{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:44:03Z","timestamp":1768290243310,"version":"3.49.0"},"reference-count":63,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Spanish Institute of Health Carlos III (FIS) cofunded by the European Union (ERDF\/ESF, \u201cA way to make Europe\u201d\/\u201cInvesting in your future\u201d","doi-asserted-by":"publisher","award":["PI21\/00546"],"award-info":[{"award-number":["PI21\/00546"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish Fundaci\u00f3n Mutua Madrile\u00f1a de Investigaci\u00f3n M\u00e9dica","award":["PI21\/00546"],"award-info":[{"award-number":["PI21\/00546"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Acute intermittent porphyria (AIP) is a metabolic disorder caused by mutations in the porphobilinogen deaminase (PBGD) gene, encoding the third enzyme of the heme synthesis pathway. Although AIP is characterized by low clinical penetrance (~1% of PBGD mutation carriers), patients with clinically stable disease report chronic symptoms and frequently show insulin resistance. This study aimed to evaluate the beneficial impact of nutritional interventions on correct carbohydrate dysfunctions in a mouse model of AIP that reproduces insulin resistance and altered glucose metabolism. The addition of spores of Bacillus coagulans in drinking water for 12 weeks modified the gut microbiome composition in AIP mice, ameliorated glucose tolerance and hyperinsulinemia, and stimulated fat disposal in adipose tissue. Lipid breakdown may be mediated by muscles burning energy and heat dissipation by brown adipose tissue, resulting in a loss of fatty tissue and improved lean\/fat tissue ratio. Probiotic supplementation also improved muscle glucose uptake, as measured using Positron Emission Tomography (PET) analysis. In conclusion, these data provide a proof of concept that probiotics, as a dietary intervention in AIP, induce relevant changes in intestinal bacteria composition and improve glucose uptake and muscular energy utilization. Probiotics may offer a safe, efficient, and cost-effective option to manage people with insulin resistance associated with AIP.<\/jats:p>","DOI":"10.3390\/ijms241511938","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:45:02Z","timestamp":1690332302000},"page":"11938","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nutritional Interventions with Bacillus coagulans Improved Glucose Metabolism and Hyperinsulinemia in Mice with Acute Intermittent Porphyria"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9433-3492","authenticated-orcid":false,"given":"Miriam","family":"Longo","sequence":"first","affiliation":[{"name":"Hepatology: Porphyrias & Carcinogenesis Laboratory, Solid Tumors Program, CIMA-University of Navarra, 31008 Pamplona, Spain"},{"name":"Medicine and Metabolic Diseases, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore 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Disease","volume":"37","author":"Chen","year":"2016","journal-title":"Hum. Mutat."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1046\/j.1365-2796.1997.00189.x","article-title":"Acute Intermittent Porphyria: Prevalence of Mutations in the Porphobilinogen Deaminase Gene in Blood Donors in France","volume":"242","author":"Nordmann","year":"1997","journal-title":"J. Intern. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s10545-012-9544-4","article-title":"The Incidence of Inherited Porphyrias in Europe","volume":"36","author":"Elder","year":"2013","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13023-019-1031-7","article-title":"High Penetrance of Acute Intermittent Porphyria in a Spanish Founder Mutation Population and CYP2D6 Genotype as a Susceptibility Factor","volume":"14","year":"2019","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Di Pierro, E., De Canio, M., Mercadante, R., Savino, M., Granata, F., Tavazzi, D., Nicolli, A.M., Trevisan, A., Marchini, S., and Fustinoni, S. (2021). Laboratory Diagnosis of Porphyria. Diagnostics, 11.","DOI":"10.3390\/diagnostics11081343"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1053\/j.gastro.2022.11.034","article-title":"AGA Clinical Practice Update on Diagnosis and Management of Acute Hepatic Porphyrias: Expert Review","volume":"164","author":"Wang","year":"2023","journal-title":"Gastroenterology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1136\/jclinpath-2012-200791","article-title":"Review of Hepatocellular Cancer, Hypertension and Renal Impairment as Late Complications of Acute Porphyria and Recommendations for Patient Follow-Up","volume":"65","author":"Stewart","year":"2012","journal-title":"J. Clin. Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.jhep.2022.05.018","article-title":"Bi-Allelic Hydroxymethylbilane Synthase Inactivation Defines a Homogenous Clinico-Molecular Subtype of Hepatocellular Carcinoma","volume":"77","author":"Molina","year":"2022","journal-title":"J. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.jhep.2022.06.023","article-title":"Hydroxymethylbilane Synthase (Aka Porphobilinogen Deaminase): A Novel Metabolic Tumor Suppressor Gene in Hepatocellular Carcinoma","volume":"77","author":"Fontanellas","year":"2022","journal-title":"J. Hepatol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Solares, I., Izquierdo-S\u00e1nchez, L., Morales-Conejo, M., Jeric\u00f3, D., Castelb\u00f3n, F.J., C\u00f3rdoba, K.M., Sampedro, A., Lumbreras, C., Moreno-Aliaga, M.J., and Enr\u00edquez de Salamanca, R. (2021). High Prevalence of Insulin Resistance in Asymptomatic Patients with Acute Intermittent Porphyria and Liver-Targeted Insulin as a Novel Therapeutic Approach. Biomedicines, 9.","DOI":"10.3390\/biomedicines9030255"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/j.1365-2362.2012.02673.x","article-title":"Assessing Nutritional Status of Acute Intermittent Porphyria Patients","volume":"42","author":"Murcia","year":"2012","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ymgme.2018.12.006","article-title":"Lifestyle Factors Including Diet and Biochemical Biomarkers in Acute Intermittent Porphyria: Results from a Case-Control Study in Northern Norway","volume":"128","author":"Storjord","year":"2018","journal-title":"Mol. Genet. Metab."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s13023-021-01742-3","article-title":"Health Impact of Acute Intermittent Porphyria in Latent and Non-Recurrent Attacks Patients","volume":"16","year":"2021","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1046\/j.1365-2796.1999.0448e.x","article-title":"Effects of Diabetes Mellitus on Patients with Acute Intermittent Porphyria","volume":"245","author":"Andersson","year":"1999","journal-title":"J. Intern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Di Pierro, E., and Granata, F. (2020). Nutrients and Porphyria: An Intriguing Crosstalk. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103462"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Longo, M., Paolini, E., Meroni, M., Duca, L., Motta, I., Fracanzani, A.L., Di Pierro, E., and Dongiovanni, P. (2021). \u03b1-Lipoic Acid Improves Hepatic Metabolic Dysfunctions in Acute Intermittent Porphyria: A Proof-of-Concept Study. Diagnostics, 11.","DOI":"10.20944\/preprints202108.0117.v1"},{"key":"ref_17","first-page":"815","article-title":"Effect of Alpha Lipoic Acid Amide on Hexachlorobenzene Porphyria","volume":"47","author":"Vilas","year":"1999","journal-title":"Biochem. Mol. Biol. Int."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Mishra, S.P., Wang, B., Jain, S., Ding, J., Rejeski, J., Furdui, C.M., Kitzman, D.W., Taraphder, S., Brechot, C., and Kumar, A. (Gut, 2023). A Mechanism by Which Gut Microbiota Elevates Permeability and Inflammation in Obese\/Diabetic Mice and Human Gut, Gut, online ahead of print.","DOI":"10.1136\/gutjnl-2022-327365"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1136\/gutjnl-2021-326789","article-title":"Gut Microbiome and Health: Mechanistic Insights","volume":"71","author":"Tilg","year":"2022","journal-title":"Gut"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Leeuwendaal, N.K., Stanton, C., O\u2019Toole, P.W., and Beresford, T.P. (2022). Fermented Foods, Health and the Gut Microbiome. Nutrients, 14.","DOI":"10.3390\/nu14071527"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Patel, P., Butani, K., Kumar, A., Singh, S., and Prajapati, B.G. (2023). Effects of Fermented Food Consumption on Non-Communicable Diseases. Foods, 12.","DOI":"10.3390\/foods12040687"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Uusitupa, H.-M., Rasinkangas, P., Lehtinen, M.J., M\u00e4kel\u00e4, S.M., Airaksinen, K., Anglenius, H., Ouwehand, A.C., and Maukonen, J. (2020). Bifidobacterium animalis subsp. lactis 420 for Metabolic Health: Review of the Research. Nutrients, 12.","DOI":"10.3390\/nu12040892"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jff.2017.09.029","article-title":"Heat-Killed Bifidobacterium animalis subsp. lactis CECT 8145 Increases Lean Mass and Ameliorates Metabolic Syndrome in Cafeteria-Fed Obese Rats","volume":"38","author":"Caimari","year":"2017","journal-title":"J. Funct. Foods"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/1751-7915.13769","article-title":"Lipoteichoic Acid from Bifidobacterium animalis subsp. lactis BPL1: A Novel Postbiotic That Reduces Fat Deposition via IGF-1 Pathway","volume":"15","author":"Balaguer","year":"2022","journal-title":"Microb. Biotechnol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Urtasun, R., D\u00edaz-G\u00f3mez, J., Ara\u00f1a, M., Pajares, M.J., Oneca, M., Torre, P., Jim\u00e9nez, M., Munilla, G., Barajas, M., and Enc\u00edo, I. (2020). A Combination of Apple Vinegar Drink with Bacillus coagulans Ameliorates High Fat Diet-Induced Body Weight Gain, Insulin Resistance and Hepatic Steatosis. Nutrients, 12.","DOI":"10.3390\/nu12092504"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1757-4749-4-13","article-title":"Bacillus coagulans GBI-30, 6086 Limits the Recurrence of Clostridium Difficile-Induced Colitis Following Vancomycin Withdrawal in Mice","volume":"4","author":"Fitzpatrick","year":"2012","journal-title":"Gut Pathog."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.3945\/jn.114.199802","article-title":"Bacillus coagulans GBI-30, 6086 Modulates Faecalibacterium Prausnitzii in Older Men and Women","volume":"145","author":"Nyangale","year":"2015","journal-title":"J. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12986-020-00515-2","article-title":"Bacillus coagulans GBI-30, 6086 Improves Amino Acid Absorption from Milk Protein","volume":"17","author":"Stecker","year":"2020","journal-title":"Nutr. Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1093\/jn\/nxz071","article-title":"Glucose- and Lipid-Related Biomarkers Are Affected in Healthy Obese or Hyperglycemic Adults Consuming a Whole-Grain Pasta Enriched in Prebiotics and Probiotics: A 12-Week Randomized Controlled Trial","volume":"149","author":"Angelino","year":"2019","journal-title":"J. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Walden, K.E., Hagele, A.M., Orr, L.S., Gross, K.N., Krieger, J.M., J\u00e4ger, R., and Kerksick, C.M. (Probiotics Antimicrob. Proteins, 2022). Probiotic BC30 Improves Amino Acid Absorption from Plant Protein Concentrate in Older Women, Probiotics Antimicrob. Proteins, online ahead of print.","DOI":"10.1007\/s12602-022-10028-4"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3920\/BM2018.0037","article-title":"Spores of Bacillus coagulans GBI-30, 6086 Show High Germination, Survival and Enzyme Activity in a Dynamic, Computer-Controlled in Vitro Model of the Gastrointestinal Tract","volume":"10","author":"Keller","year":"2019","journal-title":"Benef. Microbes"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/gme.0b013e31817dacf7","article-title":"Impact of Resistance Training with or without Caloric Restriction on Physical Capacity in Obese Older Women","volume":"16","author":"Bouchard","year":"2009","journal-title":"Menopause"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1038\/s41598-018-20529-4","article-title":"Effects of Blood Glucose Level on 18F Fluorodeoxyglucose (18F-FDG) Uptake for PET\/CT in Normal Organs: An Analysis on 5623 Patients","volume":"8","author":"Sprinz","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1093\/hmg\/ddw013","article-title":"Glucose Metabolism during Fasting Is Altered in Experimental Porphobilinogen Deaminase Deficiency","volume":"25","author":"Collantes","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Maliszewska, K., and Kretowski, A. (2021). Brown Adipose Tissue and Its Role in Insulin and Glucose Homeostasis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041530"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Stadlbauer, V. (2023). Liver-Gut-Interaction: Role of Microbiome Transplantation in the Future Treatment of Metabolic Disease. J. Pers. Med., 13.","DOI":"10.3390\/jpm13020220"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Kumari, V.B.C., Huligere, S.S., Alotaibi, G., Al Mouslem, A.K., Bahauddin, A.A., Shivanandappa, T.B., and Ramu, R. (2023). Antidiabetic Activity of Potential Probiotics Limosilactobacillus spp., Levilactobacillus spp., and Lacticaseibacillus spp. Isolated from Fermented Sugarcane Juice: A Comprehensive In Vitro and In Silico Study. Nutrients, 15.","DOI":"10.3390\/nu15081882"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1177\/0004563212474555","article-title":"Best Practice Guidelines on Clinical Management of Acute Attacks of Porphyria and Their Complications","volume":"50","author":"Stein","year":"2013","journal-title":"Ann. Clin. Biochem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1126\/science.aar3318","article-title":"Hyperglycemia Drives Intestinal Barrier Dysfunction and Risk for Enteric Infection","volume":"359","author":"Thaiss","year":"2018","journal-title":"Science"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Solares, I., Jeric\u00f3, D., C\u00f3rdoba, K.M., Morales-Conejo, M., Ena, J., Enr\u00edquez de Salamanca, R., and Fontanellas, A. (2022). Understanding Carbohydrate Metabolism and Insulin Resistance in Acute Intermittent Porphyria. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010051"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.cell.2005.06.040","article-title":"Nutritional Regulation of Hepatic Heme Biosynthesis and Porphyria through PGC-1\u03b1","volume":"122","author":"Handschin","year":"2005","journal-title":"Cell"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.tox.2011.08.014","article-title":"How Porphyrinogenic Drugs Modeling Acute Porphyria Impair the Hormonal Status That Regulates Glucose Metabolism. Their Relevance in the Onset of This Disease","volume":"290","author":"Matkovic","year":"2011","journal-title":"Toxicology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e0064122","DOI":"10.1128\/spectrum.00641-22","article-title":"Bacillus coagulans in Combination with Chitooligosaccharides Regulates Gut Microbiota and Ameliorates the DSS-Induced Colitis in Mice","volume":"10","author":"Liu","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Yu, D., Meng, X., de Vos, W.M., Wu, H., Fang, X., and Maiti, A.K. (2021). Implications of Gut Microbiota in Complex Human Diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222312661"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1136\/gutjnl-2012-302167","article-title":"Intestinal Microbiota in Functional Bowel Disorders: A Rome Foundation Report","volume":"62","author":"Barbara","year":"2013","journal-title":"Gut"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41575-021-00499-1","article-title":"The Promise of the Gut Microbiome as Part of Individualized Treatment Strategies","volume":"19","author":"Schupack","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Past\u00e9n, A., P\u00e9rez-Hern\u00e1ndez, N., A\u00f1orve-Morga, J., Jim\u00e9nez-Alvarado, R., Cari\u00f1o-Cort\u00e9s, R., Sosa-Lozada, T., and Fern\u00e1ndez-Mart\u00ednez, E. (2022). The Activity of Prebiotics and Probiotics in Hepatogastrointestinal Disorders and Diseases Associated with Metabolic Syndrome. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23137229"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Gradisteanu Pircalabioru, G., Corcionivoschi, N., Gundogdu, O., Chifiriuc, M.-C., Marutescu, L.G., Ispas, B., and Savu, O. (2021). Dysbiosis in the Development of Type I Diabetes and Associated Complications: From Mechanisms to Targeted Gut Microbes Manipulation Therapies. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052763"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Carpi, R.Z., Barbalho, S.M., Sloan, K.P., Laurindo, L.F., Gonzaga, H.F., Grippa, P.C., Zutin, T.L.M., Girio, R.J.S., Repetti, C.S.F., and Detregiachi, C.R.P. (2022). The Effects of Probiotics, Prebiotics and Synbiotics in Non-Alcoholic Fat Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH): A Systematic Review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23158805"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1093\/bbb\/zbaa116","article-title":"Comparative Evaluation for Thermostability and Gastrointestinal Survival of Probiotic Bacillus coagulans MTCC 5856","volume":"85","author":"Majeed","year":"2021","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Vallianou, N.G., Kounatidis, D., Tsilingiris, D., Panagopoulos, F., Christodoulatos, G.S., Evangelopoulos, A., Karampela, I., and Dalamaga, M. (2023). The Role of Next-Generation Probiotics in Obesity and Obesity-Associated Disorders: Current Knowledge and Future Perspectives. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24076755"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s40168-022-01306-y","article-title":"Orally Administered Odoribacter Laneus Improves Glucose Control and Inflammatory Profile in Obese Mice by Depleting Circulating Succinate","volume":"10","author":"Calvo","year":"2022","journal-title":"Microbiome"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.omtn.2021.05.010","article-title":"MRNA-Based Therapy in a Rabbit Model of Variegate Porphyria Offers New Insights into the Pathogenesis of Acute Attacks","volume":"25","author":"Jiang","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"67004","DOI":"10.1289\/EHP11874","article-title":"Evaluation of the Impact of BaP Exposure on the Gut Microbiota and Allergic Responses in an OVA-Sensitized Mouse Model","volume":"131","author":"Du","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s40168-020-00906-w","article-title":"Multi-Omics Analysis Reveals the Influence of Genetic and Environmental Risk Factors on Developing Gut Microbiota in Infants at Risk of Celiac Disease","volume":"8","author":"Leonard","year":"2020","journal-title":"Microbiome"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1178155","DOI":"10.3389\/fendo.2023.1178155","article-title":"Can Prebiotics Help Tackle the Childhood Obesity Epidemic?","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Endocrinol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"976406","DOI":"10.3389\/fmicb.2022.976406","article-title":"Potential of Gut-Derived Short-Chain Fatty Acids to Control Enteric Pathogens","volume":"13","author":"Zhan","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"768996","DOI":"10.3389\/fgene.2021.768996","article-title":"Metabolic Fuel for Epigenetic: Nuclear Production Meets Local Consumption","volume":"12","author":"Boon","year":"2021","journal-title":"Front. Genet."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.chom.2015.05.012","article-title":"Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life","volume":"17","author":"Roswall","year":"2015","journal-title":"Cell Host Microbe"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"131741","DOI":"10.1016\/j.jhazmat.2023.131741","article-title":"Bacillus coagulans (Weizmannia coagulans) XY2 Attenuates Cu-Induced Oxidative Stress via DAF-16\/FoxO and SKN-1\/Nrf2 Pathways and Gut Microbiota Regulation","volume":"457","author":"Gao","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Celis, A.I., Relman, D.A., and Huang, K.C. (2023). The Impact of Iron and Heme Availability on the Healthy Human Gut Microbiome in Vivo and in Vitro. Cell Chem. Biol., 30.","DOI":"10.1016\/j.chembiol.2022.12.001"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1600620","DOI":"10.1002\/mnfr.201600620","article-title":"Phylogenetic Profile of Gut Microbiota in Healthy Adults after Moderate Intake of Red Wine","volume":"61","author":"Barroso","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"W310","DOI":"10.1093\/nar\/gkad407","article-title":"MicrobiomeAnalyst 2.0: Comprehensive Statistical, Functional and Integrative Analysis of Microbiome Data","volume":"51","author":"Lu","year":"2023","journal-title":"Nucleic Acids Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/15\/11938\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:19:01Z","timestamp":1760127541000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/15\/11938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,26]]},"references-count":63,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["ijms241511938"],"URL":"https:\/\/doi.org\/10.3390\/ijms241511938","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,26]]}}}