{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T14:30:45Z","timestamp":1783434645852,"version":"3.54.6"},"reference-count":78,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Research Council","award":["DFG ProMoAge, GRK 2155"],"award-info":[{"award-number":["DFG ProMoAge, GRK 2155"]}]},{"name":"German Research Council","award":["371\/05\/15"],"award-info":[{"award-number":["371\/05\/15"]}]},{"name":"Deutsche Diabetes Stiftung","award":["DFG ProMoAge, GRK 2155"],"award-info":[{"award-number":["DFG ProMoAge, GRK 2155"]}]},{"name":"Deutsche Diabetes Stiftung","award":["371\/05\/15"],"award-info":[{"award-number":["371\/05\/15"]}]},{"name":"EU (Epihealth, EpihealthNET)","award":["DFG ProMoAge, GRK 2155"],"award-info":[{"award-number":["DFG ProMoAge, GRK 2155"]}]},{"name":"EU (Epihealth, EpihealthNET)","award":["371\/05\/15"],"award-info":[{"award-number":["371\/05\/15"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Maternal diabetes mellitus in early pregnancy leads to hyperlipidemia in reproductive tract organs and an altered embryonic environment. To investigate the consequences on embryonic metabolism, the effect of high environmental-lipid levels was studied in rabbit blastocysts cultured with a lipid mixture in vitro and in blastocysts from diabetic, hyperlipidemic rabbits in vivo. The gene and protein expression of marker molecules involved in lipid metabolism and stress response were analyzed. In diabetic rabbits, the expression of embryoblast genes encoding carnitine palmityl transferase 1 and peroxisome proliferator-activated receptors \u03b1 and \u03b3 increased, whereas trophoblast genes encoding for proteins associated with fatty acid synthesis and \u03b2-oxidation decreased. Markers for endoplasmic (activating transcription factor 4) and oxidative stress (nuclear factor erythroid 2-related factor 2) were increased in embryoblasts, while markers for cellular redox status (superoxide dismutase 2) and stress (heat shock protein 70) were increased in trophoblasts from diabetic rabbits. The observed regulation pattern in vivo was consistent with an adaptation response to the hyperlipidemic environment, suggesting that maternal lipids have an impact on the intracellular metabolism of the preimplantation embryo in diabetic pregnancy and that embryoblasts are particularly vulnerable to metabolic stress.<\/jats:p>","DOI":"10.3390\/ijms241411776","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:47:03Z","timestamp":1690159623000},"page":"11776","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ectopic Lipid Accumulation Correlates with Cellular Stress in Rabbit Blastocysts from Diabetic Mothers"],"prefix":"10.3390","volume":"24","author":[{"given":"Maria","family":"Schindler","sequence":"first","affiliation":[{"name":"Institute of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University, 06108 Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia Mareike","family":"Geisler","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University, 06108 Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Seeling","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University, 06108 Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Navarrete Santos","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University, 06108 Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1172\/JCI41229","article-title":"Making the blastocyst: Lessons from the mouse","volume":"120","author":"Cockburn","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1530\/REP-11-0484","article-title":"Metabolism of the preimplantation embryo: 40 years on","volume":"143","author":"Leese","year":"2012","journal-title":"Reproduction"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cll.2013.03.017","article-title":"New concepts in diabetic embryopathy","volume":"33","author":"Zhao","year":"2013","journal-title":"Clin. Lab. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.metabol.2007.06.020","article-title":"Changes in plasma lipids and increased low-density lipoprotein susceptibility to oxidation in pregnancies complicated by gestational diabetes: Consequences of obesity","volume":"56","author":"Bonet","year":"2007","journal-title":"Metab. Clin. Exp."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1038\/sj.ejcn.1600984","article-title":"Metabolic adaptations in pregnancy and their implications for the availability of substrates to the fetus","volume":"54","author":"Herrera","year":"2000","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.2337\/diacare.18.12.1550","article-title":"Maternal serum triglyceride, glucose tolerance, and neonatal birth weight ratio in pregnancy","volume":"18","author":"Nolan","year":"1995","journal-title":"Diabetes Care"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1210\/en.2007-1273","article-title":"One-cell zygote transfer from diabetic to nondiabetic mouse results in congenital malformations and growth retardation in offspring","volume":"149","author":"Wyman","year":"2008","journal-title":"Endocrinology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mce.2018.10.010","article-title":"A short periconceptional exposure to maternal type-1 diabetes is sufficient to disrupt the feto-placental phenotype in a rabbit model","volume":"480","author":"Thieme","year":"2019","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"R99","DOI":"10.1530\/REP-21-0238","article-title":"Homeostatic regulation of lipid droplet content in mammalian oocytes and embryos","volume":"162","author":"Ibayashi","year":"2021","journal-title":"Reproduction"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.bbadis.2011.02.014","article-title":"PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation","volume":"1812","author":"Varga","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.biochem.77.061307.091829","article-title":"Fat and beyond: The diverse biology of PPARgamma","volume":"77","author":"Tontonoz","year":"2008","journal-title":"Annu. Rev. Biochem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"612089","DOI":"10.1155\/2010\/612089","article-title":"Peroxisome proliferator-activated receptor alpha target genes","volume":"2010","author":"Rakhshandehroo","year":"2010","journal-title":"PPAR Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0022-2275(20)31655-2","article-title":"Disturbances in the normal regulation of SREBP-sensitive genes in PPAR alpha-deficient mice","volume":"42","author":"Patel","year":"2001","journal-title":"J. Lipid Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1042\/BJ20041896","article-title":"A role for PPARalpha in the control of SREBP activity and lipid synthesis in the liver","volume":"389","author":"Knight","year":"2005","journal-title":"Biochem. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.biochi.2010.08.001","article-title":"Hormonal and nutritional regulation of SCD1 gene expression","volume":"93","author":"Mauvoisin","year":"2011","journal-title":"Biochimie"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1152\/advan.00052.2006","article-title":"PGC-1alpha: A key regulator of energy metabolism","volume":"30","author":"Liang","year":"2006","journal-title":"Adv. Physiol. Educ."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4330\/wjc.v5.i6.164","article-title":"Peroxisome-proliferator-activated receptors regulate redox signaling in the cardiovascular system","volume":"5","author":"Kim","year":"2013","journal-title":"World J. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cardiores.2007.06.027","article-title":"Cardiac peroxisome proliferator-activated receptor gamma is essential in protecting cardiomyocytes from oxidative damage","volume":"76","author":"Ding","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"H93","DOI":"10.1152\/ajpheart.00037.2007","article-title":"Role of oxidative stress in cardiac dysfunction of PPARalpha\u2212\/\u2212 mice","volume":"293","author":"Guellich","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1210\/me.2002-0020","article-title":"Identification of a functional peroxisome proliferator-activated receptor response element in the rat catalase promoter","volume":"16","author":"Girnun","year":"2002","journal-title":"Mol. Endocrinol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"641087","DOI":"10.1155\/2012\/641087","article-title":"PPAR\u03b3 and Oxidative Stress: Con(\u03b2) Catenating NRF2 and FOXO","volume":"2012","author":"Polvani","year":"2012","journal-title":"PPAR Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3389\/fgene.2019.00435","article-title":"Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1\u03b1 Signaling Pathways","volume":"10","author":"Gureev","year":"2019","journal-title":"Front. Genet."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/biof.5520170124","article-title":"Molecular chaperones, stress proteins and redox homeostasis","volume":"17","author":"Papp","year":"2003","journal-title":"Biofactors"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0014-5793(96)00730-2","article-title":"Heat shock protein hsp70 overexpression confers resistance against nitric oxide","volume":"391","author":"Bellmann","year":"1996","journal-title":"FEBS Lett."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6124","DOI":"10.1093\/emboj\/17.21.6124","article-title":"Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases","volume":"17","author":"Wissing","year":"1998","journal-title":"EMBO J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1186\/2193-1801-2-431","article-title":"Hyperglycaemia and oxidative stress upregulate HSP60 & HSP70 expression in HeLa cells","volume":"2","author":"Hall","year":"2013","journal-title":"Springerplus"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/bdrb.20330","article-title":"Endoplasmic reticulum stress in maternal diabetes-induced cardiac malformations during critical cardiogenesis period","volume":"95","author":"Zhao","year":"2012","journal-title":"Birth Defects Res. B Dev. Reprod. Toxicol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1177\/1933719111434543","article-title":"Reduction in embryonic malformations and alleviation of endoplasmic reticulum stress by nitric oxide synthase inhibition in diabetic embryopathy","volume":"19","author":"Zhao","year":"2012","journal-title":"Reprod. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.3109\/14767058.2012.677963","article-title":"The essential role of protein kinase C\u03b4 in diabetes-induced neural tube defects","volume":"25","author":"Cao","year":"2012","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Cho, H., Wu, M., Zhang, L., Thompson, R., Nath, A., and Chan, C. (2013). Signaling dynamics of palmitate-induced ER stress responses mediated by ATF4 in HepG2 cells. BMC Syst. Biol., 7.","DOI":"10.1186\/1752-0509-7-9"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1210\/en.2012-2096","article-title":"cAMP-responsive element binding protein: A vital link in embryonic hormonal adaptation","volume":"154","author":"Schindler","year":"2013","journal-title":"Endocrinology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1432-0436.2006.00052.x","article-title":"Energy metabolism of the inner cell mass and trophectoderm of the mouse blastocyst","volume":"74","author":"Houghton","year":"2006","journal-title":"Differentiation"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/jez.1402670310","article-title":"Energy metabolism of the trophectoderm and inner cell mass of the mouse blastocyst","volume":"267","author":"Hewitson","year":"1993","journal-title":"J. Exp. Zool."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1530\/REP-15-0523","article-title":"Maternal diabetes promotes mTORC1 downstream signalling in rabbit preimplantation embryos","volume":"151","author":"Schindler","year":"2016","journal-title":"Reproduction"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1210\/en.2013-1760","article-title":"Maternal diabetes leads to unphysiological high lipid accumulation in rabbit preimplantation embryos","volume":"155","author":"Schindler","year":"2014","journal-title":"Endocrinology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/molehr\/gaaa063","article-title":"Embryonic fatty acid metabolism in diabetic pregnancy: The difference between embryoblasts and trophoblasts","volume":"26","author":"Schindler","year":"2020","journal-title":"Mol. Hum. Reprod."},{"key":"ref_37","first-page":"1736","article-title":"Fetal and maternal lipoprotein metabolism in human pregnancy complicated by type I diabetes mellitus","volume":"83","author":"Kilby","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1067\/mlc.2000.111004","article-title":"Maternal and fetal serum lipid and lipoprotein concentrations and compositions in type 1 diabetic pregnancy: Relationship with maternal glycemic control","volume":"136","author":"Merzouk","year":"2000","journal-title":"J. Lab. Clin. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1038\/s41467-022-31323-2","article-title":"Dynamic enlargement and mobilization of lipid droplets in pluripotent cells coordinate morphogenesis during mouse peri-implantation development","volume":"13","author":"Mau","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1159\/000342583","article-title":"Expression profile of fatty acid metabolism genes in preimplantation blastocysts of obese and non-obese mice","volume":"5","author":"Schmidt","year":"2012","journal-title":"Obes. Facts"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Mishima, T., Miner, J.H., Morizane, M., Stahl, A., and Sadovsky, Y. (2011). The expression and function of fatty acid transport protein-2 and -4 in the murine placenta. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0025865"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"E1083-91","DOI":"10.1210\/jc.2010-2084","article-title":"Fatty acid binding protein 4 regulates intracellular lipid accumulation in human trophoblasts","volume":"96","author":"Scifres","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"S126","DOI":"10.1194\/jlr.R800084-JLR200","article-title":"Structural and functional analysis of fatty acid-binding proteins","volume":"50","author":"Storch","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"6744","DOI":"10.1021\/bi700047a","article-title":"Continuous nucleocytoplasmic shuttling underlies transcriptional activation of PPARgamma by FABP4","volume":"46","author":"Ayers","year":"2007","journal-title":"Biochemistry"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1210\/en.2007-0211","article-title":"Ligand-activated peroxisome proliferator activated receptor gamma alters placental morphology and placental fatty acid uptake in mice","volume":"148","author":"Schaiff","year":"2007","journal-title":"Endocrinology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1172\/JCI27989","article-title":"Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis","volume":"116","author":"Lefebvre","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1093\/humrep\/dex087","article-title":"Adiponectin stimulates lipid metabolism via AMPK in rabbit blastocysts","volume":"32","author":"Schindler","year":"2017","journal-title":"Hum. Reprod."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/(SICI)1098-2795(199603)43:3<323::AID-MRD6>3.0.CO;2-S","article-title":"Effects of metabolic inhibitors on mouse preimplantation embryo development and the energy metabolism of isolated inner cell masses","volume":"43","author":"Hewitson","year":"1996","journal-title":"Mol. Reprod. Dev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1095\/biolreprod.110.084145","article-title":"Beta-oxidation is essential for mouse oocyte developmental competence and early embryo development","volume":"83","author":"Dunning","year":"2010","journal-title":"Biol. Reprod."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1095\/biolreprod.113.109058","article-title":"A requirement for fatty acid oxidation in the hormone-induced meiotic maturation of mouse oocytes","volume":"89","author":"Valsangkar","year":"2013","journal-title":"Biol. Reprod."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1530\/REP-14-0015","article-title":"Fatty acid metabolism during maturation affects glucose uptake and is essential to oocyte competence","volume":"148","author":"Paczkowski","year":"2014","journal-title":"Reproduction"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"6358","DOI":"10.1073\/pnas.0931394100","article-title":"Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero","volume":"100","author":"Chirala","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.plipres.2013.12.001","article-title":"Regulation of energy metabolism by long-chain fatty acids","volume":"53","author":"Nakamura","year":"2014","journal-title":"Prog. Lipid Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2527\/2004.821231x","article-title":"Insulin and dexamethasone regulate stearoyl-CoA desaturase mRNA levels and fatty acid synthesis in ovine adipose tissue explants","volume":"82","author":"Daniel","year":"2004","journal-title":"J. Anim. Sci."},{"key":"ref_55","first-page":"R1253","article-title":"Insulin increases fatty acid synthase gene transcription in human adipocytes","volume":"274","author":"Claycombe","year":"1998","journal-title":"Am. J. Physiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00041433-200306000-00008","article-title":"Lipotoxicity: When tissues overeat","volume":"14","author":"Schaffer","year":"2003","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1194\/jlr.M600299-JLR200","article-title":"Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death","volume":"47","author":"Borradaile","year":"2006","journal-title":"J. Lipid Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1242\/dev.114850","article-title":"Mitochondrial dysfunction in oocytes of obese mothers: Transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors","volume":"142","author":"Wu","year":"2015","journal-title":"Development"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0093-691X(00)00332-0","article-title":"Effect of oxidative stress on development and DNA damage in in-vitro cultured bovine embryos by comet assay","volume":"54","author":"Takahashi","year":"2000","journal-title":"Theriogenology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.3748\/wjg.v13.i34.4539","article-title":"Pathogenesis and management issues for non-alcoholic fatty liver disease","volume":"13","author":"Duvnjak","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/humrep\/den346","article-title":"DNA damage and metabolic activity in the preimplantation embryo","volume":"24","author":"Sturmey","year":"2009","journal-title":"Hum. Reprod."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.redox.2016.10.004","article-title":"Taurine promotes cognitive function in prenatally stressed juvenile rats via activating the Akt-CREB-PGC1\u03b1 pathway","volume":"10","author":"Jia","year":"2016","journal-title":"Redox Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0092-8674(00)80611-X","article-title":"Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1","volume":"98","author":"Wu","year":"1999","journal-title":"Cell"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s12276-021-00560-8","article-title":"The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling","volume":"53","author":"Bhattarai","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1210\/en.2010-0187","article-title":"Maternal diabetes impairs gastrulation and insulin and IGF-I receptor expression in rabbit blastocysts","volume":"151","author":"Ramin","year":"2010","journal-title":"Endocrinology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S1043-2760(00)00341-6","article-title":"Hyperglycemia and apoptosis: Mechanisms for congenital malformations and pregnancy loss in diabetic women","volume":"12","author":"Moley","year":"2001","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1101\/gad.13.10.1211","article-title":"Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls","volume":"13","author":"Kaufman","year":"1999","journal-title":"Genes Dev."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev-med-043010-144749","article-title":"Role of endoplasmic reticulum stress in metabolic disease and other disorders","volume":"63","author":"Ozcan","year":"2012","journal-title":"Annu. Rev. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"25350","DOI":"10.1074\/jbc.M113.470526","article-title":"ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice","volume":"288","author":"Xiao","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_70","first-page":"259","article-title":"Advances in rabbit embryo culture","volume":"Volume 1978","author":"Daniels","year":"1978","journal-title":"Methods in Mammalian Reproduction"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/REP-12-0091","article-title":"Rabbit as a reproductive model for human health","volume":"144","author":"Fischer","year":"2012","journal-title":"Reproduction"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature17173","article-title":"High-fat diet enhances stemness and tumorigenicity of intestinal progenitors","volume":"531","author":"Beyaz","year":"2016","journal-title":"Nature"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41467-017-00331-y","article-title":"Critical role for arginase 2 in obesity-associated pancreatic cancer","volume":"8","author":"Zaytouni","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00429-004-0388-z","article-title":"Expression of the insulin-responsive glucose transporter isoform 4 in blastocysts of C57\/BL6 mice","volume":"208","author":"Tonack","year":"2004","journal-title":"Anat. Embryol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/rda.13462","article-title":"Glyoxalase 1 expression is downregulated in preimplantation blastocysts of diabetic rabbits","volume":"54","author":"Seeling","year":"2019","journal-title":"Reprod. Domest. Anim."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.mce.2012.03.007","article-title":"Insulin growth factor adjustment in preimplantation rabbit blastocysts and uterine tissues in response to maternal type 1 diabetes","volume":"358","author":"Thieme","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"de Nivelle, J., Thoma, J., Toto Nienguesso, A., Seeling, T., Jung, J.-S., Navarrete Santos, A., and Schindler, M. (2020). Rabbit as an Aging Model in Reproduction: Advanced Maternal Age Alters GLO1 Expression in the Endometrium at the Time of Implantation. Appl. Sci., 10.","DOI":"10.3390\/app10217732"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1071\/RD15542","article-title":"Cholesterol metabolism in rabbit blastocysts under maternal diabetes","volume":"29","author":"Pendzialek","year":"2017","journal-title":"Reprod. Fertil. Dev."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/14\/11776\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:16:53Z","timestamp":1760127413000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/14\/11776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,21]]},"references-count":78,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["ijms241411776"],"URL":"https:\/\/doi.org\/10.3390\/ijms241411776","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,21]]}}}