{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:18:41Z","timestamp":1792603121590,"version":"4.5.0"},"reference-count":59,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"SATT Nord de France"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Photodynamic therapy (PDT) has shown improvements in cancer treatment and in the induction of a proper anti-tumor immune response. However, current photosensitizers (PS) lack tumor specificity, resulting in reduced efficacy and side effects in patients with intraperitoneal ovarian cancer (OC). In order to target peritoneal metastases of OC, which overexpress folate receptor (FR\u03b1) in 80% of cases, we proposed a targeted PDT using a PS coupled with folic acid. Herein, we applied this targeted PDT in an in vivo mouse model of peritoneal ovarian carcinomatosis. The efficacy of the treatment was evaluated in mice without and with human peripheral blood mononuclear cell (PBMC) reconstitution. When mice were reconstituted, using a fractionized PDT protocol led to a significantly higher decrease in the tumor growth than that obtained in the non-reconstituted mice (p = 0.0469). Simultaneously, an immune response was reflected by an increase in NK cells, and both CD4+ and CD8+ T cells were activated. A promotion in cytokines IFN\u03b3 and TNF\u03b1 and an inhibition in cytokines TGF\u03b2, IL-8, and IL-10 was also noticed. Our work showed that a fractionized FR\u03b1-targeted PDT protocol is effective for the treatment of OC and goes beyond local induction of tumor cell death, with the promotion of a subsequent anti-tumor response.<\/jats:p>","DOI":"10.3390\/ijms241411288","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T01:40:02Z","timestamp":1689039602000},"page":"11288","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Folate Receptor Targeted Photodynamic Therapy: A Novel Way to Stimulate Anti-Tumor Immune Response in Intraperitoneal Ovarian Cancer"],"prefix":"10.3390","volume":"24","author":[{"given":"Martha","family":"Baydoun","sequence":"first","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, U1189-ONCOTHAI-Assisted Laser Therapy and Immunotherapy for Oncology, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"Boidin","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, U1189-ONCOTHAI-Assisted Laser Therapy and Immunotherapy for Oncology, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Leroux","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, U1189-ONCOTHAI-Assisted Laser Therapy and Immunotherapy for Oncology, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sophie","family":"Vignion-Dewalle","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, U1189-ONCOTHAI-Assisted Laser Therapy and Immunotherapy for Oncology, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Quilbe","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, U1189-ONCOTHAI-Assisted Laser Therapy and Immunotherapy for Oncology, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume Paul","family":"Grolez","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, U1189-ONCOTHAI-Assisted Laser Therapy and Immunotherapy for Oncology, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6855-9754","authenticated-orcid":false,"given":"Henri","family":"Aza\u00efs","sequence":"additional","affiliation":[{"name":"Department of Gynecological and Breast Surgery and Oncology, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Piti\u00e9-Salp\u00eatri\u00e8re University Hospital, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7659-3864","authenticated-orcid":false,"given":"C\u00e9line","family":"Frochot","sequence":"additional","affiliation":[{"name":"Laboratoire des R\u00e9actions et G\u00e9nie des Proc\u00e9d\u00e9s (LRGP), CNRS-Universit\u00e9 de Lorraine, 1 Rue Grandville, 54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Moral\u00e8s","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, U1189-ONCOTHAI-Assisted Laser Therapy and Immunotherapy for Oncology, 59000 Lille, France"},{"name":"INSERM UMR9020-UMR-S 1277\u2013Canther\u2013Cancer Heterogeneity, Plasticity and Resistance to Therapies, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadira","family":"Delhem","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, U1189-ONCOTHAI-Assisted Laser Therapy and Immunotherapy for Oncology, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1186\/s40425-019-0826-3","article-title":"Immunogenic Cell Death Induced by a New Photodynamic Therapy Based on Photosens and Photodithazine","volume":"7","author":"Turubanova","year":"2019","journal-title":"J. Immunother. 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