{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:14:49Z","timestamp":1790702089479,"version":"4.1.0"},"reference-count":151,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007088","name":"Jagiellonian University Medical College","doi-asserted-by":"publisher","award":["N42\/DBS\/000252"],"award-info":[{"award-number":["N42\/DBS\/000252"]}],"id":[{"id":"10.13039\/501100007088","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Researchers active in the field of inflammatory skin diseases from the spectrum of dermatitis and eczema are well aware of a considerable overlap in the clinical pictures and proposed sets of diagnostic criteria for these diseases, which can hardly be overcome through the clinical or epidemiological research. In effect, patients are included in studies based on vague and overlapping criteria, while heterogeneous study populations may, in turn, lead to non-representative outcomes and continued confusion. In this narrative review, a systematics of diseases from the spectrum of dermatitis and eczema is proposed based on the origins of causative factors and the pathomechanisms involved. Difficulties in differentiating between these diseases are discussed, and the extent to which advances in the \u201comics\u201d sciences might help to overcome them is considered. Of all the \u201comics\u201d research in this field, more than 90% of the published papers were devoted to atopic dermatitis, with a striking underrepresentation of other diseases from the spectrum of dermatitis and eczema, conditions which collectively exceed the rates of atopic dermatitis by far. A greater \u201comics\u201d research effort is urgently needed to tackle other dermatitides, like allergic, irritant and protein contact dermatitis, as well as radiation, seborrheic, stasis or autoimmune dermatitis. Atopic dermatitis findings should be validated not only against healthy donors but also other dermatitides. A clinic-oriented approach is proposed for future \u201comics\u201d studies in the field of dermatitis and eczema.<\/jats:p>","DOI":"10.3390\/ijms241310468","type":"journal-article","created":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T01:49:32Z","timestamp":1687398572000},"page":"10468","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Diseases from the Spectrum of Dermatitis and Eczema: Can \u201cOmics\u201d Sciences Help with Better Systematics and More Accurate Differential Diagnosis?"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5968-0555","authenticated-orcid":false,"given":"Radoslaw","family":"Spiewak","sequence":"first","affiliation":[{"name":"Department of Experimental Dermatology and Cosmetology, Faculty of Pharmacy, Jagiellonian University Medical College, ul. Medyczna 9, 30-688 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.3892\/etm.2021.10769","article-title":"Spongiotic reaction patterns in autoimmune bullous dermatoses (Review)","volume":"22","author":"Balan","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/bjd.16340","article-title":"Systematic review of atopic dermatitis disease definition in studies using routinely collected health data","volume":"178","author":"Dizon","year":"2018","journal-title":"Br. J. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Rathore, H., and Nolet, L.M. (2012). 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