{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:33:01Z","timestamp":1791495181212,"version":"4.3.4"},"reference-count":77,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Endothelial and epithelial cells are morphologically different and play a critical role in host defense during Candida albicans infection. Both cells respond to C. albicans infection by activating various signaling pathways and gene expression patterns. Their interactions with these pathogens can have beneficial and detrimental effects, and a better understanding of these interactions can help guide the development of new therapies for C. albicans infection. To identify the differences and similarities between human endothelial and oral epithelial cell transcriptomics during C. albicans infection, we performed consensus WGCNA on 32 RNA-seq samples by relating the consensus modules to endothelial-specific modules and analyzing the genes connected. This analysis resulted in the identification of 14 distinct modules. We demonstrated that the magenta module correlates significantly with C. albicans infection in each dataset. In addition, we found that the blue and cyan modules in the two datasets had opposite correlation coefficients with a C. albicans infection. However, the correlation coefficients and p-values between the two datasets were slightly different. Functional analyses of the hub of genes from endothelial cells elucidated the enrichment in TNF, AGE-RAGE, MAPK, and NF-\u03baB signaling. On the other hand, glycolysis, pyruvate metabolism, amino acid, fructose, mannose, and vitamin B6 metabolism were enriched in epithelial cells. However, mitophagy, necroptosis, apoptotic processes, and hypoxia were enriched in both endothelial and epithelial cells. Protein\u2013protein interaction analysis using STRING and CytoHubba revealed STAT3, SNRPE, BIRC2, and NFKB2 as endothelial hub genes, while RRS1, SURF6, HK2, and LDHA genes were identified in epithelial cells. Understanding these similarities and differences may provide new insights into the pathogenesis of C. albicans infections and the development of new therapeutic targets and interventional strategies.<\/jats:p>","DOI":"10.3390\/ijms241411748","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:47:03Z","timestamp":1690159623000},"page":"11748","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Consensus Gene Network Analysis Identifies the Key Similarities and Differences in Endothelial and Epithelial Cell Dynamics after Candida albicans Infection"],"prefix":"10.3390","volume":"24","author":[{"given":"Surabhi","family":"Naik","sequence":"first","affiliation":[{"name":"Department of Surgery, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8093-8637","authenticated-orcid":false,"given":"Akram","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Center for Biomedical Informatics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Alonso-Monge, R., Gresnigt, M.S., Rom\u00e1n, E., Hube, B., and Pla, J. (2021). Candida albicans Colonization of the Gastrointestinal Tract: A Double-Edged Sword. PLoS Pathog., 17.","DOI":"10.1371\/journal.ppat.1009710"},{"key":"ref_2","unstructured":"(2023, February 20). Candida Infections of the Mouth, Throat, and Esophagus |Fungal Diseases| CDC, Available online: https:\/\/www.cdc.gov\/fungal\/diseases\/candidiasis\/thrush\/index.html."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1093\/infdis\/jiz365","article-title":"Vaginal Epithelial Cells Discriminate Between Yeast and Hyphae of Candida in Women Who Are Colonized or Have Vaginal Candidiasis","volume":"220","author":"Roselletti","year":"2019","journal-title":"J. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/femspd\/ftx029","article-title":"The Significance of Candida in the Human Respiratory Tract: Our Evolving Understanding","volume":"75","author":"Pendleton","year":"2017","journal-title":"Pathog. Dis."},{"key":"ref_5","unstructured":"(2023, February 20). About Invasive Candidiasis |Invasive Candidiasis| Candidiasis |Types of Diseases|Fungal Diseases| CDC, Available online: https:\/\/www.cdc.gov\/fungal\/diseases\/candidiasis\/invasive\/definition.html."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"18026","DOI":"10.1038\/nrdp.2018.26","article-title":"Invasive Candidiasis","volume":"4","author":"Pappas","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/jac\/dkz400","article-title":"Molecular and Genetic Basis of Azole Antifungal Resistance in the Opportunistic Pathogenic Fungus Candida albicans","volume":"75","author":"Nishimoto","year":"2020","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"68S","DOI":"10.1592\/phco.26.6part2.68S","article-title":"Candida Resistance and Its Clinical Relevance","volume":"26","author":"Klepser","year":"2006","journal-title":"Pharmacotherapy"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1101\/gr.187427.114","article-title":"New Signaling Pathways Govern the Host Response to C. albicans Infection in Various Niches","volume":"125","author":"Liu","year":"2015","journal-title":"Genome Res."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"W\u00e4chtler, B., Citiulo, F., Jablonowski, N., F\u00f6rster, S., Dalle, F., Schaller, M., Wilson, D., and Hube, B. (2012). Candida albicans-Epithelial Interactions: Dissecting the Roles of Active Penetration, Induced Endocytosis and Host Factors on the Infection Process. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0036952"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1086\/589516","article-title":"Transcriptome Profile of the Vascular Endothelial Cell Response to Candida albicans","volume":"198","author":"Barker","year":"2008","journal-title":"J. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1128\/IAI.00332-08","article-title":"Candida albicans-Endothelial Cell Interactions: A Key Step in the Pathogenesis of Systemic Candidiasis","volume":"76","author":"Grubb","year":"2008","journal-title":"Infect. Immun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.4049\/jimmunol.1600823","article-title":"Endothelial MAPKs Direct ICAM-1 Signaling to Divergent Inflammatory Functions","volume":"198","author":"Dragoni","year":"2017","journal-title":"J. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Kong, D.H., Kim, Y.K., Kim, M.R., Jang, J.H., and Lee, S. (2018). Emerging Roles of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Immunological Disorders and Cancer. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19041057"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1128\/iai.63.3.976-983.1995","article-title":"Penetration and Damage of Endothelial Cells by Candida albicans","volume":"63","author":"Filler","year":"1995","journal-title":"Infect. Immun."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e00915-18","DOI":"10.1128\/mBio.00915-18","article-title":"Candida albicans-Induced Epithelial Damage Mediates Translocation through Intestinal Barriers","volume":"9","author":"Allert","year":"2018","journal-title":"mBio"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"958480","DOI":"10.3389\/froh.2022.958480","article-title":"Antimicrobial Peptides: Defending the Mucosal Epithelial Barrier","volume":"3","author":"Johnstone","year":"2022","journal-title":"Front. Oral Health"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1080\/21505594.2015.1012981","article-title":"Candida albicans-Epithelial Interactions and Pathogenicity Mechanisms: Scratching the Surface","volume":"6","author":"Moyes","year":"2015","journal-title":"Virulence"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3389\/fcimb.2021.666900","article-title":"Antimicrobial Peptides Human Beta-Defensin-2 and -3 Protect the Gut During Candida albicans Infections Enhancing the Intestinal Barrier Integrity: In Vitro Study","volume":"11","author":"Fusco","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.cell.2011.08.015","article-title":"Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection","volume":"146","author":"Teijaro","year":"2011","journal-title":"Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1128\/IAI.73.8.4588-4595.2005","article-title":"Invasive Phenotype of Candida albicans Affects the Host Proinflammatory Response to Infection","volume":"73","author":"Villar","year":"2005","journal-title":"Infect. Immun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"639","DOI":"10.2217\/fmb.12.28","article-title":"Invasive Fungal Infections in Solid Organ Transplant Recipients","volume":"7","author":"Shoham","year":"2012","journal-title":"Future Microbiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e13623","DOI":"10.1111\/ctr.13623","article-title":"Candida Infections in Solid Organ Transplantation: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice","volume":"33","author":"Aslam","year":"2019","journal-title":"Clin. Transplant."},{"key":"ref_24","unstructured":"Barros, N., and Mansour, M.K. (2021). Emerging Transplant Infections, Springer."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"917636","DOI":"10.3389\/fgene.2022.917636","article-title":"Coexpression Network Analysis of Human Candida Infection Reveals Key Modules and Hub Genes Responsible for Host-Pathogen Interactions","volume":"13","author":"Naik","year":"2022","journal-title":"Front. Genet."},{"key":"ref_26","first-page":"1487","article-title":"Diabetes Mellitus as a Risk Factor for Periodontal Disease Development","volume":"20","author":"Obradovic","year":"2019","journal-title":"J. Environ. Prot. Ecol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"\u00c1ngel Gonz\u00e1lez-Moles, M., and Ramos-Garc\u00eda, P. (2021). Oral Health Problems in Diabetic Patients: A Critical Review of the Literature. J. Clin. Med., 10.","DOI":"10.3390\/jcm10225383"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"16556","DOI":"10.1073\/pnas.1218219110","article-title":"NF-\u039aB Inhibitor Targeted to Activated Endothelium Demonstrates a Critical Role of Endothelial NF-\u039aB in Immune-Mediated Diseases","volume":"110","author":"Sehnert","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ben-Abdallah, M., Sturny-Lecl\u00e8re, A., Av\u00e9, P., Louise, A., Moyrand, F., Weih, F., Janbon, G., and M\u00e9met, S. (2012). Fungal-Induced Cell Cycle Impairment, Chromosome Instability and Apoptosis via Differential Activation of NF-\u039aB. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002555"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Correia, I., Prieto, D., Rom\u00e1n, E., Wilson, D., Hube, B., Alonso-Monge, R., and Pla, J. (2020). Cooperative Role of MAPK Pathways in the Interaction of Candida albicans with the Host Epithelium. Microorganisms, 8.","DOI":"10.3390\/microorganisms8010048"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"6915","DOI":"10.1126\/scisignal.abj6915","article-title":"The Candida albicans Toxin Candidalysin Mediates Distinct Epithelial Inflammatory Responses through P38 and EGFR-ERK Pathways","volume":"15","author":"Nikou","year":"2022","journal-title":"Sci. Signal."},{"key":"ref_32","first-page":"2137","article-title":"Correlation of Atherogenesis with an Infection of Candida albicans","volume":"7","author":"Nurgeldiyeva","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1046\/j.1462-5822.2002.00232.x","article-title":"Endocytosis of Candida albicans by Vascular Endothelial Cells Is Associated with Tyrosine Phosphorylation of Specific Host Cell Proteins","volume":"4","author":"Belanger","year":"2002","journal-title":"Cell. Microbiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1128\/iai.42.1.374-384.1983","article-title":"Adherence and Penetration of Vascular Endothelium by Candida Yeasts","volume":"42","author":"Klotz","year":"1983","journal-title":"Infect. Immun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrrheum.2015.169","article-title":"TNF Biology, Pathogenic Mechanisms and Emerging Therapeutic Strategies","volume":"12","author":"Kalliolias","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Hennigs, J.K., Matuszcak, C., Trepel, M., and K\u00f6rbelin, J. (2021). Vascular Endothelial Cells: Heterogeneity and Targeting Approaches. Cells, 10.","DOI":"10.3390\/cells10102712"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1186\/ar576","article-title":"Endothelial Activation: Intracellular Signaling Pathways","volume":"4","author":"Pober","year":"2002","journal-title":"Arthritis Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.4049\/jimmunol.1601066","article-title":"Epithelial TNF Receptor Signaling Promotes Mucosal Repair in IBD","volume":"199","author":"Bradford","year":"2017","journal-title":"J. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s12276-021-00561-7","article-title":"Advanced Glycation End Products (AGEs) and Other Adducts in Aging-Related Diseases and Alcohol-Mediated Tissue Injury","volume":"53","author":"Rungratanawanich","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Nowotny, K., Jung, T., H\u00f6hn, A., Weber, D., and Grune, T. (2015). Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus. Biomolecules, 5.","DOI":"10.3390\/biom5010194"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Calvi\u00f1o, J., Cigarran, S., Gonzalez-Tabares, L., Menendez, N., Latorre, J., Cillero, S., Millan, B., Cobelo, C., Sanjurjo-Amado, A., and Quispe, J. (2018). Advanced Glycation End Products (AGEs) Estimated by Skin Autofluorescence Are Related with Cardiovascular Risk in Renal Transplant. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0201118"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Radi\u0107, J., Vu\u010dkovi\u0107, M., Gelemanovi\u0107, A., Kolak, E., Bu\u010dan Nenadi\u0107, D., Begovi\u0107, M., and Radi\u0107, M. (2022). Associations between Advanced Glycation End Products, Body Composition and Mediterranean Diet Adherence in Kidney Transplant Recipients. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph191711060"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1600-6143.2006.01617.x","article-title":"Blockade of RAGE Suppresses Alloimmune Reactions in Vitro and Delays Allograft Rejection in Murine Heart Transplantation","volume":"7","author":"Moser","year":"2007","journal-title":"Am. J. Transplant."},{"key":"ref_44","first-page":"6283","article-title":"Differential Regulation of Vascular Cell Adhesion Molecule 1 Gene Expression by Specific NF-Kappa B Subunits in Endothelial and Epithelial Cells","volume":"13","author":"Shu","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.immuni.2018.04.010","article-title":"Cell-Specific Imd-NF-\u03baB Responses Enable Simultaneous Antibacterial Immunity and Intestinal Epithelial Cell Shedding upon Bacterial Infection","volume":"48","author":"Zhai","year":"2018","journal-title":"Immunity"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/nri3897","article-title":"Immune Defence against Candida Fungal Infections","volume":"15","author":"Netea","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1161\/CIRCRESAHA.107.169664","article-title":"H-Ras Regulates Angiogenesis and Vascular Permeability by Activation of Distinct Downstream Effectors","volume":"102","author":"Serban","year":"2008","journal-title":"Circ. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1161\/CIRCRESAHA.120.318003","article-title":"Endothelial Cell Receptors in Tissue Lipid Uptake and Metabolism","volume":"128","author":"Abumrad","year":"2021","journal-title":"Circ. Res."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Nakamura, Y., and Shimizu, Y. (2023). Cellular and Molecular Control of Lipid Metabolism in Idiopathic Pulmonary Fibrosis: Clinical Application of the Lysophosphatidic Acid Pathway. Cells, 12.","DOI":"10.3390\/cells12040548"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Basante-Bedoya, M.A., Bogliolo, S., Garcia-Rodas, R., Zaragoza, O., Arkowitz, R.A., and Bassilana, M. (2022). Two Distinct Lipid Transporters Together Regulate Invasive Filamentous Growth in the Human Fungal Pathogen Candida albicans. PLoS Genet., 18.","DOI":"10.1101\/2022.08.30.505893"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.hlc.2021.09.016","article-title":"Chronic Rejection and Atherosclerosis in Post-Transplant Cardiovascular Mortality: Two Sides of the Same Coin","volume":"31","author":"Otunla","year":"2022","journal-title":"Heart Lung Circ."},{"key":"ref_52","first-page":"871","article-title":"Accelerated Arteriosclerosis in Heart Transplant Recipients Is Associated with a T-Lymphocyte-Mediated Endothelialitis","volume":"137","author":"Hruban","year":"1990","journal-title":"Am. J. Pathol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"III-27","DOI":"10.1161\/01.CIR.0000131515.03336.f8","article-title":"Role of Endothelial Dysfunction in Atherosclerosis","volume":"109","author":"Davignon","year":"2004","journal-title":"Circulation"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Pellon, A., Begum, N., Nasab, S.D.S., Harzandi, A., Shoaie, S., and Moyes, D.L. (2022). Role of Cellular Metabolism during Candida-Host Interactions. Pathogens, 11.","DOI":"10.3390\/pathogens11020184"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fcimb.2020.00081","article-title":"New Insights in Candida albicans Innate Immunity at the Mucosa: Toxins, Epithelium, Metabolism, and Beyond","volume":"10","author":"Drummond","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.tim.2014.07.001","article-title":"Metabolism Impacts upon Candida Immunogenicity and Pathogenicity at Multiple Levels","volume":"22","author":"Brown","year":"2014","journal-title":"Trends Microbiol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Silao, F.G.S., and Ljungdahl, P.O. (2022). Amino Acid Sensing and Assimilation by the Fungal Pathogen Candida albicans in the Human Host. Pathogens, 11.","DOI":"10.3390\/pathogens11010005"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"562051","DOI":"10.3389\/fnut.2020.562051","article-title":"Potential Role of Vitamin B6 in Ameliorating the Severity of COVID-19 and Its Complications","volume":"7","author":"Kumrungsee","year":"2020","journal-title":"Front. Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Parra, M., Stahl, S., and Hellmann, H. (2018). Vitamin B6 and Its Role in Cell Metabolism and Physiology. Cells, 7.","DOI":"10.3390\/cells7070084"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1080\/15548627.2016.1183080","article-title":"Iron-Depletion Promotes Mitophagy to Maintain Mitochondrial Integrity in Pathogenic Yeast Candida glabrata","volume":"12","author":"Nagi","year":"2016","journal-title":"Autophagy"},{"key":"ref_61","first-page":"10","article-title":"Mitophagy and Innate Immunity in Infection","volume":"43","author":"Cho","year":"2020","journal-title":"Mol. Cells"},{"key":"ref_62","first-page":"3","article-title":"Apoptosis, Oncosis, and Necrosis. An Overview of Cell Death","volume":"146","author":"Majno","year":"1995","journal-title":"Am. J. Pathol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e128834","DOI":"10.1172\/jci.insight.128834","article-title":"Necroptosis: A Crucial Pathogenic Mediator of Human Disease","volume":"4","author":"Choi","year":"2019","journal-title":"JCI Insight"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/sj.cdd.4401161","article-title":"Degradation of Chromosomal DNA during Apoptosis","volume":"10","author":"Nagata","year":"2003","journal-title":"Cell Death Differ."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/ar800","article-title":"DNA Degradation during Apoptotic Cell Death","volume":"5","author":"Nagata","year":"2003","journal-title":"Arthritis Res. Ther."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Lukenaite, B., Griciune, E., Leber, B., Strupas, K., Stiegler, P., and Schemmer, P. (2022). Necroptosis in Solid Organ Transplantation: A Literature Overview. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073677"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e1975","DOI":"10.1038\/cddis.2015.316","article-title":"Role of Necroptosis in the Pathogenesis of Solid Organ Injury","volume":"6","author":"Zhao","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1111\/ajt.12779","article-title":"RIPK3-Mediated Necroptosis Regulates Cardiac Allograft Rejection","volume":"14","author":"Pavlosky","year":"2014","journal-title":"Am. J. Transplant."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5473817","DOI":"10.1155\/2018\/5473817","article-title":"Review Article Regulated Cell Death as a Therapeutic Target for Novel Antifungal Peptides and Biologics","volume":"2018","author":"Yeaman","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1097\/TXD.0000000000000673","article-title":"Invasive Candida Infections in Liver Transplant Recipients: Clinical Features and Risk Factors for Mortality","volume":"3","author":"Bassetti","year":"2017","journal-title":"Transplant. Direct"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e01318-18","DOI":"10.1128\/mBio.01318-18","article-title":"Hypoxia Promotes Immune Evasion by Triggering \u03b2-Glucan Masking on the Candida albicans Cell Surface via Mitochondrial and CAMP-Protein Kinase A Signaling","volume":"9","author":"Pradhan","year":"2018","journal-title":"mBio"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3389\/fmicb.2021.633047","article-title":"Role for IL-1 Family Cytokines in Fungal Infections","volume":"12","author":"Griffiths","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3389\/fcimb.2019.00471","article-title":"Face\/Off: The Interchangeable Side of Candida albicans","volume":"9","author":"Cottier","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_74","first-page":"1694","article-title":"The Interactions Between Candida albicans and Mucosal Immunity","volume":"12","author":"Zhou","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.micinf.2016.10.008","article-title":"Impact of HIF-1\u03b1 and Hypoxia on Fungal Growth Characteristics and Fungal Immunity","volume":"19","author":"Friedrich","year":"2017","journal-title":"Microbes Infect."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","article-title":"Affy-Analysis of Affymetrix GeneChip Data at the Probe Level","volume":"20","author":"Gautier","year":"2004","journal-title":"Bioinformatics"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Langfelder, P., and Horvath, S. (2008). WGCNA: An R Package for Weighted Correlation Network Analysis. 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