{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:38:35Z","timestamp":1792708715519,"version":"4.5.0"},"reference-count":260,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32 HL154602"],"award-info":[{"award-number":["F32 HL154602"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL155095"],"award-info":[{"award-number":["R01 HL155095"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Asthma is a heterogenous chronic inflammatory lung disease with endotypes that manifest different immune system profiles, severity, and responses to current therapies. Regardless of endotype, asthma features increased immune cell infiltration, inflammatory cytokine release, and airway remodeling. Lung macrophages are also heterogenous in that there are separate subsets and, depending on the environment, different effector functions. Lung macrophages are important in recruitment of immune cells such as eosinophils, neutrophils, and monocytes that enhance allergic inflammation and initiate T helper cell responses. Persistent lung remodeling including mucus hypersecretion, increased airway smooth muscle mass, and airway fibrosis contributes to progressive lung function decline that is insensitive to current asthma treatments. Macrophages secrete inflammatory mediators that induce airway inflammation and remodeling. Additionally, lung macrophages are instrumental in protecting against pathogens and play a critical role in resolution of inflammation and return to homeostasis. This review summarizes current literature detailing the roles and existing knowledge gaps for macrophages as key inflammatory orchestrators in asthma pathogenesis. We also raise the idea that modulating inflammatory responses in lung macrophages is important for alleviating asthma.<\/jats:p>","DOI":"10.3390\/ijms241310451","type":"journal-article","created":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T01:49:32Z","timestamp":1687398572000},"page":"10451","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":108,"title":["Macrophages Orchestrate Airway Inflammation, Remodeling, and Resolution in Asthma"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0027-9545","authenticated-orcid":false,"suffix":"Jr.","given":"Rodney D.","family":"Britt","sequence":"first","affiliation":[{"name":"Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH 43215, USA"},{"name":"Department of Pediatrics, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anushka","family":"Ruwanpathirana","sequence":"additional","affiliation":[{"name":"Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH 43215, USA"},{"name":"Biomedical Sciences Graduate Program, College of Medicine, The Ohio State University, Columbus, OH 43205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3683-1706","authenticated-orcid":false,"given":"Maria L.","family":"Ford","sequence":"additional","affiliation":[{"name":"Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH 43215, USA"},{"name":"Biomedical Sciences Graduate Program, College of Medicine, The Ohio State University, Columbus, OH 43205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6962-3316","authenticated-orcid":false,"given":"Brandon W.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH 43215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Gordon, S., and Pluddemann, A. (2017). Tissue macrophages: Heterogeneity and functions. BMC Biol., 15.","DOI":"10.1186\/s12915-017-0392-4"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/imm.13154","article-title":"Origin and ontogeny of lung macrophages: From mice to humans","volume":"160","author":"Evren","year":"2020","journal-title":"Immunology"},{"key":"ref_3","unstructured":"Naeem, A., Rai, S.N., and Pierre, L. (2023). Treasure Island, StatPearls."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bj.2017.09.004","article-title":"Macrophage phagocytosis cracking the defect code in COPD","volume":"40","author":"Jubrail","year":"2017","journal-title":"Biomed. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.3389\/fimmu.2018.01777","article-title":"Alveolar Macrophages in the Resolution of Inflammation, Tissue Repair, and Tolerance to Infection","volume":"9","author":"Allard","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/all.12536","article-title":"Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge","volume":"70","author":"Mathie","year":"2015","journal-title":"Allergy"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"L787","DOI":"10.1152\/ajplung.00226.2021","article-title":"TLR4 is required for macrophage efferocytosis during resolution of ventilator-induced lung injury","volume":"321","author":"Su","year":"2021","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"S502","DOI":"10.1067\/mai.2003.94","article-title":"6. Asthma","volume":"111","author":"Lemanske","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1172\/JCI80911","article-title":"High IFN-gamma and low SLPI mark severe asthma in mice and humans","volume":"125","author":"Raundhal","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1164\/rccm.201901-0016OC","article-title":"The Projected Economic and Health Burden of Uncontrolled Asthma in the United States","volume":"200","author":"Yaghoubi","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.jaci.2013.10.011","article-title":"Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis","volume":"133","author":"Moore","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.jaci.2013.11.042","article-title":"Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data","volume":"133","author":"Wu","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1164\/rccm.200906-0896OC","article-title":"Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program","volume":"181","author":"Moore","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/all.13626","article-title":"FoxO1 is a critical regulator of M2-like macrophage activation in allergic asthma","volume":"74","author":"Chung","year":"2019","journal-title":"Allergy"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"632049","DOI":"10.1155\/2013\/632049","article-title":"Characterization of macrophage phenotypes in three murine models of house-dust-mite-induced asthma","volume":"2013","author":"Draijer","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Essilfie, A.T., Simpson, J.L., Horvat, J.C., Preston, J.A., Dunkley, M.L., Foster, P.S., Gibson, P.G., and Hansbro, P.M. (2011). Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease. PLoS Pathog., 7.","DOI":"10.1371\/journal.ppat.1002244"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jaci.2020.04.018","article-title":"Sputum microbiome profiles identify severe asthma phenotypes of relative stability at 12 to 18 months","volume":"147","author":"Brinkman","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2174\/1871523020666210920100707","article-title":"Inflammation in Asthma Pathogenesis: Role of T Cells, Macrophages, Epithelial Cells and Type 2 Inflammation","volume":"20","author":"Alobaidi","year":"2021","journal-title":"Anti-Inflamm. Anti-Allergy Agents Med. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"583042","DOI":"10.3389\/fimmu.2020.583042","article-title":"Cross-Talk Between Alveolar Macrophages and Lung Epithelial Cells is Essential to Maintain Lung Homeostasis","volume":"11","author":"Bissonnette","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2006.10.016","article-title":"The effect of oxidative stress on macrophages and lung epithelial cells: The role of phosphodiesterases 1 and 4","volume":"168","author":"Brown","year":"2007","journal-title":"Toxicol. Lett."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00011-019-01233-z","article-title":"Macrophage migration inhibitory factor (MIF) controls cytokine release during respiratory syncytial virus infection in macrophages","volume":"68","author":"Muraro","year":"2019","journal-title":"Inflamm. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/00063198-200001000-00004","article-title":"Airway inflammation and remodeling in asthma","volume":"6","author":"Fahy","year":"2000","journal-title":"Curr. Opin. Pulm. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.jaci.2004.11.051","article-title":"Airway fibroblasts exhibit a synthetic phenotype in severe asthma","volume":"115","author":"Lewis","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"111797","DOI":"10.1016\/j.celrep.2022.111797","article-title":"Recruited monocytes\/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis","volume":"41","author":"Oz","year":"2022","journal-title":"Cell Rep."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Saito, A., Horie, M., and Nagase, T. (2018). TGF-beta Signaling in Lung Health and Disease. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19082460"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1900646","DOI":"10.1183\/13993003.00646-2019","article-title":"A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF\/M-CSFR signalling in monocyte-derived alveolar macrophages","volume":"55","author":"Joshi","year":"2020","journal-title":"Eur. Respir. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","article-title":"Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage","volume":"20","author":"Aran","year":"2019","journal-title":"Nat. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.immuni.2022.08.010","article-title":"Biology of lung macrophages in health and disease","volume":"55","author":"Aegerter","year":"2022","journal-title":"Immunity"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1800103","DOI":"10.1183\/13993003.00103-2018","article-title":"Location or origin? What is critical for macrophage propagation of lung fibrosis?","volume":"51","author":"Zhou","year":"2018","journal-title":"Eur. Respir. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1165\/rcmb.2013-0086MA","article-title":"Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung","volume":"49","author":"Misharin","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1165\/rcmb.2017-0328ED","article-title":"Monocyte-derived Alveolar Macrophages: The Dark Side of Lung Repair?","volume":"58","author":"Budinger","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Hetzel, M., Ackermann, M., and Lachmann, N. (2021). Beyond \u201cBig Eaters\u201d: The Versatile Role of Alveolar Macrophages in Health and Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073308"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1084\/jem.20131199","article-title":"Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF","volume":"210","author":"Guilliams","year":"2013","journal-title":"J. Exp. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.immuni.2013.04.004","article-title":"Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes","volume":"38","author":"Hashimoto","year":"2013","journal-title":"Immunity"},{"key":"ref_35","first-page":"L97","article-title":"Degradation of surfactant protein D by alveolar macrophages","volume":"274","author":"Dong","year":"1998","journal-title":"Am. J. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cell.2020.08.020","article-title":"Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis","volume":"183","author":"Neupane","year":"2020","journal-title":"Cell"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"11","DOI":"10.26508\/lsa.202201458","article-title":"ScRNA-seq expression of IFI27 and APOC2 identifies four alveolar macrophage superclusters in healthy BALF","volume":"5","author":"Li","year":"2022","journal-title":"Life Sci. Alliance"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.cellimm.2018.02.001","article-title":"The interstitial macrophage: A long-neglected piece in the puzzle of lung immunity","volume":"330","author":"Liegeois","year":"2018","journal-title":"Cell. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1164\/rccm.201911-2105OC","article-title":"Localization of Macrophages in the Human Lung via Design-based Stereology","volume":"201","author":"Hume","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.4049\/jimmunol.1302269","article-title":"In vivo characterization of alveolar and interstitial lung macrophages in rhesus macaques: Implications for understanding lung disease in humans","volume":"192","author":"Cai","year":"2014","journal-title":"J. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41385-021-00480-w","article-title":"The impact of the lung environment on macrophage development, activation and function: Diversity in the face of adversity","volume":"15","author":"Bain","year":"2022","journal-title":"Mucosal Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1165\/rcmb.2016-0361OC","article-title":"Three Unique Interstitial Macrophages in the Murine Lung at Steady State","volume":"57","author":"Gibbings","year":"2017","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/intimm\/dxw012","article-title":"IL-10-producing lung interstitial macrophages prevent neutrophilic asthma","volume":"28","author":"Kawano","year":"2016","journal-title":"Int. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5160794","DOI":"10.1155\/2018\/5160794","article-title":"Lung Interstitial Macrophages: Past, Present, and Future","volume":"2018","author":"Schyns","year":"2018","journal-title":"J. Immunol. Res"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"437","DOI":"10.2174\/156652408785160907","article-title":"Role of IL-10 in the resolution of airway inflammation","volume":"8","author":"Ogawa","year":"2008","journal-title":"Curr. Mol. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"753940","DOI":"10.3389\/fimmu.2021.753940","article-title":"Diversity of Macrophages in Lung Homeostasis and Diseases","volume":"12","author":"Hou","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.3389\/fimmu.2019.02759","article-title":"More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis","volume":"10","author":"Gschwandtner","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_48","first-page":"14.2.1","article-title":"Activation of murine macrophages","volume":"14","author":"Mosser","year":"2008","journal-title":"Curr. Protoc. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Edin, S., Wikberg, M.L., Dahlin, A.M., Rutegard, J., Oberg, A., Oldenborg, P.A., and Palmqvist, R. (2012). The distribution of macrophages with a M1 or M2 phenotype in relation to prognosis and the molecular characteristics of colorectal cancer. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047045"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12967-020-02251-w","article-title":"Alternatively activated macrophages; a double-edged sword in allergic asthma","volume":"18","author":"Abdelaziz","year":"2020","journal-title":"J. Transl. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/1044667031000137629","article-title":"FIZZ1 and Ym as tools to discriminate between differentially activated macrophages","volume":"9","author":"Raes","year":"2002","journal-title":"Dev. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1683347","DOI":"10.1080\/2162402X.2019.1683347","article-title":"The M2 macrophage marker CD206: A novel prognostic indicator for acute myeloid leukemia","volume":"9","author":"Xu","year":"2020","journal-title":"Oncoimmunology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/mi.2012.74","article-title":"The alveolar macrophages in asthma: A double-edged sword","volume":"5","author":"Balhara","year":"2012","journal-title":"Mucosal Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0306-3623(95)02045-4","article-title":"The eosinophil and its role in asthma","volume":"27","author":"Thomas","year":"1996","journal-title":"Gen. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1002\/eji.1830171210","article-title":"Recombinant human interleukin 5 is an eosinophil differentiation factor but has no activity in standard human B cell growth factor assays","volume":"17","author":"Clutterbuck","year":"1987","journal-title":"Eur. J. Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/bbrc.1997.6958","article-title":"Eotaxin expression and eosinophilic inflammation in asthma","volume":"236","author":"Mattoli","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1146\/annurev.immunol.17.1.701","article-title":"The IL-4 receptor: Signaling mechanisms and biologic functions","volume":"17","author":"Nelms","year":"1999","journal-title":"Annu. Rev. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.jaci.2017.10.005","article-title":"Biomarkers for severe eosinophilic asthma","volume":"140","author":"Yancey","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_59","first-page":"3","article-title":"Targeting the IL-5 pathway in eosinophilic asthma: A comparison of mepolizumab to benralizumab in the reduction of peripheral eosinophil counts","volume":"17","author":"Ghassemian","year":"2021","journal-title":"Act. Murine Macrophages"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2147\/JAA.S78049","article-title":"Benralizumab: A unique IL-5 inhibitor for severe asthma","volume":"9","author":"Tan","year":"2016","journal-title":"J. Asthma Allergy"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.jaci.2018.05.003","article-title":"Novel peptide nanoparticle-biased antagonist of CCR3 blocks eosinophil recruitment and airway hyperresponsiveness","volume":"143","author":"Grozdanovic","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cellimm.2013.03.001","article-title":"Broncho-alveolar macrophages express chemokines associated with leukocyte migration in a mouse model of asthma","volume":"281","author":"Siddiqui","year":"2013","journal-title":"Cell. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"13952","DOI":"10.1074\/jbc.M406037200","article-title":"Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation","volume":"280","author":"Pope","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.4049\/jimmunol.1400580","article-title":"Resident alveolar macrophages suppress, whereas recruited monocytes promote, allergic lung inflammation in murine models of asthma","volume":"193","author":"Zaslona","year":"2014","journal-title":"J. Immunol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.4049\/jimmunol.1300460","article-title":"Alendronate attenuates eosinophilic airway inflammation associated with suppression of Th2 cytokines, Th17 cytokines, and eotaxin-2","volume":"191","author":"Sasaki","year":"2013","journal-title":"J. Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.it.2017.07.003","article-title":"Neutrophilic Inflammation in Asthma and Association with Disease Severity","volume":"38","author":"Ray","year":"2017","journal-title":"Trends Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41423-020-00608-1","article-title":"Interleukin-6 mediates neutrophil mobilization from bone marrow in pulmonary hypertension","volume":"18","author":"Florentin","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"33123","DOI":"10.1038\/srep33123","article-title":"Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions","volume":"6","author":"Sawant","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.pupt.2016.09.005","article-title":"The effects of a CXCR1\/CXCR2 antagonist on neutrophil migration in mild atopic asthmatic subjects","volume":"41","author":"Todd","year":"2016","journal-title":"Pulm. Pharmacol. Ther."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jaci.2008.07.007","article-title":"Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages","volume":"122","author":"Goleva","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13223-015-0081-1","article-title":"Therapeutic potential of anti-IL-6 therapies for granulocytic airway inflammation in asthma","volume":"11","author":"Chu","year":"2015","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1165\/rcmb.2008-0170OC","article-title":"Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-\/- mice","volume":"40","author":"Bruscia","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1900827","DOI":"10.1183\/13993003.00827-2019","article-title":"Airway G-CSF identifies neutrophilic inflammation and contributes to asthma progression","volume":"55","author":"Kim","year":"2020","journal-title":"Eur. Respir. J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.3389\/fimmu.2018.02718","article-title":"Non-redundant Functions of IL-6 Produced by Macrophages and Dendritic Cells in Allergic Airway Inflammation","volume":"9","author":"Gubernatorova","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/cea.13811","article-title":"Neutrophilic asthma features increased airway classical monocytes","volume":"51","author":"Niessen","year":"2021","journal-title":"Clin. Exp. Allergy"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/ATVBAHA.116.308198","article-title":"Monocyte Conversion During Inflammation and Injury","volume":"37","author":"Kratofil","year":"2017","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1165\/rcmb.2014-0255OC","article-title":"Recruited alveolar macrophages, in response to airway epithelial-derived monocyte chemoattractant protein 1\/CCl2, regulate airway inflammation and remodeling in allergic asthma","volume":"52","author":"Lee","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"L162","DOI":"10.1152\/ajplung.00182.2012","article-title":"Macrophage\/epithelial cell CCL2 contributes to rhinovirus-induced hyperresponsiveness and inflammation in a mouse model of allergic airways disease","volume":"304","author":"Schneider","year":"2013","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1093\/rheumatology\/keab064","article-title":"CCL2 produced by CD68+\/CD163+ macrophages as a promising clinical biomarker of microscopic polyangiitis-interstitial lung disease","volume":"60","author":"Matsuda","year":"2021","journal-title":"Rheumatology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"L1018","DOI":"10.1152\/ajplung.00086.2006","article-title":"Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury","volume":"291","author":"Zhao","year":"2006","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/cea.13505","article-title":"Lipopolysaccharide induces steroid-resistant exacerbations in a mouse model of allergic airway disease collectively through IL-13 and pulmonary macrophage activation","volume":"50","author":"Hadjigol","year":"2020","journal-title":"Clin. Exp. Allergy"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Ford, A.Q., Dasgupta, P., Mikhailenko, I., Smith, E.M., Noben-Trauth, N., and Keegan, A.D. (2012). Adoptive transfer of IL-4Ralpha+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation. BMC Immunol., 13.","DOI":"10.1186\/1471-2172-13-6"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e126832","DOI":"10.1172\/jci.insight.126832","article-title":"miR-511-3p protects against cockroach allergen-induced lung inflammation by antagonizing CCL2","volume":"4","author":"Do","year":"2019","journal-title":"JCI Insight"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"aaa6566","DOI":"10.1126\/science.aaa6566","article-title":"Innate lymphoid cells. Innate lymphoid cells: A new paradigm in immunology","volume":"348","author":"Eberl","year":"2015","journal-title":"Science"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.coi.2013.02.010","article-title":"Development and function of group 2 innate lymphoid cells","volume":"25","author":"Walker","year":"2013","journal-title":"Curr. Opin. Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"42413","DOI":"10.1038\/srep42413","article-title":"Interleukin-33 produced by M2 macrophages and other immune cells contributes to Th2 immune reaction of IgG4-related disease","volume":"7","author":"Furukawa","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.4049\/jimmunol.1700144","article-title":"Early Postnatal Secondhand Smoke Exposure Disrupts Bacterial Clearance and Abolishes Immune Responses in Muco-Obstructive Lung Disease","volume":"199","author":"Lewis","year":"2017","journal-title":"J. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/imm.12931","article-title":"Antigen-specific airway IL-33 production depends on FcgammaR-mediated incorporation of the antigen by alveolar macrophages in sensitized mice","volume":"155","author":"Nabe","year":"2018","journal-title":"Immunology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/mi.2015.34","article-title":"Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis","volume":"9","author":"Borthwick","year":"2016","journal-title":"Mucosal Immunol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: Mechanism and functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"952509","DOI":"10.3389\/fimmu.2022.952509","article-title":"M2 Macrophages promote IL-33 expression, ILC2 expansion and mucous metaplasia in response to early life rhinovirus infections","volume":"13","author":"Han","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e143509","DOI":"10.1172\/jci.insight.143509","article-title":"STING activation in alveolar macrophages and group 2 innate lymphoid cells suppresses IL-33-driven type 2 immunopathology","volume":"6","author":"She","year":"2021","journal-title":"JCI Insight"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1165\/rcmb.2021-0042OC","article-title":"TLR7 Agonist Suppresses Group 2 Innate Lymphoid Cell-mediated Inflammation via IL-27-Producing Interstitial Macrophages","volume":"65","author":"Okuzumi","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/09629350120054518","article-title":"Anti-inflammatory cytokines in asthma and allergy: Interleukin-10, interleukin-12, interferon-gamma","volume":"10","author":"Chung","year":"2001","journal-title":"Mediat. Inflamm."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0091-6749(00)90176-3","article-title":"IL-18 deficiency selectively enhances allergen-induced eosinophilia in mice","volume":"105","author":"Kodama","year":"2000","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"eaba4177","DOI":"10.1126\/science.aba4177","article-title":"Liver type 1 innate lymphoid cells develop locally via an interferon-gamma-dependent loop","volume":"371","author":"Bai","year":"2021","journal-title":"Science"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e1287","DOI":"10.1002\/cti2.1287","article-title":"Quantification and role of innate lymphoid cell subsets in Chronic Obstructive Pulmonary Disease","volume":"10","author":"Blomme","year":"2021","journal-title":"Clin. Transl. Immunol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cell.2017.09.052","article-title":"ILC1 Confer Early Host Protection at Initial Sites of Viral Infection","volume":"171","author":"Weizman","year":"2017","journal-title":"Cell"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s12931-022-02046-1","article-title":"Th1 cytokines synergize to change gene expression and promote corticosteroid insensitivity in pediatric airway smooth muscle","volume":"23","author":"Jackson","year":"2022","journal-title":"Respir. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"L71","DOI":"10.1152\/ajplung.00547.2017","article-title":"Th1 cytokines TNF-alpha and IFN-gamma promote corticosteroid resistance in developing human airway smooth muscle","volume":"316","author":"Britt","year":"2019","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1084\/jem.20072713","article-title":"Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22","volume":"206","author":"Takatori","year":"2009","journal-title":"J. Exp. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00011-013-0608-1","article-title":"Interleukin-22 produced by alveolar macrophages during activation of the innate immune response","volume":"62","author":"Hansson","year":"2013","journal-title":"Inflamm. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.4049\/jimmunol.149.9.3078","article-title":"Detection of alveolar macrophage-derived IL-1 beta in asthma. Inhibition with corticosteroids","volume":"149","author":"Borish","year":"1992","journal-title":"J. Immunol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/s41577-022-00707-2","article-title":"A guide to antigen processing and presentation","volume":"22","author":"Pishesha","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"adf2043","DOI":"10.1126\/scisignal.adf2043","article-title":"Macrophages present antigens in allergic asthma","volume":"15","author":"VanHook","year":"2022","journal-title":"Sci. Signal."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"5300","DOI":"10.4049\/jimmunol.160.11.5300","article-title":"Macrophages induce cellular immunity by activating Th1 cell responses and suppressing Th2 cell responses","volume":"160","author":"Desmedt","year":"1998","journal-title":"J. Immunol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1016\/j.bbadis.2014.06.008","article-title":"Enhancement of CD147 on M1 macrophages induces differentiation of Th17 cells in the lung interstitial fibrosis","volume":"1842","author":"Geng","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"6117","DOI":"10.4049\/jimmunol.181.9.6117","article-title":"IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma","volume":"181","author":"Song","year":"2008","journal-title":"J. Immunol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12931-021-01762-4","article-title":"Lung macrophages drive mucus production and steroid-resistant inflammation in chronic bronchitis","volume":"22","author":"Andelid","year":"2021","journal-title":"Respir. Res."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Kim, J.Y., Sohn, J.H., Choi, J.M., Lee, J.H., Hong, C.S., Lee, J.S., and Park, J.W. (2012). Alveolar macrophages play a key role in cockroach-induced allergic inflammation via TNF-alpha pathway. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047971"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e20190865","DOI":"10.1084\/jem.20190865","article-title":"Distinct functions of tissue-resident and circulating memory Th2 cells in allergic airway disease","volume":"217","author":"Rahimi","year":"2020","journal-title":"J. Exp. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/ni.2744","article-title":"The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin","volume":"14","author":"Mackay","year":"2013","journal-title":"Nat. Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.4049\/jimmunol.1201305","article-title":"The molecular signature of tissue resident memory CD8 T cells isolated from the brain","volume":"189","author":"Wakim","year":"2012","journal-title":"J. Immunol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.cell.2019.07.032","article-title":"Effector T(H)17 Cells Give Rise to Long-Lived T(RM) Cells that Are Essential for an Immediate Response against Bacterial Infection","volume":"178","author":"Pallis","year":"2019","journal-title":"Cell"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1146\/annurev-immunol-051116-052350","article-title":"Th2 Cells in Health and Disease","volume":"35","author":"Nakayama","year":"2017","journal-title":"Annu. Rev. Immunol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"269rv1","DOI":"10.1126\/scitranslmed.3010641","article-title":"Resident memory T cells in human health and disease","volume":"7","author":"Clark","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.4049\/jimmunol.1700257","article-title":"Biased Generation and In Situ Activation of Lung Tissue-Resident Memory CD4 T Cells in the Pathogenesis of Allergic Asthma","volume":"200","author":"Turner","year":"2018","journal-title":"J. Immunol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.coi.2019.05.011","article-title":"Human lung tissue resident memory T cells in health and disease","volume":"59","author":"Snyder","year":"2019","journal-title":"Curr. Opin. Immunol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41385-021-00461-z","article-title":"Tissue resident memory T cells in the respiratory tract","volume":"15","author":"Zheng","year":"2022","journal-title":"Mucosal Immunol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fimmu.2016.00107","article-title":"Origin, Localization, and Immunoregulatory Properties of Pulmonary Phagocytes in Allergic Asthma","volume":"7","author":"Hoffmann","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.3389\/fimmu.2020.01276","article-title":"Antigen Cross-Presentation by Macrophages","volume":"11","author":"Muntjewerff","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/mi.2017.101","article-title":"IL-15 supports the generation of protective lung-resident memory CD4 T cells","volume":"11","author":"Strutt","year":"2018","journal-title":"Mucosal Immunol."},{"key":"ref_123","first-page":"105","article-title":"In vitro release of interleukin-15 by broncho-alveolar lavage cells and peripheral blood mononuclear cells from patients with different lung diseases","volume":"11","author":"Zissel","year":"2000","journal-title":"Eur. Cytokine Netw."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1126\/science.1257530","article-title":"T cell memory. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells","volume":"346","author":"Iijima","year":"2014","journal-title":"Science"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2102130","DOI":"10.1183\/13993003.02130-2021","article-title":"IgA(+) memory B-cells are significantly increased in patients with asthma and small airway dysfunction","volume":"60","author":"Habener","year":"2022","journal-title":"Eur. Respir. J."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nri3632","article-title":"The production and regulation of IgE by the immune system","volume":"14","author":"Wu","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nri2322","article-title":"The regulation of IgA class switching","volume":"8","author":"Cerutti","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nm.2755","article-title":"IgE and mast cells in allergic disease","volume":"18","author":"Galli","year":"2012","journal-title":"Nat. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.jaci.2006.02.039","article-title":"The role of the mast cell in the pathophysiology of asthma","volume":"117","author":"Bradding","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/j.1365-2222.2005.02246.x","article-title":"Interleukin-4 production by human alveolar macrophages","volume":"35","author":"Pouliot","year":"2005","journal-title":"Clin. Exp. Allergy"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/imm.12071","article-title":"Interleukin-33 and alveolar macrophages contribute to the mechanisms underlying the exacerbation of IgE-mediated airway inflammation and remodelling in mice","volume":"139","author":"Mizutani","year":"2013","journal-title":"Immunology"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ebiom.2019.03.080","article-title":"IgE re-programs alternatively-activated human macrophages towards pro-inflammatory anti-tumoural states","volume":"43","author":"Pellizzari","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1117749","DOI":"10.3389\/fimmu.2023.1117749","article-title":"IgA-producing B cells in lung homeostasis and disease","volume":"14","author":"Bertrand","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_134","first-page":"2565","article-title":"Role of IgA in the defense against respiratory infections IgA deficient mice exhibited increased susceptibility to intranasal infection with Mycobacterium bovis BCG","volume":"23","author":"Rodriguez","year":"2005","journal-title":"Vaccine"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1164\/rccm.201703-0561OC","article-title":"Bronchial Epithelial IgA Secretion Is Impaired in Asthma. Role of IL-4\/IL-13","volume":"197","author":"Ladjemi","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"e13677","DOI":"10.14814\/phy2.13677","article-title":"Effect of LysM+ macrophage depletion on lung pathology in mice with chronic bronchitis","volume":"6","author":"Saini","year":"2018","journal-title":"Physiol. Rep."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1172\/JCI28756","article-title":"Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis","volume":"116","author":"Hartson","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"570661","DOI":"10.3389\/fimmu.2020.570661","article-title":"Inducible Bronchus-Associated Lymphoid Tissue (iBALT) Attenuates Pulmonary Pathology in a Mouse Model of Allergic Airway Disease","volume":"11","author":"Hwang","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_139","first-page":"21","article-title":"Role of iBALT in Respiratory Immunity","volume":"426","author":"Randall","year":"2020","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"L1194","DOI":"10.1152\/ajplung.00244.2021","article-title":"Corticosteroid insensitivity persists in the absence of STAT1 signaling in severe allergic airway inflammation","volume":"321","author":"Lewis","year":"2021","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.immuni.2016.11.010","article-title":"Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1alpha Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation","volume":"45","author":"Kuroda","year":"2016","journal-title":"Immunity"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.jaci.2016.08.032","article-title":"Mechanism of T(H)2\/T(H)17-predominant and neutrophilic T(H)2\/T(H)17-low subtypes of asthma","volume":"139","author":"Liu","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"L692","DOI":"10.1152\/ajplung.00092.2014","article-title":"Cigarette smoke-induced iBALT mediates macrophage activation in a B cell-dependent manner in COPD","volume":"307","author":"Hager","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1164\/ajrccm.164.supplement_2.2106066","article-title":"Remodeling of the airway epithelium in asthma","volume":"164","author":"Fahy","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1152\/japplphysiol.00342.2018","article-title":"Airway smooth muscle proliferation and inflammation in asthma","volume":"125","author":"James","year":"2018","journal-title":"J. Appl. Physiol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.ai.2019.05.001","article-title":"The airway epithelium in asthma","volume":"142","author":"Bonser","year":"2019","journal-title":"Adv. Immunol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1183\/09031936.97.10071655","article-title":"Airway mucosa: Secretory cells, mucus and mucin genes","volume":"10","author":"Jeffery","year":"1997","journal-title":"Eur. Respir. J."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"L603","DOI":"10.1152\/ajplung.00283.2020","article-title":"First contact: The role of respiratory cilia in host-pathogen interactions in the airways","volume":"319","author":"Kuek","year":"2020","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1883965","DOI":"10.1080\/21688370.2021.1883965","article-title":"Airway tight junctions as targets of viral infections","volume":"9","author":"Linfield","year":"2021","journal-title":"Tissue Barriers"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.alit.2017.08.011","article-title":"Role of airway epithelial barrier dysfunction in pathogenesis of asthma","volume":"67","author":"Gon","year":"2018","journal-title":"Allergol. Int."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1172\/JCI5844","article-title":"Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions","volume":"104","author":"Wan","year":"1999","journal-title":"J. Clin. Investig."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jaci.2011.05.038","article-title":"Defective epithelial barrier function in asthma","volume":"128","author":"Xiao","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nature12902","article-title":"Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity","volume":"506","author":"Westphalen","year":"2014","journal-title":"Nature"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41577-020-00477-9","article-title":"Regulation of immune responses by the airway epithelial cell landscape","volume":"21","author":"Hewitt","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1172\/JCI0215217","article-title":"Mucus clearance as a primary innate defense mechanism for mammalian airways","volume":"109","author":"Knowles","year":"2002","journal-title":"J. Clin. Investig."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1165\/rcmb.2009-0151TR","article-title":"Advances in mucous cell metaplasia: A plug for mucus as a therapeutic focus in chronic airway disease","volume":"42","author":"Curran","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41467-020-20499-0","article-title":"Disulfide disruption reverses mucus dysfunction in allergic airway disease","volume":"12","author":"Morgan","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0002-9343(03)00241-9","article-title":"Characterization of airway plugging in fatal asthma","volume":"115","author":"Kuyper","year":"2003","journal-title":"Am. J. Med."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1164\/ajrccm.163.2.2004039","article-title":"Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression","volume":"163","author":"Ordonez","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1378\/chest.101.4.916","article-title":"Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack","volume":"101","author":"Aikawa","year":"1992","journal-title":"Chest"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1165\/ajrcmb.18.1.2627","article-title":"Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung","volume":"18","author":"Hancock","year":"1998","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1165\/rcmb.2016-0019PS","article-title":"Physiological Mechanisms of Airway Hyperresponsiveness in Obese Asthma","volume":"54","author":"Bates","year":"2016","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/rr12","article-title":"Activation of tumor necrosis factor receptor 1 in airway smooth muscle: A potential pathway that modulates bronchial hyper-responsiveness in asthma?","volume":"1","author":"Amrani","year":"2000","journal-title":"Respir. Res."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1586\/17476348.2015.1063422","article-title":"IL-1beta: A key modulator in asthmatic airway smooth muscle hyper-reactivity","volume":"9","author":"Liao","year":"2015","journal-title":"Expert Rev. Respir. Med."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1046\/j.1440-1711.2001.00980.x","article-title":"Tumour necrosis factor-alpha: The role of this multifunctional cytokine in asthma","volume":"79","author":"Thomas","year":"2001","journal-title":"Immunol. Cell Biol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1016\/j.bbamcr.2016.04.001","article-title":"Cross-talk between macrophages and smooth muscle cells impairs collagen and metalloprotease synthesis and promotes angiogenesis","volume":"1863","author":"Butoi","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"S241","DOI":"10.1038\/sj.bjp.0707487","article-title":"Fibroblasts as novel therapeutic targets in chronic inflammation","volume":"153","author":"Flavell","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/thx.2005.051979","article-title":"Matrix metalloproteinases in destructive pulmonary pathology","volume":"61","author":"Elkington","year":"2006","journal-title":"Thorax"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Chung, F.T., Huang, H.Y., Lo, C.Y., Huang, Y.C., Lin, C.W., He, C.C., He, J.R., Sheng, T.F., and Wang, C.H. (2019). Increased Ratio of Matrix Metalloproteinase-9 (MMP-9)\/Tissue Inhibitor Metalloproteinase-1 from Alveolar Macrophages in Chronic Asthma with a Fast Decline in FEV(1) at 5-Year Follow-up. J. Clin. Med., 8.","DOI":"10.3390\/jcm8091451"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1165\/ajrcmb.17.5.2562","article-title":"Increased release of matrix metalloproteinase-9 in bronchoalveolar lavage fluid and by alveolar macrophages of asthmatics","volume":"17","author":"Mautino","year":"1997","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1183\/09031936.06.00130004","article-title":"The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma","volume":"27","author":"Boxall","year":"2006","journal-title":"Eur. Respir. J."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1164\/ajrccm.156.1.9612018","article-title":"Matrix metalloproteinase expression and production by alveolar macrophages in emphysema","volume":"156","author":"Finlay","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1046\/j.1365-2249.1996.d01-811.x","article-title":"Release of transforming growth factor-beta (TGF-beta) and fibronectin by alveolar macrophages in airway diseases","volume":"106","author":"Vignola","year":"1996","journal-title":"Clin. Exp. Immunol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1124\/jpet.107.128538","article-title":"Chemokine receptor 2 blockade prevents asthma in a cynomolgus monkey model","volume":"324","author":"Mellado","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1111\/all.12444","article-title":"CCL2 release by airway smooth muscle is increased in asthma and promotes fibrocyte migration","volume":"69","author":"Singh","year":"2014","journal-title":"Allergy"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1152\/physiol.00050.2018","article-title":"Airway Innervation and Plasticity in Asthma","volume":"34","author":"Kistemaker","year":"2019","journal-title":"Physiology"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"eaar8477","DOI":"10.1126\/scitranslmed.aar8477","article-title":"Eosinophils increase airway sensory nerve density in mice and in human asthma","volume":"10","author":"Drake","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/JLB.3MR1117-426R","article-title":"Eosinophil and airway nerve interactions in asthma","volume":"104","author":"Drake","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/MCP.0000000000000344","article-title":"Anticholinergic drugs in asthma therapy","volume":"23","author":"Vitale","year":"2017","journal-title":"Curr. Opin. Pulm. Med."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1084\/jem.185.12.2143","article-title":"Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma","volume":"185","author":"Lee","year":"1997","journal-title":"J. Exp. Med."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1586\/ers.10.29","article-title":"Neurotrophins in lung health and disease","volume":"4","author":"Prakash","year":"2010","journal-title":"Expert Rev. Respir. Med."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1096\/fj.201801002R","article-title":"Smooth muscle brain-derived neurotrophic factor contributes to airway hyperreactivity in a mouse model of allergic asthma","volume":"33","author":"Britt","year":"2019","journal-title":"FASEB J."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ccm.2012.06.006","article-title":"Resolution of inflammation in asthma","volume":"33","author":"Levy","year":"2012","journal-title":"Clin. Chest Med."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.jaci.2020.10.005","article-title":"Clearance of apoptotic cells by lung alveolar macrophages prevents development of house dust mite-induced asthmatic lung inflammation","volume":"147","author":"Miki","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1378\/chest.129.6.1673","article-title":"Burying the dead: The impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease","volume":"129","author":"Vandivier","year":"2006","journal-title":"Chest"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"e779","DOI":"10.1002\/iid3.779","article-title":"Progranulin deficiency suppresses allergic asthma and enhances efferocytosis via PPAR-gamma\/MFG-E8 regulation in macrophages","volume":"11","author":"Huang","year":"2023","journal-title":"Immun. Inflamm. Dis."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.jaci.2017.03.024","article-title":"Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma","volume":"140","author":"Grabiec","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1700196","DOI":"10.1183\/13993003.00196-2017","article-title":"Macrophage dysfunction in the pathogenesis and treatment of asthma","volume":"50","author":"Fricker","year":"2017","journal-title":"Eur. Respir. J."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-2222.2012.04075.x","article-title":"Impaired macrophage phagocytosis in non-eosinophilic asthma","volume":"43","author":"Simpson","year":"2013","journal-title":"Clin. Exp. Allergy"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/all.14535","article-title":"Sputum macrophage diversity and activation in asthma: Role of severity and inflammatory phenotype","volume":"76","author":"Tiotiu","year":"2021","journal-title":"Allergy"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1164\/rccm.202203-0482OC","article-title":"NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease","volume":"207","author":"Ryan","year":"2023","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.freeradbiomed.2011.04.040","article-title":"Vitamin E prevents NRF2 suppression by allergens in asthmatic alveolar macrophages in vivo","volume":"51","author":"Dworski","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1016\/j.cmet.2021.10.015","article-title":"Efferocytosis induces macrophage proliferation to help resolve tissue injury","volume":"33","author":"Gerlach","year":"2021","journal-title":"Cell Metab."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3389\/fmed.2020.00191","article-title":"Airway Remodeling in Asthma","volume":"7","author":"Hough","year":"2020","journal-title":"Front. Med."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1096\/fj.201601222R","article-title":"Treating inflammation and infection in the 21st century: New hints from decoding resolution mediators and mechanisms","volume":"31","author":"Serhan","year":"2017","journal-title":"FASEB J."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.pharmthera.2018.01.004","article-title":"Towards targeting resolution pathways of airway inflammation in asthma","volume":"186","author":"Barnig","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1046\/j.1365-2222.2000.00095.x","article-title":"Epithelial damage and response","volume":"30","author":"Holgate","year":"2000","journal-title":"Clin. Exp. Allergy"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.imbio.2010.05.025","article-title":"IL-10 regulation of macrophage VEGF production is dependent on macrophage polarisation and hypoxia","volume":"215","author":"Wu","year":"2010","journal-title":"Immunobiology"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"108553","DOI":"10.1016\/j.celrep.2020.108553","article-title":"Airway-Associated Macrophages in Homeostasis and Repair","volume":"33","author":"Engler","year":"2020","journal-title":"Cell Rep."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.yjmcc.2016.12.010","article-title":"IL-33 enhances macrophage M2 polarization and protects mice from CVB3-induced viral myocarditis","volume":"103","author":"Wang","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.1038\/s41467-020-18466-w","article-title":"IL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration","volume":"11","author":"Dagher","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.7150\/ijbs.59715","article-title":"MicroRNA-370 carried by M2 macrophage-derived exosomes alleviates asthma progression through inhibiting the FGF1\/MAPK\/STAT1 axis","volume":"17","author":"Li","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"106065","DOI":"10.1016\/j.intimp.2019.106065","article-title":"Long non-coding RNA SNHG16 promotes lipopolysaccharides-induced acute pneumonia in A549 cells via targeting miR-370-3p\/IGF2 axis","volume":"78","author":"Zhang","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1165\/rcmb.2009-0244OC","article-title":"Interleukin-13-induced mucous metaplasia increases susceptibility of human airway epithelium to rhinovirus infection","volume":"43","author":"Boushey","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1164\/ajrccm.154.3.8810601","article-title":"The relationship between upper respiratory infections and hospital admissions for asthma: A time-trend analysis","volume":"154","author":"Johnston","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1060748","DOI":"10.3389\/fcimb.2022.1060748","article-title":"Rhinovirus increases Moraxella catarrhalis adhesion to the respiratory epithelium","volume":"12","author":"Dissanayake","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1136\/bmj.310.6989.1225","article-title":"Community study of role of viral infections in exacerbations of asthma in 9-11 year old children","volume":"310","author":"Johnston","year":"1995","journal-title":"BMJ"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.jaci.2018.08.051","article-title":"IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive antiviral immunity","volume":"143","author":"Ravanetti","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1164\/rccm.201406-1039OC","article-title":"IL-33-dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in vivo","volume":"190","author":"Jackson","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.4049\/jimmunol.1000286","article-title":"Rhinovirus infection of allergen-sensitized and -challenged mice induces eotaxin release from functionally polarized macrophages","volume":"185","author":"Nagarkar","year":"2010","journal-title":"J. Immunol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1465-9921-15-63","article-title":"Macrophage activation state determines the response to rhinovirus infection in a mouse model of allergic asthma","volume":"15","author":"Hong","year":"2014","journal-title":"Respir. Res."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1152\/physiolgenomics.00122.2017","article-title":"Rhinovirus infection induces distinct transcriptome profiles in polarized human macrophages","volume":"50","author":"Rajput","year":"2018","journal-title":"Physiol. Genom."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jaci.2012.02.010","article-title":"Determinants of asthma after severe respiratory syncytial virus bronchiolitis","volume":"130","author":"Bacharier","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.3389\/fimmu.2017.01643","article-title":"Functional Impairment of Mononuclear Phagocyte System by the Human Respiratory Syncytial Virus","volume":"8","author":"Bohmwald","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1012048","DOI":"10.3389\/fimmu.2022.1012048","article-title":"Alveolar macrophages and airway hyperresponsiveness associated with respiratory syncytial virus infection","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1084\/jem.20140825","article-title":"Alveolar macrophage-derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes","volume":"212","author":"Goritzka","year":"2015","journal-title":"J. Exp. Med."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1159\/000446824","article-title":"Alveolar Macrophages Can Control Respiratory Syncytial Virus Infection in the Absence of Type I Interferons","volume":"8","author":"Makris","year":"2016","journal-title":"J. Innate Immun."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12931-015-0282-7","article-title":"Alveolar macrophages support interferon gamma-mediated viral clearance in RSV-infected neonatal mice","volume":"16","author":"Eichinger","year":"2015","journal-title":"Respir. Res."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1097\/INF.0000000000001007","article-title":"Reduced Expression of HLA-DR on Monocytes During Severe Respiratory Syncytial Virus Infections","volume":"35","author":"Ahout","year":"2016","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1165\/rcmb.2013-0414OC","article-title":"Alveolar macrophages contribute to the pathogenesis of human metapneumovirus infection while protecting against respiratory syncytial virus infection","volume":"51","author":"Kolli","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1365-2249.2006.03114.x","article-title":"Effects of alveolar macrophage depletion on liposomal vaccine protection against respiratory syncytial virus (RSV)","volume":"145","author":"Benoit","year":"2006","journal-title":"Clin. Exp. Immunol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.intimp.2015.10.022","article-title":"Respiratory macrophages and dendritic cells mediate respiratory syncytial virus-induced IL-33 production in TLR3- or TLR7-dependent manner","volume":"29","author":"Qi","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/mi.2010.6","article-title":"Control of RSV-induced lung injury by alternatively activated macrophages is IL-4R alpha-, TLR4-, and IFN-beta-dependent","volume":"3","author":"Shirey","year":"2010","journal-title":"Mucosal Immunol."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1164\/rccm.201806-1095OC","article-title":"Human Rhinovirus Impairs the Innate Immune Response to Bacteria in Alveolar Macrophages in Chronic Obstructive Pulmonary Disease","volume":"199","author":"Finney","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Porto, B.N., Litvack, M.L., Cen, Y., Lok, I., Bouch, S., Norris, M.J., Duan, W., Ackerley, C., Post, M., and Moraes, T.J. (2021). Alveolar-like Macrophages Attenuate Respiratory Syncytial Virus Infection. Viruses, 13.","DOI":"10.3390\/v13101960"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"624","DOI":"10.3390\/v6020624","article-title":"Respiratory syncytial virus persistence in macrophages upregulates Fcgamma receptors expression","volume":"6","author":"Gaona","year":"2014","journal-title":"Viruses"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/08828240151061347","article-title":"Persistence of respiratory syncytial virus in macrophages alters phagocytosis and pro-inflammatory cytokine production","volume":"14","author":"Ortega","year":"2001","journal-title":"Viral Immunol."},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Cooper, G.E., Pounce, Z.C., Wallington, J.C., Bastidas-Legarda, L.Y., Nicholas, B., Chidomere, C., Robinson, E.C., Martin, K., Tocheva, A.S., and Christodoulides, M. (2016). Viral Inhibition of Bacterial Phagocytosis by Human Macrophages: Redundant Role of CD36. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0163889"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"eabq5126","DOI":"10.1126\/scitranslmed.abq5126","article-title":"Understanding respiratory microbiome-immune system interactions in health and disease","volume":"15","author":"Rudloff","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jaci.2016.10.046","article-title":"Eosinophilic airway inflammation in asthmatic patients is associated with an altered airway microbiome","volume":"140","author":"Sverrild","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12931-016-0479-4","article-title":"The Microbiome and the Pathophysiology of Asthma","volume":"17","author":"Sullivan","year":"2016","journal-title":"Respir. Res."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.rmed.2017.08.016","article-title":"Sputum microbiota in severe asthma patients: Relationship to eosinophilic inflammation","volume":"131","author":"Li","year":"2017","journal-title":"Respir. Med."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jaci.2017.03.044","article-title":"Inflammatory phenotypes in patients with severe asthma are associated with distinct airway microbiology","volume":"141","author":"Taylor","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_234","doi-asserted-by":"crossref","unstructured":"Valverde-Molina, J., and Garcia-Marcos, L. (2023). Microbiome and Asthma: Microbial Dysbiosis and the Origins, Phenotypes, Persistence, and Severity of Asthma. Nutrients, 15.","DOI":"10.3390\/nu15030486"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1111\/all.15375","article-title":"Nontypeable Haemophilus influenzae infection of pulmonary macrophages drives neutrophilic inflammation in severe asthma","volume":"77","author":"Ackland","year":"2022","journal-title":"Allergy"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jaci.2017.06.031","article-title":"Effect of home exposure to Staphylococcus aureus on asthma in adolescents","volume":"141","author":"Davis","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.jaci.2014.10.052","article-title":"Staphylococcus aureus colonization is associated with wheeze and asthma among US children and young adults","volume":"135","author":"Davis","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1136\/thoraxjnl-2011-200160","article-title":"Combined Haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma","volume":"67","author":"Essilfie","year":"2012","journal-title":"Thorax"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1183\/13993003.00405-2015","article-title":"Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma","volume":"47","author":"Simpson","year":"2016","journal-title":"Eur. Respir. J."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"24898","DOI":"10.18632\/oncotarget.24653","article-title":"Long-term exposure to low-dose Haemophilus influenzae during allergic airway disease drives a steroid-resistant neutrophilic inflammation and promotes airway remodeling","volume":"9","author":"Yang","year":"2018","journal-title":"Oncotarget"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"723481","DOI":"10.3389\/fcimb.2021.723481","article-title":"Dual RNASeq Reveals NTHi-Macrophage Transcriptomic Changes During Intracellular Persistence","volume":"11","author":"Ackland","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1465-9921-15-72","article-title":"Impaired macrophage phagocytosis of bacteria in severe asthma","volume":"15","author":"Liang","year":"2014","journal-title":"Respir. Res."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jaip.2017.11.020","article-title":"Childhood Asthma: Is It All About Bacteria and Not About Viruses? A Pro\/Con Debate","volume":"6","author":"Beigelman","year":"2018","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0140-6736(17)31281-3","article-title":"Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): A randomised, double-blind, placebo-controlled trial","volume":"390","author":"Gibson","year":"2017","journal-title":"Lancet"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1164\/rccm.201809-1739OC","article-title":"Long-Term Azithromycin Reduces Haemophilus influenzae and Increases Antibiotic Resistance in Severe Asthma","volume":"200","author":"Taylor","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/j.1440-1843.2012.02135.x","article-title":"Low-dose azithromycin improves phagocytosis of bacteria by both alveolar and monocyte-derived macrophages in chronic obstructive pulmonary disease subjects","volume":"17","author":"Hodge","year":"2012","journal-title":"Respirology"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jcf.2013.08.007","article-title":"Impact of azithromycin treatment on macrophage gene expression in subjects with cystic fibrosis","volume":"13","author":"Cory","year":"2014","journal-title":"J. Cyst. Fibros."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1128\/AAC.01424-09","article-title":"Azithromycin alters macrophage phenotype and pulmonary compartmentalization during lung infection with Pseudomonas","volume":"54","author":"Feola","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.4049\/jimmunol.1801228","article-title":"Azithromycin Polarizes Macrophages to an M2 Phenotype via Inhibition of the STAT1 and NF-kappaB Signaling Pathways","volume":"203","author":"Haydar","year":"2019","journal-title":"J. Immunol."},{"key":"ref_250","first-page":"CD002741","article-title":"Antibiotics for exacerbations of asthma","volume":"6","author":"Normansell","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12931-019-1233-5","article-title":"Use of antibiotics and asthma medication for acute lower respiratory tract infections in people with and without asthma: Retrospective cohort study","volume":"21","author":"Denholm","year":"2020","journal-title":"Respir. Res."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"L678","DOI":"10.1152\/ajplung.00518.2016","article-title":"Nonantibiotic macrolides restore airway macrophage phagocytic function with potential anti-inflammatory effects in chronic lung diseases","volume":"312","author":"Hodge","year":"2017","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jaci.2021.12.765","article-title":"Recent advances in the immunopathogenesis of severe asthma","volume":"149","author":"Ramakrishnan","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.jaci.2018.06.008","article-title":"Paucigranulocytic asthma: Uncoupling of airway obstruction from inflammation","volume":"143","author":"Tliba","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1111\/all.15087","article-title":"An altered sputum macrophage transcriptome contributes to the neutrophilic asthma endotype","volume":"77","author":"Fricker","year":"2022","journal-title":"Allergy"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"530","DOI":"10.2500\/aap.2021.42.210060","article-title":"Paucigranulocytic asthma: Do sputum macrophages matter?","volume":"42","author":"Olgac","year":"2021","journal-title":"Allergy Asthma Proc."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41385-020-00356-5","article-title":"Macrophage metabolic reprogramming during chronic lung disease","volume":"14","author":"Ogger","year":"2021","journal-title":"Mucosal Immunol."},{"key":"ref_258","first-page":"628","article-title":"Metabolic reprogramming of macrophages and its involvement in inflammatory diseases","volume":"20","author":"Guo","year":"2021","journal-title":"EXCLI J."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"eadd8945","DOI":"10.1126\/sciimmunol.add8945","article-title":"Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation","volume":"8","author":"Fabre","year":"2023","journal-title":"Sci. Immunol."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"13259","DOI":"10.1038\/s41598-021-92626-w","article-title":"Interactions of nasal epithelium with macrophages and dendritic cells variously alter urban PM-induced inflammation in healthy, asthma and COPD","volume":"11","author":"Proboszcz","year":"2021","journal-title":"Sci. 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