{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:01:22Z","timestamp":1793275282851,"version":"4.5.0"},"reference-count":115,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education of the Russian Federation","award":["075-15-2022-311"],"award-info":[{"award-number":["075-15-2022-311"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is one of the most widespread neurodegenerative diseases. Most of the current AD therapeutic developments are directed towards improving neuronal cell function or facilitating A\u03b2 amyloid clearance from the brain. However, some recent evidence suggests that astrocytes may play a significant role in the pathogenesis of AD. In this paper, we evaluated the effects of the optogenetic activation of Gq-coupled exogenous receptors expressed in astrocytes as a possible way of restoring brain function in the AD mouse model. We evaluated the effects of the optogenetic activation of astrocytes on long-term potentiation, spinal morphology and behavioral readouts in 5xFAD mouse model of AD. We determined that in vivo chronic activation of astrocytes resulted in the preservation of spine density, increased mushroom spine survival, and improved performance in cognitive behavioral tests. Furthermore, chronic optogenetic stimulation of astrocytes resulted in the elevation of EAAT-2 glutamate uptake transporter expression, which could be a possible explanation for the observed in vivo neuroprotective effects. The obtained results suggest that the persistent activation of astrocytes may be considered a potential therapeutic approach for the treatment of AD and possibly other neurodegenerative disorders.<\/jats:p>","DOI":"10.3390\/ijms24129969","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T09:54:32Z","timestamp":1686304472000},"page":"9969","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Activation of Gq-Coupled Receptors in Astrocytes Restores Cognitive Function in Alzheimer\u2019s Disease Mice Model"],"prefix":"10.3390","volume":"24","author":[{"given":"Evgenii","family":"Gerasimov","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, Khlopina St. 11, 194021 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7006-6951","authenticated-orcid":false,"given":"Ilya","family":"Bezprozvanny","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, Khlopina St. 11, 194021 St. Petersburg, Russia"},{"name":"Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga L.","family":"Vlasova","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, Khlopina St. 11, 194021 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.neuroscience.2004.09.053","article-title":"The Neurobiology of Glia in the Context of Water and Ion Homeostasis","volume":"129","author":"Simard","year":"2004","journal-title":"Neuroscience"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.tins.2013.04.004","article-title":"Emerging Role for Astroglial Networks in Information Processing: From Synapse to Behavior","volume":"36","author":"Pannasch","year":"2013","journal-title":"Trends Neurosci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/function\/zqab069","article-title":"Inclusive Brain: From Neuronal Doctrine to the Active Milieu","volume":"3","author":"Semyanov","year":"2022","journal-title":"Function"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"102209","DOI":"10.1016\/j.pneurobio.2021.102209","article-title":"Optogenetic Stimulation of CA3 Pyramidal Neurons Restores Synaptic Deficits to Improve Spatial Short-Term Memory in APP\/PS1 Mice","volume":"209","author":"Yang","year":"2022","journal-title":"Prog. 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