{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:33:44Z","timestamp":1785447224491,"version":"3.56.0"},"reference-count":37,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006595","name":"Romanian Ministry of Education and Research, CCCDI-UEFISCDI","doi-asserted-by":"publisher","award":["PN-III-P2-2.1-PED-2019-1897"],"award-info":[{"award-number":["PN-III-P2-2.1-PED-2019-1897"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006595","name":"Romanian Ministry of Education and Research, CCCDI-UEFISCDI","doi-asserted-by":"publisher","award":["ANR-16-RHUS-0003"],"award-info":[{"award-number":["ANR-16-RHUS-0003"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Research Agency (ANR)","award":["PN-III-P2-2.1-PED-2019-1897"],"award-info":[{"award-number":["PN-III-P2-2.1-PED-2019-1897"]}]},{"name":"National Research Agency (ANR)","award":["ANR-16-RHUS-0003"],"award-info":[{"award-number":["ANR-16-RHUS-0003"]}]},{"name":"COST (European Cooperation in Science and Technology)","award":["PN-III-P2-2.1-PED-2019-1897"],"award-info":[{"award-number":["PN-III-P2-2.1-PED-2019-1897"]}]},{"name":"COST (European Cooperation in Science and Technology)","award":["ANR-16-RHUS-0003"],"award-info":[{"award-number":["ANR-16-RHUS-0003"]}]},{"name":"EU-CardioRNA COST Action CA17129","award":["PN-III-P2-2.1-PED-2019-1897"],"award-info":[{"award-number":["PN-III-P2-2.1-PED-2019-1897"]}]},{"name":"EU-CardioRNA COST Action CA17129","award":["ANR-16-RHUS-0003"],"award-info":[{"award-number":["ANR-16-RHUS-0003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Coronary artery disease (CAD) is a leading cause of mortality worldwide. In this study, we aimed to assess the potential of plasma long non-coding RNAs (lncRNAs) LIPCAR and MALAT1 and microRNAs (miRNAs) miR-142-3p and miR-155-5p to discriminate unstable CAD patients from stable ones. 23 stable angina (SA), 21 unstable angina (UA), and 50 ST-segment elevation myocardial infarction (STEMI) patients were enrolled; their plasma was collected. ncRNA plasma levels were evaluated using RT-qPCR. All measured ncRNA levels were significantly increased in UA patients\u2019 plasma compared to SA patients\u2019 plasma and in STEMI-with major adverse cardiovascular event (MACE) patients\u2019 plasma vs. STEMI-without MACE patients\u2019 plasma. ROC analysis showed that increased levels of LIPCAR and MALAT1 were associated with UA, and the prognostic model improved with the addition of miR-155-5p levels. The assessed lncRNAs discriminated between hyperglycemic (HG) and normoglycemic (NG) UA patients, and they were associated with MACE incidence in STEMI patients; this prediction was improved by the addition of miR-142-3p levels to the ROC multivariate model. We propose LIPCAR and MALAT1 as effective diagnostic markers for vulnerable CAD, their association with HG in UA patients, and as robust predictors for unfavorable evolution of STEMI patients.<\/jats:p>","DOI":"10.3390\/ijms241512076","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T07:35:24Z","timestamp":1690529724000},"page":"12076","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Elevated Levels of Circulating lncRNAs LIPCAR and MALAT1 Predict an Unfavorable Outcome in Acute Coronary Syndrome Patients"],"prefix":"10.3390","volume":"24","author":[{"given":"Teodora","family":"Barbalata","sequence":"first","affiliation":[{"name":"Lipidomics Department, Institute of Cellular Biology and Pathology \u201cNicolae Simionescu\u201d of the Romanian Academy, 8 Bogdan Petriceicu Hasdeu Street, 050568 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1394-9085","authenticated-orcid":false,"given":"Loredan S.","family":"Niculescu","sequence":"additional","affiliation":[{"name":"Lipidomics Department, Institute of Cellular Biology and Pathology \u201cNicolae Simionescu\u201d of the Romanian Academy, 8 Bogdan Petriceicu Hasdeu Street, 050568 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camelia S.","family":"Stancu","sequence":"additional","affiliation":[{"name":"Lipidomics Department, Institute of Cellular Biology and Pathology \u201cNicolae Simionescu\u201d of the Romanian Academy, 8 Bogdan Petriceicu Hasdeu Street, 050568 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5471-1487","authenticated-orcid":false,"given":"Florence","family":"Pinet","sequence":"additional","affiliation":[{"name":"U1167-RID-AGE-Facteurs de Risque et D\u00e9terminants Mol\u00e9culaires des Maladies Li\u00e9es au Vieillissement, Institut Pasteur de Lille, Universit\u00e9 de Lille, INSERM, CHU Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca V.","family":"Sima","sequence":"additional","affiliation":[{"name":"Lipidomics Department, Institute of Cellular Biology and Pathology \u201cNicolae Simionescu\u201d of the Romanian Academy, 8 Bogdan Petriceicu Hasdeu Street, 050568 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","article-title":"2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes","volume":"41","author":"Knuuti","year":"2020","journal-title":"Eur. 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