{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:59:46Z","timestamp":1785189586228,"version":"3.55.0"},"reference-count":63,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008993","name":"University of Zagreb","doi-asserted-by":"publisher","award":["20286437"],"award-info":[{"award-number":["20286437"]}],"id":[{"id":"10.13039\/100008993","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The aim of this study was to investigate the therapeutic potential of resveratrol in combination with cisplatin on the inhibition of tumour angiogenesis, growth, and macrophage polarization in mice bearing the solid form of an Ehrlich ascites tumour (EAT) that were exposed to whole-body hyperthermia treatment. In addition, we investigated whether a multimodal approach with hyperthermia and resveratrol could abolish cisplatin resistance in tumour cells through the modulation of histone deacetylase (HDAC) activity and levels of heat shock proteins (HSP70\/HSP90) and contribute to the direct toxicity of cisplatin on tumour cells. The tumour was induced by injecting 1 \u00d7 106 EAT cells subcutaneously (sc) into the thighs of Balb\/c mice. The mice were treated with resveratrol per os for five consecutive days beginning on day 2 after tumour injection and\/or by injecting cisplatin intraperitoneally (ip) at a dose of 2.5 mg\/kg on days 10 and 12 and at a dose of 5 mg\/kg on day 15. Immediately thereafter, the mice were exposed to systemic hyperthermia for 15 min at a temperature of 41 \u00b0C. The obtained results showed that the administration of resveratrol did not significantly contribute to the antitumour effect of cisplatin and hyperthermia, but it partially contributed to the immunomodulatory effect and to the reduction of cisplatin toxicity and to a slight increase in animal survival. This treatment schedule did not affect microvessel density, but it inhibited tumour growth and modulated macrophage polarization to the M1 phenotype. Furthermore, it abolished the resistance of tumour cells to cisplatin by modulating HDAC activity and the concentration of HSP70 and HSP90 chaperones, contributing to the increased lifespan of mice. However, the precise mechanism of the interaction between resveratrol, cisplatin, and hyperthermia needs to be investigated further.<\/jats:p>","DOI":"10.3390\/ijms241311073","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:33:42Z","timestamp":1688517222000},"page":"11073","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Role of Hyperthermia in Potentiation of Anti-Angiogenic Effect of Cisplatin and Resveratrol in Mice Bearing Solid Form of Ehrlich Ascites Tumour"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9259-3103","authenticated-orcid":false,"given":"Darko","family":"Ku\u010dan","sequence":"first","affiliation":[{"name":"Division of Abdominal Surgery and Organ Transplantation, Department of Surgery, University Hospital Merkur, Zaj\u010deva 19, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5102-3606","authenticated-orcid":false,"given":"Nada","family":"Or\u0161oli\u0107","sequence":"additional","affiliation":[{"name":"Division of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6182-755X","authenticated-orcid":false,"given":"Dyana","family":"Odeh","sequence":"additional","affiliation":[{"name":"Division of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5916-8815","authenticated-orcid":false,"given":"Snje\u017eana","family":"Rami\u0107","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Cancer Hospital, Sestre Milosrdnice University Hospital Centre, Ilica 197, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Jakopovi\u0107","sequence":"additional","affiliation":[{"name":"Dr Myko San\u2014Health from Mushrooms Co., Miramarska Cesta 109, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3152-3563","authenticated-orcid":false,"given":"Jelena","family":"Kne\u017eevi\u0107","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Ru\u0111er Bo\u0161kovi\u0107 Institute, Bijeni\u010dka Cesta 54, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5037-3919","authenticated-orcid":false,"given":"Maja","family":"Jazvin\u0161\u0107ak Jembrek","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Ru\u0111er Bo\u0161kovi\u0107 Institute, Bijeni\u010dka Cesta 54, 10000 Zagreb, Croatia"},{"name":"School of Medicine, Catholic University of Croatia, Ilica 242, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3389\/fonc.2018.00248","article-title":"Unraveling the Role of Angiogenesis in Cancer Ecosystems","volume":"8","author":"Casanovas","year":"2018","journal-title":"Front. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/BF03032599","article-title":"The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis","volume":"7","author":"John","year":"2001","journal-title":"Pathol. Oncol. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.matbio.2015.04.004","article-title":"Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature","volume":"44\u201346","author":"Deryugina","year":"2015","journal-title":"Matrix Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/bs.apha.2017.08.002","article-title":"Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease","volume":"81","author":"Wang","year":"2018","journal-title":"Adv. Pharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Teleanu, R.I., Chircov, C., Grumezescu, A.M., and Teleanu, D.M. (2019). Tumor Angiogenesis and Anti-Angiogenic Strategies for Cancer Treatment. J. Clin. Med., 9.","DOI":"10.3390\/jcm9010084"},{"key":"ref_6","first-page":"6445","article-title":"Quercetin and hyperthermia modulate cisplatin-induced DNA damage in tumor and normal tissues in vivo","volume":"7","author":"Car","year":"2014","journal-title":"Tumor Biol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Or\u0161oli\u0107, N., Odeh, D., Jembrek, M.J., Kne\u017eevi\u0107, J., and Ku\u010dan, D. (2020). Interactions between Cisplatin and Quercetin at Physiological and Hyperthermic Conditions on Cancer Cells In Vitro and In Vivo. Molecules, 25.","DOI":"10.3390\/molecules25143271"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1038\/sj.bjc.6600268","article-title":"Anti-angiogenic action of hyperthermia by suppressing gene expression and production of tumour-derived vascular endothelial growth factor in vivo and in vitro","volume":"86","author":"Sawaji","year":"2002","journal-title":"Br. J. Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"34048","DOI":"10.18632\/oncotarget.25954","article-title":"The antiangiogenic action of cisplatin on endothelial cells is mediated through the release of tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells","volume":"9","author":"Ramer","year":"2018","journal-title":"Oncotarget"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Bandolik, J.J., Hamacher, A., Schrenk, C., Weishaupt, R., and Kassack, M.U. (2019). Class I-Histone Deacetylase (HDAC) Inhibition is Superior to pan-HDAC Inhibition in Modulating Cisplatin Potency in High Grade Serous Ovarian Cancer Cell Lines. Int. J. Mol. Sci., 2.","DOI":"10.3390\/ijms20123052"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Chhabra, G., Singh, C.K., Amiri, D., Akula, N., and Ahmad, N. (2021). Recent Advancements on Immunomodulatory Mechanisms of Resveratrol in Tumor Microenvironment. Molecules, 26.","DOI":"10.3390\/molecules26051343"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Yang, M.D., Sun, Y., Zhou, W.J., Xie, X.Z., Zhou, Q.M., Lu, Y.Y., and Su, S.B. (2021). Resveratrol Enhances Inhibition Effects of Cisplatin on Cell Migration and Invasion and Tumor Growth in Breast Cancer MDA-MB-231 Cell Models In Vivo and In Vitro. Molecules, 26.","DOI":"10.3390\/molecules26082204"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1158\/1535-7163.MCT-05-0198","article-title":"Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1alpha and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells","volume":"4","author":"Zhang","year":"2005","journal-title":"Mol. Cancer Ther."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Venturelli, S., Berger, A., B\u00f6cker, A., Busch, C., Weiland, T., Noor, S., Leischner, C., Schleicher, S., Mayer, M., and Weiss, T.S. (2013). Resveratrol as a pan-HDAC inhibitor alters the acetylation status of histone proteins in human-derived hepatoblastoma cells. PLoS ONE, 8.","DOI":"10.1371\/annotation\/5b9a8614-1009-40ca-b90b-db817fe445c9"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7346","DOI":"10.1038\/sj.onc.1208879","article-title":"Inhibition of histone deacetylase 3 stimulates apoptosis induced by heat shock under acidic conditions in human maxillary cancer","volume":"24","author":"Narita","year":"2005","journal-title":"Oncogene"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Per\u0161e, M. (2021). Cisplatin Mouse Models: Treatment, Toxicity and Translatability. Biomedicines, 9.","DOI":"10.3390\/biomedicines9101406"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"115851","DOI":"10.1016\/j.taap.2021.115851","article-title":"Resveratrol and its nanocrystals: A promising approach for cancer therapy?","volume":"435","author":"Odeh","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.2174\/156652412803306666","article-title":"Dual Role of Heat Shock Proteins (HSPs) in Anti-Tumor Immunity","volume":"12","author":"Multhoff","year":"2012","journal-title":"Curr. Mol. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.2353\/ajpath.2008.080158","article-title":"Nitric oxide regulates tumor cell cross-talk with stromal cells in the tumor microenvironment of the liver","volume":"173","author":"Decker","year":"2008","journal-title":"Am. J. Pathol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.4161\/cc.5.21.3409","article-title":"Effects of histone deacetylase inhibitors on HIF-1","volume":"5","author":"Liang","year":"2006","journal-title":"Cell Cycle"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1364\/BOE.6.000544","article-title":"Digital separation of diaminobenzidine-stained tissues via an automatic color-filtering for immunohistochemical quantification","volume":"6","author":"Fu","year":"2015","journal-title":"Biomed. Opt. Express"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Pittayapruek, P., Meephansan, J., Prapapan, O., Komine, M., and Ohtsuki, M. (2016). Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17060868"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Sun, Y., Zhou, Q.M., Lu, Y.Y., Zhang, H., Chen, Q.L., Zhao, M., and Su, S.B. (2019). Resveratrol Inhibits the Migration and Metastasis of MDA-MB-231 Human Breast Cancer by Reversing TGF-\u03b21-Induced Epithelial-Mesenchymal Transition. Molecules, 24.","DOI":"10.3390\/molecules24061131"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.biopha.2005.06.001","article-title":"Effect of resveratrol on matrix metalloproteinase-2 (MMP-2) and Secreted Protein Acidic and Rich in Cysteine (SPARC) on human cultured glioblastoma cells","volume":"59","author":"Gagliano","year":"2005","journal-title":"Biomed. Pharmacother."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3892\/ol.2015.3888","article-title":"Resveratrol suppresses human glioblastoma cell migration and invasion via activation of RhoA\/ROCK signaling pathway","volume":"1","author":"Xiong","year":"2016","journal-title":"Oncol. Lett."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.canlet.2021.05.001","article-title":"Resveratrol for cancer therapy: Challenges and future perspectives","volume":"515","author":"Ren","year":"2021","journal-title":"Cancer Lett."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/pros.24029","article-title":"Resveratrol inhibits the tumor migration and invasion by upregulating TET1 and reducing TIMP2\/3 methylation in prostate carcinoma cells","volume":"80","author":"Wang","year":"2020","journal-title":"Prostate"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1387\/ijdb.041811af","article-title":"Matrix metalloproteinases in cancer: From new functions to improved inhibition strategies","volume":"48","author":"Folgueras","year":"2004","journal-title":"Int. J. Dev. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1002\/jps.23755","article-title":"Synergism between propolis and hyperthermal intraperitoneal chemotherapy with cisplatin on ehrlich ascites tumor in mice","volume":"102","author":"Car","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Lee, S., Son, B., Park, G., Kim, H., Kang, H., Jeon, J., Youn, H., and Youn, B. (2018). Immunogenic Effect of Hyperthermia on Enhancing Radiotherapeutic Efficacy. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092795"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1158\/1078-0432.CCR-13-3141","article-title":"Molecular Pathways: The Immunogenic Effects of Platinum-Based Chemotherapeutics","volume":"20","author":"Hato","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.3389\/fimmu.2019.01654","article-title":"Cytotoxic chemotherapy as an immune stimulus: A molecular perspective on turning up the immunological heat on cancer","volume":"10","author":"Opzoomer","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5384","DOI":"10.1158\/1078-0432.CCR-14-1298","article-title":"Cisplatin-Induced Antitumor Immunomodulation: A Review of Preclinical and Clinical Evidence","volume":"20","author":"Adusumilli","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1007\/s00262-008-0505-6","article-title":"Cancer chemotherapy: Not only a direct cytotoxic effect, but also an adjuvant for antitumor immunity","volume":"57","author":"Lionel","year":"2008","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nrc1256","article-title":"Tumour-educated macrophages promote tumour progression and metastasis","volume":"4","author":"Pollard","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3389\/fimmu.2014.00532","article-title":"Metabolism via arginase or nitric oxide synthase: Two competing arginine pathways in macrophages","volume":"5","author":"Rath","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Or\u0161oli\u0107, N., and Jazvin\u0161\u0107ak Jembrek, M. (2022). Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231810479"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.trecan.2017.07.005","article-title":"Nitric Oxide: The Forgotten Child of Tumor Metabolism","volume":"3","author":"Achreja","year":"2017","journal-title":"Trends Cancer"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Navasardyan, I., and Bonavida, B. (2021). Regulation of T Cells in Cancer by Nitric Oxide. Cells, 10.","DOI":"10.3390\/cells10102655"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Or\u0161oli\u0107, N., Kun\u0161ti\u0107, M., Kukolj, M., Odeh, D., and An\u010di\u0107, D. (2020). Natural Phenolic Acid, Product of the Honey Bee, for the Control of Oxidative Stress, Peritoneal Angiogenesis, and Tumor Growth in Mice. Molecules, 25.","DOI":"10.3390\/molecules25235583"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Giatromanolaki, A., Tsolou, A., Daridou, E., Kouroupi, M., Chlichlia, K., and Koukourakis, M.I. (2020). iNOS Expression by Tumor-Infiltrating Lymphocytes, PD-L1 and Prognosis in Non-Small-Cell Lung Cancer. Cancers, 12.","DOI":"10.3390\/cancers12113276"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Khan, F.H., Dervan, E., Bhattacharyya, D.D., McAuliffe, J.D., Miranda, K.M., and Glynn, S.A. (2020). The Role of Nitric Oxide in Cancer: Master Regulator or Not?. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249393"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"McGinity, C.L., Palmieri, E.M., Somasundaram, V., Bhattacharyya, D.D., Ridnour, L.A., Cheng, R.Y.S., Ryan, A.E., Glynn, S.A., Thomas, D.D., and Miranda, K.M. (2021). Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22137068"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nrc1910","article-title":"The role of nitric oxide in tumour progression","volume":"6","author":"Fukumura","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.1158\/0008-5472.CAN-04-4505","article-title":"Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: A mechanism of tumor evasion","volume":"65","author":"Zea","year":"2005","journal-title":"Cancer Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1600-065X.2008.00608.x","article-title":"Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: Mechanisms and therapeutic perspectives","volume":"222","author":"Ochoa","year":"2008","journal-title":"Immunol. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.immuni.2009.04.014","article-title":"The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment","volume":"30","author":"Delgoffe","year":"2009","journal-title":"Immunity"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.4049\/jimmunol.1302167","article-title":"Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses","volume":"193","author":"Sahin","year":"2014","journal-title":"J. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3389\/fimmu.2014.00614","article-title":"Molecular mechanisms that influence the macrophage m1-m2 polarization balance","volume":"5","author":"Wang","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/imm.12876","article-title":"Endoplasmic reticulum stress induced LOX-1+ CD15+ polymorphonuclear myeloid-derived suppressor cells in hepatocellular carcinoma","volume":"154","author":"Nan","year":"2018","journal-title":"Immunology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e129756","DOI":"10.1172\/jci.insight.129756","article-title":"Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues","volume":"4","author":"Lowe","year":"2019","journal-title":"JCI Insight"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"eabd7819","DOI":"10.1126\/sciadv.abd7819","article-title":"High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging","volume":"7","author":"Chen","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e125679","DOI":"10.1172\/jci.insight.125679","article-title":"Angiocrine signals regulate quiescence and therapy resistance in bone metastasis","volume":"4","author":"Singh","year":"2019","journal-title":"JCI Insight"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"41383","DOI":"10.1074\/jbc.M107566200","article-title":"TNFalpha and oxLDL reduce protein S-nitrosylation in endothelial cells","volume":"276","author":"Hoffmann","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2174\/092986706776360987","article-title":"Vascular dysfunction in aging: Potential effects of resveratrol, an anti-inflammatory phytoestrogen","volume":"13","author":"Labinskyy","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"8","DOI":"10.18632\/aging.102646","article-title":"Resveratrol targets PD-L1 glycosylation and dimerization to enhance antitumor T-cell immunity","volume":"12","author":"Verdura","year":"2020","journal-title":"Aging"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Ribatti, D., Solimando, A.G., and Pezzella, F. (2021). The Anti-VEGF(R) Drug Discovery Legacy: Improving Attrition Rates by Breaking the Vicious Cycle of Angiogenesis in Cancer. Cancers, 13.","DOI":"10.3390\/cancers13143433"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Ko, J.H., Sethi, G., Um, J.Y., Shanmugam, M.K., Arfuso, F., Kumar, A.P., Bishayee, A., and Ahn, K.S. (2017). The role of resveratrol in cancer therapy. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122589"},{"key":"ref_59","unstructured":"Narodne, N. (2013). Zakon o Izmjenama i Dopunama Zakona o Za\u0161titi \u017divotinja (Law on Amendments to the Law on Animal Welfare), Narodne Novine."},{"key":"ref_60","unstructured":"Narodne, N. (2013). Pravilnik o Za\u0161titi \u017divotnja Koje se Koriste u Znanstvene Svrhe (Regulation on the Protection of Animals Used for Scientific Purposes), Narodne Novine."},{"key":"ref_61","unstructured":"National Research Council (2011). Guide for the Care and Use of Laboratory Animals, National Academies Press. [8th ed.]."},{"key":"ref_62","first-page":"e3801","article-title":"Protocol for long duration whole body hyperthermia in mice","volume":"66","author":"Duhan","year":"2012","journal-title":"J. Vis. Exp."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF00666038","article-title":"Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors","volume":"36","author":"Weidner","year":"1995","journal-title":"Breast Cancer Res. Treat."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/13\/11073\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:05:57Z","timestamp":1760126757000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/13\/11073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,4]]},"references-count":63,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["ijms241311073"],"URL":"https:\/\/doi.org\/10.3390\/ijms241311073","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,4]]}}}