year":"1989","journal-title":"J. Neuroimmunol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/BF00334499","article-title":"The complex of microglial cells and amyloid star in three-dimensional reconstruction","volume":"81","author":"Wegiel","year":"1990","journal-title":"Acta Neuropathol."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/42257","article-title":"Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E","volume":"388","author":"Barger","year":"1997","journal-title":"Nature"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.biopsych.2014.05.006","article-title":"Alzheimer\u2019s disease risk genes and mechanisms of disease pathogenesis","volume":"77","author":"Karch","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"S295","DOI":"10.3233\/JAD-2012-129027","article-title":"The neuroimmune system in Alzheimer\u2019s disease: The glass is half full","volume":"33","author":"Hickman","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.neurobiolaging.2013.11.026","article-title":"Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice","volume":"35","author":"Jiang","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1038\/npp.2014.164","article-title":"Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer\u2019s disease","volume":"39","author":"Jiang","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12974-020-01980-5","article-title":"Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer\u2019s disease models","volume":"18","author":"Fassler","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mad.2006.11.013","article-title":"Polymorphisms of pro-inflammatory genes and Alzheimer\u2019s disease risk: A pharmacogenomic approach","volume":"128","author":"Candore","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/epi.13294","article-title":"Health and economic benefits of public financing of epilepsy treatment in India: An agent-based simulation model","volume":"57","author":"Megiddo","year":"2016","journal-title":"Epilepsia"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.nbd.2009.12.009","article-title":"Seizures in the developing brain result in a long-lasting decrease in GABA(B) inhibitory postsynaptic currents in the rat hippocampus","volume":"37","author":"Qu","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/epi.13269","article-title":"50 Hz hippocampal stimulation in refractory epilepsy: Higher level of basal glutamate predicts greater release of glutamate","volume":"57","author":"Cavus","year":"2016","journal-title":"Epilepsia"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1528-1167.2010.02622.x","article-title":"Glutamate and GABA in the balance: Convergent pathways sustain seizures during status epilepticus","volume":"51","author":"Naylor","year":"2010","journal-title":"Epilepsia"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"9544","DOI":"10.1523\/JNEUROSCI.5117-14.2015","article-title":"Parvalbumin-Positive Inhibitory Interneurons Oppose Propagation But Favor Generation of Focal Epileptiform Activity","volume":"35","author":"Sessolo","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"8607038","DOI":"10.1155\/2016\/8607038","article-title":"Plasticity of Hippocampal Excitatory-Inhibitory Balance: Missing the Synaptic Control in the Epileptic Brain","volume":"2016","author":"Bonansco","year":"2016","journal-title":"Neural Plast."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1111\/j.1528-1167.2008.01603.x","article-title":"Decreased hippocampal volume on MRI is associated with increased extracellular glutamate in epilepsy patients","volume":"49","author":"Cavus","year":"2008","journal-title":"Epilepsia"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s11011-008-9106-5","article-title":"Hippocampal extracellular GABA correlates with metabolism in human epilepsy","volume":"23","author":"Pan","year":"2008","journal-title":"Metab. Brain Dis."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.neuroscience.2015.06.013","article-title":"Increased extracellular levels of glutamate in the hippocampus of chronically epileptic rats","volume":"301","author":"Soukupova","year":"2015","journal-title":"Neuroscience"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.phrs.2016.09.019","article-title":"Pharmacological modulation in mesial temporal lobe epilepsy: Current status and future perspectives","volume":"113 Pt A","author":"Gambardella","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1177\/1073858420901474","article-title":"Gliotransmission: A Novel Target for the Development of Antiseizure Drugs","volume":"26","author":"Riquelme","year":"2020","journal-title":"Neuroscientist"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.expneurol.2011.09.033","article-title":"Epilepsy and brain inflammation","volume":"244","author":"Vezzani","year":"2013","journal-title":"Exp. Neurol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1528-1167.2008.01490.x","article-title":"Glia as a source of cytokines: Implications for neuronal excitability and survival","volume":"49","author":"Vezzani","year":"2008","journal-title":"Epilepsia"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/s12974-016-0727-z","article-title":"Brain region and epilepsy-associated differences in inflammatory mediator levels in medically refractory mesial temporal lobe epilepsy","volume":"13","author":"Strauss","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jns.2010.06.002","article-title":"Why mesial temporal lobe epilepsy with hippocampal sclerosis is progressive: Uncontrolled inflammation drives disease progression?","volume":"296","author":"Yang","year":"2010","journal-title":"J. Neurol. Sci."},{"key":"ref_237","doi-asserted-by":"crossref","unstructured":"Hiragi, T., Ikegaya, Y., and Koyama, R. (2018). Microglia after Seizures and in Epilepsy. Cells, 7.","DOI":"10.3390\/cells7040026"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.nbd.2007.08.012","article-title":"Innate and adaptive immunity during epileptogenesis and spontaneous seizures: Evidence from experimental models and human temporal lobe epilepsy","volume":"29","author":"Ravizza","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrneurol.2010.178","article-title":"The role of inflammation in epilepsy","volume":"7","author":"Vezzani","year":"2011","journal-title":"Nat. Rev. Neurol."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nm.2127","article-title":"Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures","volume":"16","author":"Maroso","year":"2010","journal-title":"Nat. Med."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bcp.2017.12.021","article-title":"The P2X7 receptor: A main player in inflammation","volume":"151","author":"Adinolfi","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fnins.2017.00021","article-title":"The ATP-Gated P2X7 Receptor As a Target for the Treatment of Drug-Resistant Epilepsy","volume":"11","author":"Beamer","year":"2017","journal-title":"Front. Neurosci."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/epi4.12242","article-title":"Pharmacological targeting of brain inflammation in epilepsy: Therapeutic perspectives from experimental and clinical studies","volume":"3","author":"Ravizza","year":"2018","journal-title":"Epilepsia Open."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"5920","DOI":"10.1523\/JNEUROSCI.4009-15.2016","article-title":"Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy","volume":"36","author":"Artalejo","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1002\/glia.22285","article-title":"Adenosine dysfunction in epilepsy","volume":"60","author":"Boison","year":"2012","journal-title":"Glia"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0140-6736(03)15166-5","article-title":"Loss of glutamine synthetase in the human epileptogenic hippocampus: Possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy","volume":"363","author":"Eid","year":"2004","journal-title":"Lancet"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0014-2999(02)01846-0","article-title":"Glial membrane channels and receptors in epilepsy: Impact for generation and spread of seizure activity","volume":"447","author":"Seifert","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0166-2236(98)01349-6","article-title":"Tripartite synapses: Glia, the unacknowledged partner","volume":"22","author":"Araque","year":"1999","journal-title":"Trends Neurosci."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1126\/science.1144640","article-title":"Astrocytes potentiate transmitter release at single hippocampal synapses","volume":"317","author":"Perea","year":"2007","journal-title":"Science"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1111\/j.1460-9568.2011.07631.x","article-title":"Glutamate released spontaneously from astrocytes sets the threshold for synaptic plasticity","volume":"33","author":"Bonansco","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.neuroscience.2018.12.021","article-title":"Microglia and the Purinergic Signaling System","volume":"405","author":"Calovi","year":"2019","journal-title":"Neuroscience"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"eaar3796","DOI":"10.1126\/scitranslmed.aar3796","article-title":"Pannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy","volume":"10","author":"Dossi","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1002\/glia.23519","article-title":"Blocking TNF\u03b1-driven astrocyte purinergic signaling restores normal synaptic activity during epileptogenesis","volume":"66","author":"Nikolic","year":"2018","journal-title":"Glia"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1523\/JNEUROSCI.2625-17.2017","article-title":"Role of Purinergic Receptor P2Y1 in Spatiotemporal Ca","volume":"38","author":"Shigetomi","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1002\/glia.22817","article-title":"Enhanced astroglial Ca2+ signaling increases excitatory synaptic strength in the epileptic brain","volume":"63","author":"Morales","year":"2015","journal-title":"Glia"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"E197","DOI":"10.1073\/pnas.1111098109","article-title":"Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission","volume":"109","author":"Pascual","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3389\/fncel.2018.00446","article-title":"Astroglial Ca","volume":"12","author":"Wellmann","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1093\/cercor\/bhy196","article-title":"Ca2+ Signals in Astrocytes Facilitate Spread of Epileptiform Activity","volume":"28","author":"Heuser","year":"2018","journal-title":"Cereb. Cortex"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1111\/epi.13850","article-title":"Expression and function of the metabotropic purinergic P2Y receptor family in experimental seizure models and patients with drug-refractory epilepsy","volume":"58","author":"Alves","year":"2017","journal-title":"Epilepsia"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.bbamcr.2016.11.007","article-title":"A calcium-sensitive feed-forward loop regulating the expression of the ATP-gated purinergic P2X7 receptor via specificity protein 1 and microRNA-22","volume":"1864","author":"Engel","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Cell. Res."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.cell.2011.07.022","article-title":"Astrocytes are endogenous regulators of basal transmission at central synapses","volume":"146","author":"Panatier","year":"2011","journal-title":"Cell"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jtbi.2011.09.013","article-title":"Functional contributions of astrocytes in synchronization of a neuronal network model","volume":"292","author":"Amiri","year":"2012","journal-title":"J. Theor. Biol."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"E3280","DOI":"10.1073\/pnas.1522180113","article-title":"Active dendrites regulate the impact of gliotransmission on rat hippocampal pyramidal neurons","volume":"113","author":"Ashhad","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/glia.22318","article-title":"Astrocyte calcium signaling and epilepsy","volume":"60","author":"Carmignoto","year":"2012","journal-title":"Glia"},{"key":"ref_266","doi-asserted-by":"crossref","unstructured":"G\u00f3mez-Gonzalo, M., Losi, G., Chiavegato, A., Zonta, M., Cammarota, M., Brondi, M., Vetri, F., Uva, L., Pozzan, T., and de Curtis, M. (2010). An excitatory loop with astrocytes contributes to drive neurons to seizure threshold. PLoS Biol., 8.","DOI":"10.1371\/journal.pbio.1000352"},{"key":"ref_267","unstructured":"American Psychiatric, A. (2016). Anxiety disorders: DSM-5 Selections, American Psychiatric Association Publishing."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1017\/S2045796021000275","article-title":"Global, regional and national burden of anxiety disorders from 1990 to 2019: Results from the Global Burden of Disease Study 2019","volume":"30","author":"Yang","year":"2021","journal-title":"Epidemiol. Psychiatr. Sci."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1176\/appi.ajp.2020.20030305","article-title":"The Critical Relationship Between Anxiety and Depression","volume":"177","author":"Kalin","year":"2020","journal-title":"Am. J. Psychiatry"},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1111\/j.1360-0443.2010.02902.x","article-title":"Mental disorders as risk factors for substance use, abuse and dependence: Results from the 10-year follow-up of the National Comorbidity Survey","volume":"105","author":"Swendsen","year":"2010","journal-title":"Addiction"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3233\/ADR-210294","article-title":"The Relationship Between Anxiety and Alzheimer\u2019s Disease","volume":"5","author":"Mendez","year":"2021","journal-title":"J. Alzheimers Dis. Rep."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jpsychores.2014.12.002","article-title":"Anxiety in epilepsy: A neglected disorder","volume":"78","author":"Gandy","year":"2015","journal-title":"J. Psychosom. Res."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.genhosppsych.2007.12.006","article-title":"Anxiety disorders and comorbid medical illness","volume":"30","author":"Davidson","year":"2008","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"e027925","DOI":"10.1136\/bmjopen-2018-027925","article-title":"Systematic review and meta-analysis of the association between peripheral inflammatory cytokines and generalised anxiety disorder","volume":"9","author":"Costello","year":"2019","journal-title":"BMJ Open."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.bbi.2020.11.007","article-title":"Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala","volume":"91","author":"Zheng","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.neuropharm.2014.10.014","article-title":"Cytokines and chemokines as biomarkers of ethanol-induced neuroinflammation and anxiety-related behavior: Role of TLR4 and TLR2","volume":"89","author":"Pascual","year":"2015","journal-title":"Neuropharmacology"},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1038\/npp.2015.357","article-title":"High-Fat Diet Induced Anxiety and Anhedonia: Impact on Brain Homeostasis and Inflammation","volume":"41","author":"Dutheil","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bbi.2018.11.316","article-title":"Brain tumor necrosis factor-\u03b1 mediates anxiety-like behavior in a mouse model of severe obesity","volume":"77","author":"Fourrier","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"108317","DOI":"10.1016\/j.jnutbio.2019.108317","article-title":"High-refined carbohydrate diet consumption induces neuroinflammation and anxiety-like behavior in mice","volume":"77","author":"Gomes","year":"2020","journal-title":"J. Nutr. Biochem."},{"key":"ref_280","unstructured":"World Health Organization (2020). World Health Statistics 2020: Monitoring Health for the SDGs, Sustainable Development Goals."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"e177","DOI":"10.1016\/j.jacc.2019.03.010","article-title":"2019 ACC\/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"74","author":"Arnett","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11897-014-0231-7","article-title":"Targeting interleukin-1 in heart failure and inflammatory heart disease","volume":"12","author":"Raleigh","year":"2015","journal-title":"Curr. Heart Fail. Rep."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"106921","DOI":"10.1016\/j.vph.2021.106921","article-title":"Ischemic heart disease and cardioprotection: Focus on estrogenic hormonal setting and microvascular health","volume":"141","author":"Querio","year":"2021","journal-title":"Vascul Pharmacol."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"4293206","DOI":"10.1155\/2020\/4293206","article-title":"NLRP3 Inflammasome and Its Central Role in the Cardiovascular Diseases","volume":"2020","author":"Tong","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1515\/cclm-2012-0600","article-title":"Association of nucleotide-binding oligomerization domain-like receptor 3 inflammasome and adverse clinical outcomes in patients with idiopathic dilated cardiomyopathy","volume":"51","author":"Luo","year":"2013","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/s41419-019-1491-7","article-title":"HSP70 is a negative regulator of NLRP3 inflammasome activation","volume":"10","author":"Martine","year":"2019","journal-title":"Cell. Death Dis."},{"key":"ref_287","doi-asserted-by":"crossref","unstructured":"Mezzaroma, E., Abbate, A., and Toldo, S. (2021). NLRP3 Inflammasome Inhibitors in Cardiovascular Diseases. Molecules, 26.","DOI":"10.3390\/molecules26040976"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"101523","DOI":"10.1016\/j.redox.2020.101523","article-title":"NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy","volume":"34","author":"Zeng","year":"2020","journal-title":"Redox Biol."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mce.2014.01.002","article-title":"Estrogen and the female heart","volume":"389","author":"Knowlton","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.yjmcc.2004.02.005","article-title":"Estrogen and regulation of heat shock protein expression in female cardiomyocytes: Cross-talk with NF kappa B signaling","volume":"36","author":"Hamilton","year":"2004","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"H455","DOI":"10.1152\/ajpheart.2001.280.1.H455","article-title":"Heat-shock factor-1, steroid hormones, and regulation of heat-shock protein expression in the heart","volume":"280","author":"Knowlton","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1152\/physiolgenomics.00184.2011","article-title":"Quantitative proteomic analysis reveals novel mitochondrial targets of estrogen deficiency in the aged female rat heart","volume":"44","author":"Lancaster","year":"2012","journal-title":"Physiol. Genom."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"401","DOI":"10.33594\/000000227","article-title":"Genistein and 17beta-Estradiol Protect Hepatocytes from Fatty Degeneration by Mechanisms Involving Mitochondria, Inflammasome and Kinases Activation","volume":"54","author":"Farruggio","year":"2020","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"174644","DOI":"10.1016\/j.ejphar.2021.174644","article-title":"Syringaresinol attenuates sepsis-induced cardiac dysfunction by inhibiting inflammation and pyroptosis in mice","volume":"913","author":"Wei","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_295","doi-asserted-by":"crossref","unstructured":"Margina, D., Ungurianu, A., Purdel, C., Tsoukalas, D., Sarandi, E., Thanasoula, M., Tekos, F., Mesnage, R., Kouretas, D., and Tsatsakis, A. (2020). Chronic Inflammation in the Context of Everyday Life: Dietary Changes as Mitigating Factors. Int. J. Environ. Res. Public. Health, 17.","DOI":"10.3390\/ijerph17114135"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.3389\/fimmu.2020.02021","article-title":"Anti-inflammatory and Neuroprotective Agents in Clinical Trials for CNS Disease and Injury: Where Do We Go From Here?","volume":"11","author":"Mallah","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s12031-017-0968-z","article-title":"Inhibition of P2X7 Receptor Ameliorates Nuclear Factor-Kappa B Mediated Neuroinflammation Induced by Status Epilepticus in Rat Hippocampus","volume":"63","author":"Huang","year":"2017","journal-title":"J. Mol. Neurosci."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1111\/epi.12257","article-title":"Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079","volume":"54","author":"Mesuret","year":"2013","journal-title":"Epilepsia"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/12\/10083\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:54:08Z","timestamp":1760126048000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/12\/10083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,13]]},"references-count":298,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["ijms241210083"],"URL":"https:\/\/doi.org\/10.3390\/ijms241210083","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,13]]}}}