{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:24:52Z","timestamp":1792016692914,"version":"4.4.0"},"reference-count":205,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"National Science and Technology STI2030-Major Projects","doi-asserted-by":"publisher","award":["2022ZD0206800"],"award-info":[{"award-number":["2022ZD0206800"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"National Science and Technology STI2030-Major Projects","doi-asserted-by":"publisher","award":["92049102"],"award-info":[{"award-number":["92049102"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"National Science and Technology STI2030-Major Projects","doi-asserted-by":"publisher","award":["7222113"],"award-info":[{"award-number":["7222113"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022ZD0206800"],"award-info":[{"award-number":["2022ZD0206800"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92049102"],"award-info":[{"award-number":["92049102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["7222113"],"award-info":[{"award-number":["7222113"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["2022ZD0206800"],"award-info":[{"award-number":["2022ZD0206800"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["92049102"],"award-info":[{"award-number":["92049102"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7222113"],"award-info":[{"award-number":["7222113"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Early-life stress during critical periods of brain development can have long-term effects on physical and mental health. Oxytocin is a critical social regulator and anti-inflammatory hormone that modulates stress-related functions and social behaviors and alleviates diseases. Oxytocin-related neural systems show high plasticity in early postpartum and adolescent periods. Early-life stress can influence the oxytocin system long term by altering the expression and signaling of oxytocin receptors. Deficits in social behavior, emotional control, and stress responses may result, thus increasing the risk of anxiety, depression, and other stress-related neuropsychiatric diseases. Oxytocin is regarded as an important target for the treatment of stress-related neuropsychiatric disorders. Here, we describe the history of oxytocin and its role in neural circuits and related behaviors. We then review abnormalities in the oxytocin system in early-life stress and the functions of oxytocin in treating stress-related neuropsychiatric disorders.<\/jats:p>","DOI":"10.3390\/ijms241310430","type":"journal-article","created":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T01:49:32Z","timestamp":1687398572000},"page":"10430","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Role of Oxytocin in Early-Life-Stress-Related Neuropsychiatric Disorders"],"prefix":"10.3390","volume":"24","author":[{"given":"Yue","family":"Jin","sequence":"first","affiliation":[{"name":"Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Song","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Quan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2820-450X","authenticated-orcid":false,"given":"Hong","family":"Qing","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1089\/ars.2012.4720","article-title":"Severe life stress and oxidative stress in the brain: From animal models to human pathology","volume":"18","author":"Schiavone","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1176\/jnp.10.2.230a","article-title":"A syndrome produced by diverse nocuous agents. 1936","volume":"10","author":"Selye","year":"1998","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3389\/fpsyt.2019.00118","article-title":"Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation","volume":"10","author":"Agorastos","year":"2019","journal-title":"Front. Psychiatry"},{"key":"ref_4","first-page":"70","article-title":"Early Life Stress, Hormones, and Neurodevelopmental Disorders","volume":"96","author":"Makris","year":"2022","journal-title":"Horm. Res. Paediatr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-981-32-9705-0_9","article-title":"The Role of Early Life Stress in HPA Axis and Anxiety","volume":"1191","author":"Juruena","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.chiabu.2008.12.007","article-title":"Childhood emotional maltreatment and later psychological distress among college students: The mediating role of maladaptive schemas","volume":"33","author":"Wright","year":"2009","journal-title":"Child. Abus. Negl."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neubiorev.2018.08.014","article-title":"The impact of early life stress on the central oxytocin system and susceptibility for drug addiction: Applicability of oxytocin as a pharmacotherapy","volume":"110","author":"Baracz","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Colleluori, G., Galli, C., Severi, I., Perugini, J., and Giordano, A. (2022). Early Life Stress, Brain Development, and Obesity Risk: Is Oxytocin the Missing Link?. Cells, 11.","DOI":"10.3390\/cells11040623"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.cobeha.2018.06.018","article-title":"The impact of oxytocin on stress: The role of sex","volume":"23","author":"Love","year":"2018","journal-title":"Curr. Opin. Behav. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1159\/000123566","article-title":"Oxytocin unlike vasopressin is a stress hormone in the rat","volume":"37","author":"Lang","year":"1983","journal-title":"Neuroendocrinology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fnmol.2012.00077","article-title":"Neuropeptides as mediators of the early-life impact on the brain; implications for alcohol use disorders","volume":"5","author":"Nylander","year":"2012","journal-title":"Front. Mol. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Leng, G. (2018). The Heart of the Brain: The Hypothalamus and Its Hormones, The MIT Press.","DOI":"10.7551\/mitpress\/11060.001.0001"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1521\/pdps.2017.45.4.499","article-title":"The Role of Oxytocin and Vasopressin in Attachment","volume":"45","author":"Carter","year":"2017","journal-title":"Psychodyn. Psychiatry"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41593-018-0286-y","article-title":"Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism","volume":"22","author":"Balland","year":"2019","journal-title":"Nat. Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1126\/science.556308","article-title":"Immunoreactive vasopressin and oxytocin: Concentration in individual human hypothalamic nuclei","volume":"200","author":"George","year":"1978","journal-title":"Science"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.regpep.2006.03.008","article-title":"Oxytocin is expressed throughout the human gastrointestinal tract","volume":"135","author":"Ohlsson","year":"2006","journal-title":"Regul. Pept."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e12549","DOI":"10.1111\/jne.12549","article-title":"Diversity of oxytocin neurons: Beyond magno- and parvocellular cell types?","volume":"30","author":"Althammer","year":"2017","journal-title":"J. Neuroendocrinol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1210\/endrev\/bnz012","article-title":"Metabolic Effects of Oxytocin","volume":"41","author":"McCormack","year":"2020","journal-title":"Endocr. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0006-8993(80)90354-6","article-title":"Separate neurons in the paraventricular nucleus project to the median eminence and to the medulla or spinal cord","volume":"198","author":"Swanson","year":"1980","journal-title":"Brain Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/s41593-020-0674-y","article-title":"Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons","volume":"23","author":"Tang","year":"2020","journal-title":"Nat. Neurosci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.neuron.2011.11.030","article-title":"Evoked axonal oxytocin release in the central amygdala attenuates fear response","volume":"73","author":"Knobloch","year":"2012","journal-title":"Neuron"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Baldi, E., Costa, A., Rani, B., Passani, M.B., Blandina, P., Romano, A., and Provensi, G. (2021). Oxytocin and Fear Memory Extinction: Possible Implications for the Therapy of Fear Disorders?. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221810000"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.6153132","article-title":"Synthesis, transport, and release of posterior pituitary hormones","volume":"207","author":"Brownstein","year":"1980","journal-title":"Science"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.yfrne.2004.05.001","article-title":"Vasopressin and oxytocin release within the brain: A dynamic concept of multiple and variable modes of neuropeptide communication","volume":"25","author":"Landgraf","year":"2004","journal-title":"Front. Neuroendocr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.tins.2012.08.004","article-title":"Balance of brain oxytocin and vasopressin: Implications for anxiety, depression, and social behaviors","volume":"35","author":"Neumann","year":"2012","journal-title":"Trends Neurosci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.neuron.2017.07.002","article-title":"Oxytocin Mobilizes Midbrain Dopamine toward Sociality","volume":"95","author":"Charlet","year":"2017","journal-title":"Neuron"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0014-5793(69)80215-2","article-title":"Oxytocinase and its possible significance in the degradation of oxytocin during pregnancy","volume":"4","author":"Sjoholm","year":"1969","journal-title":"FEBS Lett."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1152\/physrev.00031.2017","article-title":"The Oxytocin Receptor: From Intracellular Signaling to Behavior","volume":"98","author":"Jurek","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yfrne.2015.04.003","article-title":"Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior","volume":"40","author":"Dumais","year":"2016","journal-title":"Front. Neuroendocr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neuron.2012.09.025","article-title":"Neuromodulation by oxytocin and vasopressin","volume":"76","author":"Stoop","year":"2012","journal-title":"Neuron"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1152\/physrev.2001.81.2.629","article-title":"The oxytocin receptor system: Structure, function, and regulation","volume":"81","author":"Gimpl","year":"2001","journal-title":"Physiol. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"102328","DOI":"10.1016\/j.pneurobio.2022.102328","article-title":"Emerging role of astrocytes in oxytocin-mediated control of neural circuits and brain functions","volume":"217","author":"Baudon","year":"2022","journal-title":"Prog. Neurobiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1126\/science.aan4994","article-title":"Gating of social reward by oxytocin in the ventral tegmental area","volume":"357","author":"Hung","year":"2017","journal-title":"Science"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.neuron.2016.03.033","article-title":"Oxytocin Enhances Social Recognition by Modulating Cortical Control of Early Olfactory Processing","volume":"90","author":"Oettl","year":"2016","journal-title":"Neuron"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1038\/s41467-017-02173-0","article-title":"Hippocampal oxytocin receptors are necessary for discrimination of social stimuli","volume":"8","author":"Raam","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Knoop, M., Possovre, M.-L., Jacquens, A., Charlet, A., Baud, O., and Darbon, P. (2022). The Role of Oxytocin in Abnormal Brain Development: Effect on Glial Cells and Neuroinflammation. Cells, 11.","DOI":"10.3390\/cells11233899"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.yfrne.2017.10.004","article-title":"Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery","volume":"51","author":"Song","year":"2018","journal-title":"Front. Neuroendocr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"102079","DOI":"10.1016\/j.npep.2020.102079","article-title":"The role of oxytocin and vasopressin dysfunction in cognitive impairment and mental disorders","volume":"83","author":"Abramova","year":"2020","journal-title":"Neuropeptides"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/s41593-021-00800-0","article-title":"Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents","volume":"24","author":"Wahis","year":"2021","journal-title":"Nat. Neurosci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12974-016-0541-7","article-title":"Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice","volume":"13","author":"Yuan","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"E183","DOI":"10.1152\/ajpendo.00346.2016","article-title":"Regulation of the macrophage oxytocin receptor in response to inflammation","volume":"312","author":"Szeto","year":"2017","journal-title":"Am. J. Physiology. Endocrinol. Metab."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Inoue, T., Yamakage, H., Tanaka, M., Kusakabe, T., Shimatsu, A., and Satoh-Asahara, N. (2019). Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia. Cells, 8.","DOI":"10.3390\/cells8060527"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1038\/s41467-020-17514-9","article-title":"Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model","volume":"11","author":"Guttenplan","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex","volume":"34","author":"Zhang","year":"2014","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41593-022-01022-8","article-title":"Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain","volume":"25","author":"Marsh","year":"2022","journal-title":"Nat. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuron.2018.12.006","article-title":"Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing","volume":"101","author":"Li","year":"2019","journal-title":"Neuron"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"864007","DOI":"10.3389\/fimmu.2022.864007","article-title":"Oxytocin and Related Peptide Hormones: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis","volume":"13","author":"Mehdi","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1042\/CS20190756","article-title":"Oxytocin system alleviates intestinal inflammation by regulating macrophages polarization in experimental colitis","volume":"133","author":"Tang","year":"2019","journal-title":"Clin. Sci. (Lond. Engl. 1979)"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e00030-19","DOI":"10.1128\/JVI.00030-19","article-title":"PPAR-\u03b3 in Macrophages Limits Pulmonary Inflammation and Promotes Host Recovery following Respiratory Viral Infection","volume":"93","author":"Huang","year":"2019","journal-title":"J. Virol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1476-5381.2010.01037.x","article-title":"Subchronic treatment of rats with oxytocin results in improved adipocyte differentiation and increased gene expression of factors involved in adipogenesis","volume":"162","author":"Eckertova","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nature11270","article-title":"Deconstruction of a neural circuit for hunger","volume":"488","author":"Atasoy","year":"2012","journal-title":"Nature"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"109411","DOI":"10.1016\/j.celrep.2021.109411","article-title":"Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation","volume":"36","author":"Li","year":"2021","journal-title":"Cell Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.neuron.2023.03.014","article-title":"Oxytocin promotes prefrontal population activity via the PVN-PFC pathway to regulate pain","volume":"111","author":"Liu","year":"2023","journal-title":"Neuron"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/dneu.22452","article-title":"Oxytocin modulation of neural circuits for social behavior","volume":"77","author":"Marlin","year":"2017","journal-title":"Dev. Neurobiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.psyneuen.2018.05.028","article-title":"Role of oxytocin in the ventral tegmental area in social reinforcement","volume":"95","author":"Borland","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41386-022-01348-8","article-title":"Neural circuits regulating prosocial behaviors","volume":"48","author":"Walsh","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.neuron.2017.06.003","article-title":"Biased Oxytocinergic Modulation of Midbrain Dopamine Systems","volume":"95","author":"Xiao","year":"2017","journal-title":"Neuron"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.psyneuen.2016.09.001","article-title":"Activation of oxytocin receptors, but not arginine-vasopressin V1a receptors, in the ventral tegmental area of male Syrian hamsters is essential for the reward-like properties of social interactions","volume":"74","author":"Song","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s41586-019-1075-9","article-title":"Oxytocin-dependent reopening of a social reward learning critical period with MDMA","volume":"569","author":"Nardou","year":"2019","journal-title":"Nature"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.biopsych.2015.05.013","article-title":"Dissecting the Role of Oxytocin in the Formation and Loss of Social Relationships","volume":"79","author":"Hurlemann","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1749-6632.2009.04504.x","article-title":"Empathy toward strangers triggers oxytocin release and subsequent generosity","volume":"1167","author":"Barraza","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/s41583-018-0072-6","article-title":"The neural mechanisms and circuitry of the pair bond","volume":"19","author":"Walum","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1242\/jeb.142182","article-title":"Intergenerational transmission of sociality: The role of parents in shaping social behavior in monogamous and non-monogamous species","volume":"220","author":"Perkeybile","year":"2017","journal-title":"J. Exp. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"5981","DOI":"10.1073\/pnas.89.13.5981","article-title":"Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles","volume":"89","author":"Insel","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e1099","DOI":"10.1038\/tp.2017.72","article-title":"Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women","volume":"7","author":"Bethlehem","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Freeman, S.M., and Young, L.J. (2016). Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications. J. Neuroendocrinol., 28.","DOI":"10.1111\/jne.12382"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"112790","DOI":"10.1016\/j.bbr.2020.112790","article-title":"Oxytocin in the anterior cingulate cortex is involved in helping behaviour","volume":"393","author":"Yamagishi","year":"2020","journal-title":"Behav. Brain Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1126\/science.aac4785","article-title":"Oxytocin-dependent consolation behavior in rodents","volume":"351","author":"Burkett","year":"2016","journal-title":"Science"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/scientificamerican0979-219","article-title":"Thinking about the brain","volume":"241","author":"Crick","year":"1979","journal-title":"Sci. Am."},{"key":"ref_70","first-page":"20122765","article-title":"Urinary oxytocin and social bonding in related and unrelated wild chimpanzees","volume":"280","author":"Crockford","year":"2013","journal-title":"Proc. Biol. Sci."},{"key":"ref_71","first-page":"20133096","article-title":"Food sharing is linked to urinary oxytocin levels and bonding in related and unrelated wild chimpanzees","volume":"281","author":"Wittig","year":"2014","journal-title":"Proc. Biol. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1073\/pnas.1616812114","article-title":"Oxytocin reactivity during intergroup conflict in wild chimpanzees","volume":"114","author":"Samuni","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"6661","DOI":"10.1073\/pnas.76.12.6661","article-title":"Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin","volume":"76","author":"Pedersen","year":"1979","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/j.neubiorev.2011.02.006","article-title":"Development of auditory cortical synaptic receptive fields","volume":"35","author":"Froemke","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41586-021-03814-7","article-title":"Oxytocin neurons enable social transmission of maternal behaviour","volume":"596","author":"Carcea","year":"2021","journal-title":"Nature"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1016\/j.neuron.2022.03.033","article-title":"Plasticity of neural connections underlying oxytocin-mediated parental behaviors of male mice","volume":"110","author":"Inada","year":"2022","journal-title":"Neuron"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.yhbeh.2019.02.014","article-title":"Role of oxytocin in the medial preoptic area (MPOA) in the modulation of paternal behavior in mandarin voles","volume":"110","author":"Yuan","year":"2019","journal-title":"Horm. Behav."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"105268","DOI":"10.1016\/j.psyneuen.2021.105268","article-title":"Associations between oxytocin and empathy in humans: A systematic literature review","volume":"129","author":"Osorio","year":"2021","journal-title":"Psychoneuroendocrinology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1126\/science.abq5158","article-title":"Evolutionarily conserved role of oxytocin in social fear contagion in zebrafish","volume":"379","author":"Akinrinade","year":"2023","journal-title":"Science"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nature03701","article-title":"Oxytocin increases trust in humans","volume":"435","author":"Kosfeld","year":"2005","journal-title":"Nature"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.cub.2018.02.044","article-title":"Oxytocin Signaling in the Lateral Septum Prevents Social Fear during Lactation","volume":"28","author":"Menon","year":"2018","journal-title":"Curr. Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.1105636","article-title":"Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala","volume":"308","author":"Huber","year":"2005","journal-title":"Science"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0306-4530(97)00045-0","article-title":"Effects of stress and glucocorticoids on CNS oxytocin receptor binding","volume":"22","author":"Liberzon","year":"1997","journal-title":"Psychoneuroendocrinology"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2019.07.046","article-title":"Oxytocin and Stress: Neural Mechanisms, Stress-Related Disorders, and Therapeutic Approaches","volume":"417","author":"Matsushita","year":"2019","journal-title":"Neuroscience"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nature12330","article-title":"Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons","volume":"500","author":"Owen","year":"2013","journal-title":"Nature"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev-neuro-102320-102847","article-title":"Oxytocin, Neural Plasticity, and Social Behavior","volume":"44","author":"Froemke","year":"2021","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.neuron.2016.01.041","article-title":"A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing","volume":"89","author":"Eliava","year":"2016","journal-title":"Neuron"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1016\/j.bbadis.2016.07.004","article-title":"Signaling in dopamine D2 receptor-oxytocin receptor heterocomplexes and its relevance for the anxiolytic effects of dopamine and oxytocin interactions in the amygdala of the rat","volume":"1862","author":"Tarakanov","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1177\/1073858420960111","article-title":"Oxytocin and the Neurobiology of Prosocial Behavior","volume":"27","author":"Marsh","year":"2021","journal-title":"Neuroscientist"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.biopsych.2014.10.015","article-title":"Oxytocin facilitates the extinction of conditioned fear in humans","volume":"78","author":"Eckstein","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"E3123","DOI":"10.1073\/pnas.1508097112","article-title":"Oxytocin modulates fMRI responses to facial expression in macaques","volume":"112","author":"Liu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.cub.2019.04.070","article-title":"Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice","volume":"29","author":"Ferretti","year":"2019","journal-title":"Curr. Biol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neuron.2019.04.029","article-title":"A Fear Memory Engram and Its Plasticity in the Hypothalamic Oxytocin System","volume":"103","author":"Hasan","year":"2019","journal-title":"Neuron"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1038\/s41467-021-23064-5","article-title":"Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats","volume":"12","author":"Oliveira","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"26406","DOI":"10.1073\/pnas.2011890117","article-title":"Extrahypothalamic oxytocin neurons drive stress-induced social vigilance and avoidance","volume":"117","author":"Torres","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_96","first-page":"271","article-title":"Sex differences among oxytocin-immunoreactive neuronal systems in the mouse hypothalamus","volume":"3","author":"Haussler","year":"1990","journal-title":"J. Chem. Neuroanat."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00359-013-0870-2","article-title":"Sociality and oxytocin and vasopressin in the brain of male and female dominant and subordinate mandarin voles","volume":"200","author":"Qiao","year":"2014","journal-title":"J. Comp. Physiol. A"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Wang, Y., Xu, L., Pan, Y., Wang, Z., and Zhang, Z. (2013). Species differences in the immunoreactive expression of oxytocin, vasopressin, tyrosine hydroxylase and estrogen receptor alpha in the brain of Mongolian gerbils (Meriones unguiculatus) and Chinese striped hamsters (Cricetulus barabensis). PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0065807"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.neuroscience.2010.05.064","article-title":"Oxytocin and vasopressin immunoreactive staining in the brains of Brandt\u2019s voles (Lasiopodomys brandtii) and greater long-tailed hamsters (Tscherskia triton)","volume":"169","author":"Xu","year":"2010","journal-title":"Neuroscience"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.cell.2014.09.020","article-title":"Oxytocin modulates female sociosexual behavior through a specific class of prefrontal cortical interneurons","volume":"159","author":"Nakajima","year":"2014","journal-title":"Cell"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.cell.2016.08.067","article-title":"A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors","volume":"167","author":"Li","year":"2016","journal-title":"Cell"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"23242","DOI":"10.1073\/pnas.1820836117","article-title":"Critical period regulation across multiple timescales","volume":"117","author":"Reh","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1002\/dev.21230","article-title":"Naturalistic rodent models of chronic early-life stress","volume":"56","author":"Molet","year":"2014","journal-title":"Dev. Psychobiol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.biopsych.2019.12.018","article-title":"Plasticity of the Reward Circuitry After Early-Life Adversity: Mechanisms and Significance","volume":"87","author":"Birnie","year":"2020","journal-title":"Biol. Psychiatry"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/npp.2015.181","article-title":"Toward Understanding How Early-Life Stress Reprograms Cognitive and Emotional Brain Networks","volume":"41","author":"Chen","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0736-5748(98)00019-7","article-title":"Postnatal maternal separation during the stress hyporesponsive period enhances the adrenocortical response to novelty in adult rats by affecting feedback regulation in the CA1 hippocampal field","volume":"16","author":"Biagini","year":"1998","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0006-8993(02)02985-2","article-title":"Neonatal maternal separation reduces hippocampal mossy fiber density in adult Long Evans rats","volume":"950","author":"Huot","year":"2002","journal-title":"Brain Res."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Derks, N.A., Krugers, H.J., Hoogenraad, C.C., Joels, M., and Sarabdjitsingh, R.A. (2016). Effects of Early Life Stress on Synaptic Plasticity in the Developing Hippocampus of Male and Female Rats. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0164551"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1176\/appi.ajp.2012.11091347","article-title":"Fragmentation and unpredictability of early-life experience in mental disorders","volume":"169","author":"Baram","year":"2012","journal-title":"Am. J. Psychiatry"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1111\/ejn.13294","article-title":"Peripheral and central alterations affecting spinal nociceptive processing and pain at adulthood in rats exposed to neonatal maternal deprivation","volume":"44","author":"Juif","year":"2016","journal-title":"Eur. J. Neurosci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13148-021-01017-5","article-title":"Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression","volume":"13","author":"Danoff","year":"2021","journal-title":"Clin. Epigenetics"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1046\/j.0007-1331.2002.00776.x","article-title":"Naturally occurring differences in maternal care are associated with the expression of oxytocin and vasopressin (V1a) receptors: Gender differences","volume":"14","author":"Francis","year":"2002","journal-title":"J. Neuroendocrinol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nn.2312","article-title":"Coding of pleasant touch by unmyelinated afferents in humans","volume":"12","author":"Loken","year":"2009","journal-title":"Nat. Neurosci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1365-2826.2012.02280.x","article-title":"Maternal contact differentially modulates central and peripheral oxytocin in rat pups during a brief regime of mother-pup interaction that induces a filial huddling preference","volume":"24","author":"Kojima","year":"2012","journal-title":"J. Neuroendocrinol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3200\/MONO.132.1.5-94","article-title":"The communicative functions of touch in humans, nonhuman primates, and rats: A review and synthesis of the empirical research","volume":"132","author":"Hertenstein","year":"2006","journal-title":"Genet. Soc. Gen. Psychol. Monogr."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e13049","DOI":"10.1111\/jne.13049","article-title":"The oxytocin system and early-life experience-dependent plastic changes","volume":"33","author":"Onaka","year":"2021","journal-title":"J. Neuroendocrinol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"11769","DOI":"10.1073\/pnas.1706206114","article-title":"Early rearing history influences oxytocin receptor epigenetic regulation in rhesus macaques","volume":"114","author":"Baker","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"12736","DOI":"10.1073\/pnas.221224598","article-title":"Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors","volume":"98","author":"Champagne","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"110279","DOI":"10.1016\/j.pnpbp.2021.110279","article-title":"Adolescent oxytocin administration reduces depression-like behaviour induced by early life stress in adult male and female rats","volume":"110","author":"Thornton","year":"2021","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1523\/JNEUROSCI.5593-08.2009","article-title":"Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice","volume":"29","author":"Yoshida","year":"2009","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuroscience.2013.08.048","article-title":"Immunohistochemical localization of oxytocin receptors in human brain","volume":"253","author":"Boccia","year":"2013","journal-title":"Neuroscience"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3389\/fnmol.2018.00246","article-title":"Long-Term Isolation Elicits Depression and Anxiety-Related Behaviors by Reducing Oxytocin-Induced GABAergic Transmission in Central Amygdala","volume":"11","author":"Han","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0006-8993(97)01159-1","article-title":"Stress increases oxytocin release within the hypothalamic paraventricular nucleus","volume":"781","author":"Nishioka","year":"1998","journal-title":"Brain Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1891\/0730-0832.31.5.311","article-title":"Music therapy research in the NICU: An updated meta-analysis","volume":"31","author":"Standley","year":"2012","journal-title":"Neonatal Netw. NN"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/ANC.0000000000000558","article-title":"Parent Engagement Correlates With Parent and Preterm Infant Oxytocin Release During Skin-to-Skin Contact","volume":"19","author":"Vittner","year":"2019","journal-title":"Adv. Neonatal Care Off. J. Natl. Assoc. Neonatal Nurses"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1177\/1099800417735633","article-title":"Increase in Oxytocin from Skin-to-Skin Contact Enhances Development of Parent-Infant Relationship","volume":"20","author":"Vittner","year":"2018","journal-title":"Biol. Res. Nurs."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/imhj.21938","article-title":"NICU music therapy effects on maternal mental health and preterm infant\u2019s emotional arousal","volume":"42","author":"Palazzi","year":"2021","journal-title":"Infant Ment. Health J."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"17301","DOI":"10.1038\/s41598-021-96840-4","article-title":"Maternal speech decreases pain scores and increases oxytocin levels in preterm infants during painful procedures","volume":"11","author":"Filippa","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"91","DOI":"10.14712\/fb2017063030091","article-title":"Oxytocin Modulates Expression of Neuron and Glial Markers in the Rat Hippocampus","volume":"63","author":"Havranek","year":"2017","journal-title":"Folia Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrn2038","article-title":"Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms","volume":"8","author":"Block","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nn.4201","article-title":"Astrocyte calcium signaling: The third wave","volume":"19","author":"Bazargani","year":"2016","journal-title":"Nat. Neurosci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bbi.2015.09.017","article-title":"Maternal separation activates microglial cells and induces an inflammatory response in the hippocampus of male rat pups, independently of hypothalamic and peripheral cytokine levels","volume":"55","author":"Roque","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1080\/10253890.2019.1604666","article-title":"Early life stress by repeated maternal separation induces long-term neuroinflammatory response in glial cells of male rats","volume":"22","author":"Banqueri","year":"2019","journal-title":"Stress"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1126\/science.aat0473","article-title":"Glia as architects of central nervous system formation and function","volume":"362","author":"Allen","year":"2018","journal-title":"Science"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"e20362","DOI":"10.7554\/eLife.20362","article-title":"Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks","volume":"5","author":"Perea","year":"2016","journal-title":"eLife"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1073\/pnas.1813562116","article-title":"Priming of microglia with IFN-gamma slows neuronal gamma oscillations in situ","volume":"116","author":"Ta","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"11758","DOI":"10.1096\/fj.201900910R","article-title":"Schema-like learning and memory consolidation acting through myelination","volume":"33","author":"Hasan","year":"2019","journal-title":"FASEB J."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s41386-020-0653-8","article-title":"Oxytocin induces long-lasting adaptations within amygdala circuitry in autism: A treatment-mechanism study with randomized placebo-controlled design","volume":"45","author":"Alaerts","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1002\/glia.23205","article-title":"Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function","volume":"65","author":"Sardinha","year":"2017","journal-title":"Glia"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Panaro, M.A., Benameur, T., and Porro, C. (2020). Hypothalamic Neuropeptide Brain Protection: Focus on Oxytocin. J. Clin. Med., 9.","DOI":"10.3390\/jcm9051534"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1111\/j.1755-5949.2010.00154.x","article-title":"Dopamine and oxytocin interactions underlying behaviors: Potential contributions to behavioral disorders","volume":"16","author":"Baskerville","year":"2010","journal-title":"CNS Neurosci. Ther."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1212\/WNL.44.1.84","article-title":"Decreased number of oxytocin-immunoreactive neurons in the paraventricular nucleus of the hypothalamus in Parkinson\u2019s disease","volume":"44","author":"Purba","year":"1994","journal-title":"Neurology"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s42003-019-0325-6","article-title":"Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice","volume":"2","author":"Yamamoto","year":"2019","journal-title":"Commun. Biol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/s41592-022-01597-x","article-title":"A fluorescent sensor for real-time measurement of extracellular oxytocin dynamics in the brain","volume":"19","author":"Ino","year":"2022","journal-title":"Nat. Methods"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Qian, T., Wang, H., Wang, P., Geng, L., Mei, L., Osakada, T., Wang, L., Tang, Y., Kania, A., and Grinevich, V. (2023). A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments. Nat. Biotechnol.","DOI":"10.1038\/s41587-022-01561-2"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"919890","DOI":"10.3389\/fnins.2022.919890","article-title":"Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior","volume":"16","author":"Zhao","year":"2022","journal-title":"Front. Neurosci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.ridd.2012.02.001","article-title":"Transcutaneous electrical acupoint stimulation in children with autism and its impact on plasma levels of arginine-vasopressin and oxytocin: A prospective single-blinded controlled study","volume":"33","author":"Zhang","year":"2012","journal-title":"Res. Dev. Disabil."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Moerkerke, M., Peeters, M., de Vries, L., Daniels, N., Steyaert, J., Alaerts, K., and Boets, B. (2021). Endogenous Oxytocin Levels in Autism-A Meta-Analysis. Brain Sci., 11.","DOI":"10.3390\/brainsci11111545"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"8119","DOI":"10.1073\/pnas.1705521114","article-title":"Intranasal oxytocin treatment for social deficits and biomarkers of response in children with autism","volume":"114","author":"Parker","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.biopsych.2009.09.020","article-title":"Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders","volume":"67","author":"Guastella","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.biopsych.2006.05.030","article-title":"Oxytocin increases retention of social cognition in autism","volume":"61","author":"Hollander","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1056\/NEJMoa2103583","article-title":"Intranasal Oxytocin in Children and Adolescents with Autism Spectrum Disorder","volume":"385","author":"Sikich","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1073\/pnas.0910249107","article-title":"Promoting social behavior with oxytocin in high-functioning autism spectrum disorders","volume":"107","author":"Andari","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/mp.2015.162","article-title":"The effect of oxytocin nasal spray on social interaction deficits observed in young children with autism: A randomized clinical crossover trial","volume":"21","author":"Yatawara","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/2040-2392-3-16","article-title":"Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: A randomized controlled trial","volume":"3","author":"Anagnostou","year":"2012","journal-title":"Mol. Autism"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1017\/S0033291711001413","article-title":"Emotion recognition and oxytocin in patients with schizophrenia","volume":"42","author":"Averbeck","year":"2012","journal-title":"Psychol. Med."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.biopsych.2010.04.039","article-title":"Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patients","volume":"68","author":"Feifel","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.eurpsy.2014.08.007","article-title":"Additional intranasal oxytocin to escitalopram improves depressive symptoms in resistant depression: An open trial","volume":"30","author":"Scantamburlo","year":"2015","journal-title":"Eur. Psychiatry"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"110098","DOI":"10.1016\/j.pnpbp.2020.110098","article-title":"Oxytocin effects on the cognition of women with postpartum depression: A randomized, placebo-controlled clinical trial","volume":"111","author":"Donadon","year":"2021","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1176\/appi.ajp.2013.13020263","article-title":"Oxytocin and reduction of social threat hypersensitivity in women with borderline personality disorder","volume":"170","author":"Bertsch","year":"2013","journal-title":"Am. J. Psychiatry"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1093\/scan\/nsq085","article-title":"Oxytocin can hinder trust and cooperation in borderline personality disorder","volume":"6","author":"Bartz","year":"2011","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0149-7634(99)00024-X","article-title":"Ethological research in clinical psychiatry: The study of nonverbal behavior during interviews","volume":"23","author":"Troisi","year":"1999","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.pnpbp.2017.09.023","article-title":"Oxytocin selectively modulates brain processing of disgust in Huntington\u2019s disease gene carriers","volume":"81","author":"Labuschagne","year":"2018","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1038\/npp.2010.123","article-title":"Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder","volume":"35","author":"Labuschagne","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.psyneuen.2009.01.005","article-title":"A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder","volume":"34","author":"Guastella","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/j.psyneuen.2012.04.018","article-title":"Oxytocin selectively moderates negative cognitive appraisals in high trait anxious males","volume":"37","author":"Alvares","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1038\/npp.2015.299","article-title":"Intranasal Oxytocin Administration Dampens Amygdala Reactivity towards Emotional Faces in Male and Female PTSD Patients","volume":"41","author":"Koch","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"ref_169","first-page":"265","article-title":"Neuroinflammation in autism spectrum disorders","volume":"9","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12974-016-0575-x","article-title":"Neonatal inflammatory pain and systemic inflammatory responses as possible environmental factors in the development of autism spectrum disorder of juvenile rats","volume":"13","author":"Lee","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Iannucci, A., Caneparo, V., Raviola, S., Debernardi, I., Colangelo, D., Miggiano, R., Griffante, G., Landolfo, S., Gariglio, M., and De Andrea, M. (2020). Toll-like receptor 4-mediated inflammation triggered by extracellular IFI16 is enhanced by lipopolysaccharide binding. PLoS Pathog., 16.","DOI":"10.1371\/journal.ppat.1008811"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1742-2094-11-4","article-title":"Association of social and cognitive impairment and biomarkers in autism spectrum disorders","volume":"11","author":"Alabdali","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.biopha.2018.07.148","article-title":"Oxytocin improves animal behaviors and ameliorates oxidative stress and inflammation in autistic mice","volume":"107","author":"Wang","year":"2018","journal-title":"Biomed. Pharmacother. Biomed. Pharmacother."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Friuli, M., Eramo, B., Valenza, M., Scuderi, C., Provensi, G., and Romano, A. (2021). Targeting the Oxytocinergic System: A Possible Pharmacological Strategy for the Treatment of Inflammation Occurring in Different Chronic Diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910250"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.biopsych.2014.11.010","article-title":"An Early Postnatal Oxytocin Treatment Prevents Social and Learning Deficits in Adult Mice Deficient for Magel2, a Gene Involved in Prader-Willi Syndrome and Autism","volume":"78","author":"Meziane","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.1093\/hmg\/ddq424","article-title":"A single postnatal injection of oxytocin rescues the lethal feeding behaviour in mouse newborns deficient for the imprinted Magel2 gene","volume":"19","author":"Schaller","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neuropharm.2018.10.036","article-title":"Prosocial effects of an oxytocin metabolite, but not synthetic oxytocin receptor agonists, in a mouse model of autism","volume":"144","author":"Moy","year":"2019","journal-title":"Neuropharmacology"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.conb.2007.01.009","article-title":"Autism spectrum disorders: Developmental disconnection syndromes","volume":"17","author":"Geschwind","year":"2007","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"26527","DOI":"10.1038\/srep26527","article-title":"Alteration of functional connectivity in autism spectrum disorder: Effect of age and anatomical distance","volume":"6","author":"Long","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.neuron.2021.11.031","article-title":"Oxytocin normalizes altered circuit connectivity for social rescue of the Cntnap2 knockout mouse","volume":"110","author":"Choe","year":"2022","journal-title":"Neuron"},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Goh, K.K., Chen, C.Y., Wu, T.H., Chen, C.H., and Lu, M.L. (2022). Crosstalk between Schizophrenia and Metabolic Syndrome: The Role of Oxytocinergic Dysfunction. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23137092"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/0706743718773728","article-title":"An Overview of Animal Models Related to Schizophrenia","volume":"64","author":"Winship","year":"2019","journal-title":"Can. J. Psychiatry"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3109\/15622975.2012.677547","article-title":"Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: A case-control study","volume":"14","author":"Montag","year":"2013","journal-title":"World J. Biol. Psychiatry Off. J. World Fed. Soc. Biol. Psychiatry"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.schres.2012.05.018","article-title":"Adjunctive intranasal oxytocin improves verbal memory in people with schizophrenia","volume":"139","author":"Feifel","year":"2012","journal-title":"Schizophr. Res."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Goh, K.K., Chen, C.H., and Lane, H.Y. (2021). Oxytocin in Schizophrenia: Pathophysiology and Implications for Future Treatment. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22042146"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1177\/0269881114555252","article-title":"Developing treatments for cognitive deficits in schizophrenia: The challenge of translation","volume":"29","author":"Young","year":"2015","journal-title":"J. Psychopharmacol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1016\/j.neubiorev.2013.09.012","article-title":"Towards improved animal models for evaluating social cognition and its disruption in schizophrenia: The CNTRICS initiative","volume":"37","author":"Millan","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/77040","article-title":"Social amnesia in mice lacking the oxytocin gene","volume":"25","author":"Ferguson","year":"2000","journal-title":"Nat. Genet."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"8278","DOI":"10.1523\/JNEUROSCI.21-20-08278.2001","article-title":"Oxytocin in the medial amygdala is essential for social recognition in the mouse","volume":"21","author":"Ferguson","year":"2001","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.npep.2007.02.002","article-title":"Social approach behaviors in oxytocin knockout mice: Comparison of two independent lines tested in different laboratory environments","volume":"41","author":"Crawley","year":"2007","journal-title":"Neuropeptides"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0924-977X(91)90010-R","article-title":"Oxytocin but not vasopressin facilitates social recognition following injection into the medial preoptic area of the rat brain","volume":"1","author":"Popik","year":"1991","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3389\/fpsyt.2019.00217","article-title":"Decreased Serum Oxytocin and Increased Homocysteine in First-Episode Schizophrenia Patients","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Psychiatry"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1017\/neu.2014.20","article-title":"Oxytocin and vasopressin levels are decreased in the plasma of male schizophrenia patients","volume":"26","author":"Jobst","year":"2014","journal-title":"Acta Neuropsychiatr."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.2147\/NDT.S169619","article-title":"Atrial natriuretic peptide and posterior pituitary neurohormone changes in patients with acute schizophrenia","volume":"14","author":"Guzel","year":"2018","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.psychres.2018.03.048","article-title":"Associations of oxytocin and vasopressin plasma levels with neurocognitive, social cognitive and meta cognitive function in schizophrenia","volume":"270","author":"Lysaker","year":"2018","journal-title":"Psychiatry Res."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/08039488.2018.1554698","article-title":"Assessing the relationship between attachment, parental attitude and plasma oxytocin in schizophrenia patients and their unaffected siblings","volume":"73","author":"Taneli","year":"2019","journal-title":"Nord. J. Psychiatry"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.schres.2014.12.023","article-title":"Plasma oxytocin levels predict olfactory identification and negative symptoms in individuals with schizophrenia","volume":"162","author":"Strauss","year":"2015","journal-title":"Schizophr. Res."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.schres.2015.01.022","article-title":"Endogenous oxytocin levels are associated with the perception of emotion in dynamic body expressions in schizophrenia","volume":"162","author":"Strauss","year":"2015","journal-title":"Schizophr. Res."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"11489","DOI":"10.1523\/JNEUROSCI.3984-05.2005","article-title":"Oxytocin modulates neural circuitry for social cognition and fear in humans","volume":"25","author":"Kirsch","year":"2005","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.psyneuen.2014.07.014","article-title":"A meta-analytic review of the impact of intranasal oxytocin administration on cortisol concentrations during laboratory tasks: Moderation by method and mental health","volume":"49","author":"Cardoso","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jad.2017.08.041","article-title":"Meta-analytic review of the effects of a single dose of intranasal oxytocin on threat processing in humans","volume":"225","author":"Leppanen","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1038\/npp.2014.53","article-title":"Modulation of resting-state amygdala-frontal functional connectivity by oxytocin in generalized social anxiety disorder","volume":"39","author":"Dodhia","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"e258","DOI":"10.1038\/tp.2013.34","article-title":"Sniffing around oxytocin: Review and meta-analyses of trials in healthy and clinical groups with implications for pharmacotherapy","volume":"3","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.psychres.2014.11.048","article-title":"The many faces of oxytocin: Implications for psychiatry","volume":"226","author":"Zik","year":"2015","journal-title":"Psychiatry Res."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.psyneuen.2013.06.019","article-title":"The role of oxytocin in social bonding, stress regulation and mental health: An update on the moderating effects of context and interindividual differences","volume":"38","author":"Olff","year":"2013","journal-title":"Psychoneuroendocrinology"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/13\/10430\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:57:50Z","timestamp":1760126270000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/13\/10430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,21]]},"references-count":205,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["ijms241310430"],"URL":"https:\/\/doi.org\/10.3390\/ijms241310430","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,21]]}}}