{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:12:03Z","timestamp":1760148723411,"version":"build-2065373602"},"reference-count":125,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Centre National de la Recherche Scientifique (CNRS)","award":["FRM-EQUIPE-2017","ANR-MCORGLAUC-2020","3R-INSERM-2019"],"award-info":[{"award-number":["FRM-EQUIPE-2017","ANR-MCORGLAUC-2020","3R-INSERM-2019"]}]},{"name":"Foundation for Medical Research","award":["FRM-EQUIPE-2017","ANR-MCORGLAUC-2020","3R-INSERM-2019"],"award-info":[{"award-number":["FRM-EQUIPE-2017","ANR-MCORGLAUC-2020","3R-INSERM-2019"]}]},{"name":"National Research Funding Agency","award":["FRM-EQUIPE-2017","ANR-MCORGLAUC-2020","3R-INSERM-2019"],"award-info":[{"award-number":["FRM-EQUIPE-2017","ANR-MCORGLAUC-2020","3R-INSERM-2019"]}]},{"name":"National Institute for Health and Medical Research","award":["FRM-EQUIPE-2017","ANR-MCORGLAUC-2020","3R-INSERM-2019"],"award-info":[{"award-number":["FRM-EQUIPE-2017","ANR-MCORGLAUC-2020","3R-INSERM-2019"]}]},{"name":"IDEX-Paris-Saclay University","award":["FRM-EQUIPE-2017","ANR-MCORGLAUC-2020","3R-INSERM-2019"],"award-info":[{"award-number":["FRM-EQUIPE-2017","ANR-MCORGLAUC-2020","3R-INSERM-2019"]}]},{"name":"FRM, INSERM, and ANR grants","award":["FRM-EQUIPE-2017","ANR-MCORGLAUC-2020","3R-INSERM-2019"],"award-info":[{"award-number":["FRM-EQUIPE-2017","ANR-MCORGLAUC-2020","3R-INSERM-2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The neural crest, a unique cell population originating from the primitive neural field, has a multi-systemic and structural contribution to vertebrate development. At the cephalic level, the neural crest generates most of the skeletal tissues encasing the developing forebrain and provides the prosencephalon with functional vasculature and meninges. Over the last decade, we have demonstrated that the cephalic neural crest (CNC) exerts an autonomous and prominent control on the development of the forebrain and sense organs. The present paper reviews the primary mechanisms by which CNC can orchestrate vertebrate encephalization. Demonstrating the role of the CNC as an exogenous source of patterning for the forebrain provides a novel conceptual framework with profound implications for understanding neurodevelopment. From a biomedical standpoint, these data suggest that the spectrum of neurocristopathies is broader than expected and that some neurological disorders may stem from CNC dysfunctions.<\/jats:p>","DOI":"10.3390\/ijms24129844","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T02:58:32Z","timestamp":1686193112000},"page":"9844","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Emerging Roles of the Cephalic Neural Crest in Brain Development and Developmental Encephalopathies"],"prefix":"10.3390","volume":"24","author":[{"given":"Emmanuel","family":"Bruet","sequence":"first","affiliation":[{"name":"Paris-Saclay Institute of Neuroscience, NeuroPSI, CNRS, Paris-Saclay University, Campus CEA Saclay, B\u00e2t 151, 151 Route de la Rotonde, 91400 Saclay, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Amarante-Silva","sequence":"additional","affiliation":[{"name":"Paris-Saclay Institute of Neuroscience, NeuroPSI, CNRS, Paris-Saclay University, Campus CEA Saclay, B\u00e2t 151, 151 Route de la Rotonde, 91400 Saclay, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Gorojankina","sequence":"additional","affiliation":[{"name":"Paris-Saclay Institute of Neuroscience, NeuroPSI, CNRS, Paris-Saclay University, Campus CEA Saclay, B\u00e2t 151, 151 Route de la Rotonde, 91400 Saclay, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Creuzet","sequence":"additional","affiliation":[{"name":"Paris-Saclay Institute of Neuroscience, NeuroPSI, CNRS, Paris-Saclay University, Campus CEA Saclay, B\u00e2t 151, 151 Route de la Rotonde, 91400 Saclay, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1126\/science.220.4594.268","article-title":"Neural crest and the origin of vertebrates: A new head","volume":"220","author":"Gans","year":"1983","journal-title":"Science"},{"key":"ref_2","unstructured":"Le Douarin, N.M. 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