{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:43:11Z","timestamp":1791502991445,"version":"4.3.4"},"reference-count":41,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["22007022"],"award-info":[{"award-number":["22007022"]}]},{"name":"National Natural Science Foundation of China","award":["21867004"],"award-info":[{"award-number":["21867004"]}]},{"name":"National Natural Science Foundation of China","award":["QjhKYZi[2021]041"],"award-info":[{"award-number":["QjhKYZi[2021]041"]}]},{"name":"National Natural Science Foundation of China","award":["ZZK[2021]034"],"award-info":[{"award-number":["ZZK[2021]034"]}]},{"name":"Guizhou Provincial Department of Education","award":["22007022"],"award-info":[{"award-number":["22007022"]}]},{"name":"Guizhou Provincial Department of Education","award":["21867004"],"award-info":[{"award-number":["21867004"]}]},{"name":"Guizhou Provincial Department of Education","award":["QjhKYZi[2021]041"],"award-info":[{"award-number":["QjhKYZi[2021]041"]}]},{"name":"Guizhou Provincial Department of Education","award":["ZZK[2021]034"],"award-info":[{"award-number":["ZZK[2021]034"]}]},{"name":"Guizhou Provincial Natural Science Foundation","award":["22007022"],"award-info":[{"award-number":["22007022"]}]},{"name":"Guizhou Provincial Natural Science Foundation","award":["21867004"],"award-info":[{"award-number":["21867004"]}]},{"name":"Guizhou Provincial Natural Science Foundation","award":["QjhKYZi[2021]041"],"award-info":[{"award-number":["QjhKYZi[2021]041"]}]},{"name":"Guizhou Provincial Natural Science Foundation","award":["ZZK[2021]034"],"award-info":[{"award-number":["ZZK[2021]034"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Rice bacterial leaf blight is a destructive bacterial disease caused by Xanthomonas oryzae pv. oryzae (Xoo) that seriously threatens crop yields and their associated economic benefits. In this study, a series of improved dissolubility 7-aliphatic amine tryptanthrin derivatives was designed and synthesized, and their potency in antibacterial applications was investigated. Notably, compound 6e exhibited excellent activity against Xoo, with an EC50 value of 2.55 \u03bcg\/mL, compared with the positive control bismerthiazol (EC50 = 35.0 \u03bcg\/mL) and thiodiazole copper (EC50 = 79.4 \u03bcg\/mL). In vivo assays demonstrated that 6e exhibited a significant protective effect on rice leaves. After exposure, the morphology of the bacteria was partially atrophied by SEM. Furthermore, 6e increased the accumulation of intracellular reactive oxygen species, causing cell apoptosis and the formation of bacterial biofilms. All the results indicated that 6e could be a potential agrochemical bactericide for controlling phytopathogenic bacteria.<\/jats:p>","DOI":"10.3390\/ijms241310900","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T16:06:37Z","timestamp":1688141197000},"page":"10900","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Discovery and Mechanism of Novel 7-Aliphatic Amine Tryptanthrin Derivatives against Phytopathogenic Bacteria"],"prefix":"10.3390","volume":"24","author":[{"given":"Xuesha","family":"Long","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3653-8762","authenticated-orcid":false,"given":"Guanglong","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Long","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congyu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengpeng","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenchao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China"},{"name":"National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China"},{"name":"Guizhou Engineering Laboratory for Synthetic Drugs, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiping","family":"Ouyang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China"},{"name":"National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China"},{"name":"Guizhou Engineering Laboratory for Synthetic Drugs, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12284-019-0358-y","article-title":"Resistance Genes and their Interactions with Bacterial Blight\/Leaf Streak Pathogens (Xanthomonas oryzae) in Rice (Oryza sativa L.)-an Updated Review","volume":"13","author":"Jiang","year":"2020","journal-title":"Rice"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"104695","DOI":"10.1016\/j.pestbp.2020.104695","article-title":"Design and synthesis of novel 1,3,4-oxadiazole sulfone compounds containing 3,4-dichloroisothiazolylamide moiety and evaluation of rice bacterial activity","volume":"170","author":"Xiang","year":"2020","journal-title":"Pestic. 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