{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:44:48Z","timestamp":1791582288567,"version":"4.3.4"},"reference-count":226,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001543","name":"Neurological Foundation of New Zealand","doi-asserted-by":"publisher","award":["2110 PRG"],"award-info":[{"award-number":["2110 PRG"]}],"id":[{"id":"10.13039\/501100001543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001543","name":"Neurological Foundation of New Zealand","doi-asserted-by":"publisher","award":["7720015"],"award-info":[{"award-number":["7720015"]}],"id":[{"id":"10.13039\/501100001543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001543","name":"Neurological Foundation of New Zealand","doi-asserted-by":"publisher","award":["7722005"],"award-info":[{"award-number":["7722005"]}],"id":[{"id":"10.13039\/501100001543","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jean Cathie Bequest","award":["2110 PRG"],"award-info":[{"award-number":["2110 PRG"]}]},{"name":"Jean Cathie Bequest","award":["7720015"],"award-info":[{"award-number":["7720015"]}]},{"name":"Jean Cathie Bequest","award":["7722005"],"award-info":[{"award-number":["7722005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Tinnitus is originally derived from the Latin verb tinnire, which means \u201cto ring\u201d. Tinnitus, a complex disorder, is a result of sentient cognizance of a sound in the absence of an external auditory stimulus. It is reported in children, adults, and older populations. Patients suffering from tinnitus often present with hearing loss, anxiety, depression, and sleep disruption in addition to a hissing and ringing in the ear. Surgical interventions and many other forms of treatment have been only partially effective due to heterogeneity in tinnitus patients and a lack of understanding of the mechanisms of tinnitus. Although researchers across the globe have made significant progress in understanding the underlying mechanisms of tinnitus over the past few decades, tinnitus is still deemed to be a scientific enigma. This review summarises the role of the limbic system in tinnitus development and provides insight into the development of potential target-specific tinnitus therapies.<\/jats:p>","DOI":"10.3390\/ijms24129889","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T03:29:48Z","timestamp":1686194988000},"page":"9889","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Targeting the Limbic System: Insights into Its Involvement in Tinnitus"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7401-4355","authenticated-orcid":false,"given":"Anurag","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand"},{"name":"Brain Health Research Centre, University of Otago, Dunedin 9016, New Zealand"},{"name":"The Eisdell Moore Centre for Research in Hearing and Balance Disorders, University of Auckland, Auckland 1023, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1961-7118","authenticated-orcid":false,"given":"Paul F.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand"},{"name":"Brain Health Research Centre, University of Otago, Dunedin 9016, New Zealand"},{"name":"The Eisdell Moore Centre for Research in Hearing and Balance Disorders, University of Auckland, Auckland 1023, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand"},{"name":"Brain Health Research Centre, University of Otago, Dunedin 9016, New Zealand"},{"name":"The Eisdell Moore Centre for Research in Hearing and Balance Disorders, University of Auckland, Auckland 1023, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.pbr.2020.12.002","article-title":"Tinnitus and tinnitus disorder: Theoretical and operational definitions (an international multidisciplinary proposal)","volume":"260","author":"Schlee","year":"2021","journal-title":"Prog. 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