{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:21:03Z","timestamp":1760149263211,"version":"build-2065373602"},"reference-count":121,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2021R1A2C1008804"],"award-info":[{"award-number":["NRF-2021R1A2C1008804"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Psoriasis is a chronic inflammatory skin disease characterized by cutaneous eruptions and pruritus. Because the genetic backgrounds of psoriasis are only partially revealed, an integrative and rigorous study is necessary. We conducted a transcriptome-wide association study (TWAS) with the new Genotype-Tissue Expression version 8 reference panels, including some tissue and multi-tissue panels that were not used previously. We performed tissue-specific heritability analyses on genome-wide association study data to prioritize the tissue panels for TWAS analysis. TWAS and colocalization (COLOC) analyses were performed with eight tissues from the single-tissue panels and the multi-tissue panels of context-specific genetics (CONTENT) to increase tissue specificity and statistical power. From TWAS, we identified the significant associations of 101 genes in the single-tissue panels and 64 genes in the multi-tissue panels, of which 26 genes were replicated in the COLOC. Functional annotation and network analyses identified that the genes were associated with psoriasis and\/or immune responses. We also suggested drug candidates that interact with jointly significant genes through a conditional and joint analysis. Together, our findings may contribute to revealing the underlying genetic mechanisms and provide new insights into treatments for psoriasis.<\/jats:p>","DOI":"10.3390\/ijms241411717","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T01:52:35Z","timestamp":1689904355000},"page":"11717","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Transcriptome-Wide Analysis of Psoriasis: Identifying the Potential Causal Genes and Drug Candidates"],"prefix":"10.3390","volume":"24","author":[{"given":"Yeonbin","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Life Sciences, Dongguk University, Seoul 04620, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2247-3194","authenticated-orcid":false,"given":"Jaeseung","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Dongguk University, Seoul 04620, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yubin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Dongguk University, Seoul 04620, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunyoung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Dongguk University, Seoul 04620, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngtae","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Dongguk University, Seoul 04620, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byunghyuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Dongguk University-Seoul, Goyang 10326, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wonhee","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Dongguk University, Seoul 04620, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","article-title":"Psoriasis","volume":"386","author":"Boehncke","year":"2015","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.autrev.2014.01.008","article-title":"Diagnosis and classification of psoriasis","volume":"13","author":"Raychaudhuri","year":"2014","journal-title":"Autoimmun. 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