{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:27:06Z","timestamp":1793230026255,"version":"4.5.0"},"reference-count":188,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy, Bucharest","id":[{"id":"https:\/\/ror.org\/04fm87419","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Neurodegenerative diseases are, according to recent studies, one of the main causes of disability and death worldwide. Interest in molecular genetics has started to experience exponential growth thanks to numerous advancements in technology, shifts in the understanding of the disease as a phenomenon, and the change in the perspective regarding gene editing and the advantages of this action. The aim of this paper is to analyze the newest approaches in genetics and molecular sciences regarding four of the most important neurodegenerative disorders: Alzheimer\u2019s disease, Parkinson\u2019s disease, Huntington\u2019s disease, and amyotrophic lateral sclerosis. We intend through this review to focus on the newest treatment, diagnosis, and predictions regarding this large group of diseases, in order to obtain a more accurate analysis and to identify the emerging signs that could lead to a better outcome in order to increase both the quality and the life span of the patient. Moreover, this review could provide evidence of future possible novel therapies that target the specific genes and that could be useful to be taken into consideration when the classical approaches fail to shed light.<\/jats:p>","DOI":"10.3390\/ijms241310809","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T00:41:45Z","timestamp":1687999305000},"page":"10809","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":119,"title":["Unraveling Molecular and Genetic Insights into Neurodegenerative Diseases: Advances in Understanding Alzheimer\u2019s, Parkinson\u2019s, and Huntington\u2019s Diseases and Amyotrophic Lateral Sclerosis"],"prefix":"10.3390","volume":"24","author":[{"given":"Alexandru Vlad","family":"Ciurea","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Neurosurgery Department, Sanador Clinical Hospital, 010991 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurel George","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Bihor County Emergency Clinical Hospital, 410167 Oradea, Romania"},{"name":"Department of Neurosurgery, Faculty of Medicine, Oradea University, 410610 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razvan-Adrian","family":"Covache-Busuioc","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6347-9958","authenticated-orcid":false,"given":"Horia-Petre","family":"Costin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca-Andrei","family":"Glavan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9232-1176","authenticated-orcid":false,"given":"Antonio-Daniel","family":"Corlatescu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4997-2690","authenticated-orcid":false,"given":"Vicentiu Mircea","family":"Saceleanu","sequence":"additional","affiliation":[{"name":"Neurosurgery Department, Sibiu County Emergency Hospital, 550245 Sibiu, Romania"},{"name":"Neurosurgery Department, \u201cLucian Blaga\u201d University of Medicine, 550024 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"key":"ref_1","first-page":"401","article-title":"The genetic revolution and the physician\u2019s duty of confidentiality: The role of the old Hippocratic virtues in the regulation of the new genetic intimacy","volume":"18","author":"Berry","year":"1997","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/mgg3.199","article-title":"Johann Gregor Mendel: Paragon of experimental science","volume":"4","year":"2016","journal-title":"Mol. 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