{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:17:40Z","timestamp":1768439860487,"version":"3.49.0"},"reference-count":83,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Telocytes\/CD34+ stromal cells (TCs\/CD34+ SCs) have been studied in numerous organs and tissues, but their presence and characteristics in the parathyroid glands have not been explored. Using immunological and ultrastructural procedures, we assess the location, arrangement, and behavior of TCs\/CD34+ SCs in normal human parathyroids, during their development and in their most frequent pathologic conditions. In normal parathyroids, TCs\/CD34+ SCs show a small somatic body and long thin processes with a moniliform aspect, form labyrinthine systems, connect other neighboring TCs\/CD34+ SCs, vessels, adipocytes, and parenchymal cells directly or by extracellular vesicles, and associate with collagen I. TCs\/CD34+ SCs and collagen I are absent around vessels and adipocytes within parenchymal clusters. In developing parathyroids, TCs\/CD34+ SC surround small parenchymal nests and adipocytes. In hyperplastic parathyroids, TCs\/CD34+ SCs are prominent in some thickened internodular septa and surround small extraglandular parenchymal cell nests. TCs\/CD34+ SCs are present in delimiting regions with compressed parathyroids and their capsule in adenomas but absent in most adenomatous tissue. In conclusion, TCs\/CD34+ SCs are an important cellular component in the human parathyroid stroma, except around vessels within parenchymal nests. They show typical characteristics, including those of connecting cells, are present in developing parathyroids, and participate in the most frequent parathyroid pathology, including hyperplastic and adenomatous parathyroids.<\/jats:p>","DOI":"10.3390\/ijms241512118","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T01:26:40Z","timestamp":1690766800000},"page":"12118","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Telocytes\/CD34+ Stromal Cells in the Normal, Hyperplastic, and Adenomatous Human Parathyroid Glands"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1449-8738","authenticated-orcid":false,"given":"Lucio","family":"D\u00edaz-Flores","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine, University of La Laguna, 38071 La Laguna, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine, University of La Laguna, 38071 La Laguna, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5457-0912","authenticated-orcid":false,"given":"Miriam","family":"Gonz\u00e1lez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine, University of La Laguna, 38071 La Laguna, Spain"},{"name":"Canary Biomedical Technology Institute, University of La Laguna, 38071 La Laguna, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria del Pino","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Pathology, Eurofins Megalab\u2013Hospiten Hospitals, 38100 La Laguna, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Luis","family":"Carrasco","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine, University of La Laguna, 38071 La Laguna, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4503-1148","authenticated-orcid":false,"given":"Juan Francisco","family":"Madrid","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Histology, School of Medicine, Campus of International Excellence \u201cCampus Mare Nostrum\u201d, IMIB-Arrixaca, University of Murcia, 30100 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Lucio","family":"D\u00edaz-Flores","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine, University of La Laguna, 38071 La Laguna, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/j.1582-4934.2010.01059.x","article-title":"Telocytes\u2014A case of serendipity: The winding way from interstitial cells of Cajal (ICC), via Interstitial Cajal-Like Cells (ICLC) to TELOCYTES","volume":"14","author":"Popescu","year":"2010","journal-title":"J. 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