{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:39:48Z","timestamp":1790998788036,"version":"4.1.0"},"reference-count":266,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["ISRM\/12(61)2019"],"award-info":[{"award-number":["ISRM\/12(61)2019"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ICMR-National Institute of Traditional Medicine","award":["ISRM\/12(61)2019"],"award-info":[{"award-number":["ISRM\/12(61)2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Hepatitis B infection caused by the hepatitis B virus is a life-threatening cause of liver fibrosis, cirrhosis, and hepatocellular carcinoma. Researchers have produced multiple in vivo models for hepatitis B virus (HBV) and, currently, there are no specific laboratory animal models available to study HBV pathogenesis or immune response; nonetheless, their limitations prevent them from being used to study HBV pathogenesis, immune response, or therapeutic methods because HBV can only infect humans and chimpanzees. The current study is the first of its kind to identify a suitable chemically induced liver cirrhosis\/HCC model that parallels HBV pathophysiology. Initially, data from the peer-reviewed literature and the GeneCards database were compiled to identify the genes that HBV and seven drugs (acetaminophen, isoniazid, alcohol, D-galactosamine, lipopolysaccharide, thioacetamide, and rifampicin) regulate. Functional enrichment analysis was performed in the STRING server. The network HBV\/Chemical, genes, and pathways were constructed by Cytoscape 3.6.1. About 1546 genes were modulated by HBV, of which 25.2% and 17.6% of the genes were common for alcohol and lipopolysaccharide-induced hepatitis. In accordance with the enrichment analysis, HBV activates the signaling pathways for apoptosis, cell cycle, PI3K-Akt, TNF, JAK-STAT, MAPK, chemokines, NF-kappa B, and TGF-beta. In addition, alcohol and lipopolysaccharide significantly activated these pathways more than other chemicals, with higher gene counts and lower FDR scores. In conclusion, alcohol-induced hepatitis could be a suitable model to study chronic HBV infection and lipopolysaccharide-induced hepatitis for an acute inflammatory response to HBV.<\/jats:p>","DOI":"10.3390\/ijms241311146","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T01:41:36Z","timestamp":1688694096000},"page":"11146","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["System Biology Investigation Revealed Lipopolysaccharide and Alcohol-Induced Hepatocellular Carcinoma Resembled Hepatitis B Virus Immunobiology and Pathogenesis"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1219-1962","authenticated-orcid":false,"given":"Vishal S.","family":"Patil","sequence":"first","affiliation":[{"name":"ICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi 590010, India"},{"name":"KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research, Belagavi 590010, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3609-549X","authenticated-orcid":false,"given":"Darasaguppe R.","family":"Harish","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi 590010, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh H.","family":"Sampat","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi 590010, India"},{"name":"KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research, Belagavi 590010, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6594-8615","authenticated-orcid":false,"given":"Subarna","family":"Roy","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi 590010, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7598-5973","authenticated-orcid":false,"given":"Sunil S.","family":"Jalalpure","sequence":"additional","affiliation":[{"name":"KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research, Belagavi 590010, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8187-2120","authenticated-orcid":false,"given":"Pukar","family":"Khanal","sequence":"additional","affiliation":[{"name":"KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research, Belagavi 590010, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swarup S.","family":"Gujarathi","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi 590010, India"},{"name":"KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research, Belagavi 590010, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsha V.","family":"Hegde","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi 590010, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1002\/hep.22881","article-title":"Hepatitis B: The virus and disease","volume":"49","author":"Liang","year":"2009","journal-title":"Hepatology"},{"key":"ref_2","first-page":"69","article-title":"Hepatitis B Virus\u2014Related Hepatocellular Hepatitis Hepatocellular Carcinoma: Carcinoma: Carcinogenesis, Prevention, and Treatment","volume":"13","author":"Niu","year":"2017","journal-title":"Updates Liver Cancer"},{"key":"ref_3","unstructured":"(2022, March 06). 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