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Science and Technology Agency of Japan","award":["JP18K19450"],"award-info":[{"award-number":["JP18K19450"]}]},{"name":"Japan Science and Technology Agency of Japan","award":["JPMJMS2021"],"award-info":[{"award-number":["JPMJMS2021"]}]},{"name":"Japan Science and Technology Agency of Japan","award":["JP190H04808"],"award-info":[{"award-number":["JP190H04808"]}]},{"name":"Ministry of Education, Culture, Sports, Science, and Technology of Japan","award":["JP18gk0110018"],"award-info":[{"award-number":["JP18gk0110018"]}]},{"name":"Ministry of Education, Culture, Sports, Science, and Technology of Japan","award":["JP21gk0110047"],"award-info":[{"award-number":["JP21gk0110047"]}]},{"name":"Ministry of Education, Culture, Sports, Science, and Technology of Japan","award":["JP21fk0108137"],"award-info":[{"award-number":["JP21fk0108137"]}]},{"name":"Ministry of Education, Culture, Sports, Science, and Technology of Japan","award":["JP22gk0110061"],"award-info":[{"award-number":["JP22gk0110061"]}]},{"name":"Ministry of Education, Culture, Sports, Science, and Technology of Japan","award":["JP17fm0208004"],"award-info":[{"award-number":["JP17fm0208004"]}]},{"name":"Ministry of Education, Culture, Sports, Science, and Technology of Japan","award":["JP19ek0410053"],"award-info":[{"award-number":["JP19ek0410053"]}]},{"name":"Ministry of Education, Culture, Sports, Science, and Technology of Japan","award":["20K09642"],"award-info":[{"award-number":["20K09642"]}]},{"name":"Ministry of Education, Culture, Sports, Science, and Technology of Japan","award":["23K0888"],"award-info":[{"award-number":["23K0888"]}]},{"name":"Ministry of Education, Culture, Sports, Science, and Technology of Japan","award":["JP18H05279"],"award-info":[{"award-number":["JP18H05279"]}]},{"name":"Ministry of Education, Culture, Sports, Science, and Technology of Japan","award":["JP18K19450"],"award-info":[{"award-number":["JP18K19450"]}]},{"name":"Ministry of Education, Culture, Sports, Science, and Technology of Japan","award":["JPMJMS2021"],"award-info":[{"award-number":["JPMJMS2021"]}]},{"name":"Ministry of Education, Culture, Sports, Science, and Technology of Japan","award":["JP190H04808"],"award-info":[{"award-number":["JP190H04808"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Anti-\u03b22-glycoprotein I\/HLA-DR (anti-\u03b22GPI\/HLA-DR) antibody has been reported to be associated with antiphospholipid syndrome and recurrent pregnancy loss (RPL). We conducted a prospective multicenter cross-sectional study aimed at evaluating whether the anti-\u03b22GPI\/HLA-DR antibody is associated with adverse obstetric outcomes and RPL. From 2019 to 2021, serum anti-\u03b22GPI\/HLA-DR antibody levels (normal, &lt;73.3 U) were measured in 462 women with RPL, 124 with fetal growth restriction (FGR), 138 with hypertensive disorders of pregnancy (HDP), 71 with preterm delivery before 34 gestational weeks (preterm delivery (PD) \u2264 34 GWs), and 488 control women who experienced normal delivery, by flow cytometry analysis. The adjusted odds ratios (aORs) of anti-\u03b22GPI\/HLA-DR antibody positivity for adverse obstetric outcomes and RPL were evaluated on the basis of comparisons between the control and each patient group, using multivariable logistic regression analysis. The following were the positivity rates for the anti-\u03b22GPI\/HLA-DR antibody in the patient and control groups: RPL, 16.9%; FGR, 15.3%; HDP, 17.4%; PD \u2264 34 GWs, 11.3%; and the control, 5.5%. It was demonstrated that anti-\u03b22GPI\/HLA-DR antibody positivity was a significant risk factor for RPL (aOR, 3.3 [95% confidence interval {CI} 1.9\u20135.6], p &lt; 0.001), FGR (2.7 [1.3\u20135.3], p &lt; 0.01), and HDP (2.7 [1.4\u20135.3], p &lt; 0.01) although not for PD \u2264 34 GWs. For the first time, our study demonstrated that the anti-\u03b22GPI\/HLA-DR antibody is involved in the pathophysiology underlying FGR and HDP, as well as RPL.<\/jats:p>","DOI":"10.3390\/ijms241310958","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T16:06:37Z","timestamp":1688141197000},"page":"10958","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Anti-\u03b22-glycoprotein I\/HLA-DR Antibody and Adverse Obstetric Outcomes"],"prefix":"10.3390","volume":"24","author":[{"given":"Kenji","family":"Tanimura","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8940-3708","authenticated-orcid":false,"given":"Shigeru","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Toyama, Toyama 930-0194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Toyama, Toyama 930-0194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Yamanashi, Yamanashi 409-3898, Japan"},{"name":"Department of Obstetrics and Gynecology, Teine Keijinkai Hospital, Sapporo 006-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Teine Keijinkai Hospital, Sapporo 006-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Teine Keijinkai Hospital, Sapporo 006-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Deguchi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiya","family":"Nakatsuka","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Okayama University, Okayama 700-8558, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nagamatsu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo 113-8655, Japan"},{"name":"Department of Obstetrics and Gynecology, International University of Health and Welfare Narita Hospital, Narita 286-8520, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo 113-8655, Japan"},{"name":"Department of Obstetrics and Gynecology, International University of Health and Welfare Narita Hospital, Narita 286-8520, Japan"},{"name":"Sanno Hospital, Tokyo 107-0052, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Kobashi","sequence":"additional","affiliation":[{"name":"Department of Public Health, Dokkyo Medical University, Tochigi 321-0293, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Arase","sequence":"additional","affiliation":[{"name":"Department of Immunochemistry, Research Institute for Microbial Disease, Osaka University, Suita 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9839-2214","authenticated-orcid":false,"given":"Hideto","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"},{"name":"Center for Recurrent Pregnancy Loss, Teine Keijinkai Hospital, Sapporo 006-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/intimm\/dxs155","article-title":"Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules","volume":"25","author":"Jiang","year":"2013","journal-title":"Int. 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