{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:02:59Z","timestamp":1791856979951,"version":"4.3.4"},"reference-count":64,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UNAM-PAPIIT","award":["IA202021"],"award-info":[{"award-number":["IA202021"]}]},{"name":"UNAM-PAPIIT","award":["IA205423"],"award-info":[{"award-number":["IA205423"]}]},{"name":"UNAM-PAPIIT","award":["IN206322"],"award-info":[{"award-number":["IN206322"]}]},{"name":"UNAM-PAPIIT","award":["319433"],"award-info":[{"award-number":["319433"]}]},{"DOI":"10.13039\/501100003141","name":"Ciencia B\u00e1sica y\/o Ciencia de Frontera Modalidad: Paradigmas y Controversias de la Ciencia 2022","doi-asserted-by":"publisher","award":["IA202021"],"award-info":[{"award-number":["IA202021"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Ciencia B\u00e1sica y\/o Ciencia de Frontera Modalidad: Paradigmas y Controversias de la Ciencia 2022","doi-asserted-by":"publisher","award":["IA205423"],"award-info":[{"award-number":["IA205423"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Ciencia B\u00e1sica y\/o Ciencia de Frontera Modalidad: Paradigmas y Controversias de la Ciencia 2022","doi-asserted-by":"publisher","award":["IN206322"],"award-info":[{"award-number":["IN206322"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Ciencia B\u00e1sica y\/o Ciencia de Frontera Modalidad: Paradigmas y Controversias de la Ciencia 2022","doi-asserted-by":"publisher","award":["319433"],"award-info":[{"award-number":["319433"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is the most common neurodegenerative disorder worldwide. Histopathologically, AD presents two pathognomonic hallmarks: (1) neurofibrillary tangles, characterized by intracellular deposits of hyperphosphorylated tau protein, and (2) extracellular amyloid deposits (amyloid plaques) in the brain vasculature (cerebral amyloid angiopathy; CAA). It has been proposed that vascular amyloid deposits could trigger neurovascular unit (NVU) dysfunction in AD. The NVU is composed primarily of astrocytic feet, endothelial cells, pericytes, and basement membrane. Although physical exercise is hypothesized to have beneficial effects against AD, it is unknown whether its positive effects extend to ameliorating CAA and improving the physiology of the NVU. We used the triple transgenic animal model for AD (3xTg-AD) at 13 months old and analyzed through behavioral and histological assays, the effect of voluntary physical exercise on cognitive functions, amyloid angiopathy, and the NVU. Our results show that 3xTg-AD mice develop vascular amyloid deposits which correlate with cognitive deficits and NVU alteration. Interestingly, the physical exercise regimen decreases amyloid angiopathy and correlates with an improvement in cognitive function as well as in the underlying integrity of the NVU components. Physical exercise could represent a key therapeutic approach in cerebral amyloid angiopathy and NVU stability in AD patients.<\/jats:p>","DOI":"10.3390\/ijms241311134","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:34:30Z","timestamp":1688603670000},"page":"11134","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effects of Voluntary Physical Exercise on the Neurovascular Unit in a Mouse Model of Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0574-8814","authenticated-orcid":false,"given":"Jes\u00fas","family":"Andrade-Guerrero","sequence":"first","affiliation":[{"name":"Laboratorio de Patog\u00e9nesis Molecular, Laboratorio 4, Edificio A4, Carrera M\u00e9dico Cirujano, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Tlalnepantla 54090, Mexico"},{"name":"Departamento de Neurobiolog\u00eda del Desarrollo y Neurofisiolog\u00eda, Instituto de Neurobiolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Quer\u00e9taro 76230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Orta-Salazar","sequence":"additional","affiliation":[{"name":"Departamento de Neurobiolog\u00eda del Desarrollo y Neurofisiolog\u00eda, Instituto de Neurobiolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Quer\u00e9taro 76230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Citlaltepetl","family":"Salinas-Lara","sequence":"additional","affiliation":[{"name":"Red MEDICI, Carrera M\u00e9dico Cirujano, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Tlalnepantla 54090, Mexico"},{"name":"Departamento de Neuropatolog\u00eda, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Su\u00e1rez, Ciudad de M\u00e9xico 14269, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0637-5239","authenticated-orcid":false,"given":"Carlos","family":"S\u00e1nchez-Garibay","sequence":"additional","affiliation":[{"name":"Departamento de Neuropatolog\u00eda, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Su\u00e1rez, Ciudad de M\u00e9xico 14269, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Daniel","family":"Rodr\u00edguez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratorio de Patog\u00e9nesis Molecular, Laboratorio 4, Edificio A4, Carrera M\u00e9dico Cirujano, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Tlalnepantla 54090, Mexico"},{"name":"Red MEDICI, Carrera M\u00e9dico Cirujano, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Tlalnepantla 54090, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Vargas-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Departamento de Neurobiolog\u00eda del Desarrollo y Neurofisiolog\u00eda, Instituto de Neurobiolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Quer\u00e9taro 76230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayeli","family":"Barron-Leon","sequence":"additional","affiliation":[{"name":"Departamento de Neurobiolog\u00eda del Desarrollo y Neurofisiolog\u00eda, Instituto de Neurobiolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Quer\u00e9taro 76230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Ledesma-Alonso","sequence":"additional","affiliation":[{"name":"Departamento de Neurobiolog\u00eda del Desarrollo y Neurofisiolog\u00eda, Instituto de Neurobiolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Quer\u00e9taro 76230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda","family":"Diaz-Cintra","sequence":"additional","affiliation":[{"name":"Departamento de Neurobiolog\u00eda del Desarrollo y Neurofisiolog\u00eda, Instituto de Neurobiolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Quer\u00e9taro 76230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5013-3608","authenticated-orcid":false,"given":"Luis O.","family":"Soto-Rojas","sequence":"additional","affiliation":[{"name":"Laboratorio de Patog\u00e9nesis Molecular, Laboratorio 4, Edificio A4, Carrera M\u00e9dico Cirujano, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Tlalnepantla 54090, Mexico"},{"name":"Red MEDICI, Carrera M\u00e9dico Cirujano, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Tlalnepantla 54090, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"key":"ref_1","unstructured":"(2023, June 10). 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