{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:45:24Z","timestamp":1789494324588,"version":"build-2803163510"},"reference-count":55,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Topoisomerases, common targets for anti-cancer therapeutics, are crucial enzymes for DNA replication, transcription, and many other aspects of DNA metabolism. The potential anti-cancer effects of thiosemicarbazones (TSC) and metal\u2013TSC complexes have been demonstrated to target several biological processes, including DNA metabolism. Human topoisomerases were discovered among the molecular targets for TSCs, and metal-chelated TSCs specifically displayed significant inhibition of topoisomerase II. The processes by which metal\u2013TSCs or TSCs inhibit topoisomerases are still being studied. In this brief review, we summarize the TSCs and metal\u2013TSCs that inhibit various types of human topoisomerases, and we note some of the key unanswered questions regarding this interesting class of diverse compounds.<\/jats:p>","DOI":"10.3390\/ijms241512010","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T01:27:46Z","timestamp":1690421266000},"page":"12010","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes"],"prefix":"10.3390","volume":"24","author":[{"given":"Xiaohua","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Chemistry, Vanderbilt University, Nashville, TN 37240, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren A.","family":"Fielding","sequence":"additional","affiliation":[{"name":"Department of Biological, Physical and Human Sciences, Freed Hardeman University, Henderson, TN 38340, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hunter","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Tennessee Tech University, Cookeville, TN 38505, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Tennessee Tech University, Cookeville, TN 38505, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward C.","family":"Lisic","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Tennessee Tech University, Cookeville, TN 38505, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9683-6723","authenticated-orcid":false,"given":"Joseph E.","family":"Deweese","sequence":"additional","affiliation":[{"name":"Department of Biological, Physical and Human Sciences, Freed Hardeman University, Henderson, TN 38340, USA"},{"name":"Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37240, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nrm.2016.111","article-title":"Roles of eukaryotic topoisomerases in transcription, replication and genomic stability","volume":"17","author":"Pommier","year":"2016","journal-title":"Nat. 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