{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:27:44Z","timestamp":1788546464562,"version":"build-2803163510"},"reference-count":38,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"F\u00e9d\u00e9ration Fran\u00e7aise de Cardiologie"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cardiac complications are frequently found following a stroke in humans whose pathophysiological mechanism remains poorly understood. We used machine learning to analyse a large set of data from a metabolipidomic study assaying 630 metabolites in a rat stroke model to investigate metabolic changes affecting the heart within 72 h after a stroke. Twelve rats undergoing a stroke and 28 rats undergoing the sham procedure were investigated. A plasmatic signature consistent with the literature with notable lipid metabolism remodelling was identified. The post-stroke heart showed a discriminant metabolic signature, in comparison to the sham controls, involving increased collagen turnover, increased arginase activity with decreased nitric oxide synthase activity as well as an altered amino acid metabolism (including serine, asparagine, lysine and glycine). In conclusion, these results demonstrate that brain injury induces a metabolic remodelling in the heart potentially involved in the pathophysiology of stroke heart syndrome.<\/jats:p>","DOI":"10.3390\/ijms241512000","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T01:27:46Z","timestamp":1690421266000},"page":"12000","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Combined Metabolipidomic and Machine Learning Approach in a Rat Model of Stroke Reveals a Deleterious Impact of Brain Injury on Heart Metabolism"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2287-7252","authenticated-orcid":false,"given":"Xavier","family":"Dieu","sequence":"first","affiliation":[{"name":"MITOVASC, SFR ICAT, CNRS, INSERM, Universit\u00e9 d\u2019Angers, F-49000 Angers, France"},{"name":"Service de Biochimie et Biologie Mol\u00e9culaire, CHU Angers, F-49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Tamareille","sequence":"additional","affiliation":[{"name":"MITOVASC, SFR ICAT, CNRS, INSERM, Universit\u00e9 d\u2019Angers, F-49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aglae","family":"Herbreteau","sequence":"additional","affiliation":[{"name":"MITOVASC, SFR ICAT, CNRS, INSERM, Universit\u00e9 d\u2019Angers, F-49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Lebeau","sequence":"additional","affiliation":[{"name":"MITOVASC, SFR ICAT, CNRS, INSERM, Universit\u00e9 d\u2019Angers, F-49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Chao De La Barca","sequence":"additional","affiliation":[{"name":"MITOVASC, SFR ICAT, CNRS, INSERM, Universit\u00e9 d\u2019Angers, F-49000 Angers, France"},{"name":"Service de Biochimie et Biologie Mol\u00e9culaire, CHU Angers, F-49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6871-8711","authenticated-orcid":false,"given":"Floris","family":"Chabrun","sequence":"additional","affiliation":[{"name":"MITOVASC, SFR ICAT, CNRS, INSERM, Universit\u00e9 d\u2019Angers, F-49000 Angers, France"},{"name":"Service de Biochimie et Biologie Mol\u00e9culaire, CHU Angers, F-49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0802-4608","authenticated-orcid":false,"given":"Pascal","family":"Reynier","sequence":"additional","affiliation":[{"name":"MITOVASC, SFR ICAT, CNRS, INSERM, Universit\u00e9 d\u2019Angers, F-49000 Angers, France"},{"name":"Service de Biochimie et Biologie Mol\u00e9culaire, CHU Angers, F-49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Mirebeau-Prunier","sequence":"additional","affiliation":[{"name":"MITOVASC, SFR ICAT, CNRS, INSERM, Universit\u00e9 d\u2019Angers, F-49000 Angers, France"},{"name":"Service de Biochimie et Biologie Mol\u00e9culaire, CHU Angers, F-49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Prunier","sequence":"additional","affiliation":[{"name":"MITOVASC, SFR ICAT, CNRS, INSERM, Universit\u00e9 d\u2019Angers, F-49000 Angers, France"},{"name":"Service de Cardiologie, CHU Angers, F-49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S1474-4422(18)30336-3","article-title":"Stroke\u2013Heart Syndrome: Clinical Presentation and Underlying Mechanisms","volume":"17","author":"Scheitz","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1016\/j.jacc.2020.10.009","article-title":"Post-Stroke Cardiovascular Complications and Neurogenic Cardiac Injury","volume":"76","author":"Sposato","year":"2020","journal-title":"J. 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