{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:50:34Z","timestamp":1782978634046,"version":"3.54.5"},"reference-count":61,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research to Prevent Blindness","award":["JCYJ20180507183409601"],"award-info":[{"award-number":["JCYJ20180507183409601"]}]},{"name":"Research to Prevent Blindness","award":["P0039545"],"award-info":[{"award-number":["P0039545"]}]},{"name":"Research to Prevent Blindness","award":["P0039595"],"award-info":[{"award-number":["P0039595"]}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Commission","doi-asserted-by":"publisher","award":["JCYJ20180507183409601"],"award-info":[{"award-number":["JCYJ20180507183409601"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Commission","doi-asserted-by":"publisher","award":["P0039545"],"award-info":[{"award-number":["P0039545"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Commission","doi-asserted-by":"publisher","award":["P0039595"],"award-info":[{"award-number":["P0039595"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Centre for SHARP Vision","award":["JCYJ20180507183409601"],"award-info":[{"award-number":["JCYJ20180507183409601"]}]},{"name":"Research Centre for SHARP Vision","award":["P0039545"],"award-info":[{"award-number":["P0039545"]}]},{"name":"Research Centre for SHARP Vision","award":["P0039595"],"award-info":[{"award-number":["P0039595"]}]},{"name":"InnoHK initiative and the Hong Kong Special Administrative Region Government","award":["JCYJ20180507183409601"],"award-info":[{"award-number":["JCYJ20180507183409601"]}]},{"name":"InnoHK initiative and the Hong Kong Special Administrative Region Government","award":["P0039545"],"award-info":[{"award-number":["P0039545"]}]},{"name":"InnoHK initiative and the Hong Kong Special Administrative Region Government","award":["P0039595"],"award-info":[{"award-number":["P0039595"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>To explore the temporal profile of retinal proteomes specific to primary and secondary retinal ganglion cell (RGC) loss. Unilateral partial optic nerve transection (pONT) was performed on the temporal side of the rat optic nerve. Temporal and nasal retinal samples were collected at 1, 4 and 8 weeks after pONT (n = 4 each) for non-biased profiling with a high-resolution hybrid quadrupole time-of-flight mass spectrometry running on label-free SWATHTM acquisition (SCIEX). An information-dependent acquisition ion library was generated using ProteinPilot 5.0 and OneOmics cloud bioinformatics. Combined proteome analysis detected 2531 proteins with a false discovery rate of &lt;1%. Compared to the nasal retina, 10, 25 and 61 significantly regulated proteins were found in the temporal retina at 1, 4, and 8 weeks, respectively (p &lt; 0.05, FC \u2265 1.4 or \u22640.7). Eight proteins (ALDH1A1, TRY10, GFAP, HBB-B1, ALB, CDC42, SNCG, NEFL) were differentially expressed for at least two time points. The expressions of ALDH1A1 and SNCG at nerve fibers were decreased along with axonal loss. Increased ALDH1A1 localization in the inner nuclear layer suggested stress response. Increased GFAP expression demonstrated regional reactivity of astrocytes and Muller cells. Meta-analysis of gene ontology showed a pronounced difference in endopeptidase and peptidase inhibitor activity. Temporal proteomic profiling demonstrates established and novel protein targets associated with RGC damage.<\/jats:p>","DOI":"10.3390\/ijms241512109","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T07:35:24Z","timestamp":1690529724000},"page":"12109","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Differential Responses of Retinal Neurons and Glia Revealed via Proteomic Analysis on Primary and Secondary Retinal Ganglion Cell Degeneration"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6968-1754","authenticated-orcid":false,"given":"Jacky M. K.","family":"Kwong","sequence":"first","affiliation":[{"name":"Ophthalmology, Stein Eye Institute, University of California Los Angeles, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Caprioli","sequence":"additional","affiliation":[{"name":"Ophthalmology, Stein Eye Institute, University of California Los Angeles, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne C. Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Ophthalmology, Stein Eye Institute, University of California Los Angeles, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Song","sequence":"additional","affiliation":[{"name":"Ophthalmology, Stein Eye Institute, University of California Los Angeles, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8719-2217","authenticated-orcid":false,"given":"Feng-Juan","family":"Yu","sequence":"additional","affiliation":[{"name":"Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China"},{"name":"Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0464-1705","authenticated-orcid":false,"given":"Jingfang","family":"Bian","sequence":"additional","affiliation":[{"name":"Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China"},{"name":"Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2724-8968","authenticated-orcid":false,"given":"Ying-Hon","family":"Sze","sequence":"additional","affiliation":[{"name":"Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"King-Kit","family":"Li","sequence":"additional","affiliation":[{"name":"Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7720-7507","authenticated-orcid":false,"given":"Chi-Wai","family":"Do","sequence":"additional","affiliation":[{"name":"Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China"},{"name":"Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Hong Kong, China"},{"name":"Centre for Eye and Vision Research (CEVR), The Hong Kong Polytechnic University, 17W, Hong Kong Science Park, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1938-8397","authenticated-orcid":false,"given":"Chi-Ho","family":"To","sequence":"additional","affiliation":[{"name":"Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China"},{"name":"Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Hong Kong, China"},{"name":"Centre for Eye and Vision Research (CEVR), The Hong Kong Polytechnic University, 17W, Hong Kong Science Park, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3511-5620","authenticated-orcid":false,"given":"Thomas Chuen","family":"Lam","sequence":"additional","affiliation":[{"name":"Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China"},{"name":"Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Hong Kong, China"},{"name":"Centre for Eye and Vision Research (CEVR), The Hong Kong Polytechnic University, 17W, Hong Kong Science Park, Hong Kong, China"},{"name":"Shenzhen Research Institute, The Hong Kong Polytechnic University, Shenzhen 518052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"740939","DOI":"10.3389\/fphys.2021.740939","article-title":"Traumatic Brain Injury: Mechanisms of Glial Response","volume":"12","author":"Mira","year":"2021","journal-title":"Front. 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