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Considering the elevated number of accidents and high morbidity and mortality rates, the World Health Organization reclassified this disease to category A of neglected diseases. In Latin America, Bothrops genus snakes are mainly responsible for snakebites in humans, whose pathophysiology is characterized by local and systemic inflammatory and degradative processes, triggering prothrombotic and hemorrhagic events, which lead to various complications, organ damage, tissue loss, amputations, and death. The activation of the multicellular blood system, hemostatic alterations, and activation of the inflammatory response are all well-documented in Bothrops envenomings. However, the interface between inflammation and coagulation is still a neglected issue in the toxinology field. Thromboinflammatory pathways can play a significant role in some of the major complications of snakebite envenoming, such as stroke, venous thromboembolism, and acute kidney injury. In addition to exacerbating inflammation and cell interactions that trigger vaso-occlusion, ischemia\u2013reperfusion processes, and, eventually, organic damage and necrosis. In this review, we discuss the role of inflammatory pathways in modulating coagulation and inducing platelet and leukocyte activation, as well as the inflammatory production mediators and induction of innate immune responses, among other mechanisms that are altered by Bothrops venoms.<\/jats:p>","DOI":"10.3390\/ijms241411508","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:35:04Z","timestamp":1689554104000},"page":"11508","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Crosstalk of Inflammation and Coagulation in Bothrops Snakebite Envenoming: Endogenous Signaling Pathways and Pathophysiology"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5712-9137","authenticated-orcid":false,"given":"Joeliton S.","family":"Cavalcante","sequence":"first","affiliation":[{"name":"Graduate Program in Tropical Diseases, Botucatu Medical School (FMB), S\u00e3o Paulo State University (UNESP\u2014Univ Estadual Paulista), Botucatu 18618-687, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis Emanuel Garcia","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Department of Bioprocess and Biotechnology, School of Agriculture, Agronomic Sciences School, S\u00e3o Paulo State University (UNESP\u2014Univ Estadual Paulista), Botucatu 18618-687, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0344-6900","authenticated-orcid":false,"given":"Norival A.","family":"Santos-Filho","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, S\u00e3o Paulo State University (UNESP\u2014Univ Estadual Paulista), Araraquara 14800-900, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4572-3109","authenticated-orcid":false,"given":"Marco Aur\u00e9lio","family":"Sartim","sequence":"additional","affiliation":[{"name":"Laboratory of Bioprospection, University Nilton Lins, Manaus 69058-030, Amazonas, Brazil"},{"name":"Research & Development Department, Nilton Lins Foundation, Manaus 69058-030, Amazonas, Brazil"},{"name":"Graduate Program in Tropical Medicine, Department of Research at Funda\u00e7\u00e3o de Medicina Tropical Dr. Heitor Vieira Dourado, Amazonas State University, Manaus 69850-000, Amazonas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"de Almeida Baldo","sequence":"additional","affiliation":[{"name":"Institute of Biosciences, S\u00e3o Paulo State University (UNESP\u2014Univ Estadual Paulista), Botucatu 18618-687, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisele","family":"Brasileiro","sequence":"additional","affiliation":[{"name":"Graduate Program in Tropical Medicine, Department of Research at Funda\u00e7\u00e3o de 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Amazonas, Brazil"},{"name":"Graduate Program in Tropical Medicine, Department of Research at Funda\u00e7\u00e3o de Medicina Tropical Dr. Heitor Vieira Dourado, Amazonas State University, Manaus 69850-000, Amazonas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0848-1940","authenticated-orcid":false,"given":"Wuelton Marcelo","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Research & Development Department, Nilton Lins Foundation, Manaus 69058-030, Amazonas, Brazil"},{"name":"Graduate Program in Tropical Medicine, Department of Research at Funda\u00e7\u00e3o de Medicina Tropical Dr. Heitor Vieira Dourado, Amazonas State University, Manaus 69850-000, Amazonas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6952-0512","authenticated-orcid":false,"suffix":"Jr.","given":"Rui Seabra","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Graduate Program in Tropical Diseases, Botucatu Medical School (FMB), S\u00e3o Paulo State University (UNESP\u2014Univ Estadual Paulista), Botucatu 18618-687, S\u00e3o Paulo, Brazil"},{"name":"Center for Translational Science and Development of Biopharmaceuticals FAPESP\/CEVAP-UNESP, Botucatu 18610-307, S\u00e3o Paulo, Brazil"},{"name":"Center for the Study of Venoms and Venomous Animals (CEVAP), S\u00e3o Paulo State University (UNESP\u2014Univ Estadual Paulista), Botucatu 18610-307, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40409-017-0127-6","article-title":"Snakebite Envenomation Turns Again into a Neglected Tropical Disease!","volume":"23","author":"Chippaux","year":"2017","journal-title":"J. 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