{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:16:48Z","timestamp":1791908208136,"version":"4.3.4"},"reference-count":31,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Planning Project of Guangdong Province","award":["2020A1515110668"],"award-info":[{"award-number":["2020A1515110668"]}]},{"name":"Science and Technology Planning Project of Guangdong Province","award":["2021A1515110916"],"award-info":[{"award-number":["2021A1515110916"]}]},{"name":"Science and Technology Planning Project of Guangdong Province","award":["2220002000296"],"award-info":[{"award-number":["2220002000296"]}]},{"name":"Science and Technology Planning Project of Guangdong Province","award":["2021030103170007301"],"award-info":[{"award-number":["2021030103170007301"]}]},{"name":"Science and Technology Planning Project of Guangdong Province","award":["2020KCXTD038"],"award-info":[{"award-number":["2020KCXTD038"]}]},{"name":"Science and Technology Planning Project of Guangdong Province","award":["2021ZDJS091"],"award-info":[{"award-number":["2021ZDJS091"]}]},{"name":"Science and Technology Planning Project of Guangdong Province","award":["8194100101"],"award-info":[{"award-number":["8194100101"]}]},{"name":"Science and Technology Planning Project of Guangdong Province","award":["2021ZDZX2046"],"award-info":[{"award-number":["2021ZDZX2046"]}]},{"name":"Science and Technology Planning Project of Guangdong Province","award":["2021B1212040016"],"award-info":[{"award-number":["2021B1212040016"]}]},{"name":"Science and Technology Planning Project of Guangdong Province","award":["2022YFA1105403"],"award-info":[{"award-number":["2022YFA1105403"]}]},{"name":"Foundation and Application Foundation project support by Jiangmen City","award":["2020A1515110668"],"award-info":[{"award-number":["2020A1515110668"]}]},{"name":"Foundation and Application Foundation project support by Jiangmen City","award":["2021A1515110916"],"award-info":[{"award-number":["2021A1515110916"]}]},{"name":"Foundation and Application Foundation project support by Jiangmen City","award":["2220002000296"],"award-info":[{"award-number":["2220002000296"]}]},{"name":"Foundation and Application Foundation project support by Jiangmen City","award":["2021030103170007301"],"award-info":[{"award-number":["2021030103170007301"]}]},{"name":"Foundation and Application Foundation project support by Jiangmen City","award":["2020KCXTD038"],"award-info":[{"award-number":["2020KCXTD038"]}]},{"name":"Foundation and Application Foundation project support by Jiangmen City","award":["2021ZDJS091"],"award-info":[{"award-number":["2021ZDJS091"]}]},{"name":"Foundation and Application Foundation project support by Jiangmen City","award":["8194100101"],"award-info":[{"award-number":["8194100101"]}]},{"name":"Foundation and Application Foundation project support by Jiangmen City","award":["2021ZDZX2046"],"award-info":[{"award-number":["2021ZDZX2046"]}]},{"name":"Foundation and Application Foundation project support by Jiangmen City","award":["2021B1212040016"],"award-info":[{"award-number":["2021B1212040016"]}]},{"name":"Foundation and Application Foundation project support by Jiangmen City","award":["2022YFA1105403"],"award-info":[{"award-number":["2022YFA1105403"]}]},{"name":"Innovation team program supported by Guangdong Province","award":["2020A1515110668"],"award-info":[{"award-number":["2020A1515110668"]}]},{"name":"Innovation team program supported by Guangdong Province","award":["2021A1515110916"],"award-info":[{"award-number":["2021A1515110916"]}]},{"name":"Innovation team program supported by Guangdong Province","award":["2220002000296"],"award-info":[{"award-number":["2220002000296"]}]},{"name":"Innovation team program supported by Guangdong Province","award":["2021030103170007301"],"award-info":[{"award-number":["2021030103170007301"]}]},{"name":"Innovation team program supported by Guangdong Province","award":["2020KCXTD038"],"award-info":[{"award-number":["2020KCXTD038"]}]},{"name":"Innovation team program supported by Guangdong Province","award":["2021ZDJS091"],"award-info":[{"award-number":["2021ZDJS091"]}]},{"name":"Innovation team program supported by Guangdong Province","award":["8194100101"],"award-info":[{"award-number":["8194100101"]}]},{"name":"Innovation team program supported by Guangdong Province","award":["2021ZDZX2046"],"award-info":[{"award-number":["2021ZDZX2046"]}]},{"name":"Innovation team program supported by Guangdong Province","award":["2021B1212040016"],"award-info":[{"award-number":["2021B1212040016"]}]},{"name":"Innovation team program supported by Guangdong Province","award":["2022YFA1105403"],"award-info":[{"award-number":["2022YFA1105403"]}]},{"name":"Guangdong Province Key Program of Discipline","award":["2020A1515110668"],"award-info":[{"award-number":["2020A1515110668"]}]},{"name":"Guangdong Province Key Program of Discipline","award":["2021A1515110916"],"award-info":[{"award-number":["2021A1515110916"]}]},{"name":"Guangdong Province Key Program of Discipline","award":["2220002000296"],"award-info":[{"award-number":["2220002000296"]}]},{"name":"Guangdong Province Key Program of Discipline","award":["2021030103170007301"],"award-info":[{"award-number":["2021030103170007301"]}]},{"name":"Guangdong Province Key Program of Discipline","award":["2020KCXTD038"],"award-info":[{"award-number":["2020KCXTD038"]}]},{"name":"Guangdong Province Key Program of Discipline","award":["2021ZDJS091"],"award-info":[{"award-number":["2021ZDJS091"]}]},{"name":"Guangdong Province Key Program of Discipline","award":["8194100101"],"award-info":[{"award-number":["8194100101"]}]},{"name":"Guangdong Province Key Program of Discipline","award":["2021ZDZX2046"],"award-info":[{"award-number":["2021ZDZX2046"]}]},{"name":"Guangdong Province Key Program of Discipline","award":["2021B1212040016"],"award-info":[{"award-number":["2021B1212040016"]}]},{"name":"Guangdong Province Key Program of Discipline","award":["2022YFA1105403"],"award-info":[{"award-number":["2022YFA1105403"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2020A1515110668"],"award-info":[{"award-number":["2020A1515110668"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021A1515110916"],"award-info":[{"award-number":["2021A1515110916"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2220002000296"],"award-info":[{"award-number":["2220002000296"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021030103170007301"],"award-info":[{"award-number":["2021030103170007301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2020KCXTD038"],"award-info":[{"award-number":["2020KCXTD038"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021ZDJS091"],"award-info":[{"award-number":["2021ZDJS091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8194100101"],"award-info":[{"award-number":["8194100101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021ZDZX2046"],"award-info":[{"award-number":["2021ZDZX2046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021B1212040016"],"award-info":[{"award-number":["2021B1212040016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022YFA1105403"],"award-info":[{"award-number":["2022YFA1105403"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Special Project on Key Fields of Universities in Guangdong Province","award":["2020A1515110668"],"award-info":[{"award-number":["2020A1515110668"]}]},{"name":"Special Project on Key Fields of Universities in Guangdong Province","award":["2021A1515110916"],"award-info":[{"award-number":["2021A1515110916"]}]},{"name":"Special Project on Key Fields of Universities in Guangdong Province","award":["2220002000296"],"award-info":[{"award-number":["2220002000296"]}]},{"name":"Special Project on Key Fields of Universities in Guangdong Province","award":["2021030103170007301"],"award-info":[{"award-number":["2021030103170007301"]}]},{"name":"Special Project on Key Fields of Universities in Guangdong Province","award":["2020KCXTD038"],"award-info":[{"award-number":["2020KCXTD038"]}]},{"name":"Special Project on Key Fields of Universities in Guangdong Province","award":["2021ZDJS091"],"award-info":[{"award-number":["2021ZDJS091"]}]},{"name":"Special Project on Key Fields of Universities in Guangdong Province","award":["8194100101"],"award-info":[{"award-number":["8194100101"]}]},{"name":"Special Project on Key Fields of Universities in Guangdong Province","award":["2021ZDZX2046"],"award-info":[{"award-number":["2021ZDZX2046"]}]},{"name":"Special Project on Key Fields of Universities in Guangdong Province","award":["2021B1212040016"],"award-info":[{"award-number":["2021B1212040016"]}]},{"name":"Special Project on Key Fields of Universities in Guangdong Province","award":["2022YFA1105403"],"award-info":[{"award-number":["2022YFA1105403"]}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2020A1515110668"],"award-info":[{"award-number":["2020A1515110668"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515110916"],"award-info":[{"award-number":["2021A1515110916"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2220002000296"],"award-info":[{"award-number":["2220002000296"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2021030103170007301"],"award-info":[{"award-number":["2021030103170007301"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2020KCXTD038"],"award-info":[{"award-number":["2020KCXTD038"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2021ZDJS091"],"award-info":[{"award-number":["2021ZDJS091"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["8194100101"],"award-info":[{"award-number":["8194100101"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2021ZDZX2046"],"award-info":[{"award-number":["2021ZDZX2046"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2021B1212040016"],"award-info":[{"award-number":["2021B1212040016"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2022YFA1105403"],"award-info":[{"award-number":["2022YFA1105403"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Program of China Stem Cell and Translational Research","award":["2020A1515110668"],"award-info":[{"award-number":["2020A1515110668"]}]},{"name":"National Key Research and Development Program of China Stem Cell and Translational Research","award":["2021A1515110916"],"award-info":[{"award-number":["2021A1515110916"]}]},{"name":"National Key Research and Development Program of China Stem Cell and Translational Research","award":["2220002000296"],"award-info":[{"award-number":["2220002000296"]}]},{"name":"National Key Research and Development Program of China Stem Cell and Translational Research","award":["2021030103170007301"],"award-info":[{"award-number":["2021030103170007301"]}]},{"name":"National Key Research and Development Program of China Stem Cell and Translational Research","award":["2020KCXTD038"],"award-info":[{"award-number":["2020KCXTD038"]}]},{"name":"National Key Research and Development Program of China Stem Cell and Translational Research","award":["2021ZDJS091"],"award-info":[{"award-number":["2021ZDJS091"]}]},{"name":"National Key Research and Development Program of China Stem Cell and Translational Research","award":["8194100101"],"award-info":[{"award-number":["8194100101"]}]},{"name":"National Key Research and Development Program of China Stem Cell and Translational Research","award":["2021ZDZX2046"],"award-info":[{"award-number":["2021ZDZX2046"]}]},{"name":"National Key Research and Development Program of China Stem Cell and Translational Research","award":["2021B1212040016"],"award-info":[{"award-number":["2021B1212040016"]}]},{"name":"National Key Research and Development Program of China Stem Cell and Translational Research","award":["2022YFA1105403"],"award-info":[{"award-number":["2022YFA1105403"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The fallopian tube (FT) is an important reproductive organ in females. Ample evidence suggests that the distal end of FT is the original site of high-grade serous ovarian carcinoma (HGSC). FT may suffer from repeated injury and repair stimulated by follicular fluid (FF); however, this hypothesis has not been examined. In fact, the molecular mechanism of homeostasis, differentiation, and the transformation of fallopian tube epithelial cells (FTECs) resulting from the stimulation of FF are still enigmatic. In this study, we examined the effects of FF along with factors present in the FF on a variety of FTEC models, including primary cell culture, ALI (air\u2013liquid interface) culture, and 3D organ spheroid culture. We found that FF plays a similar role to estrogen in promoting cell differentiation and organoid formation. Moreover, FF significantly promotes cell proliferation and induces cell injury and apoptosis in high concentrations. These observations may help us to investigate the mechanisms of the initiation of HGSC.<\/jats:p>","DOI":"10.3390\/ijms241210154","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T01:32:57Z","timestamp":1686792777000},"page":"10154","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of Follicular Fluid on Physiological Characteristics and Differentiation of Fallopian Tube Epithelial Cells Implicating for Ovarian Cancer Pathogenesis"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1700-7917","authenticated-orcid":false,"given":"Maobi","family":"Zhu","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen 529000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen 529000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen 529000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen 529000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiawen","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen 529000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1737-6130","authenticated-orcid":false,"given":"Jianglin","family":"Fan","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen 529000, China"},{"name":"Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajie","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen 529000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/humupd\/dml012","article-title":"The reproductive significance of human Fallopian tube cilia","volume":"12","author":"Lyons","year":"2006","journal-title":"Hum. Reprod. Update"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1477-7827-12-60","article-title":"The hormonal composition of follicular fluid and its implications for ovarian cancer pathogenesis","volume":"12","author":"Emori","year":"2014","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Zhu, M., Iwano, T., and Takeda, S. (2019). Estrogen and EGFR Pathways Regulate Notch Signaling in Opposing Directions for Multi-Ciliogenesis in the Fallopian Tube. Cells, 8.","DOI":"10.3390\/cells8080933"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ygyno.2013.12.015","article-title":"Exposure of fallopian tube epithelium to follicular fluid mimics carcinogenic changes in precursor lesions of serous papillary carcinoma","volume":"132","author":"Brand","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1177\/1535370213508216","article-title":"Altered expression of inflammation-associated genes in oviductal cells following follicular fluid exposure: Implications for ovarian carcinogenesis","volume":"239","author":"Lau","year":"2014","journal-title":"Exp. Biol. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1093\/carcin\/bgv132","article-title":"Mutagenic, surviving and tumorigenic effects of follicular fluid in the context of p53 loss: Initiation of fimbria carcinogenesis","volume":"36","author":"Huang","year":"2015","journal-title":"Carcinogenesis"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/s41467-017-00962-1","article-title":"High grade serous ovarian carcinomas originate in the fallopian tube","volume":"8","author":"Papp","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrm4056","article-title":"Ovary and fimbrial stem cells: Biology, niche and cancer origins","volume":"16","author":"Ng","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.1158\/0008-5472.CAN-21-0536","article-title":"TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian Cancer","volume":"81","author":"Lecker","year":"2021","journal-title":"Cancer Res."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Sowamber, R., Nelson, O., Dodds, L., DeCastro, V., Paudel, I., Milea, A., Considine, M., Cope, L., Pinto, A., and Schlumbrecht, M. (2020). Integrative Transcriptome Analyses of the Human Fallopian Tube: Fimbria and Ampulla-Site of Origin of Serous Carcinoma of the Ovary. Cancers, 12.","DOI":"10.3390\/cancers12051090"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1095\/biolreprod.109.082941","article-title":"Formation of the ovarian follicular antrum and follicular fluid","volume":"82","author":"Rodgers","year":"2010","journal-title":"Biol. Reprod."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1440-169X.2007.00901.x","article-title":"Biochemical composition of ovine follicular fluid in relation to follicle size","volume":"49","author":"Nandi","year":"2007","journal-title":"Dev. Growth Differ."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"38","DOI":"10.5935\/1518-0557.20160009","article-title":"Human follicular fluid and effects on reproduction","volume":"20","author":"Basuino","year":"2016","journal-title":"JBRA Assist. Reprod."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.fertnstert.2014.11.015","article-title":"Oocyte environment: Follicular fluid and cumulus cells are critical for oocyte health","volume":"103","author":"Dumesic","year":"2015","journal-title":"Fertil. Steril."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s10815-018-1143-3","article-title":"Influence of follicular fluid and cumulus cells on oocyte quality: Clinical implications","volume":"35","author":"Giorgi","year":"2018","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S1472-6483(10)62005-6","article-title":"Novel follicular fluid factors influencing oocyte developmental potential in IVF: A review","volume":"12","author":"Baka","year":"2006","journal-title":"Reprod. Biomed. Online"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1387\/ijdb.120133cc","article-title":"The antral follicle: A microenvironment for oocyte differentiation","volume":"56","author":"Hennet","year":"2012","journal-title":"Int. J. Dev. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/humrep\/des349","article-title":"The follicular hormonal profile in low-responder patients undergoing unstimulated cycles: Is it hypoandrogenic?","volume":"28","author":"Beltran","year":"2013","journal-title":"Hum. Reprod."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.rbmo.2018.10.006","article-title":"Steroid profiles by liquid chromatography-mass spectrometry of matched serum and single dominant ovarian follicular fluid from women undergoing IVF","volume":"38","author":"Walters","year":"2019","journal-title":"Reprod. Biomed. Online"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0015-0282(02)04948-8","article-title":"Role of reactive oxygen species in the pathophysiology of human reproduction","volume":"79","author":"Agarwal","year":"2003","journal-title":"Fertil. Steril."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Zhu, M., Iwano, T., and Takeda, S. (2020). Fallopian Tube Basal Stem Cells Reproducing the Epithelial Sheets In Vitro-Stem Cell of Fallopian Epithelium. Biomolecules, 10.","DOI":"10.3390\/biom10091270"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"8989","DOI":"10.1038\/ncomms9989","article-title":"The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids","volume":"6","author":"Kessler","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Savant, S.S., Sriramkumar, S., and O\u2019Hagan, H.M. (2018). The Role of Inflammation and Inflammatory Mediators in the Development, Progression, Metastasis, and Chemoresistance of Epithelial Ovarian Cancer. Cancers, 10.","DOI":"10.3390\/cancers10080251"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1530\/ERC-11-0107","article-title":"The impact of ovulation on fallopian tube epithelial cells: Evaluating three hypotheses connecting ovulation and serous ovarian cancer","volume":"18","author":"King","year":"2011","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_25","first-page":"e2728","article-title":"Ex vivo culture of primary human fallopian tube epithelial cells","volume":"51","author":"Fotheringham","year":"2011","journal-title":"J. Vis. Exp."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.theriogenology.2011.04.021","article-title":"Modelling the porcine oviduct epithelium: A polarized in vitro system suitable for long-term cultivation","volume":"76","author":"Miessen","year":"2011","journal-title":"Theriogenology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s40104-019-0400-3","article-title":"Proteome changes of porcine follicular fluid during follicle development","volume":"10","author":"Paes","year":"2019","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Paes, V.M., de Figueiredo, J.R., Ryan, P.L., Willard, S.T., and Feugang, J.M. (2020). Comparative Analysis of Porcine Follicular Fluid Proteomes of Small and Large Ovarian Follicles. Biology, 9.","DOI":"10.3390\/biology9050101"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Palma-Vera, S.E., Schoen, J., and Chen, S. (2017). Periovulatory follicular fluid levels of estradiol trigger inflammatory and DNA damage responses in oviduct epithelial cells. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0172192"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.ygyno.2014.12.015","article-title":"Three-dimensional modeling of the human fallopian tube fimbriae","volume":"136","author":"Eddie","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/path.4875","article-title":"Tubal origin of ovarian cancer\u2014The double-edged sword of haemoglobin","volume":"242","author":"Lin","year":"2017","journal-title":"J. Pathol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/12\/10154\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:55:16Z","timestamp":1760126116000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/12\/10154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,15]]},"references-count":31,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["ijms241210154"],"URL":"https:\/\/doi.org\/10.3390\/ijms241210154","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,15]]}}}