{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:04:42Z","timestamp":1773403482564,"version":"3.50.1"},"reference-count":83,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health (NIH)","award":["HD001097"],"award-info":[{"award-number":["HD001097"]}]},{"name":"National Institutes of Health (NIH)","award":["T32GM008806"],"award-info":[{"award-number":["T32GM008806"]}]},{"name":"National Institutes of Health (NIH)","award":["W81XWH-22-1-1075"],"award-info":[{"award-number":["W81XWH-22-1-1075"]}]},{"name":"Cincinnati Children\u2019s Hospital Medical Center Proctor Scholar Award","award":["HD001097"],"award-info":[{"award-number":["HD001097"]}]},{"name":"Cincinnati Children\u2019s Hospital Medical Center Proctor Scholar Award","award":["T32GM008806"],"award-info":[{"award-number":["T32GM008806"]}]},{"name":"Cincinnati Children\u2019s Hospital Medical Center Proctor Scholar Award","award":["W81XWH-22-1-1075"],"award-info":[{"award-number":["W81XWH-22-1-1075"]}]},{"name":"Research Innovation Award","award":["HD001097"],"award-info":[{"award-number":["HD001097"]}]},{"name":"Research Innovation Award","award":["T32GM008806"],"award-info":[{"award-number":["T32GM008806"]}]},{"name":"Research Innovation Award","award":["W81XWH-22-1-1075"],"award-info":[{"award-number":["W81XWH-22-1-1075"]}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["HD001097"],"award-info":[{"award-number":["HD001097"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["T32GM008806"],"award-info":[{"award-number":["T32GM008806"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-22-1-1075"],"award-info":[{"award-number":["W81XWH-22-1-1075"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Traumatic brain injury (TBI) is a major public health concern, particularly in adolescents who have a higher mortality and incidence of visual pathway injury compared to adult patients. Likewise, we have found disparities between adult and adolescent TBI outcomes in rodents. Most interestingly, adolescents suffer a prolonged apneic period immediately post-injury, leading to higher mortality; therefore, we implemented a brief oxygen exposure paradigm to circumvent this increased mortality. Adolescent male mice experienced a closed-head weight-drop TBI and were then exposed to 100% O2 until normal breathing returned or recovered in room air. We followed mice for 7 and 30 days and assessed their optokinetic response; retinal ganglion cell loss; axonal degeneration; glial reactivity; and retinal ER stress protein levels. O2 reduced adolescent mortality by 40%, improved post-injury visual acuity, and reduced axonal degeneration and gliosis in optical projection regions. ER stress protein expression was altered in injured mice, and mice given O2 utilized different ER stress pathways in a time-dependent manner. Finally, O2 exposure may be mediating these ER stress responses through regulation of the redox-sensitive ER folding protein ERO1\u03b1, which has been linked to a reduction in the toxic effects of free radicals in other animal models of ER stress.<\/jats:p>","DOI":"10.3390\/ijms24129831","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T02:28:45Z","timestamp":1686104925000},"page":"9831","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Brief Oxygen Exposure after Traumatic Brain Injury Hastens Recovery and Promotes Adaptive Chronic Endoplasmic Reticulum Stress Responses"],"prefix":"10.3390","volume":"24","author":[{"given":"Jordyn N.","family":"Torrens","sequence":"first","affiliation":[{"name":"Division of Pediatric Rehabilitation Medicine, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6497-378X","authenticated-orcid":false,"given":"Shelby M.","family":"Hetzer","sequence":"additional","affiliation":[{"name":"Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH 45267, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2474-9764","authenticated-orcid":false,"given":"Nathan K.","family":"Evanson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rehabilitation Medicine, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1089\/neu.1995.12.579","article-title":"The effect of associated injuries, blood loss, and oxygen debt on death and disability in blunt traumatic brain injury: The need for early physiologic predictors of severity","volume":"12","author":"Siegel","year":"1995","journal-title":"J. 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