{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T18:00:56Z","timestamp":1782237656111,"version":"3.54.5"},"reference-count":22,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T00:00:00Z","timestamp":1690588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education","award":["1M15\/1\/M\/MB\/N\/23"],"award-info":[{"award-number":["1M15\/1\/M\/MB\/N\/23"]}]},{"name":"Ministry of Science and Higher Education","award":["1M15\/1\/M\/MG\/N\/21-22"],"award-info":[{"award-number":["1M15\/1\/M\/MG\/N\/21-22"]}]},{"name":"Ministry of Science and Higher Education","award":["1M15\/2\/M\/MG\/N\/22\/23"],"award-info":[{"award-number":["1M15\/2\/M\/MG\/N\/22\/23"]}]},{"name":"Medical University of Warsaw","award":["1M15\/1\/M\/MB\/N\/23"],"award-info":[{"award-number":["1M15\/1\/M\/MB\/N\/23"]}]},{"name":"Medical University of Warsaw","award":["1M15\/1\/M\/MG\/N\/21-22"],"award-info":[{"award-number":["1M15\/1\/M\/MG\/N\/21-22"]}]},{"name":"Medical University of Warsaw","award":["1M15\/2\/M\/MG\/N\/22\/23"],"award-info":[{"award-number":["1M15\/2\/M\/MG\/N\/22\/23"]}]},{"name":"Department of Pathology, Faculty of Medicine, Academy of Silesia, Katowice, Poland","award":["1M15\/1\/M\/MB\/N\/23"],"award-info":[{"award-number":["1M15\/1\/M\/MB\/N\/23"]}]},{"name":"Department of Pathology, Faculty of Medicine, Academy of Silesia, Katowice, Poland","award":["1M15\/1\/M\/MG\/N\/21-22"],"award-info":[{"award-number":["1M15\/1\/M\/MG\/N\/21-22"]}]},{"name":"Department of Pathology, Faculty of Medicine, Academy of Silesia, Katowice, Poland","award":["1M15\/2\/M\/MG\/N\/22\/23"],"award-info":[{"award-number":["1M15\/2\/M\/MG\/N\/22\/23"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Homotypic entosis is a phenomenon in which one cancer cell invades a neighboring cancer cell and is closed entirely within its entotic vacuole. The fate of entosis can lead to inner cell death or survival. Recent evidence draws attention to entosis as a novel prognostic marker in breast cancer. Nevertheless, little is known about the quantity and quality of the process of entosis in human cancer specimens. Here, for the first time, we analyze the frequency of entotic figures in a case of NOS (Non-Other Specified) breast cancer with regard to location: the primary tumor, regional lymph node, and distant metastasis. For the identification of entotic figures, cells were stained using hematoxylin\/eosin and assessed using criteria proposed by Mackay. The majority of entotic figures (65%) were found in the lymph node, 27% were found in the primary tumor, and 8% were found in the far metastasis. In the far metastases, entotic figures demonstrated an altered, atypic morphology. Interestingly, in all locations, entosis did not show any signs of cell death. Moreover, the slides were stained for E-cadherin or Ki67, and we identified proliferating (Ki67-positive) inner and outer entotic cells. Therefore, we propose additional criteria for the identification of pro-survival entotic structures in diagnostic histopathology.<\/jats:p>","DOI":"10.3390\/ijms241512142","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T01:26:40Z","timestamp":1690766800000},"page":"12142","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Fate of Entosis: From the Beginning to the End in Untreated Advanced Breast Cancer"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5399-9645","authenticated-orcid":false,"given":"Ireneusz","family":"Dziuba","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Academy of Silesia, 40-555 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7371-0121","authenticated-orcid":false,"given":"Agata M.","family":"Gawel","sequence":"additional","affiliation":[{"name":"Histology and Embryology Students\u2019 Science Association, Department of Histology and Embryology, Faculty of Medicine, Medical University of Warsaw, 02-004 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2341-6976","authenticated-orcid":false,"given":"Pawe\u0142","family":"Tyrna","sequence":"additional","affiliation":[{"name":"Histology and Embryology Students\u2019 Science Association, Department of Histology and Embryology, Faculty of Medicine, Medical University of Warsaw, 02-004 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Rybczynska","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszynski University in Warsaw, 01-815 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6931-6431","authenticated-orcid":false,"given":"Lukasz P.","family":"Bialy","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Medical University of Warsaw, 02-004 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5192-6415","authenticated-orcid":false,"given":"Izabela","family":"Mlynarczuk-Bialy","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Medical University of Warsaw, 02-004 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.cell.2007.10.040","article-title":"A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion","volume":"131","author":"Overholtzer","year":"2007","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Mlynarczuk-Bialy, I., Dziuba, I., Sarnecka, A., Platos, E., Kowalczyk, M., Pels, K.K., Wilczynski, G.M., Wojcik, C., and Bialy, L.P. 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