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C\u00e1ncer","award":["PI20\/01368"],"award-info":[{"award-number":["PI20\/01368"]}]},{"name":"Junta Asociada Provincial de Valencia de la Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer","award":["PI22\/01872"],"award-info":[{"award-number":["PI22\/01872"]}]},{"name":"Junta Asociada Provincial de Valencia de la Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer","award":["GV\/2020\/200"],"award-info":[{"award-number":["GV\/2020\/200"]}]},{"name":"Junta Asociada Provincial de Valencia de la Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer","award":["FIHGUV 2019"],"award-info":[{"award-number":["FIHGUV 2019"]}]},{"name":"Junta Asociada Provincial de Valencia de la Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer","award":["ACIF\/2020\/216"],"award-info":[{"award-number":["ACIF\/2020\/216"]}]},{"name":"Junta Asociada Provincial de Valencia de la Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer","award":["Prize SETH 2021"],"award-info":[{"award-number":["Prize SETH 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The primary objective of this study was to identify and compare the spatial distribution of tumour-infiltrating lymphocytes (TILs) and tumour-associated macrophages (TAMs) in OE and EAOC. Secondary objectives included the analysis of the relationship between immunosuppressive populations and T-cell exhaustion markers in both groups. Methods: TILs (CD3, CD4, and CD8) and macrophages (CD163) were assessed by immunochemistry. Exhaustion markers (PD-1, TIM3, CD39, and FOXP3) and their relationship with tumour-associated macrophages (CD163) were assessed by immunofluorescence on paraffin-embedded samples from n = 43 OE and n = 54 EAOC patients. Results: we observed a predominantly intraepithelial CD3+ distribution in OE but both an intraepithelial and stromal pattern in EAOC (p &lt; 0.001). TILs were more abundant in OE (p &lt; 0.001), but higher TILs significantly correlated with a longer overall survival and disease-free survival in EAOC (p &lt; 0.05). CD39 and FOXP3 significantly correlated with each other and CD163 (p &lt; 0.05) at the epithelial level in moderate\/intense CD4 EAOC, whereas in moderate\/intense CD8+, PD-1+ and TIM3+ significantly correlated (p = 0.009). Finally, T-cell exhaustion markers FOXP3-CD39 were decreased and PD-1-TIM3 were significantly increased in EAOC (p &lt; 0.05). Conclusions: the dysregulation of TILs, TAMs, and T-cell exhaustion might play a role in the malignization of OE to EAOC.<\/jats:p>","DOI":"10.3390\/ijms241512083","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T07:35:24Z","timestamp":1690529724000},"page":"12083","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of Immune Infiltrates in Ovarian Endometriosis and Endometriosis-Associated Ovarian Cancer: Relationship with Histological and Clinical Features"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5566-8479","authenticated-orcid":false,"given":"Emanuela","family":"Spagnolo","sequence":"first","affiliation":[{"name":"Department of Gynecology, La Paz University Hospital, 28046 Madrid, Spain"},{"name":"Research Institute \u201cIdiPaz\u201d, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Institut Claudius Regaud-Institut Universitaire du Cancer du Toulouse (IUCT) Oncopole, 31059 Toulouse, France"},{"name":"Centre de Recherches en Canc\u00e9rologie de Toulouse, UMR 1037 INSERM, 31100 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mascar\u00f3s-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Pathology, General University Hospital of Valencia, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0625-4901","authenticated-orcid":false,"given":"Josep","family":"Mar\u00ed-Alexandre","sequence":"additional","affiliation":[{"name":"Department of Pathology, General University Hospital of Valencia, 46014 Valencia, Spain"},{"name":"Research Laboratory in Biomarkers in Reproduction, Obstetrics and Gynecology, Research Foundation, General University Hospital of Valencia, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9287-0182","authenticated-orcid":false,"given":"Mar\u00eda","family":"Carbonell","sequence":"additional","affiliation":[{"name":"Department of Gynecology, La Paz University Hospital, 28046 Madrid, Spain"},{"name":"Research Institute \u201cIdiPaz\u201d, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Gonz\u00e1lez-Cant\u00f3","sequence":"additional","affiliation":[{"name":"Research Laboratory in Biomarkers in Reproduction, Obstetrics and Gynecology, Research Foundation, General University Hospital of Valencia, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Manuela","family":"Pena-Burgos","sequence":"additional","affiliation":[{"name":"Department of Pathology, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9246-5766","authenticated-orcid":false,"given":"B\u00e1rbara Andrea","family":"Mc Cormack","sequence":"additional","affiliation":[{"name":"Research Laboratory in Biomarkers in Reproduction, Obstetrics and Gynecology, Research Foundation, General University Hospital of Valencia, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarai","family":"Tom\u00e1s-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Research Laboratory in Biomarkers in Reproduction, Obstetrics and Gynecology, Research Foundation, General University Hospital of Valencia, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Gilabert-Estell\u00e9s","sequence":"additional","affiliation":[{"name":"Research Laboratory in Biomarkers in Reproduction, Obstetrics and Gynecology, Research Foundation, General University Hospital of Valencia, 46014 Valencia, Spain"},{"name":"Department of Obstetrics and Gynecology, General University Hospital of Valencia, 46014 Valencia, Spain"},{"name":"Department of Paediatrics, Obstetrics and Gynaecology, University of Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"L\u00f3pez-Carrasco","sequence":"additional","affiliation":[{"name":"Department of Gynecology, La Paz University Hospital, 28046 Madrid, Spain"},{"name":"Research Institute \u201cIdiPaz\u201d, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Hidalgo","sequence":"additional","affiliation":[{"name":"Department of Radiology, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4401-3084","authenticated-orcid":false,"given":"Martina Aida","family":"\u00c1ngeles","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Institut Claudius Regaud-Institut Universitaire du Cancer du Toulouse (IUCT) Oncopole, 31059 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Redondo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Gallego","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Gynecology, La Paz University Hospital, 28046 Madrid, Spain"},{"name":"Research Institute \u201cIdiPaz\u201d, La Paz University Hospital, 28046 Madrid, Spain"},{"name":"Department of Obstetrics and Gynaecology, Universidad Aut\u00f3noma Madrid, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"ref_1","first-page":"564","article-title":"The Endometrial Immune Environment of Women with Endometriosis","volume":"25","author":"Houshdaran","year":"2019","journal-title":"Hum. 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