{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:44:59Z","timestamp":1785840299995,"version":"3.56.0"},"reference-count":130,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"University of Kassel","doi-asserted-by":"publisher","award":["DFG GRK 2749-1"],"award-info":[{"award-number":["DFG GRK 2749-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Microtubule-Associated Serine\/Threonine (MAST) kinases represent an evolutionary conserved branch of the AGC protein kinase superfamily in the kinome. Since the discovery of the founding member, MAST2, in 1993, three additional family members have been identified in mammals and found to be broadly expressed across various tissues, including the brain, heart, lung, liver, intestine and kidney. The study of MAST kinases is highly relevant for unraveling the molecular basis of a wide range of different human diseases, including breast and liver cancer, myeloma, inflammatory bowel disease, cystic fibrosis and various neuronal disorders. Despite several reports on potential substrates and binding partners of MAST kinases, the molecular mechanisms that would explain their involvement in human diseases remain rather obscure. This review will summarize data on the structure, biochemistry and cell and molecular biology of MAST kinases in the context of biomedical research as well as organismal model systems in order to provide a current profile of this field.<\/jats:p>","DOI":"10.3390\/ijms241511913","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:45:02Z","timestamp":1690332302000},"page":"11913","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Microtubule-Associated Serine\/Threonine (MAST) Kinases in Development and Disease"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9415-9704","authenticated-orcid":false,"given":"Marie","family":"Rumpf","sequence":"first","affiliation":[{"name":"Department of Developmental Genetics, Institute of Biology, University of Kassel, 34321 Kassel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Pautz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Institute of Biology, University of Kassel, 34321 Kassel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Drebes","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics, Institute of Biology, University of Kassel, 34321 Kassel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7117-7653","authenticated-orcid":false,"given":"Friedrich W.","family":"Herberg","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Institute of Biology, University of Kassel, 34321 Kassel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7525-6874","authenticated-orcid":false,"given":"Hans-Arno J.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics, Institute of Biology, University of Kassel, 34321 Kassel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1126\/science.1075762","article-title":"The protein kinase complement of the human genome","volume":"298","author":"Manning","year":"2002","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"D824","DOI":"10.1093\/nar\/gkn832","article-title":"MoKCa database--mutations of kinases in cancer","volume":"37","author":"Richardson","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1126\/science.3291115","article-title":"The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains","volume":"241","author":"Hanks","year":"1988","journal-title":"Science"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1096\/fasebj.9.8.7768349","article-title":"Protein kinases 6. The eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classification","volume":"9","author":"Hanks","year":"1995","journal-title":"FASEB J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrm2822","article-title":"The nuts and bolts of AGC protein kinases","volume":"11","author":"Pearce","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/gb-2003-4-5-111","article-title":"Genomic analysis of the eukaryotic protein kinase superfamily: A perspective","volume":"4","author":"Hanks","year":"2003","journal-title":"Genome Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1021\/cr000226k","article-title":"Dynamics of cAMP-dependent protein kinase","volume":"101","author":"Johnson","year":"2001","journal-title":"Chem. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1073\/pnas.0610251104","article-title":"The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module","volume":"104","author":"Kannan","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1126\/science.1862343","article-title":"Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase","volume":"253","author":"Knighton","year":"1991","journal-title":"Science"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1124\/molpharm.121.000315","article-title":"The Tails of Protein Kinase A","volume":"101","author":"Taylor","year":"2022","journal-title":"Mol. Pharmacol."},{"key":"ref_11","first-page":"7625","article-title":"A novel 205-kilodalton testis-specific serine\/threonine protein kinase associated with microtubules of the spermatid manchette","volume":"13","author":"Walden","year":"1993","journal-title":"Mol. Cell Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1095\/biolreprod55.5.1039","article-title":"Increased activity associated with the MAST205 protein kinase complex during mammalian spermiogenesis","volume":"55","author":"Walden","year":"1996","journal-title":"Biol. Reprod."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"vbac072","DOI":"10.1093\/bioadv\/vbac072","article-title":"Reciprocal best structure hits: Using AlphaFold models to discover distant homologues","volume":"2","author":"Monzon","year":"2022","journal-title":"Bioinform. Adv."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"D439","DOI":"10.1093\/nar\/gkab1061","article-title":"AlphaFold Protein Structure Database: Massively expanding the structural coverage of protein-sequence space with high-accuracy models","volume":"50","author":"Varadi","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"D418","DOI":"10.1093\/nar\/gkac993","article-title":"InterPro in 2022","volume":"51","author":"Blum","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/bs.ircmb.2018.05.013","article-title":"Emerging Themes in PDZ Domain Signaling: Structure, Function, and Inhibition","volume":"343","author":"Liu","year":"2019","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/bies.950190606","article-title":"PDZ domains: Targeting signalling molecules to sub-membranous sites","volume":"19","author":"Ponting","year":"1997","journal-title":"Bioessays"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1126\/science.275.5296.73","article-title":"Recognition of unique carboxyl-terminal motifs by distinct PDZ domains","volume":"275","author":"Songyang","year":"1997","journal-title":"Science"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"RE7","DOI":"10.1126\/stke.2003.179.re7","article-title":"PDZ domain proteins: Plug and play!","volume":"2003","author":"Nourry","year":"2003","journal-title":"Sci. STKE"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"ra58","DOI":"10.1126\/scisignal.2002941","article-title":"Interference with the PTEN-MAST2 interaction by a viral protein leads to cellular relocalization of PTEN","volume":"5","author":"Terrien","year":"2012","journal-title":"Sci. Signal"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1478-811X-8-8","article-title":"PDZ domains and their binding partners: Structure, specificity, and modification","volume":"8","author":"Lee","year":"2010","journal-title":"Cell Commun. Signal"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.1074\/jbc.R100065200","article-title":"PDZ domains: Structural modules for protein complex assembly","volume":"277","author":"Hung","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0092-8674(00)81053-3","article-title":"Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains","volume":"84","author":"Brenman","year":"1996","journal-title":"Cell"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.chembiol.2011.06.013","article-title":"A systematic family-wide investigation reveals that ~30% of mammalian PDZ domains engage in PDZ-PDZ interactions","volume":"18","author":"Chang","year":"2011","journal-title":"Chem. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"28936","DOI":"10.1074\/jbc.M504761200","article-title":"Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine\/threonine kinases","volume":"280","author":"Valiente","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_27","first-page":"35","article-title":"Threonine phosphorylation of the MMAC1\/PTEN PDZ binding domain both inhibits and stimulates PDZ binding","volume":"60","author":"Adey","year":"2000","journal-title":"Cancer Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41580-018-0015-0","article-title":"The functions and regulation of the PTEN tumour suppressor: New modes and prospects","volume":"19","author":"Lee","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5010","DOI":"10.1128\/MCB.20.14.5010-5018.2000","article-title":"Phosphorylation of the PTEN tail regulates protein stability and function","volume":"20","author":"Vazquez","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/jbmr.4507","article-title":"Estrogen-Responsive Gene MAST4 Regulates Myeloma Bone Disease","volume":"37","author":"Cui","year":"2022","journal-title":"J. Bone Miner. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/sj.cdd.4402258","article-title":"Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen","volume":"15","author":"Loh","year":"2008","journal-title":"Cell Death Differ."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"19479","DOI":"10.1073\/pnas.0910398106","article-title":"PTEN dosage is essential for neurofibroma development and malignant transformation","volume":"106","author":"Gregorian","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"ra5","DOI":"10.1126\/scisignal.2000510","article-title":"Attenuation of rabies virulence: Takeover by the cytoplasmic domain of its envelope protein","volume":"3","author":"Prehaud","year":"2010","journal-title":"Sci. Signal"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"F428","DOI":"10.1152\/ajprenal.00161.2005","article-title":"Coexpression of MAST205 inhibits the activity of Na+\/H+ exchanger NHE3","volume":"290","author":"Wang","year":"2006","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1242\/jeb.027375","article-title":"Tethering, recycling and activation of the epithelial sodium-proton exchanger, NHE3","volume":"212","author":"Alexander","year":"2009","journal-title":"J. Exp. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/10165","article-title":"Interactions between beta 2-syntrophin and a family of microtubule-associated serine\/threonine kinases","volume":"2","author":"Lumeng","year":"1999","journal-title":"Nat. Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1093\/carcin\/23.7.1139","article-title":"Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation","volume":"23","author":"Okazaki","year":"2002","journal-title":"Carcinogenesis"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"43675","DOI":"10.1074\/jbc.M404328200","article-title":"Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability","volume":"279","author":"Xiong","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.4049\/jimmunol.172.4.2559","article-title":"Microtubule-associated serine\/threonine kinase-205 kDa and Fc gamma receptor control IL-12 p40 synthesis and NF-kappa B activation","volume":"172","author":"Zhou","year":"2004","journal-title":"J. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/gene.2008.57","article-title":"MAST3: A novel IBD risk factor that modulates TLR4 signaling","volume":"9","author":"Labbe","year":"2008","journal-title":"Genes. Immun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"M110.005751","DOI":"10.1074\/mcp.M110.005751","article-title":"Visualization and biochemical analyses of the emerging mammalian 14-3-3-phosphoproteome","volume":"10","author":"Johnson","year":"2011","journal-title":"Mol. Cell Proteom."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1042\/BJ20031332","article-title":"Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes","volume":"381","author":"Mackintosh","year":"2004","journal-title":"Biochem. J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1146\/annurev.pharmtox.40.1.617","article-title":"14-3-3 proteins: Structure, function, and regulation","volume":"40","author":"Fu","year":"2000","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5949","DOI":"10.7150\/thno.72826","article-title":"CRISPR\/Cas9-based genome-wide screening for deubiquitinase subfamily identifies USP1 regulating MAST1-driven cisplatin-resistance in cancer cells","volume":"12","author":"Tyagi","year":"2022","journal-title":"Theranostics"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4110","DOI":"10.1172\/JCI125963","article-title":"Hsp90B enhances MAST1-mediated cisplatin resistance by protecting MAST1 from proteosomal degradation","volume":"129","author":"Pan","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ccell.2018.06.012","article-title":"MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation","volume":"34","author":"Jin","year":"2018","journal-title":"Cancer Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.neuron.2018.10.044","article-title":"Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations","volume":"100","author":"Tripathy","year":"2018","journal-title":"Neuron"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"12325","DOI":"10.1074\/jbc.M112.432724","article-title":"MAST205 competes with cystic fibrosis transmembrane conductance regulator (CFTR)-associated ligand for binding to CFTR to regulate CFTR-mediated fluid transport","volume":"288","author":"Ren","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1523\/JNEUROSCI.4559-15.2017","article-title":"ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine\/Threonine Kinase 3 (Mast 3 Kinase)","volume":"37","author":"Andrade","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1038\/s41467-022-31697-3","article-title":"Mast4 determines the cell fate of MSCs for bone and cartilage development","volume":"13","author":"Kim","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0306-4522(90)90402-P","article-title":"ARPP-21, a cAMP-regulated phosphoprotein enriched in dopamine-innervated brain regions: Tissue distribution and regulation of phosphorylation in rat brain","volume":"37","author":"Girault","year":"1990","journal-title":"Neuroscience"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"9476","DOI":"10.1016\/S0021-9258(19)38874-X","article-title":"Purification and cDNA cloning of ARPP-16, a cAMP-regulated phosphoprotein enriched in basal ganglia, and of a related phosphoprotein, ARPP-19","volume":"265","author":"Horiuchi","year":"1990","journal-title":"J. Biol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1523\/JNEUROSCI.14-03-00985.1994","article-title":"Expression of mRNAs encoding ARPP-16\/19, ARPP-21, and DARPP-32 in human brain tissue","volume":"14","author":"Brene","year":"1994","journal-title":"J. Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e24998","DOI":"10.7554\/eLife.24998","article-title":"Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition","volume":"6","author":"Musante","year":"2017","journal-title":"Elife"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/ng0697-174","article-title":"SOX9 directly regulates the type-II collagen gene","volume":"16","author":"Bell","year":"1997","journal-title":"Nat. Genet."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/8792","article-title":"Sox9 is required for cartilage formation","volume":"22","author":"Bi","year":"1999","journal-title":"Nat. Genet."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1128\/MCB.17.4.2336","article-title":"SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene","volume":"17","author":"Lefebvre","year":"1997","journal-title":"Mol. Cell Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1038\/s41418-020-00670-2","article-title":"Mast4 knockout shows the regulation of spermatogonial stem cell self-renewal via the FGF2\/ERM pathway","volume":"28","author":"Lee","year":"2021","journal-title":"Cell Death Differ."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.brainres.2007.12.027","article-title":"Expression of the MAST family of serine\/threonine kinases","volume":"1195","author":"Garland","year":"2008","journal-title":"Brain Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1038\/nm.2580","article-title":"Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer","volume":"17","author":"Robinson","year":"2011","journal-title":"Nat. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s10549-009-0404-3","article-title":"Association of genetic variation in mitotic kinases with breast cancer risk","volume":"119","author":"Wang","year":"2010","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1002\/ibd.21887","article-title":"Genome-wide expression profiling implicates a MAST3-regulated gene set in colonic mucosal inflammation of ulcerative colitis patients","volume":"18","author":"Labbe","year":"2012","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s12104-008-9138-0","article-title":"1H, 13C and 15N resonance assignments of the PDZ of microtubule-associated serine\/threonine kinase 205 (MAST205) in complex with the C-terminal motif from the rabies virus glycoprotein","volume":"3","author":"Terrien","year":"2009","journal-title":"Biomol. NMR Assign."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1016\/j.humpath.2013.08.001","article-title":"MAST2 and NOTCH1 translocations in breast carcinoma and associated pre-invasive lesions","volume":"44","author":"Clay","year":"2013","journal-title":"Hum. Pathol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Eissmann, M., Schwamb, B., Melzer, I.M., Moser, J., Siele, D., Kohl, U., Rieker, R.J., Wachter, D.L., Agaimy, A., and Herpel, E. (2013). A functional yeast survival screen of tumor-derived cDNA libraries designed to identify anti-apoptotic mammalian oncogenes. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0064873"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/s41419-020-2532-y","article-title":"The circular RNA circMAST1 promotes hepatocellular carcinoma cell proliferation and migration by sponging miR-1299 and regulating CTNND1 expression","volume":"11","author":"Yu","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"19865","DOI":"10.1038\/s41598-019-56476-x","article-title":"High MAST2 mRNA expression and its role in diagnosis and prognosis of liver cancer","volume":"9","author":"Jiao","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1002\/jcb.24141","article-title":"A functional network of the tumor suppressors APC, hDlg, and PTEN, that relies on recognition of specific PDZ-domains","volume":"113","author":"Sotelo","year":"2012","journal-title":"J. Cell Biochem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bone.2018.01.021","article-title":"Young female patients with multiple myeloma have low occurrence of osteolytic lesion","volume":"110","author":"Zhang","year":"2018","journal-title":"Bone"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2174\/0929867033368484","article-title":"Cisplatin biochemical mechanism of action: From cytotoxicity to induction of cell death through interconnections between apoptotic and necrotic pathways","volume":"10","author":"Fuertes","year":"2003","journal-title":"Curr. Med. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1158\/1535-7163.MCT-15-0062","article-title":"MEK Inhibition Overcomes Cisplatin Resistance Conferred by SOS\/MAPK Pathway Activation in Squamous Cell Carcinoma","volume":"14","author":"Kong","year":"2015","journal-title":"Mol. Cancer Ther."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ccell.2018.07.010","article-title":"Pulling a MAST1 on Cisplatin Resistance","volume":"34","author":"Jaykumar","year":"2018","journal-title":"Cancer Cell"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"4960","DOI":"10.1038\/s41467-021-24845-8","article-title":"Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1","volume":"12","author":"Pan","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nrm1949","article-title":"New insights into cystic fibrosis: Molecular switches that regulate CFTR","volume":"7","author":"Guggino","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1513\/pats.2306011","article-title":"The cystic fibrosis transmembrane regulator forms macromolecular complexes with PDZ domain scaffold proteins","volume":"1","author":"Guggino","year":"2004","journal-title":"Proc. Am. Thorac. Soc."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/bs.ai.2017.05.008","article-title":"Roles of NHERF Family of PDZ-Binding Proteins in Regulating GPCR Functions","volume":"136","author":"Broadbent","year":"2017","journal-title":"Adv. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1039\/b924455g","article-title":"CFTR chloride channel in the apical compartments: Spatiotemporal coupling to its interacting partners","volume":"2","author":"Li","year":"2010","journal-title":"Integr. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"G766","DOI":"10.1152\/ajpgi.00135.2006","article-title":"The emerging role of PDZ adapter proteins for regulation of intestinal ion transport","volume":"291","author":"Lamprecht","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1091\/mbc.e09-03-0229","article-title":"Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator","volume":"21","author":"Cheng","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"4396","DOI":"10.1111\/febs.12392","article-title":"Control of cystic fibrosis transmembrane conductance regulator membrane trafficking: Not just from the endoplasmic reticulum to the Golgi","volume":"280","author":"Farinha","year":"2013","journal-title":"FEBS J."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1074\/jbc.M110177200","article-title":"A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression","volume":"277","author":"Cheng","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1074\/jbc.M308640200","article-title":"Modulation of mature cystic fibrosis transmembrane regulator protein by the PDZ domain protein CAL","volume":"279","author":"Cheng","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1095\/biolreprod.115.131185","article-title":"A Screen for Genomic Disorders of Infertility Identifies MAST2 Duplications Associated with Nonobstructive Azoospermia in Humans","volume":"93","author":"Huang","year":"2015","journal-title":"Biol. Reprod."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"5078","DOI":"10.4049\/jimmunol.169.9.5078","article-title":"Modulation of gene expression by the MHC class II transactivator","volume":"169","author":"Nagarajan","year":"2002","journal-title":"J. Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/1346-8138.15201","article-title":"Is the survival rate for acral melanoma actually worse than other cutaneous melanomas?","volume":"47","author":"Lim","year":"2020","journal-title":"J. Dermatol."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Beretov, J., Wasinger, V.C., Millar, E.K., Schwartz, P., Graham, P.H., and Li, Y. (2015). Proteomic Analysis of Urine to Identify Breast Cancer Biomarker Candidates Using a Label-Free LC-MS\/MS Approach. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0141876"},{"key":"ref_87","first-page":"100070","article-title":"Genetic Factors Associated with Prostate Cancer Conversion from Active Surveillance to Treatment","volume":"3","author":"Jiang","year":"2022","journal-title":"HGG Adv."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1038\/s41379-022-01138-z","article-title":"Identification of fusions with potential clinical significance in melanoma","volume":"35","author":"Moran","year":"2022","journal-title":"Mod. Pathol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3109\/10428194.2015.1043549","article-title":"A novel e8a2 BCR-ABL1 fusion with insertion of MAST2 exon 2 in a four-way translocation t (1;17;9;22) (p35;q24;q44;q11) in a patient with chronic myeloid leukemia","volume":"57","author":"Riva","year":"2016","journal-title":"Leuk. Lymphoma"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12957-021-02124-6","article-title":"Identification of differentially methylated genes as diagnostic and prognostic biomarkers of breast cancer","volume":"19","author":"Mao","year":"2021","journal-title":"World J. Surg. Oncol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2760899","DOI":"10.1155\/2022\/2760899","article-title":"E3 Ubiquitin Ligase CHIP Inhibits the Interaction between Hsp90beta and MAST1 to Repress Radiation Resistance in Non-Small-Cell Lung Cancer Stem Cells","volume":"2022","author":"Tan","year":"2022","journal-title":"Stem Cells Int."},{"key":"ref_92","first-page":"12","article-title":"DNA methylation analysis in malignant pheochromocytoma and paraganglioma","volume":"7","author":"Oishi","year":"2017","journal-title":"J. Clin. Transl. Endocrinol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"944000","DOI":"10.3389\/fonc.2022.944000","article-title":"Identification of an integrated kinase-related prognostic gene signature associated with tumor immune microenvironment in human uterine corpus endometrial carcinoma","volume":"12","author":"Wei","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/jhg.2015.75","article-title":"Germline mutations causing familial lung cancer","volume":"60","author":"Tomoshige","year":"2015","journal-title":"J. Hum. Genet."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Morange, P.E., Peiretti, F., Gourhant, L., Proust, C., Soukarieh, O., Pulcrano-Nicolas, A.S., Saripella, G.V., Stefanucci, L., Lacroix, R., and Ibrahim-Kosta, M. (2021). A rare coding mutation in the MAST2 gene causes venous thrombosis in a French family with unexplained thrombophilia: The Breizh MAST2 Arg89Gln variant. PLoS Genet., 17.","DOI":"10.1101\/2020.05.23.20101402"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"775479","DOI":"10.3389\/fnmol.2021.775479","article-title":"The Role of Microtubule Associated Serine\/Threonine Kinase 3 Variants in Neurodevelopmental Diseases: Genotype-Phenotype Association","volume":"14","author":"Shu","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/ana.26147","article-title":"Pathogenic MAST3 Variants in the STK Domain Are Associated with Epilepsy","volume":"90","author":"Spinelli","year":"2021","journal-title":"Ann. Neurol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10048-018-0550-z","article-title":"Clinical and genetic study of Tunisian families with genetic generalized epilepsy: Contribution of CACNA1H and MAST4 genes","volume":"19","author":"Landoulsi","year":"2018","journal-title":"Neurogenetics"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13073-017-0433-1","article-title":"Genomic diagnosis for children with intellectual disability and\/or developmental delay","volume":"9","author":"Bowling","year":"2017","journal-title":"Genome Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/mp.2014.189","article-title":"Whole-exome sequencing points to considerable genetic heterogeneity of cerebral palsy","volume":"20","author":"McMichael","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature13394","article-title":"Genome sequencing identifies major causes of severe intellectual disability","volume":"511","author":"Gilissen","year":"2014","journal-title":"Nature"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/GIM.0b013e3181e59291","article-title":"A novel microdeletion\/microduplication syndrome of 19p13.13","volume":"12","author":"Dolan","year":"2010","journal-title":"Genet. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s12031-019-01415-8","article-title":"Evaluating the Role of MAST1 as an Intellectual Disability Disease Gene: Identification of a Novel De Novo Variant in a Patient with Developmental Disabilities","volume":"70","author":"Ali","year":"2020","journal-title":"J. Mol. Neurosci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1055\/s-0040-1710588","article-title":"The Clinical Picture of a Bilateral Perisylvian Syndrome as the Initial Symptom of Mega-Corpus-Callosum Syndrome due to a MAST1-Gene Mutation","volume":"51","author":"Hecher","year":"2020","journal-title":"Neuropediatrics"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/ajmg.a.61560","article-title":"MAST1 variant causes mega-corpus-callosum syndrome with cortical malformations but without cerebellar hypoplasia","volume":"182","year":"2020","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Mainguy-Seers, S., Beaudry, F., Fernandez-Prada, C., Martin, J.G., and Lavoie, J.P. (2022). Neutrophil Extracellular Vesicles and Airway Smooth Muscle Proliferation in the Natural Model of Severe Asthma in Horses. Cells, 11.","DOI":"10.3390\/cells11213347"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"100066","DOI":"10.1016\/j.xgen.2021.100066","article-title":"Machine learning enables new insights into genetic contributions to liver fat accumulation","volume":"1","author":"Haas","year":"2021","journal-title":"Cell Genom."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"105900","DOI":"10.1016\/j.intimp.2019.105900","article-title":"MAST3 modulates the inflammatory response and proliferation of fibroblast-like synoviocytes in rheumatoid arthritis","volume":"77","author":"Xu","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"13755","DOI":"10.1074\/jbc.RA119.008238","article-title":"Structure-based optimization of a PDZ-binding motif within a viral peptide stimulates neurite outgrowth","volume":"294","author":"Khan","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/BJ20141198","article-title":"Deciphering the unconventional peptide binding to the PDZ domain of MAST2","volume":"469","author":"Delhommel","year":"2015","journal-title":"Biochem. J."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/bioinformatics\/btl529","article-title":"Interactive Tree Of Life (iTOL): An online tool for phylogenetic tree display and annotation","volume":"23","author":"Letunic","year":"2007","journal-title":"Bioinformatics"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"W293","DOI":"10.1093\/nar\/gkab301","article-title":"Interactive Tree Of Life (iTOL) v5: An online tool for phylogenetic tree display and annotation","volume":"49","author":"Letunic","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"D458","DOI":"10.1093\/nar\/gkaa937","article-title":"SMART: Recent updates, new developments and status in 2020","volume":"49","author":"Letunic","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1093\/bib\/bbx108","article-title":"MAFFT online service: Multiple sequence alignment, interactive sequence choice and visualization","volume":"20","author":"Katoh","year":"2019","journal-title":"Brief. Bioinform."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1093\/bioinformatics\/btu033","article-title":"RAxML version 8: A tool for phylogenetic analysis and post-analysis of large phylogenies","volume":"30","author":"Stamatakis","year":"2014","journal-title":"Bioinformatics"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"D1038","DOI":"10.1093\/nar\/gkac972","article-title":"The International Mouse Phenotyping Consortium: Comprehensive knockout phenotyping underpinning the study of human disease","volume":"51","author":"Groza","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"D924","DOI":"10.1093\/nar\/gkaa914","article-title":"The mouse Gene Expression Database (GXD): 2021 update","volume":"49","author":"Baldarelli","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1006\/mcne.1999.0761","article-title":"Stomatin, a MEC-2 like protein, is expressed by mammalian sensory neurons","volume":"13","author":"Mannsfeldt","year":"1999","journal-title":"Mol. Cell Neurosci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0896-6273(00)80835-1","article-title":"Serotonin inhibition of synaptic transmission: Galpha(0) decreases the abundance of UNC-13 at release sites","volume":"24","author":"Nurrish","year":"1999","journal-title":"Neuron"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0896-6273(00)80847-8","article-title":"Goalpha and diacylglycerol kinase negatively regulate the Gqalpha pathway in C. elegans","volume":"24","author":"Miller","year":"1999","journal-title":"Neuron"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1073\/pnas.1909240117","article-title":"Presynaptic MAST kinase controls opposing postsynaptic responses to convey stimulus valence in Caenorhabditis elegans","volume":"117","author":"Nakano","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"e12906","DOI":"10.1111\/acel.12906","article-title":"KIN-4\/MAST kinase promotes PTEN-mediated longevity of Caenorhabditis elegans via binding through a PDZ domain","volume":"18","author":"An","year":"2019","journal-title":"Aging Cell"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1242\/dev.104711","article-title":"The Drosophila MAST kinase Drop out is required to initiate membrane compartmentalisation during cellularisation and regulates dynein-based transport","volume":"141","author":"Hain","year":"2014","journal-title":"Development"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/mrd.1080320405","article-title":"Drop out: A third chromosome maternal-effect locus required for formation of the Drosophila cellular blastoderm","volume":"32","author":"Galewsky","year":"1992","journal-title":"Mol. Reprod. Dev."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1002\/bies.10184","article-title":"How one becomes many: Blastoderm cellularization in Drosophila melanogaster","volume":"24","author":"Mazumdar","year":"2002","journal-title":"Bioessays"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.semcdb.2022.03.028","article-title":"Membrane-actin interactions in morphogenesis: Lessons learned from Drosophila cellularization","volume":"133","author":"Sokac","year":"2023","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"jcs212795","DOI":"10.1242\/jcs.212795","article-title":"Dynamics of cortical domains in early Drosophila development","volume":"131","author":"Schmidt","year":"2018","journal-title":"J. Cell Sci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1083\/jcb.148.5.945","article-title":"Dynein-mediated cargo transport in vivo. A switch controls travel distance","volume":"148","author":"Gross","year":"2000","journal-title":"J. Cell Biol."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Meyer, W.J., Schreiber, S., Guo, Y., Volkmann, T., Welte, M.A., and Muller, H.A. (2006). Overlapping functions of argonaute proteins in patterning and morphogenesis of Drosophila embryos. PLoS Genet., 2.","DOI":"10.1371\/journal.pgen.0020134"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0092-8674(00)80947-2","article-title":"Developmental regulation of vesicle transport in Drosophila embryos: Forces and kinetics","volume":"92","author":"Welte","year":"1998","journal-title":"Cell"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/15\/11913\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:18:41Z","timestamp":1760127521000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/15\/11913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,25]]},"references-count":130,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["ijms241511913"],"URL":"https:\/\/doi.org\/10.3390\/ijms241511913","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,25]]}}}