{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:05:05Z","timestamp":1777417505683,"version":"3.51.4"},"reference-count":19,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["21-73-10029"],"award-info":[{"award-number":["21-73-10029"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The synthesis of novel, highly functionalized 5-hydroxy 3-pyrrolin-2-ones via a two-step procedure involving an addition reaction between KCN and corresponding chalcones, followed by ring condensation of the obtained \u03b2-cyano ketones with het(aryl)aldehydes under basic conditions is described. This protocol enables the preparation of various 3,5-di-aryl\/heteroaryl-4-benzyl substituted \u03b1,\u03b2-unsaturated \u03b3-hydroxy butyrolactams, which are subjects of significant interest to synthetic organic and medicinal chemistry.<\/jats:p>","DOI":"10.3390\/ijms241210213","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T01:31:31Z","timestamp":1686879091000},"page":"10213","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A New, Convenient Way to Fully Substituted \u03b1,\u03b2-Unsaturated \u03b3-Hydroxy Butyrolactams"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6644-9949","authenticated-orcid":false,"given":"Alexander V.","family":"Aksenov","sequence":"first","affiliation":[{"name":"Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0727-9652","authenticated-orcid":false,"given":"Dmitrii A.","family":"Aksenov","sequence":"additional","affiliation":[{"name":"Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0911-4093","authenticated-orcid":false,"given":"Igor A.","family":"Kurenkov","sequence":"additional","affiliation":[{"name":"Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4742-1999","authenticated-orcid":false,"given":"Alexander V.","family":"Leontiev","sequence":"additional","affiliation":[{"name":"Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7125-9066","authenticated-orcid":false,"given":"Nicolai A.","family":"Aksenov","sequence":"additional","affiliation":[{"name":"Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16236","DOI":"10.1039\/D1RA02279B","article-title":"Preparation of 3,5-Diarylsubstituted 5-Hydroxy-1,5-Dihydro-2 H-Pyrrol-2-Ones via Base-Assisted Cyclization of 3-Cyanoketones","volume":"11","author":"Aksenov","year":"2021","journal-title":"RSC Adv."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1021\/jm9606507","article-title":"Structure\u2212Activity Relationships in a Series of Orally Active \u03b3-Hydroxy Butenolide Endothelin Antagonists","volume":"40","author":"Patt","year":"1997","journal-title":"J. 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