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The most relevant findings during this last decade about the Entamoeba parasite and the disease are related to the possibility of culturing trophozoites of different isolates from infected individuals that allowed the characterization of the multiple pathogenic mechanisms of the parasite and the understanding of the host\u2013parasite relationship in the human. Second, the considerable advances in molecular biology and genetics help us to analyze the genome of Entamoeba, their genetic diversity, and the association of specific genotypes with the different amoebic forms of human amoebiasis. Based on this knowledge, culture and\/or molecular diagnostic strategies are now available to determine the Entamoeba species and genotype responsible for invasive intestinal or extraintestinal amoebiasis cases. Likewise, the extensive knowledge of the immune response in amoebiasis with the appearance of new technologies made it possible to design diagnostic tools now available worldwide. Finally, the understanding of the interaction between the Entamoeba species and the intestinal microbiota aids the understanding of the ecology of this parasite in the human environment. These relevant findings will be discussed in this review.<\/jats:p>","DOI":"10.3390\/ijms241411755","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:47:03Z","timestamp":1690159623000},"page":"11755","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Amoebiasis: Advances in Diagnosis, Treatment, Immunology Features and the Interaction with the Intestinal Ecosystem"],"prefix":"10.3390","volume":"24","author":[{"given":"Patricia","family":"Mor\u00e1n","sequence":"first","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda, Unidad de Investigaci\u00f3n en Medicina Experimental, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 06726, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica","family":"Serrano-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda, Unidad de Investigaci\u00f3n en Medicina Experimental, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 06726, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Rojas-Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda, Unidad de Investigaci\u00f3n en Medicina Experimental, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 06726, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda, Unidad de Investigaci\u00f3n en Medicina Experimental, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 06726, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio","family":"P\u00e9rez-Ju\u00e1rez","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda, Unidad de Investigaci\u00f3n en Medicina Experimental, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 06726, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric G.","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda, Unidad de Investigaci\u00f3n en Medicina Experimental, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 06726, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de los Angeles","family":"Padilla","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda, Unidad de Investigaci\u00f3n en Medicina Experimental, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 06726, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha E.","family":"Zaragoza","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda, Unidad de Investigaci\u00f3n en Medicina Experimental, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 06726, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3448-7959","authenticated-orcid":false,"given":"Tob\u00edas","family":"Portillo-Bobadilla","sequence":"additional","affiliation":[{"name":"Unidad de Bioinform\u00e1tica, Bioestad\u00edstica y Biolog\u00eda Computacional, Red de Apoyo a la Investigaci\u00f3n, Coordinaci\u00f3n de la Investigaci\u00f3n Cient\u00edfica, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)-Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Ciudad de M\u00e9xico 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Ramiro","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Estudios de Posgrado, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Xim\u00e9nez","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda, Unidad de Investigaci\u00f3n en Medicina Experimental, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 06726, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4721","DOI":"10.2147\/OTT.S194153","article-title":"Oral Microbiota and Gastrointestinal Cancer","volume":"12","author":"Zhang","year":"2019","journal-title":"OTT"},{"key":"ref_2","unstructured":"(1997). 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