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As an important trace element, strontium (Sr) has been reported to have antioxidant effects, to have anti-inflammatory effects, and to cause the inhibition of adipogenesis. The present study was undertaken to investigate the protective effects of Sr on hippocampal damage in NAFLD mice in order to elucidate the underlying mechanism of Sr in NAFLD. The mouse model of NAFLD was established by feeding mice a high-fat diet (HFD), and the mice were treated with Sr. In the NAFLD mice, we found that treatment with Sr significantly increased the density of c-Fos+ cells in the hippocampus and inhibited the expression of caspase-3 by suppressing ERS. Surprisingly, the induction of neuroinflammation and the increased expression of inflammatory cytokines in the hippocampus following an HFD were attenuated by Sr treatment. Sr significantly attenuated the activation of microglia and astrocytes induced by an HFD. The expression of phospho-p38, ERK, and NF-\u03baB was consistently significantly increased in the HFD group, and treatment with Sr decreased their expression. Moreover, Sr prevented HFD-induced damage to the ultra-structural synaptic architecture. This study implies that Sr has beneficial effects on repairing the damage to the hippocampus induced by an HFD, revealing that Sr could be a potential candidate for protection from neural damage caused by NAFLD.<\/jats:p>","DOI":"10.3390\/ijms241210248","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T10:19:22Z","timestamp":1686910762000},"page":"10248","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Strontium Attenuates Hippocampal Damage via Suppressing Neuroinflammation in High-Fat Diet-Induced NAFLD Mice"],"prefix":"10.3390","volume":"24","author":[{"given":"Shuai","family":"Wang","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyuan","family":"Zeng","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyao","family":"Xiang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songlin","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2619-4467","authenticated-orcid":false,"given":"Shanting","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jhep.2018.10.033","article-title":"Non-alcoholic fatty liver disease\u2014A global public health perspective","volume":"70","author":"Younossi","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Colognesi, M., Gabbia, D., and Martin, S.D. (2020). Depression and Cognitive Impairment\u2014Extrahepatic Manifestations of NAFLD and NASH. Biomedicines, 8.","DOI":"10.3390\/biomedicines8070229"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"He, J., Ye, J., Sun, Y., Feng, S., Chen, Y., and Zhong, B. (2022). The Additive Values of the Classification of Higher Serum Uric Acid Levels as a Diagnostic Criteria for Metabolic-Associated Fatty Liver Disease. Nutrients, 14.","DOI":"10.3390\/nu14173587"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13293-020-0281-3","article-title":"Sex-specific association between the gut microbiome and high-fat diet-induced metabolic disorders in mice","volume":"11","author":"Peng","year":"2020","journal-title":"Biol. Sex Differ."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Nuzzo, D., Galizzi, G., Amato, A., Terzo, S., Picone, P., Cristaldi, L., Mul\u00e8, F., and Di Carlo, M. (2020). Regular Intake of Pistachio Mitigates the Deleterious Effects of a High Fat-Diet in the Brain of Obese Mice. Antioxidants, 9.","DOI":"10.3390\/antiox9040317"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12944-020-01274-y","article-title":"Long term N-acetylcysteine administration rescues liver steatosis via endoplasmic reticulum stress with unfolded protein response in mice","volume":"19","author":"Tsai","year":"2020","journal-title":"Lipids Health Dis."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Tan, B.L., and Norhaizan, M.E. (2019). Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function. Nutrients, 11.","DOI":"10.3390\/nu11112579"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ko\u0142odziejska, B., St\u0119pie\u0144, N., and Kolmas, J. (2021). The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126564"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1107\/S090904951103038X","article-title":"Increased strontium uptake in trabecular bone of ovariectomized calcium-deficient rats treated with strontium ranelate or strontium chloride","volume":"18","author":"Pemmer","year":"2011","journal-title":"J. Synchrot. Radiat."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"100273","DOI":"10.1016\/j.bonr.2020.100273","article-title":"A review of the latest insights into the mechanism of action of strontium in bone","volume":"12","author":"Marx","year":"2020","journal-title":"Bone Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"36251","DOI":"10.1038\/srep36251","article-title":"Strontium inhibits titanium particle-induced osteoclast activation and chronic inflammation via suppression of NF-\u03baB pathway","volume":"6","author":"Zhu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3892\/etm.2022.11131","article-title":"The anti-inflammation effect of strontium ranelate on rat chondrocytes with or without IL-1\u03b2 in vitro","volume":"23","author":"Yu","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1442-2042.2007.01980.x","article-title":"Effects of strontium fructose 1,6-diphosphate on expression of apoptosis-related genes and oxidative stress in testes of diabetic rats","volume":"15","author":"Tang","year":"2008","journal-title":"Int. J. Urol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.biochi.2012.11.008","article-title":"Biochemical changes induced by strontium ranelate in differentiating adipocytes","volume":"95","author":"Vidal","year":"2013","journal-title":"Biochimie"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"752","DOI":"10.3389\/fendo.2018.00752","article-title":"The Effect of Intrahippocampal Insulin Infusion on Spatial Cognitive Function and Markers of Neuroinflammation in Diet-induced Obesity","volume":"9","author":"Gladding","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neurobiolaging.2005.09.003","article-title":"Studies of the effects of high fat diets on cognitive function in a rat model","volume":"26","author":"Winocur","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jneuroim.2009.11.010","article-title":"Cognitive impairment following high fat diet consumption is associated with brain inflammation","volume":"219","author":"Pistell","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Mullins, C.A., Gannaban, R.B., Khan, M.S., Shah, H., Siddik, M.A.B., Hegde, V.K., Reddy, P.H., and Shin, A.C. (2020). Neural Underpinnings of Obesity: The Role of Oxidative Stress and Inflammation in the Brain. Antioxidants, 9.","DOI":"10.3390\/antiox9101018"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"694720","DOI":"10.3389\/fimmu.2021.694720","article-title":"Dietary Betaine Mitigates Hepatic Steatosis and Inflammation Induced by a High-Fat-Diet by Modulating the Sirt1\/Srebp-1\/Ppar\u03b1 Pathway in Juvenile Black Seabream (Acanthopagrus schlegelii)","volume":"12","author":"Jin","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_20","first-page":"168","article-title":"Strontium as a substitute for calcium in the process leading to neurohypophysial hormone secretion","volume":"222","author":"Buchs","year":"1972","journal-title":"J. Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/2121233a0","article-title":"Strontium as a Substitute for Calcium in the Process of Transmitter Release at the Neuromuscular Junction","volume":"212","author":"Miledi","year":"1966","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"794","DOI":"10.3389\/fendo.2018.00794","article-title":"Osteocalcin-A Versatile Bone-Derived Hormone","volume":"9","author":"Moser","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nm.4310","article-title":"Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia","volume":"23","author":"Kesarwani","year":"2017","journal-title":"Nat. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"19324","DOI":"10.1038\/s41598-019-55709-3","article-title":"Caspase-3 knockout inhibits intervertebral disc degeneration related to injury but accelerates degeneration related to aging","volume":"9","author":"Ohnishi","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"E695","DOI":"10.1152\/ajpendo.00038.2010","article-title":"The unfolded protein response is activated in skeletal muscle by high-fat feeding: Potential role in the downregulation of protein synthesis","volume":"299","author":"Philp","year":"2010","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature07203","article-title":"From endoplasmic-reticulum stress to the inflammatory response","volume":"454","author":"Zhang","year":"2008","journal-title":"Nature"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Khan, M.H., Cai, M., Deng, J., Yu, P., Liang, H., and Yang, F. (2019). Anticancer Function and ROS-Mediated Multi-Targeting Anticancer Mechanisms of Copper (II) 2-hydroxy-1-naphthaldehyde Complexes. Molecules, 24.","DOI":"10.3390\/molecules24142544"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/sj.cdd.4401373","article-title":"Roles of CHOP\/GADD153 in endoplasmic reticulum stress","volume":"11","author":"Oyadomari","year":"2004","journal-title":"Cell Death Differ."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/nrd2755","article-title":"Cell death and endoplasmic reticulum stress: Disease relevance and therapeutic opportunities","volume":"7","author":"Kim","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12974-016-0501-2","article-title":"Cocaine-mediated induction of microglial activation involves the ER stress-TLR2 axis","volume":"13","author":"Liao","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jcmgh.2016.11.006","article-title":"Endoplasmic Reticulum Stress Regulates Hepatic Bile Acid Metabolism in Mice","volume":"3","author":"Henkel","year":"2016","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"7489","DOI":"10.1038\/ncomms8489","article-title":"Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota","volume":"6","author":"Chang","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.bbi.2020.11.007","article-title":"Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala","volume":"91","author":"Zheng","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"173035","DOI":"10.1016\/j.ejphar.2020.173035","article-title":"Microglia and mast cells generate proinflammatory cytokines in the brain and worsen inflammatory state: Suppressor effect of IL-37","volume":"875","author":"Conti","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1007\/s11064-022-03710-0","article-title":"Short-Chain Fatty Acids Reduce Oligodendrocyte Precursor Cells Loss by Inhibiting the Activation of Astrocytes via the SGK1\/IL-6 Signalling Pathway","volume":"47","author":"Gao","year":"2022","journal-title":"Neurochem. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12974-017-0838-1","article-title":"Inflammatory signature of cerebellar neurodegeneration during neonatal hyperbilirubinemia in Ugt1 -\/- mouse model","volume":"14","author":"Vodret","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1006\/bbrc.2001.5388","article-title":"Iba1 Is an Actin-Cross-Linking Protein in Macrophages\/Microglia. Biochem","volume":"286","author":"Sasaki","year":"2001","journal-title":"Biophys. Res. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.tins.2009.08.002","article-title":"Molecular dissection of reactive astrogliosis and glial scar formation","volume":"32","author":"Sofroniew","year":"2009","journal-title":"Trends Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Lara-Espinosa, J.V., Santana-Mart\u00ednez, R.A., Maldonado, P.D., Zetter, M., Becerril-Villanueva, E., P\u00e9rez-S\u00e1nchez, G., Pav\u00f3n, L., Mata-Espinosa, D., Barrios-Pay\u00e1n, J., and L\u00f3pez-Torres, M.O. (2020). Experimental Pulmonary Tuberculosis in the Absence of Detectable Brain Infection Induces Neuroinflammation and Behavioural Abnormalities in Male BALB\/c Mice. Int. J. Mol. Sci., 21.","DOI":"10.21203\/rs.3.rs-24798\/v1"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/s40168-021-01172-0","article-title":"A fiber-deprived diet causes cognitive impairment and hippocampal microglia-mediated synaptic loss through the gut microbiota and metabolites","volume":"9","author":"Shi","year":"2021","journal-title":"Microbiome"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-015-0467-5","article-title":"Non-alcoholic fatty liver disease induces signs of Alzheimer\u2019s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model","volume":"13","author":"Kim","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Zhigang, L., Patil, I.Y., Tianyi, J., Harsh, S., Walsh, J.P., Stiles, B.L., Fei, Y., Enrique, C., and Luque, R.M. (2015). High-Fat Diet Induces Hepatic Insulin Resistance and Impairment of Synaptic Plasticity. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0128274"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1039\/C6FO01562J","article-title":"Sesamol ameliorates high-fat and high-fructose induced cognitive defects via improving insulin signaling disruption in the central nervous system","volume":"8","author":"Liu","year":"2017","journal-title":"Food Funct."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3389\/fnagi.2019.00174","article-title":"Liver Dysfunction as a Novel Player in Alzheimer\u2019s Progression: Looking Outside the Brain","volume":"11","author":"Estrada","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Chang, L.C., Chung, C.Y., Chiu, C.H., Lin, H.C., and Yang, J.T. (2021). The Effect of Polybutylcyanoacrylate Nanoparticles as a Protos Delivery Vehicle on Dental Bone Formation. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094873"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.msec.2019.02.053","article-title":"Osteogenic, anti-osteoclastogenic and immunomodulatory properties of a strontium-releasing hybrid scaffold for bone repair","volume":"99","author":"Lourenco","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.msec.2017.05.042","article-title":"Strontium and strontium ranelate: Historical review of some of their functions","volume":"78","author":"Pilmane","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41467-023-36079-x","article-title":"Microbially produced vitamin B12 contributes to the lipid-lowering effect of silymarin","volume":"14","author":"Sun","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s10620-009-0815-3","article-title":"Characterization of high-fat, diet-induced, non-alcoholic steatohepatitis with fibrosis in rats","volume":"55","author":"Xu","year":"2010","journal-title":"Dig. Dis. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/bph.14095","article-title":"Tauroursodeoxycholic acid inhibits intestinal inflammation and barrier disruption in mice with non-alcoholic fatty liver disease","volume":"175","author":"Wang","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/329441a0","article-title":"Kindling stimulation induces c-fos protein(s) in granule cells of the rat dentate gyrus","volume":"329","author":"Dragunow","year":"1987","journal-title":"Nature"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.2337\/db07-1788","article-title":"Role of Central Nervous System Glucagon-Like Peptide-1 Receptors in Enteric Glucose Sensing","volume":"57","author":"Knauf","year":"2008","journal-title":"Diabetes"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"11226","DOI":"10.1038\/s41598-020-66959-x","article-title":"Sevoflurane induces neuronal activation and behavioral hyperactivity in young mice","volume":"10","author":"Yang","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00441-015-2205-9","article-title":"Endoplasmic reticulum stress-mediated inflammatory signaling pathways within the osteolytic periosteum and interface membrane in particle-induced osteolysis","volume":"363","author":"Liu","year":"2015","journal-title":"Cell Tissue Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.molcel.2015.06.020","article-title":"ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate","volume":"59","author":"Shin","year":"2015","journal-title":"Mol. Cell."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.tem.2015.05.007","article-title":"Targeting endoplasmic reticulum stress in insulin resistance","volume":"26","author":"Xavier","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13024-017-0183-y","article-title":"Endoplasmic reticulum stress and inflammation in the central nervous system","volume":"12","author":"Sprenkle","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbadis.2014.11.007","article-title":"Curcumin ameliorates testicular damage in diabetic rats by suppressing cellular stress-mediated mitochondria and endoplasmic reticulum-dependent apoptotic death","volume":"1852","author":"Rashid","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12929-019-0597-7","article-title":"Granulocyte-colony stimulating factor gene therapy as a novel therapeutics for stroke in a mouse model","volume":"27","author":"Modi","year":"2020","journal-title":"J. Biomed. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1161\/CIRCRESAHA.110.227819","article-title":"Endoplasmic reticulum stress as a therapeutic target in cardiovascular disease","volume":"107","author":"Minamino","year":"2010","journal-title":"Circ. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1681\/ASN.2017121338","article-title":"The Human FSGS-Causing ANLN R431C Mutation Induces Dysregulated PI3K\/AKT\/mTOR\/Rac1 Signaling in Podocytes","volume":"29","author":"Hall","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.biopha.2018.09.167","article-title":"Estrogen and propofol combination therapy inhibits endoplasmic reticulum stress and remarkably attenuates cerebral ischemia-reperfusion injury and OGD injury in hippocampus","volume":"108","author":"Xu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4021623","DOI":"10.1155\/2019\/4021623","article-title":"Visfatin Induces Inflammation and Insulin Resistance via the NF-\u03baB and STAT3 Signaling Pathways in Hepatocytes","volume":"2019","author":"Heo","year":"2019","journal-title":"J. Diabetes Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40035-018-0138-4","article-title":"Dynamic changes of CX3CL1\/CX3CR1 axis during microglial activation and motor neuron loss in the spinal cord of ALS mouse model","volume":"7","author":"Zhang","year":"2018","journal-title":"Transl. Neurodegener."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1172\/JCI58644","article-title":"Innate immunity in the central nervous system","volume":"122","author":"Ransohoff","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"17922","DOI":"10.1038\/s41598-017-17911-z","article-title":"Global loss of acetylcholinesterase activity with mitochondrial complexes inhibition and inflammation in brain of hypercholesterolemic mice","volume":"7","author":"Paul","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1152\/physrev.00011.2010","article-title":"Physiology of microglia","volume":"91","author":"Kettenmann","year":"2011","journal-title":"Physiol. Rev."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/1742-2094-9-111","article-title":"Heterotrimeric G protein-dependent WNT-5A signaling to ERK1\/2 mediates distinct aspects of microglia proinflammatory transformation","volume":"9","author":"Halleskog","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"776","DOI":"10.3389\/fphar.2020.00776","article-title":"Oxymatrine Attenuates Dopaminergic Neuronal Damage and Microglia-Mediated Neuroinflammation Through Cathepsin D-Dependent HMGB1\/TLR4\/NF-\u03baB Pathway in Parkinson\u2019s Disease","volume":"11","author":"Gan","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Liu, L., Dong, Y., Shan, X., Li, L., Xia, B., and Wang, H. (2019). Anti-Depressive Effectiveness of Baicalin In Vitro and In Vivo. Molecules, 24.","DOI":"10.3390\/molecules24020326"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.intimp.2016.04.023","article-title":"Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4\/MyD88 signal pathway","volume":"36","author":"Yao","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bbrc.2015.03.154","article-title":"Sesamin ameliorates lipopolysaccharide\/d-galactosamine-induced fulminant hepatic failure by suppression of Toll-like receptor 4 signaling in mice","volume":"461","author":"Ma","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Yu, X., Li, Z., Liu, X., Hu, J., Liu, R., Zhu, N., and Li, Y. (2021). The Antioxidant Effects of Whey Protein Peptide on Learning and Memory Improvement in Aging Mice Models. Nutrients, 13.","DOI":"10.3390\/nu13062100"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.1038\/s41598-018-23213-9","article-title":"Iso-\u03b1-acids, bitter components of beer, prevent obesity-induced cognitive decline","volume":"8","author":"Ayabe","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.celrep.2018.03.119","article-title":"Wnt Signaling Mediates LTP-Dependent Spine Plasticity and AMPAR Localization through Frizzled-7 Receptors","volume":"23","author":"Mcleod","year":"2018","journal-title":"Cell Rep."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1126\/science.1067020","article-title":"The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses","volume":"294","author":"Kandel","year":"2001","journal-title":"Science"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"10998","DOI":"10.1523\/JNEUROSCI.3874-16.2017","article-title":"A Role of Endogenous Progesterone in Stroke Cerebroprotection Revealed by the Neural-Specific Deletion of Its Intracellular Receptors","volume":"37","author":"Zhu","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2\u2212\u0394\u0394CT Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/12\/10248\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:56:47Z","timestamp":1760126207000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/12\/10248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,16]]},"references-count":79,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["ijms241210248"],"URL":"https:\/\/doi.org\/10.3390\/ijms241210248","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,16]]}}}