{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:39:14Z","timestamp":1793133554814,"version":"4.5.0"},"reference-count":171,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Inserm","id":[{"id":"https:\/\/ror.org\/02vjkv261","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Universit\u00e9 Paris Cit\u00e9","id":[{"id":"https:\/\/ror.org\/05f82e368","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Gefluc-Les Entreprises Contre le Cancer"},{"name":"la Ligue Contre le Cancer-Comit\u00e9 de Paris","id":[{"id":"https:\/\/ror.org\/00rkrv905","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fondation ARC"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Adult pancreatic acinar cells show high plasticity allowing them to change in their differentiation commitment. Pancreatic acinar-to-ductal metaplasia (ADM) is a cellular process in which the differentiated pancreatic acinar cells transform into duct-like cells. This process can occur as a result of cellular injury or inflammation in the pancreas. While ADM is a reversible process allowing pancreatic acinar regeneration, persistent inflammation or injury can lead to the development of pancreatic intraepithelial neoplasia (PanIN), which is a common precancerous lesion that precedes pancreatic ductal adenocarcinoma (PDAC). Several factors can contribute to the development of ADM and PanIN, including environmental factors such as obesity, chronic inflammation and genetic mutations. ADM is driven by extrinsic and intrinsic signaling. Here, we review the current knowledge on the cellular and molecular biology of ADM. Understanding the cellular and molecular mechanisms underlying ADM is critical for the development of new therapeutic strategies for pancreatitis and PDAC. Identifying the intermediate states and key molecules that regulate ADM initiation, maintenance and progression may help the development of novel preventive strategies for PDAC.<\/jats:p>","DOI":"10.3390\/ijms24129946","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T09:54:32Z","timestamp":1686304472000},"page":"9946","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Acinar-to-Ductal Metaplasia (ADM): On the Road to Pancreatic Intraepithelial Neoplasia (PanIN) and Pancreatic Cancer"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8449-7920","authenticated-orcid":false,"given":"Louis","family":"Marstrand-Dauc\u00e9","sequence":"first","affiliation":[{"name":"INSERM UMR1149, Inflammation Research Center (CRI), Universit\u00e9 Paris Cit\u00e9, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"INSERM UMR1149, Inflammation Research Center (CRI), Universit\u00e9 Paris Cit\u00e9, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00efs","family":"Chassac","sequence":"additional","affiliation":[{"name":"INSERM UMR1149, Inflammation Research Center (CRI), Universit\u00e9 Paris Cit\u00e9, 75018 Paris, France"},{"name":"Department of Pathology, Bichat Hospital, Universit\u00e9 Paris Cit\u00e9, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Nicole","sequence":"additional","affiliation":[{"name":"INSERM UMR1149, Inflammation Research Center (CRI), Universit\u00e9 Paris Cit\u00e9, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Couvelard","sequence":"additional","affiliation":[{"name":"INSERM UMR1149, Inflammation Research Center (CRI), Universit\u00e9 Paris Cit\u00e9, 75018 Paris, France"},{"name":"Department of Pathology, Bichat Hospital, Universit\u00e9 Paris Cit\u00e9, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3526-7832","authenticated-orcid":false,"given":"C\u00e9cile","family":"Haumaitre","sequence":"additional","affiliation":[{"name":"INSERM UMR1149, Inflammation Research Center (CRI), Universit\u00e9 Paris Cit\u00e9, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1158\/0008-5472.CAN-14-0155","article-title":"Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States","volume":"74","author":"Rahib","year":"2014","journal-title":"Cancer Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1097\/MPA.0000000000000786","article-title":"The Prevalence and Clinicopathological Characteristics of High-Grade Pancreatic Intraepithelial Neoplasia: Autopsy Study Evaluating the Entire Pancreatic Parenchyma","volume":"46","author":"Matsuda","year":"2017","journal-title":"Pancreas"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.jcmgh.2019.06.005","article-title":"Pancreatic Ductal Deletion of Hnf1b Disrupts Exocrine Homeostasis, Leads to Pancreatitis, and Facilitates Tumorigenesis","volume":"8","author":"Quilichini","year":"2019","journal-title":"Cell Mol. 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