{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:41:20Z","timestamp":1782290480457,"version":"3.54.5"},"reference-count":63,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Climate change and globalization have raised the risk of vector-borne disease (VBD) introduction and spread in various European nations in recent years. In Italy, viruses carried by tropical vectors have been shown to cause viral encephalitis, one of the symptoms of arboviruses, a spectrum of viral disorders spread by arthropods such as mosquitoes and ticks. Arboviruses are currently causing alarm and attention, and the World Health Organization (WHO) has released recommendations to adopt essential measures, particularly during the hot season, to restrict the spreading of the infectious agents among breeding stocks. In this scenario, rapid analysis systems are required, because they can quickly provide information on potential virus\u2013host interactions, the evolution of the infection, and the onset of disabling clinical symptoms, or serious illnesses. Such systems include bioinformatics approaches integrated with molecular evaluation. Viruses have co-evolved different strategies to transcribe their own genetic material, by changing the host\u2019s transcriptional machinery, even in short periods of time. The introduction of genetic alterations, particularly in RNA viruses, results in a continuous adaptive fight against the host\u2019s immune system. We propose an in silico pipeline method for performing a comprehensive motif analysis (including motif discovery) on entire genome sequences to uncover viral sequences that may interact with host RNA binding proteins (RBPs) by interrogating the database of known RNA binding proteins, which play important roles in RNA metabolism and biological processes. Indeed, viral RNA sequences, able to bind host RBPs, may compete with cellular RNAs, altering important metabolic processes. Our findings suggest that the proposed in silico approach could be a useful and promising tool to investigate the complex and multiform clinical manifestations of viral encephalitis, and possibly identify altered metabolic pathways as targets of pharmacological treatments and innovative therapeutic protocols.<\/jats:p>","DOI":"10.3390\/ijms241311051","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T01:32:18Z","timestamp":1688434338000},"page":"11051","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Continuous Adaptive Challenge Played by Arboviruses: An In Silico Approach to Identify a Possible Interplay between Conserved Viral RNA Sequences and Host RNA Binding Proteins (RBPs)"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6300-0604","authenticated-orcid":false,"given":"Massimiliano","family":"Chetta","sequence":"first","affiliation":[{"name":"U.O.C. Medical and Laboratory Genetics, A.O.R.N., Cardarelli, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4676-1795","authenticated-orcid":false,"given":"Anna Lisa","family":"Cammarota","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cSchola Medica Salernitana\u201d, University of Salerno, 84084 Baronissi, SA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4134-1437","authenticated-orcid":false,"given":"Margot","family":"De Marco","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cSchola Medica Salernitana\u201d, University of Salerno, 84084 Baronissi, SA, Italy"},{"name":"FIBROSYS s.r.l. Academic Spin-Off, University of Salerno, 84084 Baronissi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9235-8987","authenticated-orcid":false,"given":"Nenad","family":"Bukvic","sequence":"additional","affiliation":[{"name":"Medical Genetics Section, University Hospital Consortium Corporation Polyclinics of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6133-4483","authenticated-orcid":false,"given":"Liberato","family":"Marzullo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cSchola Medica Salernitana\u201d, University of Salerno, 84084 Baronissi, SA, Italy"},{"name":"FIBROSYS s.r.l. 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Genet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1140\/epjp\/s13360-021-01657-9","article-title":"Role of plasmonics in detection of deadliest viruses: A review","volume":"136","author":"Sohrabi","year":"2021","journal-title":"Eur. Phys. J. Plus"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Rossi, B., Barreca, F., Benvenuto, D., Braccialarghe, N., Campogiani, L., Lodi, A., Aguglia, C., Cavasio, R.A., Giacalone, M.L., and Kontogiannis, D. (2023). Human Arboviral Infections in Italy: Past, Current, and Future Challenges. Viruses, 15.","DOI":"10.3390\/v15020368"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"259382","DOI":"10.1155\/2014\/259382","article-title":"Structural differences observed in arboviruses of the alphavirus and flavivirus genera","volume":"2014","author":"Hernandez","year":"2014","journal-title":"Adv. Virol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2222\/jsv.61.211","article-title":"Virology of the family Togaviridae","volume":"61","author":"Mori","year":"2011","journal-title":"Uirusu"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Elmasri, Z., Nasal, B.L., and Jose, J. (2021). Alphavirus-Induced Membrane Rearrangements during Replication, Assembly, and Budding. Pathogens, 10.","DOI":"10.3390\/pathogens10080984"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1099\/jgv.0.000249","article-title":"Alphavirus RNA synthesis and non-structural protein functions","volume":"96","author":"Rupp","year":"2015","journal-title":"J. Gen. Virol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Azar, S.R., Campos, R.K., Bergren, N.A., Camargos, V.N., and Rossi, S.L. (2020). Epidemic Alphaviruses: Ecology, Emergence and Outbreaks. Microorganisms, 8.","DOI":"10.3390\/microorganisms8081167"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/B978-0-12-408116-1.00004-5","article-title":"Arthropod-borne flaviviruses and RNA interference: Seeking new approaches for antiviral therapy","volume":"85","author":"Smit","year":"2013","journal-title":"Adv. Virus Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1128\/JVI.72.1.73-83.1998","article-title":"Phylogeny of the genus Flavivirus","volume":"72","author":"Kuno","year":"1998","journal-title":"J. Virol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Ng, W.C., Soto-Acosta, R., Bradrick, S.S., Garcia-Blanco, M.A., and Ooi, E.E. (2017). The 5\u2032 and 3\u2032 Untranslated Regions of the Flaviviral Genome. Viruses, 9.","DOI":"10.3390\/v9060137"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3390\/v6010069","article-title":"Flavivirus entry receptors: An update","volume":"6","author":"Meertens","year":"2013","journal-title":"Viruses"},{"key":"ref_13","unstructured":"Amor, S. (2009). Manson\u2019s Tropical Diseases, Saunders Ltd."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"de Vries, L., and Harding, A.T. (2023). Mechanisms of Neuroinvasion and Neuropathogenesis by Pathologic Flaviviruses. Viruses, 15.","DOI":"10.3390\/v15020261"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13071-017-2559-9","article-title":"Mosquito-borne arboviruses of African origin: Review of key viruses and vectors","volume":"11","author":"Braack","year":"2018","journal-title":"Parasites Vectors"},{"key":"ref_16","first-page":"98","article-title":"Arthropod vectors in the evolution of bunyaviruses","volume":"35","author":"Labuda","year":"1991","journal-title":"Acta Virol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"890","DOI":"10.3389\/fphys.2019.00890","article-title":"Arboviruses and the Challenge to Establish Systemic and Persistent Infections in Competent Mosquito Vectors: The Interaction with the RNAi Mechanism","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/wrna.1151","article-title":"Poly(A) binding proteins: Are they all created equal?","volume":"4","author":"Goss","year":"2013","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"12285","DOI":"10.1074\/jbc.M117.794834","article-title":"Cytoplasmic poly(A)-binding protein 1 (PABPC1) interacts with the RNA-binding protein hnRNPLL and thereby regulates immunoglobulin secretion in plasma cells","volume":"292","author":"Peng","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"291","DOI":"10.4161\/rna.7.3.11649","article-title":"Crossing the borders: Poly(A)-binding proteins working on both sides of the fence","volume":"7","author":"Lemay","year":"2010","journal-title":"RNA Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1128\/MCB.01683-13","article-title":"Cytoplasmic poly(A) binding protein C4 serves a critical role in erythroid differentiation","volume":"34","author":"Kini","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.7150\/ijbs.46751","article-title":"Serine\/arginine-rich splicing factors: The bridge linking alternative splicing and cancer","volume":"16","author":"Zheng","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"dmm044727","DOI":"10.1242\/dmm.044727","article-title":"Silencing of CCR4-NOT complex subunits affects heart structure and function","volume":"13","author":"Volpato","year":"2020","journal-title":"Dis. Models Mech."},{"key":"ref_24","first-page":"e3821","article-title":"Sinus Bradycardia and QT Interval Prolongation in West Nile Virus Encephalitis: A Case Report","volume":"11","author":"Ajam","year":"2019","journal-title":"Cureus"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.bbrc.2022.07.073","article-title":"The RNA-binding proteins CELF1 and ELAVL1 cooperatively control the alternative splicing of CD44","volume":"626","author":"David","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4331\/wjbc.v13.i2.35","article-title":"LIN28A: A multifunctional versatile molecule with future therapeutic potential","volume":"13","author":"Wu","year":"2022","journal-title":"World J. Biol. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41531-019-0090-8","article-title":"Infection with mosquito-borne alphavirus induces selective loss of dopaminergic neurons, neuroinflammation and widespread protein aggregation","volume":"5","author":"Bantle","year":"2019","journal-title":"npj Park. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e143948","DOI":"10.1172\/jci.insight.143948","article-title":"Matrin 3 in neuromuscular disease: Physiology and pathophysiology","volume":"6","author":"Malik","year":"2021","journal-title":"JCI Insight"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"696","DOI":"10.3724\/abbs.2022046","article-title":"PTBP1 promotes IRES-mediated translation of cyclin B1 in cancer","volume":"54","author":"Fan","year":"2022","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"110212","DOI":"10.1016\/j.mehy.2020.110212","article-title":"SARS-CoV-2 dysregulation of PTBP1 and YWHAE\/Z gene expression: A primer of neurodegeneration","volume":"144","author":"Vavougios","year":"2020","journal-title":"Med. Hypotheses"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"8916","DOI":"10.1074\/jbc.M114.551754","article-title":"The U4\/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination","volume":"289","author":"Long","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"17188","DOI":"10.1074\/jbc.AC119.010419","article-title":"The RNA-binding protein SART3 promotes miR-34a biogenesis and G1 cell cycle arrest in lung cancer cells","volume":"294","author":"Sherman","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Velasco, B.R., and Izquierdo, J.M. (2022). T-Cell Intracellular Antigen 1-Like Protein in Physiology and Pathology. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23147836"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1261\/rna.078279.120","article-title":"U2AF2 binds IL7R exon 6 ectopically and represses its inclusion","volume":"27","author":"Schott","year":"2021","journal-title":"RNA"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"27386","DOI":"10.1074\/jbc.M114.589432","article-title":"Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms","volume":"289","author":"Ishii","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_36","first-page":"642496","article-title":"Evidences suggesting involvement of viruses in oral squamous cell carcinoma","volume":"2013","author":"Gupta","year":"2013","journal-title":"Patholog. Res. Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e0019622","DOI":"10.1128\/mbio.00196-22","article-title":"Y-Box Binding Protein 1 Interacts with Dengue Virus Nucleocapsid and Mediates Viral Assembly","volume":"13","author":"Kennedy","year":"2022","journal-title":"mBio"},{"key":"ref_38","first-page":"158","article-title":"Coding and Non-Coding RNAs, as Male Fertility and Infertility Biomarkers","volume":"15","author":"Aliakbari","year":"2021","journal-title":"Int. J. Fertil. Steril."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"909341","DOI":"10.3389\/fimmu.2022.909341","article-title":"Human Testicular Germ Cells, a Reservoir for Zika Virus, Lack Antiviral Response Upon Zika or Poly(I:C) Exposure","volume":"13","author":"Kuassivi","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1017\/S1355838299990647","article-title":"Dissecting FMR1, the protein responsible for fragile X syndrome, in its structural and functional domains","volume":"5","author":"Adinolfi","year":"1999","journal-title":"RNA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"10976","DOI":"10.1128\/JVI.00846-11","article-title":"Heterogeneous nuclear ribonucleoprotein A2 participates in the replication of Japanese encephalitis virus through an interaction with viral proteins and RNA","volume":"85","author":"Katoh","year":"2011","journal-title":"J. Virol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1261\/rna.064006.117","article-title":"Identification and characterization of host proteins bound to dengue virus 3\u2032 UTR reveal an antiviral role for quaking proteins","volume":"24","author":"Liao","year":"2018","journal-title":"RNA"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Lim, Y.W., James, D., Huang, J., and Lee, M. (2020). The Emerging Role of the RNA-Binding Protein SFPQ in Neuronal Function and Neurodegeneration. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197151"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"610704","DOI":"10.3389\/fgene.2020.610704","article-title":"Investigation on Potential Correlation Between Small Nuclear Ribonucleoprotein Polypeptide A and Lung Cancer","volume":"11","author":"Yuan","year":"2021","journal-title":"Front. Genet."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.gene.2019.02.025","article-title":"RNA-binding protein RBM6 as a tumor suppressor gene represses the growth and progression in laryngocarcinoma","volume":"697","author":"Wang","year":"2019","journal-title":"Gene"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"9423","DOI":"10.1038\/s41598-021-88563-3","article-title":"Rbm24 displays dynamic functions required for myogenic differentiation during muscle regeneration","volume":"11","author":"Grifone","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tree.2016.09.012","article-title":"Urbanization and Disease Emergence: Dynamics at the Wildlife-Livestock-Human Interface","volume":"32","author":"Hassell","year":"2017","journal-title":"Trends Ecol. Evol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e20200355","DOI":"10.1590\/1678-4685-gmb-2020-0355","article-title":"Zoonotic spillover: Understanding basic aspects for better prevention","volume":"44","author":"Ellwanger","year":"2021","journal-title":"Genet. Mol. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s12088-020-00860-z","article-title":"Zoonosis: An Emerging Link to Antibiotic Resistance Under \u201cOne Health Approach\u201d","volume":"60","author":"Dafale","year":"2020","journal-title":"Indian J. Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Singh, K., Mehta, D., Dumka, S., Chauhan, A.S., and Kumar, S. (2023). Quasispecies Nature of RNA Viruses: Lessons from the Past. Vaccines, 11.","DOI":"10.3390\/vaccines11020308"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1128\/MMBR.05023-11","article-title":"Viral quasispecies evolution","volume":"76","author":"Domingo","year":"2012","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_52","unstructured":"Domingo, E., Escarm\u00eds, C., Men\u00e9ndez-Arias, L., Perales, C., Herrera, M., Novella, I.S., and Holland, J.J. (2008). Origin and Evolution Viruses, Academic Press."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e01031-17","DOI":"10.1128\/JVI.01031-17","article-title":"Complexities of Viral Mutation Rates","volume":"92","author":"Peck","year":"2018","journal-title":"J. Virol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s15010-021-01677-8","article-title":"SARS-CoV-2 spike protein: Pathogenesis, vaccines, and potential therapies","volume":"49","author":"Almehdi","year":"2021","journal-title":"Infection"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Pesti, R., Kontra, L., Paul, K., Vass, I., Csorba, T., Havelda, Z., and V\u00e1rallyay, \u00c9. (2019). Differential gene expression and physiological changes during acute or persistent plant virus interactions may contribute to viral symptom differences. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0216618"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.coviro.2017.03.001","article-title":"Within host RNA virus persistence: Mechanisms and consequences","volume":"23","author":"Randall","year":"2017","journal-title":"Curr. Opin. Virol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e37663","DOI":"10.7554\/eLife.37663","article-title":"Changes in mRNA abundance drive shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription","volume":"7","author":"Gilbertson","year":"2018","journal-title":"eLife"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s43141-022-00413-5","article-title":"An in silico pipeline approach uncovers a potentially intricate network involving spike SARS-CoV-2 RNA, RNA vaccines, host RNA-binding proteins (RBPs), and host miRNAs at the cellular level","volume":"20","author":"Chetta","year":"2022","journal-title":"J. Genet. Eng. Biotechnol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/nprot.2014.083","article-title":"Motif-based analysis of large nucleotide data sets using MEME-ChIP","volume":"9","author":"Ma","year":"2014","journal-title":"Nat. Protoc."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"R24","DOI":"10.1186\/gb-2007-8-2-r24","article-title":"Quantifying similarity between motifs","volume":"8","author":"Gupta","year":"2007","journal-title":"Genome Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: Protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1002\/cpz1.90","article-title":"Gene Set Knowledge Discovery with Enrichr","volume":"1","author":"Xie","year":"2021","journal-title":"Curr. Protoc."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Lundstrom, K. (2022). Alphaviruses in Immunotherapy and Anticancer Therapy. Biomedicines, 10.","DOI":"10.3390\/biomedicines10092263"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/13\/11051\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:05:37Z","timestamp":1760126737000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/13\/11051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,4]]},"references-count":63,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["ijms241311051"],"URL":"https:\/\/doi.org\/10.3390\/ijms241311051","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,4]]}}}