{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:45:00Z","timestamp":1778899500066,"version":"3.51.4"},"reference-count":53,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F99 AG068527"],"award-info":[{"award-number":["F99 AG068527"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 CA109545"],"award-info":[{"award-number":["RO1 CA109545"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UO1 CA236979"],"award-info":[{"award-number":["UO1 CA236979"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KO1 CA218305"],"award-info":[{"award-number":["KO1 CA218305"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Samuel Waxman Cancer Research Foundation","award":["F99 AG068527"],"award-info":[{"award-number":["F99 AG068527"]}]},{"name":"Samuel Waxman Cancer Research Foundation","award":["RO1 CA109545"],"award-info":[{"award-number":["RO1 CA109545"]}]},{"name":"Samuel Waxman Cancer Research Foundation","award":["UO1 CA236979"],"award-info":[{"award-number":["UO1 CA236979"]}]},{"name":"Samuel Waxman Cancer Research Foundation","award":["KO1 CA218305"],"award-info":[{"award-number":["KO1 CA218305"]}]},{"name":"Walther Cancer Foundation Cancer Cures Venture","award":["F99 AG068527"],"award-info":[{"award-number":["F99 AG068527"]}]},{"name":"Walther Cancer Foundation Cancer Cures Venture","award":["RO1 CA109545"],"award-info":[{"award-number":["RO1 CA109545"]}]},{"name":"Walther Cancer Foundation Cancer Cures Venture","award":["UO1 CA236979"],"award-info":[{"award-number":["UO1 CA236979"]}]},{"name":"Walther Cancer Foundation Cancer Cures Venture","award":["KO1 CA218305"],"award-info":[{"award-number":["KO1 CA218305"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ovarian cancer is the sixth leading cause of cancer-related death in women, and both occurrence and mortality are increased in women over the age of 60. There are documented age-related changes in the ovarian cancer microenvironment that have been shown to create a permissive metastatic niche, including the formation of advanced glycation end products, or AGEs, that form crosslinks between collagen molecules. Small molecules that disrupt AGEs, known as AGE breakers, have been examined in other diseases, but their efficacy in ovarian cancer has not been evaluated. The goal of this pilot study is to target age-related changes in the tumor microenvironment with the long-term aim of improving response to therapy in older patients. Here, we show that AGE breakers have the potential to change the omental collagen structure and modulate the peritoneal immune landscape, suggesting a potential use for AGE breakers in the treatment of ovarian cancer.<\/jats:p>","DOI":"10.3390\/ijms24129804","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T13:42:06Z","timestamp":1686058926000},"page":"9804","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Advanced Glycation End Products as a Potential Target for Restructuring the Ovarian Cancer Microenvironment: A Pilot Study"],"prefix":"10.3390","volume":"24","author":[{"given":"Elizabeth","family":"Harper","sequence":"first","affiliation":[{"name":"Integrated Biomedical Sciences Graduate Program, University of Notre Dame, Notre Dame, IN 46556, USA"},{"name":"Department of Chemistry & Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA"},{"name":"Harper Cancer 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University of Notre Dame, Notre Dame, IN 46556, USA"},{"name":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46617, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Hammond","sequence":"additional","affiliation":[{"name":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46617, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry & Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA"},{"name":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46617, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1718-9183","authenticated-orcid":false,"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chemistry & Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA"},{"name":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46617, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Hubble","sequence":"additional","affiliation":[{"name":"Department of Chemistry & Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5509-1224","authenticated-orcid":false,"given":"Danica","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Chemistry & Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Melander","sequence":"additional","affiliation":[{"name":"Department of Chemistry & Biochemistry, University of Notre Dame, Notre Dame, IN 46556, 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