{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:23:11Z","timestamp":1760149391695,"version":"build-2065373602"},"reference-count":54,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007546","name":"French Agency for Food, Environmental and Occupational Health &amp; Safety","doi-asserted-by":"publisher","award":["EST-2016 RF-01"],"award-info":[{"award-number":["EST-2016 RF-01"]}],"id":[{"id":"10.13039\/501100007546","id-type":"DOI","asserted-by":"publisher"}]},{"name":"INSERM","award":["EST-2016 RF-01"],"award-info":[{"award-number":["EST-2016 RF-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Environmental stress can disturb the integrative functioning of the cardiovascular system and trigger a number of adaptive and\/or maladaptive cell responses. Concomitant with the expanding use of mobile communication systems, public exposure to electromagnetic fields (EMFs) raises the question of the impact of 900 MHz EMFs on cardiovascular health. Therefore, in this study, we experimentally investigated whether 915 MHz EMF exposure influenced cardiac metabolic, antioxidant, apoptotic, and fibro-inflammatory profiles in a mouse model. Healthy mice were sham-exposed or exposed to EMF for 14 days. Western blot analysis using whole cardiac tissue lysates demonstrated that there was no significant change in the expression of oxidative phosphorylation (OXPHOS) complexes between the control and EMF-exposed mice. In addition, the myocardial expression of fibro-inflammatory cytokines, antioxidant enzymes, and apoptosis-related markers remained unchanged in the EMF-challenged hearts. Finally, the structural integrity of the cardiac tissues was preserved among the groups. These findings suggest that the apoptotic, antioxidant, metabolic, and fibro-inflammatory profiles of the heart remained stable under conditions of EMF exposure in the analyzed mice.<\/jats:p>","DOI":"10.3390\/ijms241411709","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T01:52:35Z","timestamp":1689904355000},"page":"11709","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metabolic, Apoptotic and Fibro-Inflammatory Profiles of the Heart Exposed to Environmental Electromagnetic Fields"],"prefix":"10.3390","volume":"24","author":[{"given":"Lesia","family":"Savchenko","sequence":"first","affiliation":[{"name":"National Institute of Health and Medical Research (INSERM) U1297, CEDEX 4, 31432 Toulouse, France"},{"name":"University Toulouse III, 118 Route de Narbonne, CEDEX 9, 31062 Toulouse, France"},{"name":"Poltava State Medical University, 23 Shevchenko, 36000 Poltava, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7702-7784","authenticated-orcid":false,"given":"Ilenia","family":"Martinelli","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research (INSERM) U1297, CEDEX 4, 31432 Toulouse, France"},{"name":"University Toulouse III, 118 Route de Narbonne, CEDEX 9, 31062 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5518-5514","authenticated-orcid":false,"given":"Dimitri","family":"Marsal","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research (INSERM) U1297, CEDEX 4, 31432 Toulouse, France"},{"name":"University Toulouse III, 118 Route de Narbonne, CEDEX 9, 31062 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6724-2651","authenticated-orcid":false,"given":"Oksana","family":"Batkivska","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research (INSERM) U1297, CEDEX 4, 31432 Toulouse, France"},{"name":"Department of Functional and Laboratory Diagnostics, I. Horbachevsky Ternopil National Medical University, 1 Maidan Voli, 46001 Ternopil, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vyacheslav","family":"Zhdan","sequence":"additional","affiliation":[{"name":"Poltava State Medical University, 23 Shevchenko, 36000 Poltava, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Kaidashev","sequence":"additional","affiliation":[{"name":"Poltava State Medical University, 23 Shevchenko, 36000 Poltava, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Pizzinat","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research (INSERM) U1297, CEDEX 4, 31432 Toulouse, France"},{"name":"University Toulouse III, 118 Route de Narbonne, CEDEX 9, 31062 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7607-4573","authenticated-orcid":false,"given":"Frederic","family":"Boal","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research (INSERM) U1297, CEDEX 4, 31432 Toulouse, France"},{"name":"University Toulouse III, 118 Route de Narbonne, CEDEX 9, 31062 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6117-8054","authenticated-orcid":false,"given":"Helene","family":"Tronchere","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research (INSERM) U1297, CEDEX 4, 31432 Toulouse, France"},{"name":"University Toulouse III, 118 Route de Narbonne, CEDEX 9, 31062 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junwu","family":"Tao","sequence":"additional","affiliation":[{"name":"University Toulouse III, 118 Route de Narbonne, CEDEX 9, 31062 Toulouse, France"},{"name":"LAPLACE, INP-ENSEEIHT, 2 Rue Camichel, 31071 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana","family":"Kunduzova","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research (INSERM) U1297, CEDEX 4, 31432 Toulouse, France"},{"name":"University Toulouse III, 118 Route de Narbonne, CEDEX 9, 31062 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00484-020-01885-1","article-title":"Possible molecular and cellular mechanisms at the basis of atmospheric electromagnetic field bioeffects","volume":"65","author":"Cifra","year":"2021","journal-title":"Int. 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